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Protective Effects of Traditional Tibetan Medicine Zuo-Mu-A Decoction(佐木阿汤)on the Blood Parameters and Myocardium of High Altitude Polycythemia Model Rats

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Chinese Journal of Integrative Medicine 2017年第12期23卷 908-915页

作者： LU Meng-qian Nyima Tsring YU Tian-yuan WU Jian-cong Steven Wong CHEN Guo-yong pasang dekyi PAN Fan XIAN Si-tong Dorje Rinchen MAO Ying-qiu ZHANG Lin-feng YAO Bin-bin School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Tibetan Traditional Medical College Lhasa 850000China Department of Tuina Beijing Massage HospitalBeijing 100035China Information Center Beijing University of Chinese MedicineBeijing 100029China Tibet Academy of Tibetan Medicine Lhasa 850000China Center of Scientific Experiment Beijing University of Chinese MedicineBeijing 100029China

Objective: To explore the protective effects of Tibetan medicine Zuo-Mu-A Decoction(佐木阿汤, ZMAD) on the blood parameters and myocardium of high altitude polycythemia(HAPC) model rats. Methods: Forty male Wistar rats were randomly divided into 4 groups by a random number table, including the normal, model, Rhodiola rosea L.(RRL) and ZMAD groups(10 in each group). Every group was raised in Lhasa to create a HAPC model except the normal group. After modeling, rats in the RRL and the ZMAD groups were administered intragastrically with RRL(20 mL/kg) and ZMAD(7.5 mL/kg) once a day for 2 months, respectively; for the normal and the model groups, 5 mL of distilled water was administered intragastrically instead of decoction. Then routine blood and hematologic rheology parameters were taken, levels of erythropoietin and 8-hydroxy-2’-deoxyguanosine(8-OHd G) were tested, and ultrastructural change in the left ventricular myocardium was observed using transmission electron microscopy. Results: Compared with the model group, ZMAD significantly reduced the red blood cell count, hemoglobin levels, whole blood viscosity at low/middle shear rates, plasma viscosity, erythrocyte electrophoretic time, erythropoietin and 8-OHd G levels, and also increased the erythrocyte deformation index(P<0.05). There was no difference in all results between the RRL and the ZMAD groups. The cardiac muscle fibers were well-protected, mitochondrial matrix swelled mildly and ultrastructure changes were less prominent in the ZMAD group compared with the model group. Conclusion: ZMAD has significant protective effects on the blood parameters against HAPC, and also has the beneficial effect in protecting against myocardial injury.

关键词： erythropoietin hematology myocardium high altitude polycythemia traditional medicine

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