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Potential Secretory Transporters and Biosynthetic Precursors of Biological Nitrification Inhibitor 1,9-decanediol in Rice as Revealed by Transcriptome and Metabolome Analyses

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Rice science 2024年第1期31卷 87-102页

作者： dI dongwei MA Mingkun ZHANG Xiaoyang LU Yufang Herbert j.KRONZUCKER SHI Weiming State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China School of Food Science and Engineering Foshan UniversityFoshan 528000China School of BioSciences The University of MelbourneParkvilleVIC 3010Australia University of Chinese Academy of Sciences Beijing 100049China

Biological nitrification inhibitors(BNIs)are released from plant roots and inhibit the nitrification activity of microorganisms in soils,reducing NO_(3)^(‒)leaching and N2O emissions,and increasing nitrogenuse efficiency(NUE).Several recent studies have focused on the identification of new BNIs,yet little is known about the genetic loci that govern their biosynthesis and *** applied a combined transcriptomic and metabolomic analysis to investigate possible biosynthetic pathways and transporters involved in the biosynthesis and release of BNI 1,9-decanediol(1,9-d),which was previously identified in rice root *** results linked four fatty acids,icosapentaenoic acid,linoleate,norlinolenic acid,and polyhydroxy-α,ω-divarboxylic acid,with 1,9-d biosynthesis and three transporter families,namely the ATP-binding cassette protein family,the multidrug and toxic compound extrusion family,and the major facilitator superfamily,with 1,9-d release from roots into the soil *** finding provided candidates for further work on the genes implicated in the biosynthesis and secretion of 1,9-d and pinpoint genetic loci for crop breeding to improve NUE by enhancing 1,9-d secretion,with the potential to reduce NO_(3)^(‒)leaching and N2O emissions from agricultural soils.

关键词： 1,9-decanediol biological nitrification inhibitor metabolomic analysis nitrogen-use efficiency transcriptomic analysis

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Pedotransfer Functions for Estimating Soil Hydraulic Properties： A Review

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Pedosphere 2016年第4期26卷 417-430页

作者： Nitin Gorakh patil Surendra Kumar SINGH National Bureau of Soil Survey and Land Use Planning Shankaruagar P.O.Amravati RoadNagpur 440010 India

Characterization of soil hydraulic properties is important to environment management; however, it is well recognized that it is laborious, time-consuming and expensive to directly measure soil hydraulic properties. This paper reviews the development of pedotransfer functions （PTFs） used as an alternative tool to estimate soil hydraulic properties during the last two decades. Modern soil survey techniques like satellite imagery/remote sensing has been used in developing PTFs. Compared to mechanistic approaches, empirical relationships between physical properties and hydraulic properties have received wide preference for predicting soil hydraulic properties. Many PTFs based on different parametric functions can be found in the literature. A number of researchers have pursued a universal function that can describe water retention characteristics of all types of soils, but no single function can be termed generic though van Cenuchten （VG） function has been the most widely adopted. Most of the reported parametric PTFs focus on estimation of VG parameters to obtain water retention curve （WRC）. A number of physical, morphological and chemical properties have been used as predictor variables in PTFs. Conventionally, regression algorithms/techniques （statistical/neurM regression） have been used for calibrating PTFs. However, there are reports of utilizing data mining techniques, e.g., pattern recognition and genetic algorithm. It is inferred that it is critical to refine the data used for calibration to improve the accuracy and reliability of the PTFs. Many statistical indices, including root mean square error （RMSE）, index of agreement （d）, maximum absolute error （ME）, mean absolute error （MAE）, coefficient of determination （r2） and correlation coefficient （r）, have been used by different researchers to evaluate and validate PTFs. It is argued that being location specific, research interest in PTFs will continue till generic PTFs are developed and validated. In future studi

关键词： database generic PTF hydraulic conductivity predictor properties PTF development tools regression statistical indices water retention curve

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Alexa,let's train now!——A systematic review and classification approach to digital and home-based physical training interventions aiming to support healthy cognitive aging

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journal of Sport and Health Science 2024年第1期13卷 30-46页

作者： Fabian Herold Paula Theobald Thomas Gronwald Navin Kaushal Liye Zou Eling d.de Bruin Louis Bherer Notger GMüller Research Group degenerative and Chronic diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam 14476Germany Body-Brain-Mind Laboratory Shenzhen UniversityShenzhen 518060China Institute of Interdisciplinary Exercise Science and Sports Medicine MSH Medical School HamburgHamburg 20457Germany department of Health Sciences School of Health&Human SciencesIndiana UniversityIndianapolisIN 46202USA department of Health Sciences and Technology Institute of Human Movement Sciences and SportETH ZurichZurich 8093Switzerland department of Neurobiology Care Sciencesand SocietyKarolinska InstituteStockholm 17177Sweden department of Health OST-Eastern Swiss University of Applied SciencesSt.Gallen 9001Switzerland Montreal Heart Institute MontrealQC H1T 1C8Canada department of Medicine Universite de MontrealMontrealQC H3T 1J4Canada Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal MontrealQC H3W 1W5Canada

Background:There is mounting evidence that regular physical activity is an important prerequisite for healthy cognitive ***,the finding that almost one-third of the adult population does not reach the recommended level of regular physical activity calls for further public health *** this context,digital and home-based physical training interventions might be a promising alternative to center-based intervention ***,this systematic review aimed to summarize the current state of the literature on the effects of digital and home-based physical training interventions on adult cognitive ***:In this pre-registered systematic review(PROSPERO;Id:CRd42022320031),5 electronic databases(PubMed,Web of Science,Psyclnfo,SPORTdiscus,and Cochrane Library)were searched by 2 independent researchers(FH and PT)to identify eligible studies investigating the effects of digital and home-based physical training interventions on cognitive performance in *** systematic literature search yielded 8258 records(extra17 records from other sources),of which 27 controlled trials were considered *** reviewers(FH and PT)independently extracted data and assessed the risk of bias using a modified version of the Tool for the assEssment of Study qualiTy and reporting in EXercise(TESTEX scale).Results:Of the 27 reviewed studies,15 reported positive effects on cognitive and motor-cognitive outcomes(i.e.,performance improvements in measures of executive functions,working memory,and choice stepping reaction test),and a considerable heterogeneity concerning study-related,population-related,and intervention-related characteristics was noticed.A more detailed analysis suggests that,in particular,interventions using online classes and technology-based exercise devices(i.e.,step-based exergames)can improve cognitive performance in healthy older *** one-half of the reviewed studies were rated as having a high risk of bias with respect

关键词： Brain Cognition digital health Exercise-cognition Physical activity

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Recent developments in Metallic degradable Micromotors for Biomedical and Environmental Remediation Applications

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Nano-Micro Letters 2024年第3期16卷 1-35页

作者： Sourav dutta Seungmin Noh Roger Sanchis Gual Xiangzhong Chen Salvador Pané Bradley j.Nelson Hongsoo Choi department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea dGIST‑ETH Microrobotics Research Center DGISTDaegu 42988Republic of Korea Multi‑Scale Robotics Lab Institute of Robotics and Intelligent SystemsETH Zurich8092 ZurichSwitzerland Institute of Optoelectronics State Key Laboratory of Photovoltaic Science and TechnologyShanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionFudan UniversityShanghai 200433People’s Republic of China

Synthetic micromotor has gained substantial attention in biomedicine and environmental ***-based degradable micromotor composed of magnesium(Mg),zinc(Zn),and iron(Fe)have promise due to their nontoxic fuel-free propulsion,favorable biocompatibility,and safe excretion of degradation products Recent advances in degradable metallic micromotor have shown their fast movement in complex biological media,efficient cargo delivery and favorable biocompatibility.A noteworthy number of degradable metal-based micromotors employ bubble propulsion,utilizing water as fuel to generate hydrogen *** novel feature has projected degradable metallic micromotors for active in vivo drug delivery *** addition,understanding the degradation mechanism of these micromotors is also a key parameter for their design and *** propulsion efficiency and life span govern the overall performance of a degradable metallic *** we review the design and recent advancements of metallic degradable ***,we describe the controlled degradation,efficient in vivo drug delivery,and built-in acid neutralization capabilities of degradable micromotors with versatile biomedical ***,we discuss micromotors’efficacy in detecting and destroying environmental ***,we address the limitations and future research directions of degradable metallic micromotors.

关键词： Magnesium Zinc Iron Biodegradable microrobot Biomedical Environmental

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Protective effect of Luffa acutangula extracts on gastric ulceration in NIddM rats:Role of gastric mucosal glycoproteins and antioxidants

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Asian Pacific journal of Tropical Medicine 2012年第8期5卷 610-615页

作者： B.P.Pimple P.V.Kadam M.j.patil P.E.Society's Modern College of Pharmacy NigdiPuneMaharashtraIndia.411044 and Jawaharlal Nehru Technological UniversityHyderabadAndhra PradeshIndia Marathwada Mitra Mandal's College of Pharmacy ThergaonPuneMaharashtraIndia 411033

Objective:To study the comparative gastroprotective effect of Luffa acutangula methanolic extract(LAM) and aqueous extract(LAW) on typeⅡdiabetes ***:Streptozotocin(65 mg/kg,Lp.) along with nicotinamide(120 mg/kg,Lp.) was used to induce non insulin dependent diabetes mellitus(NIddM) in rats.A daily oral dose of aspirin(200 mg/kg,Lp.) was administered for initial seven days to induce gastric ulcerations in the diabetic *** and LAW were administered orally in the doses of 100,200 and 400 mg/kg once daily for 21 *** and ranitidine were used as standards for comparing the antidiabetic and antiulcer effect ***:LAM significantly(Pd mucosal glycoprotein and antioxidant enzyme level in gastric mucosa of diabetic rats than LAW(P delayed healing of gastric ulcer in diabetic rats close to the normal *** exhibited better ulcer healing effect than glibenclamide and LAW,because of its both antihyperglycemic and mucosal defensive ***:Thus,LAM is proved to be a better alternative for treating gastric ulcers co-occurring with diabetes.

关键词： Aspirin Clibenclamide Nicotinamide Ranitidine Streptozotocin

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Automating selective area electron diffraction phase identification using machine learning

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journal of Materiomics 2024年第4期10卷 896-905页

作者： M.Mika N.Tomczak C.Finney j.Carter A.Aitkaliyeva Nuclear Engineering Program in department of Materials Science University of Florida100 Rhines HallGainesville32611FLUSA department of Materials Science&Engineering Case Western Reserve University2111 Martin Luther King Jr DrCleveland44106OHUSA

Selective area electron diffraction(SAEd)patterns can provide valuable insight into the structure of a ***,the manual identification of collected patterns can be a significant bottleneck in the overall phase classification *** this work,we utilize the recent advances in computer vision and machine learning(ML)to automate the indexing of SAEd *** performance of six different ML algorithms is demonstrated using metallic plutonium-zirconium *** most successful approach trained a neural network(NN)to make a classification of the phase and zone axis,and then utilized a second NN to synthesize multiple independent predictions of different tilts in a single sample to make an overall phase *** results demonstrate that automated SAEd phase identification using ML is a viable route to accelerate materials characterization.

关键词： Selective area electron diffraction Machine learning Phase identification Metallic fuels Pu alloys

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Co^(2+) substituted Mg–Cu–Zn ferrite: Evaluation of structural,magnetic,and electromagnetic properties

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journal of Advanced Ceramics 2018年第3期7卷 207-217页

作者： L.M.THORAT j.Y.patil d.Y.NAdARGI U.R.GHOdAKE R.C.KAMBALE S.S.SURYAVANSHI department of Electronics S.M.Dnyandeo Mohekar Mahavidyalaya School of Physical Sciences Solapur University department of Electronics Shri Shivaji Mahavidyalaya department of Physics Savitribai Phule Pune University

We report the synthesis of Co^(2+)substituted Mg–Cu–Zn ferrite via citrate gel combustion process and thereby its structural,transport,and magnetic properties for the use in electromagnetic energy absorption *** polycrystalline ferrite system is investigated by interplay of stoichiometric composition with Mg_(0.25–x)Co_x Cu_(0.25)Zn_(0.5)Fe_2O_4(0≤x≤0.25).Structural investigations using X-ray diffraction(XRd)and selected area electron diffraction(SAEd)reveal the formation of spinel structure with linear growth of lattice constant due to Co^(2+)*** microstructural analysis(TEM and SEM)depicts the dense microstructure with the average grain size of 0.42–1.25μ*** elemental analysis(EdS)confirms the elemental composition of the as-prepared ferrite with respect to the initial concentrations of the synthetic composition *** observed variations in initial permeability(μ_i)and magnetic moment(_Bn)are explained based on deviation in saturation magnetization(M_s),anisotropy constant(_1K),density values,and exchange *** temperature dependence of dC resistivity confirms the semiconducting behavior of the as-prepared ferrite material,with an increase in the dC resistivity by an incorporation of ***,the effects of adding Co^(2+)on the Curie temperature,frequency dependent dielectric properties of the ferrite material are also discussed.

关键词： Co-Mg-Cu-Zn ferrite spinel phase electrical resistivity saturation magnetization anisotropy constant Curie temperature

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development and characterization of 3d-printed electroconductive pHEMA-co-MAA NP-laden hydrogels for tissue engineering

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Bio-design and Manufacturing 2024年第3期7卷 262-276页

作者： Sara de Nitto Aleksandra Serafin Alexandra Karadimou Achim Schmalenberger john j.EMulvihill Maurice N.Collins dIBRIS Polytechnic Inter-School Section University of Genoa16126 GenoaItaly School of Engineering Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of Natural Sciences Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research Institute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue engineering(TE)continues to be widely explored as a potential solution to meet critical clinical needs for diseased tissue replacement and tissue *** this study,we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHEMA-co-MAA)based hydrogel loaded with newly synthesized conductive poly(3,4-ethylene-dioxythiophene)(PEdOT)and polypyrrole(PPy)nanoparticles(NPs),and subsequently processed these hydrogels into tissue engineered constructs via three-dimensional(3d)*** presence of the NPs was critical as they altered the rheological properties during ***,all samples exhibited suitable shear thinning properties,allowing for the development of an optimized processing window for 3d *** were 3d printed into pre-determined disk-shaped configurations of 2 and 10 mm in height and diameter,*** observed that the NPs disrupted the gel crosslinking efficiencies,leading to shorter degradation times and compressive mechanical properties ranging between 450 and 550 *** conductivity of the printed hydrogels increased along with the NP concentration to(5.10±0.37)×10^(−7)S/*** vitro studies with cortical astrocyte cell cultures demonstrated that exposure to the pHEMA-co-MAA NP hydrogels yielded high cellular viability and proliferation ***,hydrogel antimicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels affected bacterial *** together,these materials show promise for various TE strategies.

关键词： Conductive nanoparticles Hydroxyethyl methacrylate(HEMA) Ultraviolet(UV)polymerization 3d printing

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Magnetic Topological dirac Semimetal Transition driven by SOC in EuMg_(2)Bi_(2)

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Chinese Physics Letters 2024年第1期41卷 63-67页

作者：王佳萌钱浩吉姜琦乔山叶茂 State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Research Center for Intelligent Chips and devices Zhejiang LabHangzhou 311121China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Magnetic topological semimetals have been at the forefront of condensed matter physics due to their ability to exhibit exotic transport *** the interplay between magnetic and topological orders in systems with broken time-reversal symmetry is crucial for realizing non-trivial quantum *** delve into the electronic structure of the rare-earth-based antiferromagnetic dirac semimetal EuMg_(2)Bi_(2) using first-principles calculations and angle-resolved photoemission *** calculations reveal that the spin-orbit coupling(SOC)in EuMg_(2)Bi_(2) prompts an insulator to topological semimetal transition,with the dirac bands protected by crystal *** linearly dispersive states near the Fermi level,primarily originating from Bi 6p orbitals,are observed on both the(001)and(100)surfaces,confirming that EuMg_(2)Bi_(2) is a three-dimensional topological dirac *** research offers pivotal insights into the interplay between magnetism,SOC and topological phase transitions in spintronics applications.

关键词： spectroscopy topological dirac

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Phloretin-induced suppression of oxidative and nitrosative stress attenuates doxorubicin-induced cardiotoxicity in rats

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Asian Pacific journal of Tropical Biomedicine 2022年第3期12卷 124-131页

作者： Shivani S.Wagh Kalpesh R.patil Umesh B.Mahajan Pradnya d.Bagal Avinash R.Wadkar Basavraj Bommanhalli Prabhakar R.patil Sameer N.Goyal Shreesh Ojha Chandragouda R.patil department of Pharmacology R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia department of Pathology Gadag Institute of Medical SciencesGadagKarnatakaIndia department of Pharmacology Navodaya Medical CollegePost Box No:26Mantralayam RoadNavodaya NagarRaichur-584103KarnatakaIndia Shri Vile Parle Kelavani Mandal's Institute of Pharmacy Dhule-424001MaharashtraIndia department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityP.O.Box 17666Al AinAbu DhabiUAE department of Pharmacology Delhi Pharmaceutical Sciences and Research UniversityMehrauli-Badarpur RoadPushp Vihar Sector-3New Delhi-110017India

Objective:To compare the cardioprotective efficacy of equimolar doses(50 mM/kg,p.o.)of phloretin and genistein against doxorubicin-induced cardiotoxicity in ***:Cardiotoxicity was induced in rats by intraperitoneal injection of 6 mg/kg doxorubicin on alternative days till the cumulative dose reached 30 mg/*** study included four treatment groups of rats(n=6):the control group(0.5%carboxymethyl cellulose solution-treated),the doxorubicin-treated group(0.5%carboxymethyl cellulose solution along with doxorubicin),the genistein-treated group(50 mM/kg/day;*** with doxorubicin)and phloretin-treated group(50 mM/kg/day;*** with doxorubicin).On the 10th day of dosing,rats were anesthetized for recording ECG,mean arterial pressure,and left ventricular *** stress,nitric oxide levels,and inflammatory cytokines were estimated in the cardiac *** function parameters(creatine kinase MB,lactate dehydrogenase,aspartate aminotransferase,and alanine transaminase)were estimated in the serum ***:Phloretin treatment inhibited doxorubicin-induced oxidative stress and also reduced nitric oxide levels in cardiac tissues of *** administration attenuated doxorubicin-induced alterations in hemodynamic parameters(heart rate,mean arterial blood pressure,and left ventricular function)and suppressed the expression of pro-inflammatory *** cardiac injury markers like creatine kinase MB,lactate dehydrogenase,aspartate aminotransferase,and alanine transaminase were reduced by both genistein and *** these effects of phloretin were more prominent than ***:Phloretin offers cardioprotection that is comparable to genistein,a clinically validated cardioprotectant against doxorubicin-induced *** studies are needed to confirm and establish the therapeutic utility of phloretin as a chemopreventive adjuvant to doxorubicin chemotherapy.

关键词： Cardiotoxicity Chemoprevention doxorubicin Genistein Phloretin Phytoestrogens Cardiac injury Hemodynamic changes

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