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Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da silva Abreu Taysse Holanda Joice Farias do Nascimento Henety Nascimento Pinheiro Rachel Menezes Castelo Hélcio silva dos Santos Thais Benincá patrícia da silva Malheiros Júlio César Sousa Prado Raquel de Oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

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Supercritical fluid technology as a sustainable alternative method for textile dyeing:An approach on waste,energy,and CO_(2)emission reduction

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Journal of Environmental Sciences 2024年第6期140卷 123-145页

作者： Carlos Rafael silva de Oliveira patrícia Viera de Oliveira Leandro Pellenz Catia Rosana Lange de Aguiar Afonso Henrique da silva Júnior Federal University of Santa Catarina Textile Engineering Department2514 João Pessoa St.BlumenauSC89036-004Brazil Federal University of Santa Catarina Chemical Engineering DepartmentS/n Biotério Central St.FlorianópolisSC88040-900Brazil

The clothing industry is considered one of the most polluting industries on the planet due to the high consumption of water,energy,chemicals/dyes,and high generation of solid waste and *** with environmental concerns,the textile ennoblement sector is the most critical of the textile production chain,especially the traditional dyeing *** an alternative to current problems,dyeing with supercritical CO_(2)(scCO_(2))has been presented as a clean and efficient process for a sustainable textile *** fluid dyeing(SFD)has shown a growing interest due to its significant impact on environmental preservation and social,economic,and financial *** main SFD benefits include economy and reuse of non-adsorbed dyes;reduction of process time and energy expenditure;capture of atmospheric CO_(2)(greenhouse gas);use and recycling of CO_(2)in SFD;generation of carbon credits;water-free process;effluent-free process;reduction of CO_(2)emission and auxiliary *** being still a non-scalable and evolving technology,SFD is the future of *** review presented a comprehensive overview of the environmental impacts caused by traditional processes and confronted the advantages of *** SFD technique was introduced,along with its latest advances and future *** and environmental gains were also discussed.

关键词： Textile industry Supercritical dyeing Sustainable processes Water free dyeing Energy saving Cleaner production

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Adipose tissue,systematic inflammation,and neurodegenerative diseases

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Neural Regeneration Research 2023年第1期18卷 38-46页

作者： Ana Paula de A.Boleti Pedro Henrique de O.Cardoso Breno Emanuel F.Frihling patrícia Souza e silva Luiz Filipe R.Nde Moraes Ludovico Migliolo S-Inova Biotech Programa de Pós-Graduação em BiotecnologiaUniversidade Católica Dom BoscoCampo GrandeMSBrazil Programa de Pós-Graduação em Biologia Celular e Molecular Programa de Pós-Graduação em BioquímicaUniversidade Federal do Rio Grande do NorteNatalBrazil

Obesity is associated with several diseases,including mental *** tissue is distributed around the internal organs,acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the *** nutritional intake results in hypertrophy and proliferation of adipocytes,leading to local hypoxia in adipose tissue and changes in these adipokine *** leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory *** presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling,which can generate a neuroinflammatory *** this review,we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive *** also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain,particularly the hypothalamus and hippocampus,and that this is partially responsible for these negative cognitive *** addition,we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system.

关键词： adiposity anti-obesity drugs hypothalamic inflammation metabolic disease neurodegenerative disease neuroinflammation

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The spindle assembly checkpoint:perspectives in tumorigenesis and cancer therapy

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Frontiers in Biology 2011年第2期6卷 147-155页

作者： Joana BARBOSA Ana Vanessa NASCIMENTO Juliana FARIA patrícia silva Hassan BOUSBAA Centro de Investigação em Ciências da Saúde(CICS) Instituto Superior de Ciências da Saúde-NorteCESPURua Central de Gandra13174585-116 Gandra PRDPortugal

Loss or gain of chromosomes,a condition known as aneuploidy,is a common feature of tumor cells and has therefore been proposed as the driving force for *** chromosomal instability can arise during mitosis as a result of mis-segregation of the duplicated sister chromatids to the two daughter *** normal cells,missegregation is usually prevented by the spindle assembly checkpoint(SAC),a sophisticated surveillance mechanism that inhibits mitotic exit until all chromosomes have successfully achieved bipolar attachment to spindle *** abrogation of SAC activity is lethal to normal as well as to tumor cells,as a consequence of massive chromosome ***,many human aneuploid tumor cells exhibit a weakened SAC activity that allows them to tolerate gains or losses of a small number of chromosomes;and interfering with this SAC residual activity may constitute a suitable strategy to kill cancer *** review focuses on the potential link between SAC and tumorigenesis,and the therapeutic strategy to target the SAC for cancer treatment.

关键词： spindle assembly checkpoint mitosis chromosome instability tumor cancer therapy

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Load Static Models for Conservation Voltage Reduction in the Presence of Harmonics

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Energy and Power Engineering 2016年第2期8卷 62-75页

作者： William Douglas Caetano patrícia Romeiro da silva Jota Electrical Engineer Department Federal Centre of Technological Education (CEFET-MG) Belo Horizonte Brazil

The Conservation Voltage Reduction (CVR) is a technique that aims to achieve the decrease of power consumption as a result of voltage reduction. The customer is supplied with the lowest possible voltage level compatible with the stipulated level by the regulatory agency. International Standards ANSI C84.1-2006 and IEEE std 1250-1995 specify the range of supply voltage to electronics equipment from 0.9 to 1.05 pu of nominal voltage. To analyse the CVR effect in distribution systems with different load characteristics (residential, commercial, industrial or a combination of these), mathematical load models are used. Typically, these equipment/load models are used to analyse load aggregation without any consideration of its nonlinearity characteristics. Aiming to analyse the nonlinear characteristics and its consequences, this paper presents a discussion of the neglected variables as well as the results of a set of measurements of nonlinear loads. Different mathematical models are applied to obtain them for each load. Using these models the load aggregation is evaluated. It is presented that although the models show adequate results for individual loads, the same does not occur for aggregated models if the harmonic contribution is not considered. Consequently, to apply the load model in CVR it is necessary to consider the harmonics presence and the model has to be done using only the fundamental frequency data. The discussion about the causes is done and the models are compared with the measurements.

关键词： CVR Load Model in the Presence of Harmonics Conservation Voltage Reduction Load Model Aggregation in the Presence of Harmonics

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Antifungal activity of natural compounds against Candida species isolated from HIV-positive patients

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 750-752页

作者： Débora Oro Andréia Heissler Eliandra Mirlei Rossi Diane Scapin patrícia da silva Malheiros Everton Boff Microbiological Research and Diagnostic Laboratory Department of Biological and Health Sciences University of Western Santa Catarina Sao Miguel Oeste Hygiene and Food Microbiology Laboratory Department of Food Sciences Food Science and Technology Institute Federal University of Rio Grande do Sul

Objective: To evaluate the antifungal effect of Cinnamomum zeylanicum(C. zeylanicum) and Melaleuca alternifolia essential oils and honey against strains of Candida sp. from HIV-positive patients in order to subsidize new therapeutic strategies for ***: The study evaluated the antifungal effect of natural antimicrobials against 30 strains of Candida sp. isolated from oral cavities in HIV-infected patients. Then, they were compared to the action of fl uconazole and amphotericin B. Antifungal susceptibility was evaluated by the broth macrodilution technique and the minimum inhibitory concentration and the minimum fungicidal concentration were ***: Among all antifungals evaluated in this study, amphotericin B was the one showing the best results; however, all compounds studied here showed inhibitory activities against isolates of Candida sp. Honey(0.031 3 to 64 μg/m L) demonstrated fungistatic activity inhibiting 70% of the isolates. C. zeylanicum essential oil(0.031 3 to 64 μg/m L) inhibited 93.3% of the Candida strains and Melaleuca alternifolia essential oil(0.031 3 to 64 μg/m L) was able to inhibit 73.3% of ***: Therefore, all natural compounds evaluated in this study, especially C. zeylanicum essential oil, may become promising agents for oral candidiasis therapy including in HIV-positive patients.

关键词： Candida sp. Essential oils Honey HIV Susceptibility

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HVDC Grid Segmentation Analysis for Blackouts Reduction

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Journal of Power and Energy Engineering 2017年第3期5卷 36-48页

作者： Grazielle Jacinta Cardoso Santos patrícia Romeiro da silva Jota Electrical Engineer Department Federal Centre of Technological Education (CEFET-MG) Belo Horizonte Brazil

Segmentation of large AC systems through DC links introduces a new concept that utilizes the advantages of direct current transmission to improve network reliability and increase power transfer capacity. Technical literature argues that the segmentation of the AC network and the introduction of DC links at these systems connection points bring benefits to system operation, once contingencies generated on one side of the DC connection point would not be reflected on the other side of DC connection, thereby reducing the likelihood of cascading shutdowns and blackouts due to load restraint on transmission lines and transformers. Amidst this scenario, this paper presents a study of the main topics regarding the use of this new network segmentation philosophy, bringing a practical point of view for the use of this concept at the electrical power system planning. The effect of DC segmentation before a contingency that would initiate major outages in an adapted electrical system model IEEE-14 bus is studied and simulations have been performed with test HVAC systems and segmented by HVDC link. The results have been compared, principally in relation to the voltage bus, reactive power generation, system losses and power flow at the lines, and demonstrated that this new concept improved the grid reliability.

关键词： DC-Segmentation Grid Segmentation DC Link Blackouts Cascading Outages

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PV Characterization System Outdoors—Case Study in Brazil

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Journal of Power and Energy Engineering 2017年第12期5卷 119-132页

作者： Pedro Rodrigues silva patrícia Romeiro da silva Jota Ana Paula Batista Research Center of Smart Energy Electrical Engineer Department Federal Centre of Technological Education (CEFET-MG) Belo Horizonte Brazil

Photovoltaic modules (PV) are tested in the industry in standard conditions and their characteristics are given in the datasheet. After installation on the site, its performance is not evaluated separately of the other parts of the PV generator. Nevertheless some discrepancies of the expected generation and the measured ones are verified. To deal with these discrepancies it is worth characterizing the module on the site and acquire data in an easy and inexpensive way. This paper presents a proposed characterization system as well as its application. A module test was performed on a site located in Brazil. At these latitudes it is common to have high amount of ultraviolet components. The characterization system measures separately the ultraviolet component, as well as the visible and global irradiations. The results obtained are analyzed and the effect of the UV variation is observed, proving the importance of doing this characterization on site after implementation of the PV system.

关键词： Photovoltaic Solar Spectrum Ultraviolet

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Residential Load Curve Analysis during Electric Vehicle Charging

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Journal of Power and Energy Engineering 2017年第3期5卷 49-61页

作者： Fernanda Cristina Martins Cortezzi patrícia Romeiro da silva Jota Electrical Engineering Department Federal Center of Technological Education of Minas Gerais—CEFET-MG Belo Horizonte Brazil

With the objective to reduce the environmental pollution, alternative initiatives have favored the evolution of the electric vehicle (EV). As the electric vehicle depends solely on battery, the grid electric power is need for charging it. This new electric load can cause concern due to the impact of consume on power system. The behavior of main electric parameters is analyzed during the recharge of EV considering an actual condition of diary charge. In sequence, the data of these electric parameters obtained during EV charging were included on residential consumer energy from Brazil. The results contribute to the understanding of the recharge of EV in different time of the day which can affect the curve of residential consumer energy and consequently will affect in different way on Power System.

关键词： Electric Vehicle Electric Vehicle Charging Power System Residential Consume

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The Phytochemical Profile and Photoprotective Potential of Bark and Leaves of Erythrina velutina Willd.—A Medicinal Species from the Caatinga Region of Brazil

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Journal of Biosciences and Medicines 2023年第12期11卷 325-342页

作者： Bruno de Almeida Andrade Allan Jonathan Chernichiarro Corrêa Ana Klarissa Soares Gomes patrícia Maria da silva Neri Cruz Aline Michaele de Saint-George Albuquerque Cheron Valerium Thijan Nobre de Almeidae Castro Décio Henrique Araújo Salvadôr de Mello Cláudia Sampaio de Andrade Lima Ricardo Yara Elba Lúcia Cavalcanti de Amorim Department of Pharmaceutical Sciences Federal University of Pernambuco Recife Brazil Pharmacy Course Mauricio de Nassau University Center Recife Brazil Department of Biophysics Federal University of Pernambuco Recife Brazil Departament of Biomedical Engineering Federal University of Pernambuco Recife Brazil

The use of medicinal plants as therapeutic and economic resources has been on the rise in recent years. In Brazil, however, increasing doubt is being cast on the quality of these products, owing to the prevalence of adulteration and fraud. Solar radiation can cause serious damage to human skin, as a result, mostly, of ultraviolet light, which is a cause of skin cancer. Photoprotective substances are capable of absorbing, reflecting, or refracting ultraviolet radiation and thus protecting skin from exposure to sunlight. The present study aimed to characterize samples and examine the phytochemical profile and photoprotective potential of bark and leaves of Erythrina velutina Willd. The samples underwent five extraction methods using 80% ethanol. The phenolic content was measured using spectrophotometry. Antioxidant activity was examined using the DPPH and the photoprotective properties of the plant extracts were assessed using the method developed by Mansur. There was a quantitative difference in some groups of metabolites, with higher levels of tannin in the bark and of flavonoids in the leaves. The latter showed greater DPPH free radical scavenging capacity than the bark, although higher levels of SPF were obtained from the bark, with no statistically significant differences between methods. The results indicate that Erythrina velutina Willd. has potential as a photoprotector.

关键词： Phytochemical Caatinga Phytochemistry Sun Protection Factor (SPF)

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