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Immunovirological Discordance and Associated Factors among People Living with HIV under Antiretroviral Treatment at Hôpital de Jour de Donka, Guinea

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Open Journal of Medical Microbiology 2024年第2期14卷 93-104页

作者： Mariama Sadjo Diallo Djiba Kaba Charles Tchibinda Delicat Issiaga Diallo Boh Fanta Diane Doufin Traore Ousmane Niabaly Oumar Mouctar Diallo Ouo-Ouo Yaramon Kolie Aly Patrice Kamano pascal Koivogui Ahmed Sékou Keita Mohamed Macire Soumah Thierno Mamadou Tounkara Mohamed Cisse Facult des Sciences et Techniques de la Sant Universit Gamal Abdel Nasser de Conakry Conakry Guine Laboratoire de Biologie Molculaire Nestor Bangoura/Helene Labrousse Hpital de Jour Donka CHU Donka Conakry Guine Centre dExcellence Africain Pour la Prvention et le Contrle des Maladies Transmissibles Conakry Guine Service de Dermatologie-Vnrologie CHU Donka Conakry Guine

The antiretroviral treatment (ART) has significantly reduced the number of new HIV/AIDS infections and related deaths. However, cases of immunovirological discordance (IVD) are found in various locations. The objective of this study was to determine the profile of People living with HIV (PLHIV) with IVD and to identify associated factors. We conducted a cross-sectional study based on the records of PLHIV under ART for at least 6 months, followed at Hpital de Jour Donka from 2015 to 2017, and having both viral load (CV) and CD4 T-cell count. Prevalence of IVD was 34.57%, with 23.87% for immunological discordance (ID) and 10.7% for virological discordance (VD). Females were predominant (66.26%), and male gender influenced IVD with a statistically significant difference (p = 0.006) and was associated with VD (p = 0.007). The average age was 38.77 11.30 years. PLHIV were classified at WHO stages 3 and 4 (86.01%). The median initial haemoglobin level was 11.5 g/L [3.2 - 12]. The mean initial CD4 T-cell count was 272.84 cells/mm3 201.6. The median initial viral load (VL) was 147,337 copies/mL [1092 - 31,675,000]. The initial CD4 T-cell count 3 was associated with IVD with a statistically significant difference (p = 0.0009) and correlated with ID (p = 0.000). Prurigo was associated with IVD with a statistically significant difference (p = 0.003). Cerebral toxoplasmosis was not associated with IVD but was associated with ID (p = 0.04). This study allowed us to describe the profile of PLHIV with IVD. The main associated factors were male gender, initial CD4 T-cell count 3, toxoplasmosis, prurigo, and herpes zoster.

关键词： HIV Antiretroviral Treatment (ART) Immunovirological Discordance Donka Guinea

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Molecular heterostructure by fusing graphene nanoribbons of different lengths through a pentagon ring junction

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Nano Research 2022年第9期15卷 8465-8469页

作者： Qiang Sun Hao Jiang Yuyi Yan Roman Fasel pascal Ruffieux Materials Genome Institute Shanghai UniversityShanghai 200444China Empa Swiss Federal Laboratories for Materials Science and TechnologyDübendorf 8600Switzerland Department of Chemistry Biochemistry and Pharmaceutical SciencesUniversity of BernBern 3012Switzerland

Graphene nanoribbons(GNRs)have attracted great research interest because of their widely tunable and unique electronic *** required atomic precision of GNRs can be realized via on-surface synthesis *** this work,through a surface assisted reaction we have longitudinally fused the pyrene-based graphene nanoribbons(pGNR)of different lengths by a pentagon ring junction,and built a molecular junction structure on Au(111).The electronic properties of the structure are studied by scanning tunneling spectroscopy(STS)combined with tight binding(TB)*** pentagon ring junction shows a weak electronic coupling effect on graphene nanoribbons,which makes the electronic properties of the two different graphene nanoribbons connected by a pentagon ring junction analogous to type I semiconductor heterojunctions.

关键词： graphene nanoribbons(GNRs) scanning tunneling spectroscopy(STS) non-contact atomic force microscopy(nc-AFM) tight-binding(TB)calculations junction structure

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Clinical application and management of temporary mechanical circulatory support:A clinical consensus

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Chinese Medical Journal 2024年第10期137卷 1135-1139页

作者： Nianguo Dong Liangwan Chen Xin Chen Huishan Wang Yingbin Xiao Xianqiang Wang Jinsong Huang Yang Yan Pramod Bonde Neel Sodha Pavan Atluri Juan Pablo Maureira AndréVincentelli Masanobu Yanase Yixuan Wang Haitao Zhang Xiaotong Hou Yoshijuki Takami pascal Leprince Thierry Folliguet Frank W Sellke Chinese Society for Thoracic and Cardiovascular Surgery Chinese Association of Cardiovascular Surgeons Cardiac Critical Care Professional Committee of Chinese Medical Association Chinese Society of Extracorporeal Life Support European Society of Cardiovascular and Endovascular Surgery French Society of Thoracic and Cardiovascular Surgery Japanese Society for Cardiovascular Surgery Japanese Society of Artificial Organs Department of Cardiovascular Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular Surgery Fujian Medical University Union HospitalFuzhouFujian 350000China Department of Thoracic and Cardiovascular Surgery Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210000China Department of Cardiovascular Surgery General Hospital of Northern Theater CommandShenyangLiaoning 110000China Department of Cardiovascular Surgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037 China Department of Cardiovascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000 China Department of Cardiovascular Surgery Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510000 China Department of Cardiovascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Cardiac Surgery Yale School of Medicine330 Cedar St204 BoardmanNew HavenCT 06510USA Department of Cardiothoracic Surgery Alpert Medical SchoolBrown University Rhode Island HospitalProvidenceRI 02912USA Department of Cardiovascular Surgery Department of SurgeryUniversity of PennsylvaniaPhiladelphiaPA 19113USA Department of Cardiovascular Surgery and Transplantation University Hospital of NancyUniversity of LorraineVandoeuvre-lès-Nancy 54500France Department of Cardiovascular Surgery University Hospital of LilleUniversity of LilleLille 59037France Department of Cardiology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan Department of Adult Surgical Intensive Care Unit Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000China Department of Cardiac Intensive Care Beijing Institute of HeartLung and B

Temporary mechanical circulatory support(tMCS)plays a pivotal role in managing severe or refractory cardiogenic shock(CS),furnishing essential hemodynamic support,and sustaining organ perfusion from hours to weeks,or to even *** the past decade,the utilization of tMCS has witnessed a signicant increase in American and European *** in Asia,the newly developed concepts and devices constituting tMCS have also made rapid ***,the absence of a consensus or standardized guidelines,especially for the Asian population considering inherited polymorphism,is *** address this knowledge gap,eight associations/societies and experts in thiseld came up with the present consensus after repeated discussions,more specically for the Asian *** comprehensively elucidates the commonly employed tMCS devices,criteria for patient selection,indications and contraindications,clinical management,and the optimal timing for implantation and *** goal of this statement is to promote the standardized application of tMCS and make reasonable decisions in clinical ***-length version of the consensus can be seen in Supplementary File,http://***/CM9/B883.

关键词： application statement discussions

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Neuro-symbolic approaches in artificial intelligence

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National Science Review 2022年第6期9卷 35-37页

作者： pascal Hitzler Aaron Eberhart Monireh Ebrahimi Md Kamruzzaman Sarker Lu Zhou Department of Computer Science Kansas State University Center for Open Source Data and AI Technologies (CODAIT) IBM Watson Department of Computing Sciences University of Hartford

Neuro-symbolic artificial intelligence refers to a field of research and applications that combines machine learning methods based on artificial neural networks, such as deep learning, with symbolic approaches to computing and artificial intelligence(AI), as can be found for example in the AI subfield of knowledge representation and reasoning.

关键词： artificial intelligence deep learning knowledge representation and reasoning neuro-symbolic integration

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m^(6)A Profile Dynamics Indicates Regulation of Oyster Development by m^(6)A-RNA Epitranscriptomes

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 742-755页

作者： Lorane Le Franc Bruno Petton pascal Favrel Guillaume Rivière Laboratoire de Biologie des Organismes et des Ecosyste`mes Aquatiques(BOREA) Muséum d’Histoire NaturelleSorbonne UniversitéUniversitéde Caen NormandieUniversitédes AntillesCNRS UMR 8067IRD14032 CaenFrance Ifremer Laboratoire des Sciences de l’Environnement MarinUMR 6539 CNRS/UBO/IRD/IfremerCentre Bretagne29280 PlouzanéFrance

The N6-methylation of RNA adenosines(N6-methyladenosine,m^(6)A)is an important regulator of gene expression with critical implications in vertebrate and insect ***,the developmental significance of epitranscriptomes in lophotrochozoan organisms remains *** methylated RNA immunoprecipitation sequencing(MeRIP-seq),we generated transcriptome-wide m^(6)A-RNA methylomes covering the entire development of the oyster from oocytes to *** RNA classes display specific m^(6)A signatures,with messenger RNAs(mRNAs)and long non-coding RNAs(lncRNAs)exhibiting distinct profiles and being highly methylated compared to transposable element(TE)*** are dynamic and correspond to the chronological steps of development(cleavage,gastrulation,organogenesis,and metamorphosis),with minimal mRNA and lncRNA methylation at the morula stage followed by a global *** m^(6)A levels are correlated with transcript levels,and shifts in methylation profiles correspond to expression *** methylated transcripts cluster according to embryo-larval stages and bear the corresponding developmental functions(cell division,signal transduction,morphogenesis,and cell differentiation).The m^(6)A level of TE transcripts is also regulated and peaks during the *** demonstrate that m^(6)A-RNA methylomes are dynamic and associated with gene expression regulation during oyster *** putative epitranscriptome implication in the cleavage,maternal-to-zygotic transition,and cell differentiation in a lophotrochozoan model brings new insights into the control and evolution of developmental processes.

关键词： RNA methylation Transcription Embryo Metamorphosis Evo-devo

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Identification of Potential Zinc Deficiency Responsive Genes and Regulatory Pathways in Rice by Weighted Gene Co-expression Network Analysis

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Rice science 2022年第6期29卷 545-558页

作者： Blaise pascal MUVUNYI LU Xiang ZHAN Junhui HE Sang YE Guoyou CAAS-IRRI Joint Laboratory for Genomics-Assisted Germplasm Enhancement Agricultural Genomics Institute in ShenzhenChinese Academy of Agricultural Sciences(CAAS)Shenzhen 518120China Rice Breeding Innovations Platform International Rice Research Institute(IRRI)Metro Manila 1301the Philippines

Zinc(Zn)malnutrition is a major public health *** biofortification of Zn in rice grain can alleviate global Zn ***,elucidating the genetic mechanisms regulating Zn deprivation response in rice is essential to identify elite genes useful for breeding high grain Zn rice ***,a meta-analysis of previous RNA-Seq studies involving Zn deficient conditions was conducted using the weighted gene co-expression network analysis(WGCNA)and other in silico prediction tools to identify modules(denoting cluster of genes with related expression pattern)of co-expressed genes,modular genes which are conserved differentially expressed genes(DEGs)across independent RNA-Seq studies,and the molecular pathways of the conserved modular *** identified 16 modules of co-expressed ***-eight and five modular DEGs were conserved in leaf and crown,and root tissues across two independent RNA-Seq *** enrichment analysis showed that 24 of the 28 conserved modular DEGs from leaf and crown tissues significantly up-regulated 2 Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways and 15 Gene Ontology(GO)terms,including the substrate-specific transmembrane transporter and the small molecule metabolic ***,the well-studied transcription factors(OsWOX11 and OsbHLH120),protein kinase(OsCDPK20 and OsMPK17),and miRNAs(OSA-MIR397A and OSA-MIR397B)were predicted to target some of the identified conserved modular *** of the 24 conserved and up-regulated modular DEGs,19 were yet to be experimentally validated as Zn deficiency responsive *** from this study provide a comprehensive insight on the molecular mechanisms of Zn deficiency response and may facilitate gene and pathway prioritization for improving Zn use efficiency and Zn biofortification in rice.

关键词： rice biofortification zinc deficiency gene expression weighted gene co-expression network analysis

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Optical Microresonators feature issue introduction

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Photonics Research 2023年第12期11卷 I0001-I0003页

作者： YUN-FENG XIAO KARTIK SRINIVASAN pascal DEL’HAYE MENGJIE YU Frontiers Science Center for Nano-optoelectronics and State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Microsystems and Nanotechnology Division Physical Measurement LaboratoryNational Institute of Standards and TechnologyGaithersburgMaryland 20899USA Max Planck Institute for the Science of Light 91058 ErlangenGermany Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCalifornia 90089USA

Optical microresonators,which confine light in both the spatial and time domains,have advanced various research areas benefiting from significantly enhanced light-matter interactions,including integrated microlasers,nonlinear frequency conversion,Kerr frequency combs,and *** the past five years,the research interests in optical microresonators have rapidly expanded and combined with other disciplines,for example,optical chaos,non-Hermitian physics,and quantum *** cutting-edge research works have enabled the creation of optical microresonators with novel properties and capabilities.

关键词： materials chaos expanded

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Dual-polarization multiplexing amorphous Si:H grating couplers for silicon photonic transmitters in the photonic BiCMOS backend of line

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Frontiers of Optoelectronics 2022年第1期15卷 143-155页

作者： Galina Georgieva Christian Mai pascal M.Seiler Anna Peczek Lars Zimmermann Hochfrequenztechnik-Photonik/Siliziumphotonik Technische Universität BerlinStraße des 17.Juni 13510623 BerlinGermany IHP-Leibnitz Institut für innovative Mikroelektronik Im Technologiepark 2515236 Frankfurt(Oder)Germany IHP Solutions GmbH Im Technologiepark 715236 Frankfurt(Oder)Germany

In this paper,we report on polarization combining two-dimensional grating couplers(2D GCs)on amorphous Si:H,fabricated in the backend of line of a photonic BiCMOS *** 2D GCs can be used as an interface of a hybrid silicon photonic coherent transmitter,which can be implemented on bulk Si *** fabricated 2D GCs operate in the telecom C-band and show an experimental coupling efficiency of−5 dB with a wafer variation of±1.2 *** for efficiency enhancement and improved performance stability in future design generations are outlined and extension toward O-band devices is also investigated.

关键词： Hybrid integration Photonic BiCMOS Amorphous silicon Two-dimensional grating coupler(2D GC) Dual-polarization coherent communication Silicon photonics

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Profile of Full-Term Births in Maternity Wards of Public Hospitals in Douala Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 705-720页

作者： Henri Essome Merlin Boten Bounyom Astrid Ndolo Kondo Ingrid Doriane Ofakem Ilick Fulbert Mangala Nkwele Irène Cyrielle Edjoa Mboe Michel Roger Ekono Alphonse Ngalame Nyong Robert Tchounzou Moustapha Bilkissou Junie Ngaha Yaneu Marga Vanina Ngono Akam Gervais Mounchikpou Ngouhouo Grâce Tocki Toutou Théophile Nana Njamen Valère Mve Koh pascal Foumane Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Laquintinie Hospital Douala Cameroon Faculty of Health Sciences University of Bamenda Bamenda Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Medicine and Biomedical Sciences University of Yaound&#233 1 Yaound&#233 Cameroon Faculty of Medicine and Pharmaceutical Sciences of Sangmelima University of Ebolowa Ebolowa Cameroon

Introduction: Pregnancy as much as childbirth constitutes a risky situation, potentially fraught with sometimes dramatic complications: maternal death. Objective: We conducted this study with the aim of establishing the profile of those giving birth in our context with the aim to anticipate operationally in the future on morbidity but more on maternal deaths. Methodology: We conducted, using a structured questionnaire, a prospective descriptive study in representative maternity wards in the city of Douala;the study variables were socio-economic, anthropometric, obstetrical and clinical. Statistical analyses were carried out with CS Pro 7.3 and SPSS version 25.0 software. The Student, Chi-square and Fischer tests were used to compare the means of the variables and the percentages. Results: We recruited 305 births for our study. The average age of our births was 28.7 years ± 6.1 with an average height of 161.6 cm ± 5.06;an average body mass index at the start of pregnancy of 28.0 kilograms/square meter and 31.3 kilograms/square meter at delivery;the average weight gain was 8.4 g ± 5.37;an average gestation of 2.84±1.90;an average parity of 2.2 ± 2.1 with an average birth interval of 27.7 months ± 23.7. The average gestational age was 39.2 weeks ± 1.21 with pregnancy pathology dominated by malaria;85.9% began their prenatal follow-up before the 14th week of amenorrhea. Conclusion: The profile of childbirth in urban Cameroon does not seem potentially dystocic compared to that of the same regional and racial area.

关键词： Profile Delivery Term Malaria Douala

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Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2-negative breast cancer

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Cancer Communications 2023年第8期43卷 943-946页

作者： François Bertucci Alexandre De Nonneville pascal Finetti Emilie Mamessier11Laboratory of Predictive Oncology Label Team“Ligue contre le cancer”Cancer Research Center of MarseillePaoli-Calmettes InstituteAix-Marseille UniversityInserm UMR1068CNRS UMR725MarseilleFrance Department of Medical Oncology Paoli-Calmettes InstituteMarseilleFrance

Dear Editor,Pembrolizumab,an immune checkpoint inhibitor(ICI),was recently approved for early-stage triple-negative breast cancer(eTNBC),and promising results have been reported in advanced hormone receptor-positive/human epidermal growth factor receptor 2-negative(HR+/HER2-)and HER2+BCs[1].Given the costs and potential toxicity,markers predictive of ICI benefits are ***,neither programmed death-ligand 1(PD-L1)expression nor other tested markers(i.e.,tumor mutational burden,microsatellite instability)effectively predict ICI benefit[2].Tertiary lymphoid structures(TLS)are secondary lymphoid organ-like aggregates that reside in the tumor microenvironment and are associated with clinical response to ICIs in metastatic melanoma,renal cell carcinoma.

关键词： lymphoid breast cancer

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