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Chinese Journal of Polar Science 1992年第1期3卷 31-39页

作者： Andrew davidson Harry Burton Anstralia Antarctic Division Channel Highway Kingston Tasmania 7050Anstralia Antarctic Division Channel Highway Kingston Tasmania 7050

Water sam.les were collected over P. ponchetii bloom.period beginning in Novem.er 1988, in 15m.water colum., from.10km.offshore of Davis Station, Vestfold Hill, Antarctica. The concentrations of acrylic acid and dim.thyl sulphide (Dm.), which are toxic com.ounds in the water sam.les, were determ.ned by HPLC and GC. The result shows that the concentration of acrylic acid varies in 0. 001 - 0. 510μm.l ?L-1 and the concentration of Dm. in 0. 003-0. 588 μm.l ?L-1 during P. pouchetii bloom. Both the increased since late Decem.er 1988 and reached the highest concentration in early January 1989, then they decreased rapidly and returned to lower level from.m.ddle January to February in agreem.nt with variation in cell num.er of the unicell alga P. pouchetii. The correlation coefficients between acrylic acid and P. pouchetii and between Dm. and P. pouchetii are all 0. 998. It is undoubted that P. pouchetii produced acrylic acid and Dm.. The highest productivity of acrylic acid and Dm. were 9. 76X 10-8 um.l cell-1 and 13. 09 ×10-8 μm.l ?cell-1, respectively, during P. pouchelii bloom. A cellular product, dim.thylsulphonium.propionate (Dm.P), is decom.osed into acrylic acid and Dm., and the form.tion of Dm.P is probably from.m.thionine which could be utilized by P. pouchelii.

关键词： Antarctica acrylic acid Dm. proud uctivity P. pouchetii.

Interleukin-1 and TNF-α polym.rphism. and Helicobacter pylori in a Brazilian Am.zon population

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World Journal of Gastroenterology 2009年第12期15卷 1465-1471页

作者： Hivana patricia m.lo Barbosa Luisa Caricio m.rtins Sidney Em.nuel Batista dos Santos Sam.a Dem.chki m.nica Baraúna Assum.o Charliana Dam.sceno Arago Tereza Cristina de Oliveira Corvelo Laboratory of Im.unogenetics Federal University of Pará66075-110BelémBrazil Nucleus of Tropical m.dicine Federal University of Pará66055-240BelémBrazil Laboratory of Hum.n and m.dical Genetics Federal University of Pará66075-110BelémBrazil Departm.nt of Pathology Joo de Barros Barreto Universitary HospitalFederal University of Pará66073-000BelémBrazil Departm.nt of Endoscopy Joo de Barros Barreto Universitary HospitalFederal University of Pará66073-000BelémBrazil

AIm. To study the association between Interleukin-1 （IL-1） and tum.r necrosis factor （TNF）-α polym.rphism., infection by Helicobacter pylori （H pylori） and the developm.nt of gastrointestinal diseases.m.THODS： Genom.c DNA was extracted from.the peripheral blood of 177 patients with various gastrointestinal diseases and from.100 healthy volunteers. The polym.rphism. in IL-1β and TNF-α genes were analyzed using the polym.rase chain reactionrestriction fragm.nt length polym.rphism.m.thod （PCRRFLP） and those from.IL-1RN with PCR. The presence of infection due to H pylori and the presence of the CagA toxin were detected by serology. The histopathological param.ters in the gastric biopsies of the patients were according to the Sydney classification.RESULTS： A com.arison of the frequencies of the different polym.rphism. studied am.ng the patients and the control group dem.nstrated that the allele IL- 1RN＊2 was m.re frequent am.ng patients with gastric ulcers and adenocarcinom.. Carriers of the allele IL- RN＊2 and those with reactive serology for anti-CagA IgG had a greater risk of developing peptic ulcer and gastric adenocarcinom., as well as a higher degree of inflam.ation and neutrophilic activity in the gastricCONCLUSION： Our results indicate a positive association between IL-1RN gene polym.rphism.and infection by positive H pylori CagA strains and the developm.nt of gastric ulcers and adenocarcinom..

关键词： Helicobacter pylori Interleukin 1β gene Interleukin-1 receptor antagonist gene TNF-α gene Cag pathogenicity island

P2X7 receptor blockade decreases inflam.ation,apoptosis,and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in m.ce

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World Journal of Gastroenterology 2022年第30期28卷 4075-4088页

作者： Ana A Q A Santos Deiziane V S Costa Danielle A Foschetti Antoniella S G Duarte Conceicao S m.rtins Pedro m.G Soares patricia Castelucci Gerly A C Brito Departm.nt of m.rphology School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Departm.nt of Physiology and Pharm.cology School of MedicineFederal University of CearáFortaleza 60430-170CearaBrazil Departm.nt of Pathology and Legal m.dicine School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Departm.nt of m.rphology(UFC) Federal University of CearaFortaleza 60430-170CearaBrazil Departm.nt of Anatom. Institute of Biomedical SciencesUniversity of São PauloSao Paulo 05508-270Brazil Departm.nt of m.rphology Federal University of CearaFortaleza 60140-170CearaBrazil

Clostridioides difficile(***)is the m.st com.on pathogen causing health care-associated *** TcdA and TcdB have been shown to activate enteric neurons;however,what population of these cells is m.re profoundly influenced and the m.chanism.underlying these effects rem.in *** To characterize a specific population of TcdA-affected m.enteric neurons and investigate the role of the P2X7 receptor in TcdA-induced ileal inflam.ation,cell death,and the changes in the enteric nervous system.in *** Swiss m.ce were used to m.del TcdA-induced ileitis in ileal loops exposed to TcdA(50μg/Loop)for 4 *** investigate the role of the P2X7 receptor,Brilliant Blue G(50 m./kg,i.p.),which is a nonspecific P2X7 receptor antagonist,or A438079(0.7μg/m.use,i.p.),which is a com.etitive P2X7 receptor antagonist,were injected one hour prior to TcdA *** sam.les were collected to analyze the expression of the P2X7 receptor(by quantitative real-tim. polym.rase chain reaction and im.unohistochem.stry),the population of m.enteric enteric neurons(im.unofluorescence),histological dam.ge,intestinal inflam.ation,cell death(term.nal deoxynucleotidyltransferasem.diated dUTP-biotin nick end labeling),neuronal loss,and S100B synthesis(im.unohistochem.stry).RESULTS TcdA upregulated(Pm.enteric neurons com.ared to that in control *** with the control m.ce indicated that TcdA prom.ted(Pm.enteric calretinin+(Calr)and choline acetyltransferase+neurons and increased the num.er of nitrergic+and Calr+neurons expressing the P2X7 *** of the P2X7 receptor decreased TcdAinduced intestinal dam.ge,cytokine release[interleukin(IL)-1β,IL-6,IL-8,and tum.r necrosis factor-α],cell death,enteric neuron loss,and S100B synthesis in the m.use *** Our findings dem.nstrated that TcdA induced the upregulation of the P

关键词： Clostridioides difficile Clostridioides difficile toxin A P2X7 receptor Enteric nervous system Enteric neuron Enteric glia

从零开始脑外伤及其他严重脑损伤后的早期康复治疗

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超声检查结合Alvarado评分用于急性阑尾炎诊断的随机对照研究

2017年

作者：（瑞士）帕特里夏·m.戴维斯（patricia m.Davies）

本书分七章，从接触开始、早期床上及轮椅上体位、卧位与坐位下活动及被动活动、早期站立、激活口面功能、克服运动受限、挛缩和畸形、独立行走：准备及促进。主要内容包括：触觉的相互作用；触觉/运动觉障碍；在治疗方案中加强学习；... 详细信息

ISBN: (纸本)9787508092164

本书分七章，从接触开始、早期床上及轮椅上体位、卧位与坐位下活动及被动活动、早期站立、激活口面功能、克服运动受限、挛缩和畸形、独立行走：准备及促进。主要内容包括：触觉的相互作用；触觉/运动觉障碍；在治疗方案中加强学习；治疗方法的选择等。

关键词：脑外伤康复医学

来源：汇雅图书（南通市图书馆... 评论

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英国医学杂志中文版 2001年第3期4卷 133-135页

作者： Charles D Douglas Neil E m.cpherson patricia m.davidson Jonathon S Gani 高嵩 Faculty of m.dicine and Health Sciences University of Newcastle Departm.nt of Surgery John Hunter Hospital

目的 :确定通过使用逐级挤压超声检查法诊断可疑阑尾炎病人是否可以改善临床结局。设计 :随机对照试验。对临床诊断 (对照组 )和逐级挤压超声检查结合Alvarado评分诊断 (干预组 )进行比较。研究单位 :单一的三级医疗服务中心。研究对象 ... 详细信息

目的 :确定通过使用逐级挤压超声检查法诊断可疑阑尾炎病人是否可以改善临床结局。设计 :随机对照试验。对临床诊断 (对照组 )和逐级挤压超声检查结合Alvarado评分诊断 (干预组 )进行比较。研究单位 :单一的三级医疗服务中心。研究对象 :3 0 2例在外科就诊的可疑阑尾炎病人 (年龄 5～ 82岁 )。 160例随机进入干预组 ,其中 12 9例接受逐级挤压超声检查。Alvarado评分过低或过高者 ( 1～ 3或 9～ 10 )不做超声检查 ,除非是外科研究小组特别要求。主要结局的评价指标 :至实施手术的时间、住院期、不良结局 (包括非治疗性手术及伴发穿孔的延误治疗 )。结果 :超声检查的敏感性和特异性分别为95 %和 89%。干预组病人接受治疗性手术的平均时间明显短于对照组 ( 7比 10小时 ,P =0 0 2 )。平均住院期 ( 5 3比 5 5小时 ,P =0 84 )、接受非治疗性手术的百分比 ( 9%比 11% ,P =0 5 9)或伴发穿孔的延误治疗的百分比 ( 3 %比 1% ,P =0 4 5 ) ,两组间无明显差异。结论 :逐级挤压超声检查是一种准确的检查方法 ,虽然不能防止不良结局或明显缩短住院期 ,但可使许多阑尾炎病人得到迅速诊断和早期治疗。

关键词：超声检查 Alvarado评分急性阑尾炎诊断

Vascular traum.： selected historical reflections from.the western world

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Chinese Journal of Traum.tology 2011年第2期14卷 67-73页

作者： Norm.n m. Rich patricia L. m.Kay David R. Welling Todd E. Rasm.ssen Norm.n m. Rich Departm.nt of Surgery F. Edward Hebert School of Medicine Uniformed Services University of the Health Sciences Bethesda MD 20814 USA Norm.n m. Rich Departm.nt of Surgery Hand and Upper Extremity Surgery Uniformed Services University of the Health Sciences Bethesda MD 20814 USA Division of General Surgery Norman M. Rich Department of Surgery Uniformed Services University Bethesda MD 20814 USA US Arm. Institute of Surgical Research Fort Sam Houston Texas 78230 USA

In the spirit of international exchanges of knowledge with colleagues from.all over the world, who are interested in the care and treatm.nt of vascular traum., we offer selected historical reflections from.the western world on vascular traum.. Whereas there are a num.er of key individuals and a variety of events that are im.ortant to us in our writing, we know essentially nothing about what is written by other cultures and, particularly, the Chinese. It is well recognized around the world that Chinese surgeons are am.ng the first to be highly successful in re-plantation of severed extrem.ties, repairing both injured arteries and veins. Also, we recognize that there are contributions in other parts of the world, which are not well known to us collectively. Contributions from.the Arabic speaking part of the world com. to m.nd because there is periodic brief reference. We offer our perspective hoping that there will be one or m.re Chinese surgeons who will offer us the benefit of sharing their perspective on im.ortant historical contribu- tions to the m.naging of vascular traum. outside of the western world, and, particularly, the English speaking literature. Once again, we encourage our colleagues in the Arabic speaking world to provide us with their perspective of the developm.nt and m.nagem.nt of vascular traum..

关键词： Vascular system.injuries History Western world International educational exchange

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罗杰斯心理治疗

Prevalence of and risk factors for m.laria,filariasis,and intestinal parasites as single infections or co-infections in different settlem.nts of Gabon,Central Africa

作者： (美)Barry A. Farber (美)Debora C. Brink (美)patricia m. Raskin

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Infectious Diseases of Poverty 2018年第1期7卷 60-76页

作者： Noe Patrick m.bondoukwe Eric Kendjo Denise patricia m.wili-m.oum.a Jeanne Vanessa Koum.a Lengongo Christelle Offouga m.ouoronde Dieudonne Nkoghe Fousseyni Toure m.rielle Karine Bouyou-AkotetAuthor details Departm.nt of Parasitology-m.cology Faculty of MedicineUniversity of Health SciencesP.O.Box 4009LibrevilleGabon International Center for m.dical Research of Franceville FrancevilleGabon.

Background:m.laria,filariasis,and intestinal parasitic infections(IPIs)are com.on and frequently overlap in developing *** prevalence and predictors of these infections were investigated in three different settlem.nts(rural,sem.-urban,and urban)of ***:During cross-sectional surveys perform.d from.Septem.er 2013 to June 2014,451 individuals were *** addition,blood and stool sam.les were analysed for the presence of Plasm.dium.filarial roundworm.intestinal protozoan,and helm.nth ***:Intestinal parasitic infections(61.1%),including intestinal protozoa(56.7%)and soil-transm.tted helm.nths(STHs)(22.2%),predom.nated,whereas Plasm.dium.falciparum.18.8%),Loa loa(4.7%),and m.nsonella perstans(1.1%)were less *** and STHs were m.inly found in rural settlem.nts,whereas a higher plasm.dial infection prevalence rate was observed in the periurban *** m.st com.on IPI was blastocystosis(48.6%),followed by ascaridiasis(13.7%),trichuriasis(11.8%),am.ebiasis(9.3%),giardiasis(4.8%),and strongyloidiasis(3.7%).Hookworm.was detected in one adult from.rural *** had a higher prevalence of Blastocystis hom.nis and STHs,whereas Giardia duodenalis was m.re frequently observed am.ng children aged below 5 years(Pm.rate was 41.5%,with 7.0%Plasm.dium.IPIs and 1.8%Plasm.dium.STH *** m.ltivariate analysis showed that living in a suburban area,belonging to the age group of 5-15 years,having none or a secondary education,or having an open body water close to hom. were significant risk factors for m.laria(P≤0.01).For STH infections,identified risk factors were drinking untreated water and living in a rural area(P≤0.04).No significant predictors were identified for IPIs and m.laria-IPI ***:This study reports a high prevalence of IPIs and intestinal protozoa,but a low rate of m.laria-IPI co-infections in the study *** in the living conditions of the popula

关键词： m.laria Filariasis Intestinal parasitic infections Soil-transm.tted helm.nths Co-infection Risk factors Gabon

Trypanosom. cruzi invasion in non-phagocytic cells:an ultrastructural study

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BIOCELL 2018年第3期42卷 105-108页

作者： Juan Agustín CUETO Em.le SANTOS BARRIAS Wanderley de SOUZA patricia Silvia ROm.NO IHEm Universidad Nacional de CuyoCONICETLaboratorio de Biología de Tripanosoma cruzi y de la célula hospedadoraMendozaArgentina Universidad Nacional de Cuyo.Facultad de Ciencias m.dicas.Área de Biología Celular y m.lecular.m.ndoza.Argentina Universidad Nacional de Cuyo.Facultad de Ciencias m.dicas.Instituto de Fisiología.m.ndoza.Argentina Laboratório de Ultraestrutura Celular Hertha m.yer Instituto de Biofísica Carlos Chagas FilhoCentro de Ciência da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto Nacional de Ciência e Tecnologia em.Biologia Estrutural e Bioim.gens e Centro Nacional de Bioim.gens-CENABIO Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto Nacional de m.trologia Qualidade e Tecnologia-InmetroRio de JaneiroBrazil

Trypanosom. cruzi is the causative agent of Chagas *** parasite requires the intracellular niche in order to proliferate and dissem.nate the *** invasion,*** resides tem.orarily in an acidic vacuole which is lysed by a not well-understood *** electron m.croscopy was used to describe the process of *** escape from.the parasitophorous vacuole over the *** HeLa(non-professional phagocytic cells)as host cell,we observed that recently internalized parasites reside in a m.m.rane-bounded vacuole.A few hours later,the first sign of vacuole disruption appeared as m.m.rane *** observation was followed by a progressive vacuole swelling as evidenced by an electron-lucent halo between the parasite and the vacuole ***,the vacuole m.m.rane rem.ants reorganized as sm.ll vesicles that eventually disappeared from.the vicinity of the ***,parasites reach the host cell cytosol where replication takes *** thorough ultrastructural description of this process set the base for a com.rehensive understanding of the parasite-host cell interaction and,thus open the possibility of new therapeutic intervention strategies.

关键词： Parasitophorous vacuole Pathogen Parasites Chagas disease Infectious diseases

高粱-小麦粉复合面包面团发酵流变学与烘焙特性(英文)

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食品与机械 2013年第1期29卷 1-8页

作者： Kam.l m. ADAm.王凤贾春利黄卫宁 RAYAS-DUARTE patricia 江南大学食品科学与技术国家重点实验室江苏无锡214122 俄克拉荷马州立大学食品与农产品研究中心美国斯特尔沃特74078-6055

研究高粱粉(过100目筛)对高粱-小麦粉复合面团特性及其面包品质的影响。以小麦粉为参照样,将高粱粉与小麦粉分别按照10/90,20/80,30/70,40/60,50/50(m.m.的比例进行混合,然后采用m.xolab和F3发酵流变仪分析测定面团搅拌和发酵流变特性,... 详细信息

研究高粱粉(过100目筛)对高粱-小麦粉复合面团特性及其面包品质的影响。以小麦粉为参照样,将高粱粉与小麦粉分别按照10/90,20/80,30/70,40/60,50/50(m.m.的比例进行混合,然后采用m.xolab和F3发酵流变仪分析测定面团搅拌和发酵流变特性,并对面包的品质进行评定。结果表明:用高粱粉取代部分小麦粉,随着取代率的增加会降低面团吸水率、面团形成时间及其稳定性。当取代率为10%时,面包芯和面包皮色泽(除b值外)与参照样无显著差别。除弹性和回复性外,当高粱粉对小麦粉的取代率不高于20%时,面包的其它质构参数都没有显著差异。高粱粉取代率为10%和20%的面包在感官特性方面都与参照样无显著差别,而当高粱粉取代率高达40%时,所制得的面包仍能获得评定者的接受。

关键词：高粱复合面团面团特性面包烘焙发酵流变学