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Efficacy of a Diabetes Specific nutritional Supplement (DSnS) on Glycemic Response in Prediabetic Adults: A Two-Armed, Open-Labelled Randomized Controlled Study

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Food and nutrition Sciences 2024年第7期15卷 612-643页

作者： Deepti Khanna Kejal Joshi Reddy Hema S. Gopalan Jaladhi Bhatt Jayanti Gupta Simran Sethi parth Joshi Manoj Pareek Department of R&D Hindustan Unilever Limited Gurugram India Mumbai India Cliantha Research Ahmedabad India

It is well known that Diabetes Specific nutritional Supplements (DSnSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSnSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose Response (ABGR) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGR of DSnS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of DSnS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DSnS with lifestyle counselling (DSnS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DSnS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). DSnS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DSnS + LC versus LC alone. no other significant changes were reported between groups. It may be concluded that DSnS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： Diabetes Specific nutritional Supplement Prediabetes Acute Blood Glucose Response Incremental Area under Curve Lifestyle Counselling

Stability-indicating assay method for determination of actarit,its process related impurities and degradation products:Insight into stability profile and degradation pathways

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Journal of Pharmaceutical Analysis 2014年第6期4卷 374-383页

作者： A.Abiramasundari Rahul P.Joshi Hitesh B.Jalani Jayesh A.Sharma Dhaivat H.pandya Amit n.pandya Vasudevan Sudarsanam Kamala K.Vasu Department of Medicinal Chemistry B.V. Pat el PERD Centre Ahmedcibad Gujarat 380054 India

The stability of the drug actarit was studied under different stress conditions like hydrolysis（acid,alkaline and neutral）,oxidation,photolysis and thermal degradation as recommended hy International Conference on Harmonization（ICH） *** was found to be unstable in acidic,basic and photolytic conditions and produced a common degradation product while oxidative stress condition produced three additional degradation *** was impassive to neutral hydrolysis,dry thermal and accelerated stability *** products were identified,isolated and characterized by different spectroscopic *** and the degradation products were synthesized by a new route using green *** chromatographic separation of the drug and its impurities was achieved in a phenomenex luna C18 column employing a step gradient elution by high performance liquid chromatography coupled to photodiode array and mass spectrometry detectors（HPLC-PDAMS）.A specilic and sensitive stability-indicating assay method for the simultaneous determination of the drug *** process related impurities and degradation products was developed and validated.

关键词： Actarit Forced degradation Stability-indicating assay method

Electron inelastic mean free paths in solids:A theoretical approach

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Chinese Physics B 2012年第9期21卷 208-214页

作者： Siddharth H.pandya B.G.Vaishnav K.n.Joshipura Department of Physics Sardar Patel University Physical Research Laboratory

In the present paper, the inelastic mean free path （IMFP） of incident electrons is calculated as a function of energy for silicon （Si）, oxides of silicon （SiO2）, SiO, and A1203 in bulk form by employing atomic/molecular inelastic cross sections derived by using a semi-empirical quantum mechanical method developed earlier. A general agreement of the present results is found with most of the available data. It is of great importance that we have been able to estimate the minimum IMFP, which corresponds to the peak of inelastic interactions of incident electrons in each solid investigated. new results are presented for SiO, for which no comparison is available. The present work is important in view of the lack of experimental data on the IMFP in solids.

关键词： electron inelastic mean free path complex potential inelastic electron scattering cross sections solids

Decay rates and electromagnetic transitions of heavy quarkonia

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Chinese Physics C 2015年第12期39卷 19-24页

作者： J.n.pandya n.R.Soni n.Devlani A.K.Rai Applied Physics Department Faculty of Technology & Engineeringthe M S University of Baroda Applied Physics Department Polytechnicthe M S University of Baroda Department of Applied Physics Sardar Vallabhbhai National Institute of Technology

The electromagnetic radiative transition widths for heavy quarkonia, as well as digamma and digluon decay widths, are computed in the framework of the extended harmonic confinement model （ERHM） and Coulomb plus power potential （CPP,） with varying potential index v. The outcome is compared with the values obtained from other theoretical models and experimental results. While the mass spectra, digamma and digluon widths from ERHM as well as CPP v=1 are in good agreement with experimental data, the electromagnetic transition widths span over a wide range for the potential models considered here making it difficult to prefer a particular model over the others because of the lack of experimental data for most transition widths.

关键词： heavy quarkonia radiative decays electromagnetic transitions

River Rafting in Mountainous Regions of Uttarakhand:Impacts,Suggested Mitigation Measures and Sustainability

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Journal of Mountain Science 2012年第4期9卷 511-522页

作者： parth Sarathi MAHAPATRA Rajiv PAnDEY Sonali PRADHAn Forest Research Institute DehradunUttarakhandIndia CSIR-Institute of Minerals and Materials Technology BhubaneswarOdishaIndia HnBG University SrinagarUttarakhandIndia Orissa University of Agriculture and Technology BhubaneswarOdishaIndia

Uttarakhand state in India is well known for its mountainous ecosystems, traditional communities and a variety of ecotourism destinations. Among various tourism activities, River Rafting along the banks of the Ganges River has increased tremendously for two decades, and has had unprecedented impacts on the traditional communities and the bio-diversity. Therefore, it is meaningful to do a comprehensive study on the various impacts associated with river rafting so as to suggest the pathways to achieve the environmental sustainability in this region. In this study, we collected primary data from randomly selected population units across all stake holders such as local people （n = too）, and camp personnel （n = 22）, through a pre-tested questionnaire survey between August 2009 and May 2010. The questionnaire contains issues on culture, social, economic, institutional and associated perceived impacts on pollution and biodiversity including views for sustainability. Secondary information was also collected from various sources and government records to supplement and strengthen the analysis. The impacts were analyzed qualitatively through a ranking mechanism to facilitate the decision making process. The perception of the interviewee about the various possible impacts of rafting was discussed with mitigating mechanism. The ranking analysis as percollected data reveals that economy and education of local community was improved significantly; however aquatic and terrestrial fauna, social cohesion and pollution （water, air, land） were significantly deteriorated. The results show that the existing practices are not sufficient to address the adverse impacts. Improvement in practices is necessary, mainly in the policy regime. Based on the analysis, some measures are recommended on how to protect community interest and environment with the development of river rafting as an ecotourism opportunity.

关键词： Eco-tourism The Ganges Impactranking Traditional community

Exclusive semileptonic decays of D and Ds mesons in the covariant confining quark model

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Frontiers of physics 2019年第6期14卷 103-132页

作者： M.A.Ivanov J.G.Korner J.n.pandya P.Santorelli n.R.Soni C.T.Tran Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear Research141980 DubnaRussia PRISMA Cluster of Excellence Institut für PhysikJohannes Gutenberg-UniversitatD-55099 MainzGermany Applied Physics Department Faculty of Technology and EngineeringThe Maharaja Sayajirao University of BarodaVadodara 390001GujaratIndia Dipartimento di Fisica"E.Pancini" Universitàdi Napoli FedericoⅡComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126 NapoliItaly Istituto nazionale di Fisica nucleare Sezione di Napoli80126 NapoliItaly

Recently,the BESⅢcollaboration has reported numerous measurements of various D(s)meson semileptonic decays with significantly improved *** with similar studies carried out at BABAR,Belle,and CLEO,new windows to a better understanding of weak and strong interactions in the charm sector have been *** light of new experimental data,we review the theoretical description and predictions for the semileptonic decays of D(s)to a pseudoscalar or a vector *** review is essentially an extended discussion of our recently published results obtained in the framework of the covariant confining quark model.

关键词： covariant quark model semileptonic decay charmed meson form factor angular distribution

Moisture-Induced non-Equilibrium Phase Segregation in Triple Cation Mixed Halide Perovskite Monitored by In Situ Characterization Techniques and Solid-State nMR

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Energy & Environmental Materials 2023年第2期6卷 185-194页

作者： Mohammad Ali Akhavan Kazemi nicolas Folastre parth Raval Michel Sliwa Jean Marie Vianney nsanzimana Sema Golonu Arnaud Demortiere Jean Rousset Olivier Lafon Laurent Delevoye G.n.Manjunatha Reddy Frédéric Sauvage Laboratoire de Réactivité et Chimie des Solides(LRCS) UMR CNRS 7314-Institut de Chimie de Picardie FR 3085Université de Picardie Jules Verne33 rue Saint LeuAmiens Cedex FR-80039France CnRS Centrale LilleUMR 8181UCCSUnitéde Catalyse et Chimie du SolideUniversité de LilleUniversitéd’ArtoisLille F-59000France UMR 8516-LASIRE-Laboratoire de Spectroscopie pour les Interactions la Réactivité et l’EnvironnementCNRSUniversitéde LilleLille F-59000France EDF R&D EDF LabBoulevard Gaspard MongePalaiseau 91120France

Environmental stability is a major bottleneck of perovskite solar *** a handful of studies are investigating the effect of moisture on the structural degradation of the *** mostly rely on ex situ experiments and on completely degraded samples,which restrict the assessment on initial and final *** combining in situ X-ray diffraction under controlled 85%relative humidity,and live observations of the water-induced degradation using liquid-cell transmission electron microscopy,we reveal two competitive degradation paths leading on one hand to the decomposition of state-of-theart mixed cation/anion(Cs_(0.05)(MA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17)I_(0.83))_(3)(CsMAFA)into PbI_(2) through a dissolution/recrystallization mechanism and,on the other hand,to a non-equilibrium phase segregation leading to CsPb_(2)Br_(5) and a Cesium-poor/iodide-rich Cs_(0.05)-x(MA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17-2y)I_(0.83)+2y)_(3) *** degradation mechanism is corroborated at atomic-scale resolution through solid-state ^(1)H and ^(133)Cs nMR *** to moisture leads to a film containing important heterogeneities in terms of morphology,photoluminescence intensities,and *** results provide new insights and consensus that complex perovskite compositions,though very performant as champion devices,are comparatively metastable,a trait that limits the chances to achieve long-term stability.

关键词： liquid-cell transmission electron microscopy moisture degradation perovskite stability phase segregation solid-state nMR

Pediatric firearm-associated fractures:Analysis of management and outcomes

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World Journal of Clinical Pediatrics 2021年第6期10卷 151-158页

作者： Virginia Lieu Laura A Carrillo nirav K pandya Ishaan Swarup Department of Orthopaedics St.Mary’s Medical CenterSan FranciscoCA 94117United States Medical College of Wisconsin MilwaukeeWI 53226United States Department of Orthopaedics UCSF Benioff Children’s Hospital OaklandOaklandCA 94609United States

BACKGROUnD Firearm-associated injuries(FAIs)are among the leading causes of morbidity and mortality in children living in the United *** victims of such injuries survive,but may experience compromised function related to musculoskeletal *** complex firearm-associated fractures(FAFs)often require specialized orthopaedic,vascular,and plastic surgical intervention,there is minimal research describing their management and *** purpose of this study is to describe the epidemiology and presentation of pediatric FAFs,as well as evaluate the management and outcomes of these *** To describe the epidemiology and presentation of pediatric FAFs,as well as evaluate the management and outcomes of these *** A retrospective chart review was performed at a major,pediatric level 1 trauma *** study included patients aged 18 or younger who presented with FAIs between *** data was collected on patients with FAFs including demographic and clinical data such as age,sex,race,payor type,fracture location,injury severity score(ISS),and radiographic and clinical *** management of FAFs was analyzed as well as need for readmission and *** statistics were used to summarize the results and univariate analyses were performed to assess differences between *** Between 2008 and 2018,there were a total of 61 patients who presented with *** this cohort,21 patients(34%)sustained FAFs(25 fractures)with a mean age of 11(Range:10 mo to 18 years old)at the time of *** 52%(n=11)of patients with FAFs were male,76%(n=8 and n=8,respectively)identified as black or other,and 71%(n=15)had government *** were most commonly noted in the upper extremity(n=7)and lower extremity(n=6).In patients with FAFs,the mean ISS at presentation was 11.38(Range:2-38),and 24%of patients(n=5)were classified as having a major *** were no significant differences in age,sex,r

关键词： Firearm Fracture Adolescent Gunshot Injury Pediatric

Permeable Reactive Barrier for the treatment of contaminated surface water in Katedan industrial development area, Hyderabad, India

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Chinese Journal Of Geochemistry 2006年第B8期25卷 117-118页

作者： Savitri Tripathi Vandana parth Phani Homeshwari M. Vittal Babu n. Murthy n.n. Sorlie J.E. Govil P.K. national Geophysical Research Institute Hyderabad India norwegian Geotechnical Institute Oslo Norway