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Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy

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World Journal of Gastroenterology 2013年第44期19卷 8056-8064页

作者： Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de matos Mnica Soldan Helena L Borges Joo C Machado Biomedical Engineering Program COPPE Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-972 Brazil Post-Graduation Program in Surgical Sciences Department of Surgery School of Medicine Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-972 Brazil Biomedical Science Institute Federal University of Rio de Janeiro Rio de JaneiroRJ 21941-972 Brazil Division of Gastroenterology Endoscopy UnitClementino Fraga Filho University Hospital Federal University of Rio de Janeiro RJ 21941-972 Brazil

AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic ***:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon *** was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM *** ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM *** image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall *** the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon *** the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and *** images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion ***:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and t

关键词： Ultrasound biomicroscopy Animal model Diagnostic imaging Colonic neoplasm Longitudinal study

Parenthood in Childbirth: Reports by Mothers and Fathers

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Advances in Reproductive Sciences 2022年第2期10卷 27-36页

作者： Mariana de Gouvêa matos Andrea Seixas Magalhães Renata Mello Department of Psychology Pontifical Catholic University of Rio de Janeiro Rio de Janeiro Brazil

Nowadays childbirth care in Brazil is mainly guided by the technocratic model, with a high rate of unnecessary interventions that may cause iatrogenesis. Emotional aspects inherent to birth tend to be disregarded in this scenario, which produces risks for the psychological health of the mother, father, and baby. The aim of this study was to look into the subjective experiences of fathers and mothers regarding childbirth in contemporary Brazil. For this purpose, a collective case study was carried out in which 30 birth reports published on personal blogs were analyzed, 15 written by women and 15 by men. The results pointed to the helplessness experienced by fathers and mothers in the face of technocratic care which may sometimes be violent, and to the idealization of health care professionals who work according to the humanized paradigm. The choice of the mode of delivery often appeared in the subjects’ discourse, denoting a scenario in which caesarean section is understood as a consumer good. Respect for the temporality of childbirth was considered essential to ensure that giving birth is not experienced in a traumatic way, and pain was reported as a central element to elaborate the symbolic death intrinsic to the process of parenthood appropriation. The lack of support from the environment seems to be a constitutive factor in the experience of obstetric violence and the writing of birth reports a resource to reinterpret this traumatic experience. We came to the conclusion that it is extremely important that the professional team be trained to understand the emotional aspects present in the childbirth experience, with interdisciplinary exchanges being a powerful resource to provide good quality of care for the parental couple.

关键词： Childbirth Humanization Obstetric Violence Parenthood Maternal Child Health

Exercise Training for the Elderly:Inflammaging and the Central Role for HSP70

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Journal of Science in Sport and Exercise 2019年第2期1卷 97-115页

作者： Carlos Henrique de Lemos Muller Jorge Roberto de matos Gisele Bettú Grigolo Helena Trevisan Schroeder Josianne Rodrigues-Krause Mauricio Krause Laboratory of Inflammation Metabolism and Exercise Research(LAPIMEX)and Laboratory of Cellular PhysiologyDepartment of PhysiologyInstitute of Basic Health SciencesFederal University of Rio Grande do SulSarmento Leite Street500Lab 0290050-170 Porto-AlegreRSBrazil School of Physical Education Physiotherapy and DanceFederal University of Rio Grande do SulPorto AlegreRSBrazil

Inflammation is a common feature of aging tissues,being involved in most,if not all,age-related *** origin of a low-grade inflammation state in aging(inflammaging)is multifactorial and may involve changes in body composition,immunosenescence,autophagy,microbiota modification and loss of *** heat shock response pathway(HSR,and HSP70 expression)plays an important role as a mechanism of resolution of inflammation and proteostasis *** this review,we sought to discuss the mechanisms that may lead to inflammaging,and the importance of the HSP70 in this ***,we also discuss how physical exercise,particularly resistance training,can improve the HSR and the inflammatory balance of elderly people.

关键词： Aging Inflammation Exercise training Cytokines Heat shock response HSP70

Lymphocyte subsets in alcoholic liver disease

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World Journal of Hepatology 2013年第2期5卷 46-55页

作者： Luís Costa matos Paulo Batista Nuno Monteiro Joo Ribeiro Maria A Cipriano Pedro Henriques Fernando Giro Armando Carvalho Faculty of Medicine of the University of Coimbra 3004-504 CoimbraPortugal Centro Hospitalar Tondela Viseu E.P.E3504-509 ViseuPortugal Department of Anatomopathology University of Coimbra Hospital3004-504 CoimbraPortugal

AIM:To compare lymphocyte subsets between healthy controls and alcoholics with liver ***:The patient cohort for this study included individuals who were suspected to have alcoholic liver disease(ALD) and who had undergone liver biopsy(for disease grading and staging,doubts about diagnosis,or concurrent liver disease;n = 56).Normal controls included patients who were admitted for elective cholecystectomy due to non-complicated gallstones(n = 27).Formalin-fixed,paraffin-embedded liver biopsy specimens were sectioned and stained with hematoxylin and eosin and Perls' Prussian *** non-alcoholic steatohepatitis score was used to assess markers of *** population subsets were determined by flow cytometry.T lymphocytes were identified(CD3+),and then further subdivided into CD4+ or CD8+ populations.B lymphocytes(CD19+) and natural killer(NK) cell numbers were also *** addition to assessing lymphocyte subpopulation differences between ALD patients and controls,we also compared subsets of alcoholic patients without cirrhosis or abstinent cirrhotic patients to normal ***:The patient cohort primarily consisted of older *** alcoholism was present in 66.1%.Reported average daily alcohol intake was 164.9 g and the average lifetime cumulative intake was 2211.6 *** was present in 39.3% of the patients and 66.1% had significant fibrosis(perisinusoidal and portal/periportal fibrosis,bridging fibrosis,or cirrhosis) in their liver *** average Mayo end-stage liver disease score was *** hereditary hemochromatosis genotypes were *** patients(n = 56) presented with significant lymphopenia(1.5 × 109/L ± 0.5 × 109/L vs 2.1 × 109/L ± 0.5 × 109/L,P < 0.0001),due to a decrease in all lymphocyte subpopulations,except for NK lymphocytes:CD3+(1013.0 ± 406.2/mm3 vs 1523.0 ± 364.6/mm3,P < 0.0001),CD4+(713.5 ± 284.7/mm3 vs 992.4 ± 274.7/mm3,P < 0.0001),CD8+(262.3 ± 140.4/mm3 vs 478.9 ± 164.6/mm3,P < 0.0001),and CD19+(120.6

关键词： Lymphocyte subsets Flow cytometry Alcoholism Alcoholic liver disease Liver fibrosis Liver biopsy HFE gene

Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 998-1010页

作者： Manoela Dias Susi de matos Lourenco Caroline Lucas Trevizani Rasmussen Spencer Luis Marques Payao Ana Flavia Teixeira Rossi Ana Elizabete Silva Juliana Garcia de Oliveira-Cucolo Department of Graduate-Level Research USCSacred Heart UniversityBauru 17011-970SPBrazil Department of Genetics and Molecular Biology FAMEMA-Marilia Medical SchoolMarília 17519-030SPBrazil Department of Biology Sao Paulo State University-UNESPSao Jose do Rio Preto 15054-000SPBrazil Department of Molecular Biological and Genetics and Molecular Biology Research Unit-UPGEMFaculty of Medicine of Sao Jose do Rio Preto-FAMERPSao Jose do Rio Preto 15090-000SPBrazil

BACKGROUND Toll-like receptors(TLRs)are the first line of host defense,and are involved in Helicobacter pylori(***)recognition and activation of both inflammatory and carcinogenic *** presence of single nucleotide polymorphisms(SNPs)in genes that activate the immune response may modulate the risk of precancerous lesions and gastric cancer(GC).Among them,Toll-like receptor 9(TLR9)polymorphisms have emerged with a risk factor of infectious diseases and cancer,however the studies are still *** To evaluate whether TLR9 rs5743836 and rs187084 SNPs contribute to the risk of gastric carcinogenesis,and its influence on mRNA *** A case-control study was conducted to evaluate two TLR9 SNPs(TLR9-1237 TCrs5743836 and TLR9-1486 CT-rs187084)in chronic gastritis(CG)and GC patients.A total of 609 DNA samples of peripheral blood[248 CG,161 GC,and 200 samples from healthy individuals(C)]were genotyped by polymerase chain reaction-restriction fragment length *** samples were tested for the *** infection using Hpx1 and Hpx2 *** polymerase chain reaction by TaqMan?assay was used to quantify TLR9 mRNA from fresh gastric tissues(48 GC,26 CG,and 14 C).RESULTS For TLR9-1237,the TC+CC or CC genotypes were associated with a higher risk of GC than C[recessive model odds ratio(OR)=5.01,95%confidence interval(CI):2.52-9.94,Pciation between the CT+TT genotypes and increased risk of both GC(dominant model OR=2.72,95%CI:1.57-4.72,P<0.0001)and CG(dominant model OR=1.79,95%CI:1.15-2.79,P=0.0094)was observed when compared to the C ***,the presence of TLR9-1237 TC/CC+TLR9-1486 CC genotypes potentiate the risk for this neoplasm(OR=18.57;95%CI:5.06-68.15,P<0.0001).The TLR9 mRNA level was significantly higher in the GC group(RQ=9.24,P<0.0001)in relation to the CG group(RQ=1.55,P=0.0010)and normal mucosa(RQ=1.0).When the sa

关键词： Toll-like receptor 9 Helicobacter pylori Gastric cancer Chronic gastritis Polymorphisms Gene expression

Association of Helicobacter pylori infection and giardiasis: Results from a study of surrogate markers for fecal exposure among children

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World Journal of Gastroenterology 2005年第18期11卷 2759-2763页

作者： Edson Duarte Moreira Jr Victor Bastos Nassri Rafaela Sousa Santos Junísia Ferraz matos Wilson Andrade de Carvalho Célia Stolve Silvani Círia Santana e Sant'Ana Núcleo de Apoio à Pesquisa Fundac■o Irm■ Dulce Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundac■o Oswaldo Cruz Salvador Bahia Brazil Diretoria Científica e Laboratório do Hospital S■o Rafael Salvador Bahia Brazil Núcleo de Apoio à Pesquisa Fundac■o Irm■Dulce Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundac■o Oswaldo Cruz Salvador Bahia Brazil Diretoria Científica e Laboratório do Hospital S■o Rafael Salvador Bahia Brazil Diretoria Científica e Laboratório do Hospital S■o Rafael Salvador Bahia Brazil Diretoria Científica e Laboratório do Hospital S(?)o Rafael Salvador Bahia Brazil Núcleo de Apoio à Pesquisa Fundac(?)o Irm(?) Dulce Salvador Bahia Brazil

AIM: To investigate whether Helicobacter pylori (H pylori) infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure. METHODS: We conducted a cross-sectional study in 121 children consecutively admitted at a pediatric hospital in Salvador, Brazil. H pyloriand HAV infection were identified by the presence of serum antibodies. Stool specimens were examined for the presence of ova and parasites. A structured questionnaire inquiring about sanitary conditions and life style was applied to each subject. RESULTS: Fifty-one of the 121 children (42.1%) were found to be seropositive for H pylori, and 45 (37.2%) for HAV. The seroprevalence of Hpyloriand HAV both increased significantly with age. Cross-tabulation of data showed that 26 (21.5%) were seropositive and 51 (42.1%) were negative for both H py/lriand HAV antibodies (x^2=7.18, OR=2.8, CI 1.30-5.97). The age adjusted OR for an HAV-infected child being H pylori positive was 2.3 (CI 1.02-5.03). The agreement between H pylori and HAV seropositivity was fair (k=0.24). After controlling for possible confounding, the variables remaining independently associated with seropositivity to H pylori were age, presence of Giardia lamblia in feces (OR=3.2, 95%CI, 1.1-9.5) and poor garbage disposal quality (OR=2.4, 95%CI, 1.1-5.1). CONCLUSION: Our data suggest that H pylori infection is associated with surrogate markers of fecal exposure. Thus, we conclude that the fecal-oral route is relevant in the transmission of HP among children in an urban setting of a developing country. The association observed between G. lamblia and H pylori infection may have several explanations. Further studies to investigate this relationship are warranted.

关键词： H pylori Hepatitis A virus Epidemiology Transmission Enteroparasites Brazil

Fine Needle Aspiration Cytology in the Diagnosis of Canine Cutaneous Transmissible Venereal Tumor—Case Report

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Open Journal of Veterinary Medicine 2014年第9期4卷 204-209页

作者： Noeme Sousa Rocha Talia Missen Tremori Joao Alexandre matos Carneiro Departament of Veterinary Clinic Faculty of Veterinary Medicine and Animal Science-UNESPBotucatuBrazil Department of Animal Reproduction and Veterinary Radiology Faculty of Veterinary Medicine and Animal Science-UNESPBotucatuBrazil

Fine needle aspiration cytology (FNAC) has been widely used in the diagnosis of lesions from various origins, especially neoplastic. The technique is simple, fast, safe, minimally invasive and inexpensive, which allows through the evaluation of cell morphology to establish prognosis, delineate surgical margins, monitor lesion growth, validate indication euthanasia during surgery and monitor chemotherapy protocols. Diagnosis of canine transmissible venereal tumor (TVT) can be accomplished with ease and precision, even to be rated, according to the degree of aggressiveness. The study objective was to demonstrate the effectiveness of the examination in the diagnosis of TVT plasmacytoid type. An eight-month dog presented to the veterinary hospital (HV), faculty of veterinary medicine and animal science, FMVZ, UNESP-Univ Estadual Paulista with clinical suspicion of cutaneous lymphoma. By presenting multiple nodular lesions, FNAC was performed to cytological diagnosis. The tissue showed cells consistent with TVT. The animal was treated, and a total cure was achieved. According to the literature, TVT mainly affects external genitalia of sexually active animals and its transmission is more frequent during intercourse. In addition, animals sexually immature and without contact to the street dogs, hardly have injuries by TVT. In this case, verrucous and ulcerated lesions on the vulva of its mother during pregnancy and childbirth infected the animal. Diffuse and predominant dorsal injuries occurred due to both exfoliation of breast tumor during delivery and immunosuppression of pup at birth, thus favoring an atypical transmission.

关键词： Cytological Diagnosis TVT Atypical Transmission

Characterization of Ultrasonic Metal Welding Process

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Journal of Environmental Science and Engineering(A) 2018年第3期7卷 125-131页

作者： Sandra matos Fernando Veloso Carlos Santos Leonardo Goncalves Emanuel Carvalho Department of Polymers University of Minho Guimaraes 4800-058 Portugal Engineering Department Aptiv Lisbon 1600-514 Portugal Polytechnic Institute of Setubal Setubal 2910-761 Portugal Superior Institute of Engineering Lisbon 1959-007 Portugal

The ultrasonic welding process for wires is being largely used on industry mainly on applications that involve the connectionbetween similar or different metals. The biggest benefit of this technology is the possibility to perform the weld without additionmaterials, like terminals, metal rings or tapes. Manufacturing of wiring harnesses demands a significant amount of joining, such aswelding, crimping or soldering, to fulfill the desired layout of the harnesses and capacity requirements, but conventional connectionprocesses, face difficulties in joining multiple cross sections mainly due to the characteristics of the processes and equipment in *** metal welding process overcomes these issues due to the solid-state characteristics inherent to the process itself that includethe excellent electrical properties of the joint. Several researches on ultrasonic metal welding are being done to define the fundamentalmechanisms behind this process and it is being seen that they are completely dependent on the cross section to be welded. With thisresearch we are trying to develop methods for process characterization and define acceptable quality parameters in this process. Themain topics addressed in this paper are the characterization the weld formation using copper-to-copper wires using optical microscopyand the analysis of insulation material when submitted to different thermal conditions.

关键词： Ultrasonic metal welding wiring harnesses insulated wires splices harness assemblies PVC (Polyvinyl Chloride)

An Overview of SWIPT Circuits and Systems

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ZTE Communications 2022年第2期20卷 13-18页

作者： Ricardo TORRES Diogo matos Felisberto PEREIRA Ricardo CORREIA Nuno Borges CARVALHO Department of Electronics telecommunications and informationUniversity of AveiroAveiro 3810Portugal Institute of Telecommunications Aveiro 3800Portugal CISeD-Research Center in Digital Services Polytechnic of ViseuViseu 3500Portugal Sinuta SA. Estarreja 3860Portugal AlmaScience Colab Madan ParqueCaparica 2829-516Portugal

From a circuit implementation perspective,this paper presents a brief overview of simultaneous wireless information and power transmission(SWIPT).By using zero-power batteryless wireless sensors,SWIPT mixes wireless power transmission with wireless communications to allow the truly practical implementation of the Internet of Things as well as many other *** this paper,technical backgrounds,problem formation,state-of-the-art solutions,circuit implementation examples,and system integrations of SWIPT are presented.

关键词： simultaneous wireless information and power transmission(SWIPT)systems backscatter communication low power commu⁃nication