Inhibition of CB1 Receptor Protects Against Cisplatin-Induced Nephrotoxicity
作者单位：Laboratory of Physiological Studies NIH/NIAAA
会议名称：《第十五届全国泌尿外科学术会议》
会议日期：2008年
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
摘 要：Objectives: The endocannabinoid system was an emerging target of pharmacotherapy. We aimed to explore the effects of pharmacologic inhibition of CB1 receptor in vivo models of cisplatin-induced nephrotoxicity. Materials and Methods: B6 male mice were treated with the CB1 antagonists AM281 or rimonabant and a single dose of cisplatin at 20 mg/kg intraperitoneally. Kidney function,