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Hiding politics in plain sight

Open Journal of Obstetrics and Gynecology（妇产科期刊） 2024年第1期

作者： Victoria Mwiinga-Kalusopa Johanna E.Maree Concepta Kwaleyela patricia Katowa-Mukwato

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Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

作者： Strach patricia

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo patricia T.Jacobson Brandon J.Vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.Gary David A.Gudis Paule V.Joseph D.P.Devanand Terry E.Goldberg Jonathan B.Overdevest Columbia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COVID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVID olfaction post-COVID condition smell dysfunction

Intrinsically photosensitive retinal ganglion cells

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Science China(Life Sciences) 2010年第1期53卷 58-67页

作者： Gary E.PICKARD patricia J.SOLLARS School of Veterinary Medicine and Biomedical Sciences University of Nebraska

A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner *** intrinsically photosensitive retinal ganglion cells(ipRGCs) express a photopigment,melanopsin,that confers upon them the ability to respond to light in the absence of all rod and cone photoreceptor *** relatively few in number,ipRGCs extend their dendrites across large expanses of the retina making them ideally suited to function as irradiance detectors to assess changes in ambient light *** in ipRGCs appears to be mediated by transient receptor potential channels more closely resembling the phototransduction cascade of invertebrate rather than vertebrate *** convey irradiance information centrally via the optic nerve to influence several *** are the primary retinal input to the hypothalamic suprachiasmatic nucleus(SCN),a circadian oscillator and biological clock,and this input entrains the SCN to the day/night *** contribute irradiance signals that regulate pupil size and they also provide signals that interface with the autonomic nervous system to regulate rhythmic gene activity in major organs of the *** also provide excitatory drive to dopaminergic amacrine cells in the retina,providing a novel basis for the restructuring of retinal circuits by *** we review the ground-breaking discoveries,current progress and directions for future investigation.

关键词： melanopsin circadian rhythms suprachiasmatic nucleus retina pupillary light reflex

The role of antioxidant micronutrients in the rate of recovery of burn patients: a systematic review

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Burns & Trauma 2016年第3期4卷 192-198页

作者： Mary Adjepong Pius Agbenorku patricia Brown Ibok Oduro Department of Biochemistry College of ScienceKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Surgery Reconstructive Plastic Surgery&Burns UnitKomfo Anokye Teaching HospitalSchool of Medical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana

Burn injury can be detrimental to the health of individuals,meanwhile victims lose proteins and micronutrients in wound *** also experience extensive protein *** make them prone to *** patients also suffer a lot of emotional trauma that reduce nutrient *** aim of this paper was to review primary evidence on the effect of antioxidant micronutrients on the recovery rate of burn *** databases such as PubMed,BioMed,and Cochrane were systematically searched between January 1,2014,and January 30,*** include vitamin A,vitamin C,vitamin E,ascorbic acid,zinc,copper,selenium,tocopherol,carotenoids,dietary intake,supplementation,wound healing,infection,recovery rate,and burn *** systematic search was done to retrieve all published data from 1990 to 2013.A total of 518 journal articles were obtained,and after the removal of duplicates,reviews,commentaries,and studies with non-human subjects,11 papers were accepted for *** review considered only papers that were published,and there might be some unpublished data that may have been ***,the wound healing time and infection rates were reduced by the administration of the antioxidant *** review revealed that there was no such published work in developing countries and children were excluded from most *** was also stated clearly that there was no uniformity in burn management;hence,there is a need for more studies on burn management in various populations.

关键词： Burn Micronutrients Recovery Infection Tocopherol Carotenoids Ascorbic acid

Xanthogranulomatous cholecystitis mimicking gallbladder cancer and causing obstructive cholestasis

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 549-552页

作者： Paulo N Martins patricia sheiner Marcelo Facciuto Department of Surgery Transplant DivisionMassachusetts General HospitalHarvard Medical School Department of Surgery Division of Hepatobiliary Surgery and TransplantationNew York Medical College Division of Transplantation Mount Sinai Hospital

BACKGROUND: Xanthogranulomatous cholecystitis (XGC) is a destructive inflammatory disease of the gallbladder that can mimic gallbladder carcinoma. METHODS: We present the case of a 35-year-old Hispanic male complaining of right upper quadrant pain and jaundice for 2 months prior to admission. He denied a history of fever, nausea/ vomiting, and weight loss. The past medical history was relevant only for diabetes. He had no previous history of jaundice or previous operations. RESULTS: CA19-9 was slightly elevated (52 U/mL). Abdominal ultrasonography showed an irregular thickening of the gallbladder wall and no gallstones were detected. CT scan also revealed an irregular thickening of the wall of the gallbladder body suggestive of malignancy. At laparotomy, the mass was adherent to the duodenum and colon, and although the frozen section biopsy was negative, the intraoperative findings were suggestive of malignancy, and the patient underwent left liver trisegmentectomy, resection of the common bile duct and Roux-en-Y hepaticojejunostomy. Pathological examination unexpectedly revealed XGC without malignancy. CONCLUSIONS: Preoperative and intraoperative differential diagnosis of XGC from gallbladder carcinoma remains a challenge when it is associated with inflammatory involvement of surrounding tissues. Since gallbladder carcinoma and XGC may coexist, radical resection is justified when malignancy cannot be completely ruled out.

关键词： xanthogranulomatous cholecystitis gallbladder cancer obstructive cholestasis

Parametric study of spark plasma sintering of Al_(20)Cr_(20)Fe_(25)Ni_(25)Mn_(10) high entropy alloy with improved microhardness and corrosion

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International Journal of Minerals,Metallurgy and Materials 2022年第1期29卷 119-127页

作者： Andries Mthisi Nicholus Malatji A.patricia I.Popoola L.Rudolf Kanyane Department of Chemical Metallurgical and Materials EngineeringTshwane University of TechnologyP.M.B.X680PretoriaSouth Africa

Multicomponent Al_(20)Cr_(20)Fe_(25)Ni_(25)Mn_(10) alloys were synthesized using spark plasma sintering at different temperatures(800,900,and 1000℃)and holding times(4,8,and 12 min)to develop a high entropy alloy(HEA).The characteristics of spark plasma-synthesized(SPSed)alloys were experimentally explored through investigation of microstructures,microhardness,and corrosion using scanning electron microscopy coupled with energy dispersive spectroscopy(EDS),Vickers microhardness tester,and potentiodynamic polarization,*** diffraction(XRD)characterization was employed to identify the phases formed on the developed *** EDS results revealed that the alloys consisted of elements selected in this work irrespective of varying sintering *** XRD,EDS,and scanning electron microscopy collectively provided evidence that the fabricated alloys were characterized by globular microstructures exhibiting face-centered cubic phase,which was formed on a basis of solid solution *** finding implies that the SPSed alloy showed the features of *** alloy produced at 1000℃ and holding time of 12 min portrayed an optimal microhardness of HV 447.97,but the value decreased to HV 329.47 after heat *** same alloy showed an outstanding corrosion resistance *** increase in temperature resulted in an Al_(20)Cr_(20)Fe_(25)Ni_(25)Mn_(10) alloy with superior density,microhardness,and corrosion resistance over the other alloys developed at different parameters.

关键词： high entropy alloy spark plasma sintering microhardness corrosion

Metabolic disease and the liver: A review

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World Journal of Hepatology 2024年第1期16卷 33-40页

作者： Márcia Vargas sheila de Castro Cardoso Toniasso patricia G Riedel Camila Pereira Baldin Francielle Lopes dos Reis Robson Martins Pereira Maria Carlota Borba Brum Dvora Joveleviths Mario Reis Alvares-da-Silva Program of Graduate Science in Gastroenterology and Hepatology Federal University of Rio Grande do SulPorto Alegre 90040-060Rio Grande do SulBrazil School of Medicine Federal University of Rio Grande do SulPorto Alegre 90040-060Brazil Program of Graduate Science in Gastroenterology and Hepatology Clinicas Hospital of Porto AlegrePorto Alegre 90410000Brazil Medicine Faculty Federal University of Rio Grande do Sul Federal University of Rio Grande do SulPorto Alegre 90040-060Brazil Division of Gastroenterology and Hepatology Clinicas Hospital of Porto AlegrePorto Alegre 90035007Brazil

Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most common liver disease worldwide,with an estimated prevalence of 31%in Latin *** presence of metabolic comorbidities coexisting with liver disease varies substantially among *** is acknowledged that obesity is boosting the type 2 diabetes mellitus“epidemic,”and both conditions are significant contributors to the increasing number of patients with *** steatohepatitis represents a condition of chronic liver inflammation and is considered the most severe form of *** diagnosis is based on the presence of steatosis,noninvasive scores and altered liver *** scores of liver fibrosis,such as serum biomarkers,which should be used in primary care to rule out advanced fibrosis,are simple,inexpensive,and widely ***,guidelines from international hepatology societies recommend using noninvasive strategies to simplify case finding and management of high-risk patients with MASLD in clinical ***,there is no definite pharmacological treatment for the *** public health policies to treat patients with risk factors for MASLD prevention is essential.

关键词： Nonalcoholic fatty liver disease Primary care Metabolic risk Liver Metabolism

Mitochondria in the context of Parkinson's disease

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Neural Regeneration Research 2017年第2期12卷 214-215页

作者： patricia Villacé Rosa M.Mella Danel Kortazar Innoprot (Innovative Technologies in Biological Systems) Derio Spain

Introduction to the disease：Parkinson’s disease（PD）is the second most common neurodegenerative disease,affecting 1–2%of the population over the age of ***,bradikynesia,postural instability and tremor are the prin... 详细信息

关键词： Mitochondria in the context of Parkinson’s disease

Exploring a need for improved preclinical models of post-stroke depression

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Neural Regeneration Research 2016年第4期11卷 561-562页

作者： Nitish Mittal patricia D.Hurn Timothy Schallert College of Pharmacy University of Texas at AustinAustinTXUSA departments of neuroscience university of texas at austinAustinTXUSA departments of psychology university of texas at austinAustinTXUSA

Depression is one of the most common neuropsychiatric disorders associated with *** in three patients who suffer from a stroke,report having depression-like *** mean prevalence for major and minor depression amongst s... 详细信息

关键词： test SSRIs