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Non-alcoholic fatty liver disease in type 2 diabetes:Emerging evidence of benefit of peroxisome proliferator-activated receptors agonists and incretin-based therapies

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World Journal of Methodology 2024年第2期14卷 38-50页

作者： Subhodip Pramanik partha pal Sayantan Ray Department of Endocrinology Neotia Getwel Multispecialty HospitalSiliguri 734010West BengalIndia Department of Medical Gastroenterology Asian Institute of GastroenterologyHyderabad 500082India Department of Endocrinology All India Institute of Medical SciencesBhubaneswarBhubaneswar 751019OdishaIndia

Nonalcoholic fatty liver disease(NAFLD)is a global epidemic,affecting more than half of the people living with type 2 diabetes(T2D).The relationship between NAFLD and T2D is bidirectional and the presence of one perpetuates the other,which significantly increases the hepatic as well as extrahepatic *** recently,there was no approved pharmacological treatment for NAFLD/nonalcoholic steatohepatitits(NASH).However,there is evidence that drugs used for diabetes may have beneficial effects on *** sensitizers acting through peroxisome proliferator-activated receptor(PPAR)modulation act on multiple levels of NAFLD ***(PPARγ agonist)and saroglitazar(PPARα/γagonist)are particularly beneficial and recommended by several authoritative bodies for treating NAFLD in T2D,although data on biopsyproven NASH are lacking with the *** data on elafibanor(PPARα/δ agonist)and Lanifibranor(pan PPAR agonist)are *** the other hand,incretin therapies based on glucagon-like peptide-1(GLP-1)receptor agonists(GLP-1RA)and dual-and triple-hormone receptor co-agonists reported impressive weight loss and may have anti-inflammatory and antifibrotic ***-1 RAs have shown beneficial effects on NAFLD/NASH and more studies on potential direct effects on liver function by dual-and triple-agonists are ***,the long-term safety of these therapies in NAFLD needs to be *** efforts among healthcare providers such as primary care doctors,hepatologists,and endocrinologists are warranted for selecting patients for the best possible management of NAFLD in T2D.

关键词： Non-alcoholic fatty liver disease Type 2 diabetes Evidence PPAR agonists Incretin-based therapies

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Structural and photoluminescence studies of Eu^(3+) doped zinc oxide nanorods prepared by precipitation method

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Journal of Rare Earths 2013年第1期31卷 37-43页

作者： partha P.pal J.Manam Department of Applied Physics Indian School of Mines

Abstract： Trivalent europium doped zinc oxide （ZnO：Eu3＋） nanocrystals were synthesized via room temperature chemical co-pre- cipitation and they were systematically characterized by means of X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR） and photoluminescence （PL） spectroscopy. The as-synthesized samples were found to have hexagonal wurtzite coexisted with the intermediate Zn5（OH）sC12·H2O phase, while the single hexagonal phase was facilitated due to the calcinations. The as obtained samples were broadly composed ofnanoflakes while the highly crystalline nanorods were formed due to low temperature annealing of the as-synthesized samples. The crystallite size of the nanoflakes and nanorods （40-90 nm） were extracted from the XRD pattern which was found to be consistent with scanning electron microscopy （SEM） measurements. The photoluminescence （PL） spectra of nanophosphors showed bright red and orange emissions at 618 and 594 nm respectively with efficient broad blue green emis- sion spectrum due to ZnO lattice. Further, a good energy transfer process from ZnO host to Eu3＋ was observed in PL emission and excitation spectra of Eu3＋ doped ZnO ions. In all, the present nanophosphors were found to have great potentiality for bio-appli- cations.

关键词： photoluminescence zinc oxide rare earth europium nanorods nanoflakes

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ZnO_(1-x)Te_x and ZnO_(1-x)S_x semiconductor alloys as competent materials for opto-electronic and solar cell applications:a comparative analysis

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Journal of Semiconductors 2017年第8期38卷 1-5页

作者： Utsa Das partha P.pal Department of Electronics Calcutta University St.Mary's Technical Campus Kolkata

ZnO1-xTex ternary alloys have great potential to work as a photovoltaic （PV） absorber in solar cells. ZnOl-xSx is also a ZnO based alloy that have uses in solar cells. In this paper we report the comparative study of various parameters of ZnO 1-x Tex and ZnO 1-x Sx for selecting it to be a competent material for solar cell applica- tions. The parameters are mainly being calculated using the well-known VCA （virtual crystal approximation） and VBAC （Valence Band Anti-Crossing） model. It was certainly being analysed that the incorporation of Te atoms produces a high band gap lower than S atoms in the host ZnO material. The spin-orbit splitting energy value of ZnOl-xTex was found to be higher than that of ZnOl-xSx. Beside this, the strain effects are also higher in ZnO^-xTex than ZnOl-xSx. The remarkable notifying result which the paper is reporting is that at a higher per- centage of Te atoms in ZnOl-xTex, the spin-orbit splitting energy value rises above the band gap value, which signifies a very less intemal carrier recombination that decreases the leakage current and increases the efficiency of the solar cell. Moreover, it also covers a wide wavelength range compared to ZnO1-x Sx.

关键词： VBAC model semiconductor alloys band gap spin-orbit splitting energy strain solar cell

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Heterogeneity of non-alcoholic fatty liver disease: Implications for clinical practice and research activity

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World Journal of Hepatology 2021年第11期13卷 1584-1610页

作者： partha pal Rajan palui Sayantan Ray Department of Medical Gastroenterology Asian Institute of GastroenterologyHyderabad 500082India Department of Endocrinology The Mission HospitalDurgapur 713212West BengalIndia Department of Endocrinology Jagannath Gupta Institute of Medical Sciences and HospitalKolkata 700137West BengalIndia Diabetes and Endocrinology Apollo ClinicBallygungeKolkata 700019West BengalIndia

Non-alcoholic fatty liver disease(NAFLD)is a heterogeneous condition with a wide spectrum of clinical presentations and natural history and disease *** is also substantial inter-individual variation and variable response to a different *** heterogeneity of NAFLD is in turn influenced by various factors primarily demographic/dietary factors,metabolic status,gut microbiome,genetic predisposition together with epigenetic *** differential impact of these factors over a variable period of time influences the clinical phenotype and natural *** to address heterogeneity partly explains the sub-optimal response to current and emerging therapies for fatty liver ***,leading experts across the globe have recently suggested a change in nomenclature of NAFLD to metabolic-associated fatty liver disease(MAFLD)which can better reflect current knowledge of heterogeneity and does not exclude concomitant factors for fatty liver disease(***,viral hepatitis,etc.).Precise identification of disease phenotypes is likely to facilitate clinical trial recruitment and expedite translational research for the development of novel and effective therapies for NAFLD/MAFLD.

关键词： Non-alcoholic fatty liver disease Metabolic-associated fatty liver disease Heterogeneity Phenotypes nomenclature Clinical trial Effective therapies

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An Upper Bound on the Higgs Self-Coupling and Higgs Boson Mass from the Positivity Condition of the Mass Matrix

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Journal of Modern Physics 2015年第4期6卷 369-373页

作者： partha Pratim pal Bolpur Sikshaniketan Ashram Vidyalaya West Bengal Bolpur India

The actual value of Higgs boson mass is difficult to determine theoretically due to lack of knowledge on the exact value of Higgs self coupling constant l. The purpose of this paper is to obtain an upper bound on the Higgs mass in the Standard Model on the basis of one-loop effective potential in the ’t Hooft-Landau gauge and MS scheme. The condition of positivity of mass matrix at ф?= ф0 (where ф0 is the absolute minimum of the effective potential) of the scalar field gives an upper bound on the Higgs self coupling as l ≤ 0.881. This condition yields an upper bound on the Higgs mass as mH ≤ 229.48 GeV.

关键词： One-Loop Effective Potential Standard Model Mass Matrix Higgs Boson Mass

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Fine needle aspiration diagnosis of isolated pancreatic tuberculosis: A case report

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World Journal of Clinical Cases 2013年第5期1卷 181-186页

作者： Nikhil Sonthalia Sayantan Ray partha pal Avishek Saha Arunansu Talukdar Department of General Medicine Medical College and HospitalKolkata 700073 India Department of General Medicine Calcutta National Medical College and HospitalKolkata 700014 India Department of General Medicine NRS Medical College and HospitalKolkata 700014 India

Tuberculosis(TB) involving the pancreas are uncommon, especially when present in immunocompetent hosts. Pancreatic TB is more frequently associated with miliary TB or widely disseminated disease. Pancreatic TB may present as cystic or solid pancreatic masses, pancreatic abscess or acute or chronic pancreatitis. Majority of the cases are diagnosed after surgical exploration for presumed pancreatic malignancy and preoperative diagnosis is quite difficult. However, improvement in imaging techniques and the resulting imageguided interventions gradually can obviate the need for more invasive diagnostic surgical procedures and expedite the planning of therapy. Herein, we report a rare case of isolated pancreatic TB which presented with pancreatic mass lesion in an immunocompetent host. Diagnosis was made by contrast enhanced computed tomography and guided fine needle aspiration of the pancreatic mass which revealed acid-fast bacillion Ziehl-Neelsen stain. The case was treated successfully with antituberculous drugs. Pancreatic tuberculosis should be considered in the differential diagnosis of a pancreatic mass when the patient is young, residing in the endemic zone of tuberculosis. Every attempt should be made to diagnose the cases to prevent unnecessary operation.

关键词： Pancreatic tuberculosis Pancreatic mass Pre-operative diagnosis Computed tomography Fine needle aspiration Antituberculous drugs

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Liver abscess caused by Burkholderia pseudomallei in a young man: A case report and review of literature

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World Journal of Clinical Cases 2014年第10期2卷 604-607页

作者： partha pal Sayantan Ray Avijit Moulick Subhasis Dey Anirban Jana Kokila Banerjee Department of General Medicine Calcutta National Medical College and Hospital Department of Endocrinology IPGMER and SSKM Hospital Department of General Medicine Bankura Sammilani Medical College and Hospital Department of Microbiology Drs. Tribedi and Roy Diagnostic Laboratory

Pyogenic liver abscess is a common entity in Indian subcontinent and is mostly caused by gram negative bacteria. Melioidosis is not commonly seen in India and only a few cases are reported. It can give rise to multiple abscesses at different sites including liver. We report a case of isolated liver abscess caused by Burkholderia pseudomallei(B. pseudomallei) in a 29-yearold recently diagnosed diabetic, immunocompetent male. Diagnosis was made by imaging and culture of pus aspirated from the abscess and he was treated with percutaneous pigtail catheter drainage followed by antibiotics(meropenem and trimethoprim-sulphmethoxazole). Melioidosis is an emerging infection in India and has high mortality rate, so early diagnosis and promptmanagement is warranted which requires clinical vigilance and an intensive microbiological workup. Clinicians should be aware of isolated liver abscess caused by B. pseudomallei in appropriate clinical settings.

关键词： Liver abscess Diabetes Burkholderia pseudomallei Emerging infection India

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Inhibition of CB1 Receptor Protects Against Cisplatin-Induced Nephrotoxicity

Inhibition of CB1 Receptor Protects Against Cisplatin-Induce...

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第十五届全国泌尿外科学术会议

作者： partha Mukhopadhyay Mohanraj Rajesh pal Pacher Laboratory of Physiological Studies NIH/NIAAA

Objectives: The endocannabinoid system was an emerging target of pharmacotherapy. We aimed to explore the effects of pharmacologic inhibition of CB1 receptor in vivo models of cisplatin-induced nephrotoxicity. Materials and Methods: B6 male mice were treated with the CB1 antagonists AM281 or rimonabant and a single dose of cisplatin at 20 mg/kg intraperitoneally. Kidney function,

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Gilbert's syndrome: High frequency of the (TA)_7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene

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World Journal of Gastroenterology 2006年第14期12卷 2269-2275页

作者： Shabana Farheen Sanghamitra Sengupta Amal Santra Suparna pal Gopal Krishna Dhali Meenakshi Chakravorty partha P Majumder Abhijit Chowdhury Human Genetics Unit Indian Statistical Institute KolkataIndia Department of Gastroenterology Institute of Postgraduate Medical Education & Research KolkataIndia Human Genetics & Genomics Division Indian Institute of Chemical Biology KolkataIndia

瞄准：在吉伯的症候群(GS ) 在 UDP-glucuronosyltransferase 1 (UGT1A1 ) 基因识别变体并且在印度在正常控制之中在 TA 插入和它的影响的印度，以及频率为 TA 插入和 GS 估计在纯合性之间的协会。方法：95 个 GS 盒子和 95 正常控制被... 详细信息

瞄准：在吉伯的症候群(GS ) 在 UDP-glucuronosyltransferase 1 (UGT1A1 ) 基因识别变体并且在印度在正常控制之中在 TA 插入和它的影响的印度，以及频率为 TA 插入和 GS 估计在纯合性之间的协会。方法：95 个 GS 盒子和 95 正常控制被选择。肝工作，另外的测试被做。倡导者和 UGT1A1 基因的所有 5 前 ons 被重新定序。对新奇 trinucleotide 插入的功能的评价被做由在 silico 分析并且由估计 UGT1A1，倡导者活动在 Hep G2 由适当构造的酶记者试金执行了房间线。结果：在 GS 病人之中， 80% 为 TA 插入是同型结合的，它比从另外的种族组的报告高好几倍。吝啬的 UCB 水平与仅仅这插入的一个拷贝在个人之中被提高，它不与有二个拷贝的那些显著地不同。在 UGT1A1 基因的许多新 DNA 变体被发现，包括在倡导者的插入在 GS 病人的一个子集(10%) 发现了的 trinucleotide (猫) ，然而并非在正常之中控制。In-silico 分析证明在倡导者和功能的分析的合拢 DNA 的显著变化在 UGT1A1 基因源于这插入的抄写效率显示出 20 褶层减小，显著地从而提高 UCB 水平。结论：GS 的基因传染病学越过种族组是可变的，在 UGT1A1 倡导者变体之中的上位相互作用调制胆红素 glucuronidation。

关键词：等位基因启动子基因表达胆红素

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CB2受体激动剂HU308对顺铂小鼠肾脏毒性的保护作用

CB2受体激动剂HU308对顺铂小鼠肾脏毒性的保护作用

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2008年浙江省泌尿外科学术年会

作者：潘昊 partha Mukhopadhyay pal Pacher 浙江大学医学院附属第一医院泌尿外科

目的:探讨CB2(cannabinoid receptor 2)受体激动剂HU308对小鼠顺铂肾脏毒性的保护作用及其机制。方法:C57BL6小鼠随机分为3组:对照组、顺铂组(顺铂20mg/kg腹腔注射)、顺铂+ HU308组(顺铂20mg/kg腹腔注射+HU308 10mg/kg腹腔注射)。72小...

目的:探讨CB2(cannabinoid receptor 2)受体激动剂HU308对小鼠顺铂肾脏毒性的保护作用及其机制。方法:C57BL6小鼠随机分为3组:对照组、顺铂组(顺铂20mg/kg腹腔注射)、顺铂+ HU308组(顺铂20mg/kg腹腔注射+HU308 10mg/kg腹腔注射)。72小时后处死小鼠,测定肾功能指标;肾组织石蜡切片分别行PAS、TUNEL、cleaved caspase3、nitrotyrosine免疫组化染色;蛋白印

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