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Gardenia jasminoides protects against cerulein-induced acute pancreatitis

World Journal of Gastroenterology 2008年第40期14卷 6188-6194页

作者： Won-Seok Jung Young-Seok Chae Do-Yun Kim Sang-Wan Seo Hee-Je park Gi-Sang Bae Tae-Hyeon Kim Hyo-Jeong Oh Ki-Jung Yun Rae-Kil park Jong-Suk Kim Eun-cheol Kim Sung-yeon Hwang Sung-Joo park Ho-Joon Song Department of Biochemistry Institute of Medical ScienceChonbuk National University Medical School Department of Herbology School of Oriental MedicineWonkwang University Kohwang Medical Institute College of MedicineKyung Hee University Department of internal medicine College of MedicineWonkwng University Department of Pathology College of MedicineWonkwng University Vestibulocochlear Research Center & Department of Microbiology College of MedicineWonkwng University Department of Oral & Maxillofacial Pathology Dental CollegeWonkwang University

AIM： To investigate the effect of Garden/a fasm/noides （GJ） on cerulein-induced acute pancreatitis （AP） in mice. METHODS： C57BL/6 mice weighing 18-20 g were divided into three groups. （1） Normal salinetreated group, （2） treatment with GJ at a dose of 0.1 g/kg, （3） treatment with GJ at a dose of 1 g/kg. GJ was administered orally （n = 6 per group） for 1 wk. Three hours later, the mice were given anintraperitoneal injection of cerulein （50 μg/kg）, a stable cholecystokinin （CCK） analogue, every hour for a total of 6h as described previously. The mice were sacrificed at 6 h after completion of cerulein injections. Blood samples were obtained to determine serum amylase, lipase and cytokine levels. The pancreas was rapidly removed for morphologic examination and scoring. A portion of pancreas was stored at -70℃ and prepared for the measurement of tissue myeloperoxidase （MPO） activity, an indicator of neutrophil sequestration, and for reverse-transcriptase PCR （RT-PCR） and real-time PCR measurements. RESULTS： Treatment with G.1 decreased significantly the severity of pancreatitis and pancreatitis-associated lung injury. Treatment with G.1 attenuated the severity of AP compared with saline-treated mice, as shown by reduction in pancreatic edema, neutrophil infiltration, serum amylase and lipase levels, serum cytokine levels, and mRNA expression of multiple inflammatory mediators. CONCLUSION： These results suggest that GJ attenuated the severity of AP as well as pancreatitisassociated lung injury.

关键词： Gardenia Jasminoides Acute pancreatitis Cerulein

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A Model for Predicting the Psychological WellBeing of Older Adults in South Korea

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International Journal of Mental Health Promotion 2023年第11期25卷 1219-1228页

作者： Hyangjin park Haeryun Cho So yeon Yoo Department of Nursing Catholic Kkottongnae UniversityCheongju28211South Korea Department of Nursing Wonkwang UniversityIksan54538South Korea Department of Nursing Kyungil UniversityGyeongsan38428South Korea

This study examined factors related to the psychological well-being of older adults and built and verified a model for predictingpsychological well-being. The participants were 350 older adults aged over 60 years who lived in South Korea and were active in thelocal community. The model proposed in this study was found to be suitable. Depression, self-efficacy, and social support had adirect effect on the psychological well-being of older adults, while depression, activities of daily living (ADLs), and self-efficacy hadan indirect effect. Self-efficacy and social support mediated the relationship between depression and psychological well-being, andself-efficacy mediated the relationship between ADLs and psychological well-being. It is necessary to develop and implement aprogram that can help alleviate depression and improve self-efficacy and social support among older adults in order toenhance their psychological well-being. Additionally, to establish a model that predicts the psychological well-being of olderadults, a study is needed to verify the model not only in Korea but also in other countries.

关键词： Older adults psychological well-being structural equation model depression self-efficacy social support

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C-terminal domain of hepatitis C virus core protein is essential for secretion

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World Journal of Gastroenterology 2005年第25期11卷 3887-3892页

作者： Soo-Ho Choi Kyu-Jin park So-yeon Kim Dong-Hwa Choi Jung-Min park Soon B. Hwang Ilsong Institute of Life Science

AIM: We have previously demonstrated that hepatitis C virus (HCV) core protein is efficiently released into the culture medium in insect cells. The objective of this study is to characterize the HCV core secretion in insect cells. METHODS: We constructed recombinant baculoviruses expressing various-length of mutant core proteins, expressed these proteins in insect cells, and examined core protein secretion in insect cells. RESULTS: Only wild type core was efficiently released into the culture medium, although the protein expression level of wild type core was lower than those of other mutant core proteins. We found that the shorter form of the core construct expressed the higher level of protein. However, if more than 18 amino acids of the core were truncated at the C-terminus, core proteins were no longer secreted into the culture medium. Membrane flotation data show that the secreted core proteins are associated with the cellular membrane protein, indicating that HCV core is secreted as a membrane complex. CONCLUSION: The C-terminal 18 amino acids of HCV core were crucial for core secretion into the culture media. Since HCV replication occurs on lipid raft membrane structure, these results suggest that HCV may utilize a unique core release mechanism to escape immune surveillance, thereby potentially representing the feature of HCV morphogenesis.

关键词： Hepatitis C virus Core secretion Morphogenesis Virus assembly

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Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord

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Neural Regeneration Research 2020年第11期15卷 2162-2168页

作者： Ju-Young Oh Tae-yeon Hwang Jae-Hwan Jang Ji-Yeun park yeonhee Ryu HyeJung Lee Hi-Joon park Acupuncture and Meridian Science Research Center Kyung Hee University26 Kyungheedae-roDongdaemun-guSeoulRepublic of Korea Department of Korean Medical Science Graduate School of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea BK21 PLUS Korean Medicine Science Center College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea College of Korean Medicine Daejeon UniversityDaejeonRepublic of Korea Korean Institute of Oriental Medicine DaejeonRepublic of Korea

Despite numerous efforts to overcome neuropathic pain,various pharmacological drugs often fail to meet the needs and have many side *** is an aluminosilicate mineral that has been reported to have an anti-inflammatory effect,but the efficacy of muscovite for neuropathic pain has not been ***,we assessed whether muscovite nanoparticles can reduce the symptoms of pain by controlling the inflammatory process observed in neuropathic *** analgesic effects of muscovite nanoparticles were explored using partial sciatic nerve ligation model of neuropathic pain,in which one-third to onehalf of the nerve trifurcation of the sciatic nerve was tightly tied to the dorsal *** nanoparticles(4 mg/100μL)was given intramuscularly to evaluate its effects on neuropathic pain(3 days per week for 4 weeks).The results showed that the muscovite nanoparticle injections significantly alleviated partial sciatic nerve ligation-induced mechanical and cold *** the spinal cord,the muscovite nanoparticle injections exhibited inhibitory effects on astrocyte and microglia activation and reduced the expression of pro-inflammatory cytokines,such as interleukin-1β,tumor necrosis factor-α,interleiukin-6 and monocyte chemoattractant protein-1,which were upregulated in the partial sciatic nerve ligation ***,the muscovite nanoparticle injections resulted in a decrease in activating transcription factor 3,a neuronal injury marker,in the sciatic *** results suggest that the analgesic effects of muscovite nanoparticle on partial sciatic nerve ligation-induced neuropathic pain may result from inhibiting activation of astrocytes and microglia as well as pro-inflammatory *** propose that muscovite nanoparticle is a potential anti-nociceptive candidate for neuropathic *** experimental protocols in this study were approved by the Institutional Animal Ethics Committee(IACUC)at Dongguk University,South Korea(approval No.2017-022-1)

关键词： astrocyte microglia muscovite nanoparticle neuropathic pain partial sciatic nerve ligation pharmacopuncture pro-inflammatory cytokine spinal cord

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Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications

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Bioactive Materials 2023年第7期25卷 555-568页

作者： Kijun park Seunghoi Kim Yejin Jo Jae park Inwoo Kim Sooyoung Hwang yeontaek Lee So yeon Kim Jungmok Seo School of Electronic and Electronic Engineering Yonsei UniversitySeoul03722Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and TechnologiesSeoul02792Republic of Korea Center for Theragnosis Biomedical Research InstituteKorea Institute of Science and TechnologiesSeoul02792Republic of Korea

Implantable biomedical devices require an anti-biofouling,mechanically robust,low friction surface for a prolonged lifespan and improved ***,there exist no methods that could provide uniform and effective coatings for medical devices with complex shapes and materials to prevent immune-related side effects and thrombosis when they encounter biological ***,we report a lubricant skin(L-skin),a coating method based on the application of thin layers of bio-adhesive and lubricant-swellable perfluoropolymer that impart anti-biofouling,frictionless,robust,and heat-mediated self-healing *** demonstrate biocompatible,mechanically robust,and sterilization-safe L-skin in applications of bioprinting,microfluidics,catheter,and long and narrow medical *** envision that diverse applications of L-skin improve device longevity,as well as anti-biofouling attributes in biomedical devices with complex shapes and material compositions.

关键词： Anti-biofouling Lubricant-infused Biomedical applications Biomaterials Biointerface

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Investigation of prodromal features in metabolic syndrome based on transcriptome analysis

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Genes & Diseases 2023年第3期10卷 708-711页

作者： Sang-Min park Musun park Hyo-Jeong Ban Su-Jin Baek Soo yeon Kim Siwoo Lee Hee-Jeong Jin Korean Medicine(KM)Data Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea

Metabolic syndrome(MetS)is a complex condition that significantly increases the risk of several diseases,including heart disease and *** with MetS show both pro-inflammatory and pro-thrombotic states;however,the state... 详细信息

关键词： diseases Metabolic Patients

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Development and characterization of novel polymorphic microsatellite markers for the Korean freshwater snail Semisulcospira coreana and cross-species amplification using next-generation sequencing

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Journal of Oceanology and Limnology 2020年第2期38卷 503-508页

作者： yeon Jung park Mi Nan LEE Eun-Mi KIM Jung Youn park Jae Koo NOH Tae-Jin CHOI Jung-Ha KANG Biotechnology Research Division National Institute of Fisheries ScienceBusan 46083Republic of Korea Department of Microbiology Pukyoung National UniversityBusan 48513Republic of Korea

Korean freshwater snails of the genus Semisulcospira are widely distributed across East *** has been a very popular nutritional food in Korea,and is an ecologically important water quality indicator because it lives only in clean ***,no microsatellite markers have been generated to study the population genetic diversity of this *** the present study,we developed and characterized 18 novel microsatellite loci from Semisulcospira coreana genomic *** microsatellites were isolated using 454 GS-FLX titanium sequencing and 18 markers were used for genotyping in *** addition,we also tested the cross-species transferability of the microsatellite markers in four additional Semisulcospira *** identified 18 polymorphic loci and the number of alleles per loci,and their polymorphism information content values ranged from 2 to 17 and 0.203 to 0.902,*** observed and expected heterozygosities of the loci ranged from 0.063 to 0.924 and 0.226 to 0.924,*** to the analysis of the cross-species transferability of these markers,four species,***,***,***,and ***,showed a very high transferability(80%–85%).These results show that this set of nuclear markers could be useful for population genetics studies of this species and closely related species.

关键词： Semisulcospira next-generation sequencing(NGS) microsatellite markers cross-species transferability

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Sensing Characteristics of Polyaniline Sensor Coated with Porous Poly(vinylidenfluoride) Layer to Methanol Gas

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稀有金属材料与工程 2006年第A3期35卷 459-462页

作者： cheol-Beom Lim Joon-Boo Yu Do-yeon Kim Sung-Ok Sohn Duk-Dong Lee Jeung-Soo Huh Department of Sensor and Display Engineering Kyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea Department of Materials Science & Metallurgy Kyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea Department of Electronic Engineering Kyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea Department of Sensor and Display Engineering Kyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea.Department of Materials Science & MetallurgyKyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea

Hydrophobic polymer [***(vinylidenfluoride)] layer was coated on polyaniline (PANi) sensor to reduce the problems of *** differences in sensitivity to methanol gas detection in various humidity condition between pure-PANi sensor and coated with poly(vinylidenfluoride) polymer (PVDF) (coated-PANi sensor) were *** the relation between the density of pore,which was coated on the layer of the PANi sensor,and sensitivity was *** fabricate the porous PVDF layer on PANi sensor,poly(vinylalcohol) (PVA),which is water-soluble polymer,was used. Coated-PANi sensor was less affected by humidity compared with pure-PANi *** higher density of pore on PVDF layer led to higher sensitivity.

关键词： polyaniline PVDF PVA methanol gas humidity

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Importance of Adaptive Photometric Augmentation for Different Convolutional Neural Network

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Computers, Materials & Continua 2022年第9期72卷 4433-4452页

作者： Saraswathi Sivamani Sun Il Chon Do yeon Choi Dong Hoon Lee Ji Hwan park AI Reliability Lab ThinkforBL Consultancy ServicesGangnamSeoulKorea Department of Biosystems Engineering Chungbuk National UniversityCheongju-siChungcheongbuk-do28644Korea

Existing segmentation and augmentation techniques on convolutional neural network(CNN)has produced remarkable progress in object ***,the nominal accuracy and performance might be downturned with the photometric variation of images that are directly ignored in the training process,along with the context of the individual CNN *** this paper,we investigate the effect of a photometric variation like brightness and sharpness on different *** observe that random augmentation of images weakens the performance unless the augmentation combines the weak limits of photometric *** approach has been justified by the experimental result obtained from the PASCAL VOC 2007 dataset,with object detection CNN algorithms such as YOLOv3(You Only Look Once),Faster R-CNN(Region-based CNN),and SSD(Single Shot Multibox Detector).Each CNN model shows performance loss for varying sharpness and brightness,ranging between−80%to 80%.It was further shown that compared to random augmentation,the augmented dataset with weak photometric changes delivered high performance,but the photometric augmentation range differs for each ***,we discuss some research questions that benefit the direction of the *** results prove the importance of adaptive augmentation for individual CNN model,subjecting towards the robustness of object detection.

关键词： Object detection photometric variation adaptive augmentation convolutional neural network

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Polyherbal formula SC-E3 inhibits rheumatoid arthritis activity in a mouse model of type-Ⅱcollagen-induced arthritis

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Journal of Integrative Medicine 2021年第3期19卷 265-273页

作者： Ju-yeon park Young-Won Kwon Sun-Ah Kim Sun-Dong park Chang-Hyun Kim Jin-Hee Kim Ju-Hee Lee College of Korean Medicine Dongguk UniversityGoyang 10326Republic of Korea Department of Medicine College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Biomedical Laboratory Science College of Health ScienceCheongju UniversityCheongju 28503Republic of Korea

Objective:SC-E3 is a polyherbal formula that contains five medicinal herbs used frequently in traditional herbal *** our previous study,we demonstrated the antioxidant and anti-inflammatory effects of *** present study examined the effects of SC-E3 in a mouse model of type-II collagen-induced arthritis(CIA).Methods:In vivo,male DBA/1 J mice were immunized by intradermal injection of bovine type-II collagen and complete or incomplete Freund’s adjuvant,to induce ***-E3 was orally administered daily for 23 *** vitro,bone marrow-derived macrophages(BMMs)were treated with macrophage colony-stimulating factor(M-CSF)and receptor activator of nuclear factor-j B ligand(RANKL)in the absence or presence of ***:Administrations of SC-E3 were found to have anti-arthritic effects in the joints of CIA mice,as evidenced by reduced paw swelling,bone erosion and deformation,inflammatory cell infiltration,and inflammation in synovial ***-E3 also reduced serum levels of tumor necrosis factor-a,interleukin-1 b,aspartate aminotransferase and alanine ***,tartrateresistant acid phosphatase-positive osteoclast numbers in the joints were significantly lower in SC-E3-treated CIA mice than in CIA *** addition,the differentiations of BMMs to multinucleated osteoclasts induced by M-CSF and RANKL stimulation were dose-dependently reduced by ***:These results suggest that SC-E3 possesses substantial anti-arthritic activity because it inhibits pro-inflammatory cytokines and osteoclastogenesis,and that SC-E3 has potential therapeutic use for the treatment of rheumatoid arthritis.

关键词： Herbal formula Anti-inflammatory Rheumatoid arthritis Collagen-induced arthritis Osteoclastogenesis

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