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Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni Ana Júlio Celestino Santos-Buelga Ana M.Gonzalez-Paramas patrícia filipe patricia Rijo Sofia A.Costa Lima Salette Reis Angela Fernandes Isabel C.F.R.Ferreira Virginia Fernandez-Ruiz patricia Morales Guido Flamini Lotfi Achour Pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de Montanha(CIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly Center for Marine Sciences(CCMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of Chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were *** and DSC were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

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Adipose tissue,systematic inflammation,and neurodegenerative diseases

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Neural Regeneration Research 2023年第1期18卷 38-46页

作者： Ana Paula de A.Boleti Pedro Henrique de O.Cardoso Breno Emanuel F.Frihling patrícia Souza e Silva Luiz filipe R.Nde Moraes Ludovico Migliolo S-Inova Biotech Programa de Pós-Graduação em BiotecnologiaUniversidade Católica Dom BoscoCampo GrandeMSBrazil Programa de Pós-Graduação em Biologia Celular e Molecular Programa de Pós-Graduação em BioquímicaUniversidade Federal do Rio Grande do NorteNatalBrazil

Obesity is associated with several diseases,including mental *** tissue is distributed around the internal organs,acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the *** nutritional intake results in hypertrophy and proliferation of adipocytes,leading to local hypoxia in adipose tissue and changes in these adipokine *** leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory *** presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling,which can generate a neuroinflammatory *** this review,we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive *** also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain,particularly the hypothalamus and hippocampus,and that this is partially responsible for these negative cognitive *** addition,we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system.

关键词： adiposity anti-obesity drugs hypothalamic inflammation metabolic disease neurodegenerative disease neuroinflammation

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Antiglycation,antioxidant,antiacne,and photoprotective activities of crude extracts and triterpene saponin fraction of Sapindus saponaria ***:An in vitro study

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Asian Pacific Journal of Tropical Biomedicine 2022年第9期12卷 391-399页

作者： Regildo M.G.Silva Gustavo R.Martins Laura M.B.Nucci filipe O.Granero Célia C.M.Figueiredo patrícia S.Santiago Luciana P.Silva Laboratory of Herbal Medicine and Natural Products Department of BiotechnologyFaculty of SciencesHumanities and LanguagesSão Paulo State UniversityAssisSão PauloBrazil Institute of Chemistry São Paulo State UniversityAraraquaraSão PauloBrazil São Paulo State University Campus de RegistroRegistroSão PauloBrazil Fundação Educacional do Município de Assis AssisSão PauloBrazil

Objective:To evaluate the photoprotective,antioxidant,antiglycation,and antiacne activities of crude extract(CESs)and triterpene saponin fraction(TSSs)of Sapindus ***:HPLC-MS purification was performed on a Symmetry TM C18 *** saponins were identified by a UV *** activity was evaluated by DPPH and O_(2)^(−)radicals scavenging,and FRAP and TBARS *** activity was assessed by relative electrophoretic mobility and inhibition of advanced glycation end products(AGEs)***,antiacne activity was determined by inhibition of Cutibacterium acnes,and photoprotective effect was evaluated by Mansur’s ***:Most of the triterpene saponins detected in the fraction by HPLC-MS analysis were hederagenin as the *** and TSSs presented varying antioxidant activity in DPPH(CESs:75.69%and TSSs:83.65%),FRAP(CESs:425.39μM TE/g DW and TSSs:649.36μM TE/g DW),TBARS(CESs:42.96%and TSSs:52.16%)and O_(2)^(−)radicals scavenging(CESs:61.33%and TSSs:86.69%)*** and TSSs also exhibited antiglycation activity comparable to bovine serum albumin treated with *** addition,CESs and TSSs showed inhibition of AGE formation(34.48%and 61.85%,respectively).Antiacne activity against Cutibacterium acnes was observed with a minimum inhibitory concentration equal to minimum bactericidal concentration(CESs:36.11µg/mL and TSSs:18.34µg/mL).In photoprotective assays,CESs and TSSs showed maximum absorbance of 1.42 to 0.20 and 2.80 to 1.30,respectively,in the wavelength range of 260 to 400 ***,CESs and TSSs showed sun protection factors of 8.89 and 14.89,***:Sapindus saponaria fruit extracts show strong antioxidant potential and antiglycation activity against bovine serum albumin glycation and AGE ***,they presented antibacterial activity against Cutibacterium acnes and photoprotective effect against UV-A and UV-B.

关键词： Photoprotective AGE formation Free radical Antioxidant Triterpene saponin Sapindus saponaria

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The Igarape Weir decelerated transport of contaminated sediment in the Paraopeba River after the failure of the B1 tailings dam(Brumadinho)

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International Journal of Sediment Research 2023年第5期38卷 673-697页

作者： Daniela patrícia Salgado Terêncio Fernando António Leal Pacheco Renato Farias do Valle Junior Maytê Maria Abreu Pires de Melo Silva Teresa Cristina Tarlé Pissarra Marília Carvalho de Melo Carlos Alberto Valera Luís filipe Sanches Fernandes Inov4Agro/Centro de Investiga??o e Tecnologias Agroambientais e Biológicas Universidade de Trás-os-Montes e Alto Douro Centro de Química de Vila Real Universidade de Trás-os-Montes e Alto Douro Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista(UNESP) Via de Acesso Prof.Paulo Donato Castellane Instituto Federal do Triangulo Mineiro Campus Uberaba Laboratório de Geoprossessamento 5. Secretaria de Estado de Meio Ambiente e Desenvolvimento Sustentável Cidade Administrativa do Estado de Minas Gerais Rodovia Jo?o Paulo II 6. Coordenadoria Regional das Promotorias de Justi?a do Meio Ambiente das Bacias dos Rios Paranaíba e Baixo Rio Grande Rua Coronel Ant?nio Rios

The B1 dam of Co rrego do Feij～ao Mine, owned by Vale, S.A. mining company and located on the FerroCarv～ao stream, collapsed and injected 2.8 Mm3of clayey, silty, and sandy iron-and manganese-rich tailings into the Paraopeba River(Minas Gerais state, Brazil). The accident occurred on 25 January2019 and the tailings have been co-transported with coarser natural sediment since then, being partly trapped in the Igarape Weir reservoir located on the Paraopeba River nearly 45 km downstream the injection point. The general purpose of the current study was to model suspended sediment transport in the vicinity of the Igarape Weir aiming to assess the concomitant barrier effect imposed by this ***, the spatial distributions of suspended clay, silt, and very fine-grained sand fractions(CSS) of sediment were mapped around the Igarape Weir under low-flow(16 m3/s) and high-flow(5 to 10,000years return period stream discharge; 699—2,699 m3/s) regimes, using RiverFlow2D as the modelling tool. The concentrations of the various grain materials in the upstream and downstream sectors were quantified linking the barrier effect to concentration reductions in the direction of stream flow. It was also a study goal to calculate differences of iron and manganese concentrations in the sediment + tailings mixtures along the Paraopeba River. The study results showed reductions in the CSS between 6.6% and18%, from upstream to downstream of the Igarape Weir, related with backwater effects, free and submerged hydraulic jumps, bank sedimentation in periods of high flow, and streambed sedimentation controlled by channel sinuosity and tailings density. These reductions were accompanied by drops in the concentrations of iron and manganese present in the clay and silt fractions, which varied between 6% and42% under low flows and between 16% and 44% under high flows. Bank sedimentation was viewed as a potential threat to the riparian vegetation in the long-term. Dredging is the poten

关键词： Sediment transport Tailings dam break Metal contamination Hydrodynamic modelling RiverFlow2D Ratio concentration analysis

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Influence of PVD-duplex-treated, Bionic Surface Structures on the Wetting Behavior for Sheet-Bulk Metal Forming Tools

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Journal of Bionic Engineering 2017年第3期14卷 520-531页

作者： Wolfgang Tiilmann Dominic Stangier Nelson filipe Lopes Dias Institute of Materials Engineering TU Dortmund 44227 Dortmund Germany Leonhard-Euler-Strafle 2

Bionic surface structures, inspired by the flora, were developed for Sheet-Bulk Metal Forming （SBMF） in order to locally control the friction condition by adjusting the wetting behavior. Five bionic structures were micromilled on ASP 2023 in annealed as well as hardened and tempered conditions. Subsequently, the structured surfaces were plasma-nitrided and coated with a CrA1N thin film. The influence of the treatment method on the structural geometry was investigated with the aid of a scanning electron microscope and 3D-profilometer. The wetting behaviors of water and deep drawing oil （Berufluid ST6007） on bionic surfaces were evaluated using contact angle measurements. The resulting micro-milled structures exhibit an almost identical shape as their bionic models. However, the roughness of the structured surfaces is influenced by the microstructure. The combination of plasma-nitriding and Physical Vapor Deposition （PVD） leads to an increase in roughness. All bionic struc- tures possess higher contact angles than that of the unstructured surfaces when wetted by water. This can be explained by the fact that the structural elevations block the spreading. When the bionic surfaces are wetted by deep drawing oil, the lubricant spreads in the structural cavities, leading to smaller contact angles. Furthermore, the anisotropy of the structure has an influence on the wetting behavior.

关键词： bionic structures sheet-bulk metal forming CrA1N PVD-duplex treatment wetting behavior

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Fragility Assessment of Pre-Northridge Steel Moment Frames Using Finite-Length Plastic Hinge Elements and Concentrated Plasticity Fracture Elements

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Computer Modeling in Engineering & Sciences 2019年第9期120卷 657-676页

作者： filipe L.A.Ribeiro Andre RBarbosa Luis CNeves National Laboratory of Civil Engineering(LNEC)&CERIS-Civil Engineering Research and Innovation for Sustainability DECivilUniversity of LisbonLisbonPortugal School of Civil and Construction Engineering Oregon State UniversityOregonUSA and University of BristolBristolUK Resilience Engineering Research Group University of NottinghamNottinghamUK.

Although pre-Northridge earthquake steel moment resisting frame buildings have been shown to be susceptible to brittle connection failures,they still represent a large fraction of the existing steel buildings in the United States of *** this study,the performance of the 3-and 9-story Los Angeles pre-Northridge SAC buildings are analyzed considering ductile and brittle beam-column connection failures,and their *** paper contributes to understanding the influence of uncertainty associated with connections brittle fracture on building interstory deformation capacity and its impact on bias and variability of fragility functions and loss *** results show that considering brittle connections leads to significantly l arger d rift demands a nd t o h igher r epair costs,particularly under intense ground *** fragility curve parameters are derived that account for the effect of the uncertainty of the strength and deformation capacity of brittle connections.

关键词： Brittle fracture finite-length p lastic h inge f ragility c urves r epair c ost ratio welded-flange connections

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Laser texturing of piston ring for tribological performance improvement

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Friction 2023年第10期11卷 1895-1905页

作者： Rita FERREIRA Óscar CARVALHO Luís SOBRAL Sandra CARVALHO filipe SILVA CMEMS-UMinho University of MinhoGuimarães 4800058Portugal LABBELS-Associate Laboratory Guimarães 4800058Portugal CEMMPRE-Center for Mechanical Engineering Materials and ProcessesUniversity of CoimbraRua Luís Reis SantosCoimbra 3030-788Portugal MAHLE Componentes de MotoresS.A.Núcleo Industrial de MurtedeCantanhede 3060-372Portugal

The radial surface coating layer of compression piston rings is used to improve their wear resistance during the internal combustion engine ***,at top dead centers,the friction coefficient of the piston ring–cylinder liner pair is detrimental to the engine’s tribological *** this work,dimples with different texture dimensions and densities were tested in a home-developed *** friction coefficient was measured for all samples,and for those with the best results,their wear resistance was *** texture with an aspect ratio of 0.25 and a density area of 15%reported the best tribological results.

关键词： piston ring surface texture friction wear

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Nano-multilayered ZrN‒Ag/Mo‒S‒N film design for stable anti-frictional performance at a wide range of temperatures

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Friction 2024年第12期12卷 2826-2837页

作者： Hongbo JU Jing LUAN Junhua XU Albano CAVALEIRO Manuel EVARISTO filipe FERNANDES School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Department of Mechanical Engineering CEMMPREARISEUniversity of CoimbraRua Luís Reis SantosCoimbra 3030-788Portugal TINT-Laboratory for Tribology and Interface Nanotechnology Faculty of Mechanical EngineeringUniversity of LjubljanaAškerčeva 6Ljubljana 1000Slovenia CIDEM ISEP-Polytechnic of PortoRua Dr.António Bernardino de AlmeidaPorto 4249-015Portugal

A multilayer film,composed by ZrN‒Ag(20 nm)and Mo‒S‒N(10 nm)layers,combining the intrinsic lubricant characteristics of each layer was deposited using DC magnetron sputtering system,to promote lubrication in a wide-range of *** results showed that the ZrN‒Ag/Mo‒S‒N multilayer film exhibited a sharp interface between the different layers.A face-centered cubic(fcc)dual-phases of ZrN and Ag co-existed in the ZrN‒Ag layers,whilst the Mo‒S‒N layers displayed a mixture of hexagonal close-packed MoS_(2)(hcp-MoS_(2))nano-particles and an amorphous *** multilayer film exhibited excellent room temperature(RT)triblogical behavior,as compared to the individual monolayer film,due to the combination of a relative high hardness with the low friction properties of both *** reorientation of MoS_(2)parallel to the sliding direction also contributed to the enhanced anti-frictional performance at *** 400℃,the reorientation of MoS_(2)as well as the formation of MoO_(3)phase were responsible for the lubrication,whilst the hard t-ZrO_(2)phase promoted abrasion and,consequently,led to increasing wear *** 600℃,the Ag_(2)MoO_(4)double-metal oxide was the responsible for the low friction and wear-resistance;furthermore,the observed transformation from t-ZrO_(2)to m-ZrO_(2),could also have contributed to the better tribological performance.

关键词： DC magnetron sputtering ZrN‒Ag/Mo‒S‒N multilayer film tribological properties tribo-phases

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A review on the scale-up of high-shear wet granulation processes and the impact of process parameters

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Particuology 2024年第9期92卷 180-195页

作者： Ana Rita Alves Marta filipe Simões Sérgio Simões João Gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical *** most critical process parameters of HSG are discussed in this *** main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all *** scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based *** engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule *** work presents the effect of different HSG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling *** aim is to review applied scale-up approaches in HSG and discuss benefits and *** is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.

关键词： High-shear wetgranulation Parametric-based Attribute-based Physics-based modelling Impeller design Scale-up

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Adsorption and affinity of Escherichia coli to different aggregate sizes of a silty clay soil

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International Journal of Sediment Research 2013年第4期28卷 535-543页

作者： filipe BEHRENDS KRAEMER Celio Ignacio CHAGAS Diego Julian COSENTINO Lucas Alejandro GARIBALDI Department of Soil Use and Management School of Agronomy Buenos Aires University National University of Rio Negro Andina branch 4. Argentina and National Scientificand Technical Research Council(CONICET) Department of Edaphology School of Agronomy Buenos Aires University

The sediments produced by water erosion are the main source of pollution of agricultural origin of surface water *** sediments may be associated to bacteria,compromising the quality of nearby water ***,to understand this biological contamination,it is necessary to find out the adsorption capacity and bacterial affinity to aggregate sizes that may result in a differential *** this end,in the present work,the distribution,adsorption capacity and affinity to different aggregate sizes of two strains of Escherichia coli in two liquid media of contrasting ionic strength were evaluated in a silty clay *** 2 μm,the 20—50um fraction was the one that showed the highest bacterial adsorption in both liquid media(37.9%).On the other hand,the highest values of bacterial affinity were found in the 20 to 50 μm fraction(coarse silt) in the low ionic strength media and 20—50 and >50 μm in the high ionic strength ***,the bacterial strains used revealed only some trends in the modification of these *** work contributes to the development and implementation of strategies to mitigate pollution,such as control of sediment generation and its subsequent capture in filter strips.

关键词： Biological contamination Surface transport Water quality

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