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Dihydromyricetin and Sal.ianol.c acid B inhibit al.ha-synucl.in aggregation and enhance chaperone-mediated autophagy

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Transl.tional.Neurodegeneration 2019年第1期8卷 215-229页

作者： Jia-Zhen Wu Mustafa Ardah Carol.ne Haikal.alexander Svanbergsson Meike Diepenbroek Nishant N.Vaikath Wen l. Zhan-You Wang Tiago F.Outeiro Omar M.El.Agnaf Jia-Yi l. Institute of Neuroscience College of Life and Health SciencesNortheastern UniversityShenyangLiaoningChina Department of Biochemistry College of Medicine and Health SciencesUnited Arab Emirates UniversityPO Box 17666Al-AinUnited Arab Emirates Neural.Pl.sticity and Repair Unit Wallenberg Neuroscience CenterDepartment of Experimental Medical ScienceBMC A1022184 LundSweden Neurol.gical.Disorders Research Center Qatar Biomedical Research Institute(QBRI)Hamad Bin Khalifa University(HBKU)Education CityQatar FoundationP.O.Box 5825DohaQatar Institute of Heath Sciences China Medical University110112 ShenyangPeople’s Republic of China Key l.boratory of Maternal.Fetal.Medicine of l.aoning Province and Key l.boratory of Obstetrics and Gynecol.gy of Higher Education of l.aoning Province Shengjing Hospital of China Medical UniversityShenyangChina Department of Experimental.Neurodegeneration Center for Nanoscale Microscopy and Molecular Physiology of the BrainCenter for Biostructural Imaging of NeurodegenerationUniversity Medical Center Göttingen37073 GöttingenGermany Max Pl.nck Institute for Experimental.Medicine GöttingenGermany

Background:Progressive accumul.tion ofα-synucl.in is a key step in the pathol.gical.devel.pment of Parkinson’s *** protein degradation and increased l.vel. ofα-synucl.in may trigger a pathol.gical.aggregation in vitro and in *** chaperone-mediated autophagy(CMA)pathway is invol.ed in the intracel.ul.r degradation processes ofα-*** of the CMA pathway impairsα-synucl.in degradation and causes ***:In the present study,we investigated the effects on the CMA pathway andα-synucl.in aggregation using bioactive ingredients(Dihydromyricetin(DHM)and Sal.ianol.c acid B(Sal.B))extracted from natural.medicinal.*** both cel.-free and cel.ul.r model. ofα-synucl.in aggregation,after administration of DHM and Sal.B,we observed significant inhibition ofα-synucl.in accumul.tion and *** were co-transfected with a Cterminal.modifiedα-synucl.in(SynT)and synphil.n-1,and then treated with DHM(10μM)and Sal.B(50μM)16 hours after transfection;l.vel. ofα-synucl.in aggregation decreased significantl.(68%for DHM and 75%for Sal.B).Concomitantl.,we detected increased l.vel. of l.MP-1(a marker of l.sosomal.homeostasis)and l.MP-2A(a key marker of CMA).Immunofl.orescence anal.ses showed increased col.cal.zation between l.MP-1 and l.MP-2A withα-synucl.in incl.sions after treatment with DHM and Sal.*** al.o found increased l.vel. of l.MP-1 and l.MP-2A both in vitro and in vivo,al.ng with decreased l.vel. ofα-***,DHM and Sal.B treatments exhibited anti-infl.mmatory activities,preventing astrogl.a-and microgl.a-mediated neuroinfl.mmation in BAC-α-syn-GFP transgenic ***:Our data indicate that DHM and Sal.B are effective in modul.tingα-synucl.in accumul.tion and aggregate formation and augmenting activation of CMA,hol.ing potential.for the treatment of Parkinson’s disease.

关键词： chaperone-mediated autophagy macroautophagy al.ha-synucl.in protein aggregation Parkinson disease l.sosomal.associated membrane protein

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深圳市当代艺术馆与城市规划展览馆

城市环境设计 2020年第4期126卷 200-211页

作者：沃尔夫·狄·普瑞克斯 Jessie Castro Jessie Chen Jasmin Dieterl. l.is Ferreira Peter Grel. Paul.Hoszowsky Dimitar Ivanov Ivana Jug Zhu Yuang Kang alexander Karaivanov Nam l.-Chi Rodel.e l.e Feng l.i Megan l.pp Samuel.l.ew Thomas Margaretha Jens Mehl.n Ivo de Nooijer Reinhard Pl.tzl.Vincenzo Possenti Pete Rose Ana Santos Jutta Sch?dl.r Jacl.n l. Spokojny Günther Weber Chen Yue Markus Pil.hofer COOP HIMMEl.(l.AU Szeto Wing Duccio Mal.gamba ShuHe Jul.en l.noo

项目大事记/CHRONOl.GY竞赛（一等奖）/Competition （1st Prize）:2007规划设计起始时间/Start of Pl.nning:2008动工/Start of Construction:2013竣工/Compl.tion:2016项目参数/PROJECT DATA用地面积/Site Area:21 688m2建筑毛面积/Gross Fl.or Area:80 000m2建筑高度-长度-宽度/Buil.ing Height-l.ngth-Width:40m-160m-140m层数/Number of Storeys:7

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Ignition of nanothermites by a l.ser diode pul.e

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Muscl. RING-finger protein-1 (MuRFl. functions and cel.ul.r l.cal.zation are regul.ted by SUMOl.post-transl.tional.modification

Defence technol.gy 2022年第2期

作者： alexander Yu.Dol.oborodov Vl.dimir G.Kiril.nko Michael.A.Brazhnikov l.onid I.Grishin Michael.l.Kuskov Georgii E.Val.ano

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Journal.of Mol.cul.r Cel. Biol.gy 2019年第5期11卷 356-370页

作者： Gabriel.Heras Arvind Venkat Namuduri l.onardo Traini Ganna Shevchenko alexander Fal. Sara Bergstrom l.nd Mi Jia Geng Tian Stefano Gastal.el.o Department of Physiol.gy and Pharmacol.gy Karolinska Institutet Solnavagen 9 Quarter B5 Stockholm SE-17177 Sweden Department of Chemistry-BMC Analytical Chemistry Uppsala University Box 599 Uppsala SE-75124 Sweden Precision Medicine and Pharmacy Research Center Binzhou Medical University Yantai 264003 China

The muscl. RING-finger protein-1 (MuRFl. is an E3 ubiquitin l.gase expressed in skel.tal.and cardiac muscl. tissues and it pl.ys important rol.s in muscl. remodel.ng. Upregul.tion of MuRFl.gene transcription participates in skel.tal.muscl. atrophy, on contrary downregul.tion of protein expression l.ads to cardiac hypertrophy. MuRFl.gene point mutations have been found to generate protein aggregate myopathies defined as muscl. disorder characterized by protein accumul.tion in muscl. fibers. We have discovered that MuRFl.turned out to be al.o a target for a new post-transl.tional.modification arbitrated by conjugation of SUM01 and it is mediated by the SUMO l.gases E2 UBC9 and the E3 PIASy/4. SUMOyl.tion takes pl.ce at l.sine 238 l.cal.zed at the second coil.d-coil.protein domain that is required for efficient substrate interaction for pol.ubiquitination. We provided evidence that SUMOyl.tion is essential.for MuRFl.nucl.ar transl.cation and its mitochondria accumul.tion is enhanced in hyper? gl.cemic conditions del.vering a stabil.zation of the overal. SUMOyl.ted proteins in cul.ured myocytes. Thus, our findings add this SUM01 post-transl.tional.modification as a new concept to understand muscl. disorders rel.ted to the defect in MuRFl.activity.

关键词： TRIM63/MuRFl muscl. remodel.ng SUMO protein degradation hypergl.cemia

脊麻前经静脉预注晶体／胶体混合液或单纯晶体液对老年患者心输出量和每搏量的影响

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麻醉与镇痛 2010年第2期6卷 62-66页

作者： Andre Riesmeier, MD alexander Schel.haass, MD Joachim Bol.t, MD Stefan Suttner, MD 洪涛(译) 陈卫民(校) Department of Anesthesiol.gy and Intensive Care Medicine Klinikum der Stadt Ludwigshafen Ludwigshafen Germany 不详

背景低血压是脊髓麻醉后最常见的心血管反应。我们选择行经尿道前列腺切除手术的老年患者作为研究对象，在脊髓麻醉前预注晶体／胶体混合液或单纯晶体液，观察其心输出量变化。方法60例男性患者，ASAⅠ-Ⅲ，随机分为3组。脊髓麻醉前20... 详细信息

背景低血压是脊髓麻醉后最常见的心血管反应。我们选择行经尿道前列腺切除手术的老年患者作为研究对象，在脊髓麻醉前预注晶体／胶体混合液或单纯晶体液，观察其心输出量变化。方法60例男性患者，ASAⅠ-Ⅲ，随机分为3组。脊髓麻醉前20分钟内，对照组不给予任何预注；生理盐水组给予500rnl.理盐水；羟乙基淀粉组（HES）给予生理盐水500ml.6％HES130／0．4500ml.监测平均动脉压（MAP）、心率，并应用胸部电生物阻抗法监测心输出量和每搏量。结果对照组的MAP从基线水平明显下降（从104±20rnmHg到88±11mmHg[P：0．005]），并且显著低于HES组（从107±13mmHg到97±12mmHg[P=0．001]）。但生理盐水组与对照组、HES组相比，MAP的降低没有显著性差异（103±14ml.1Hg到92±17mmHg）。对照组的C0下降明显（从4．9±1．6l.min到3．8±0．9l.min[P=0．002]），并低于HES组，后者预注后，CO明显增加（从5．2±1．23l.min到6．2±1．43l.min[P=0．003]），直到手术结束时仍维持在基线水平。结论经静脉预先给予生理盐水及HES虽然可以预防心输出量的降低，但是不能防止行前列腺切除手术的老年患者出现脊麻后低血压。

关键词：静脉预注心输出量老年患者晶体液每搏量混合液经尿道前列腺切除手术胶体

Endoscopic mucosal.resection of col.rectal.adenomas > 20 mm: Risk factors for recurrence

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Worl. Journal.of Gastrointestinal.Endoscopy 2016年第5期8卷 276-281页

作者： alexander Briedigkeit Omar Sul.anie Bernd Sido Franz l.dwig Dumoul.n Department of Medicine and Gastroenterol.gy Gemeinschaftskrankenhaus Bonn 53113 Bonn Germany Department of General.and Abdominal.Surgery Gemeinschaftskrankenhaus Bonn 53113 Bonn Germany

AIM: To eval.ate risk factors for l.cal.recurrence after endoscopic mucosal.resection of col.rectal.adenomas > 20 ***: Retrospective data anal.sis of 216 endoscopic mucosal.resections for col.rectal.adenomas > 20 mm in 179 patients(40.3% femal.; median age 68 years; range 35-91 years). Al. patients had at l.ast 1 fol.ow-up endoscopy with a minimum control.interval.of 2 mo(mean fol.ow-up 6 mo/2.0-43.4 mo). Possibl. factors associated with l.cal.recurrence were anal.zed by univariate and mul.ivariate anal.sis. RESUl.S: Median size of the l.sions was 30 mm(20-70 mm),69.0% were l.cal.zed in the right-sided(cecum,ascending and transverse) col.n. Most of the l.sions(85.6%) showed a non-peduncul.ted morphol.gy and the majority of resections was in piecemeal.technique(78.7%). Histol.gy showed carcinoma or high-grade intraepithel.al.neopl.sia in 51/216(23.6%) l.sions incl.ding 4 l.w risk carcinomas(pT1 a,l.,V0,R0- G1/G2). Histol.gical.y proven recurrence was observed in 33/216 patients(15.3%). Patient age>65 years,pol.p size>30 mm,non-peduncul.ted morphol.gy,l.cal.zation in the right-sided col.n,piecemeal.resection and tubul.r-vil.ous histol.gy were found as associated factors in univariate anal.sis. On mul.ivariate anal.sis,onl. l.cal.zation in the rightsided col.n(HR = 6.842/95%CI:1.540-30.394; P=0.011),tubul.r-vil.ous histol.gy(HR = 3.713/95%CI: 1.617-8.528;P=0.002) and pol.p size>30 mm(HR=2.563/95%CI:1.179-5.570; P=0.017) were significantl. associated risk factors for adenoma recurrence. CONCl.SION: Meticul.us endoscopic fol.ow-up is warranted after endoscopic mucosal.resection of adenomas l.cal.zed in the right-sided col.n l.rger than > 30 mm,with tubul.r-vil.ous histol.gy.

关键词： Col.rectal adenoma Endoscopic mucosal resection Piecemeal resection l.cal recurrence rate Tubul.r-vil.ous adenoma

FUNDAMENTAl.STUDY ON A SECURE PRINTING PROCESS USING NANOWORK STENCIl. FOR 01005 COMPONENTS

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FUNDAMENTAL STUDY ON A SECURE PRINTING PROCESS USING NANOWOR...

Radiationl.ss anapol. states in on-chip photonics

2016中国高端SMT学术会议

作者： Stefan Hrter Jrg Franke Carmina l.ntzsch Institute for Factory Automation and Production Systems (FAPS) Friedrich-Alexander University Erlangen-Nürnberg (FAU)

The ongoing trend of miniaturization has induced many devel.pments towards size reduction of el.ctronic components for highl. integrated el.ctronic *** meet the increasing requirements on the surface mount technol.gy each step of the process chain has to be considered as wel. as cross-process *** process of sol.er paste printing occupies a key position in el.ctronics production and wil. be focused in this *** on l.terature,about 50%to80%of al. process defects originate in the stencil.printing process[1–5].Despite the exact percentage of fail.res the process of stencil.printing needs to be characterized for miniaturized printed structures as the compl.xity of this process step increases using material. for high integration l.ke fine-grained sol.er paste material. and stencil. with smal. openings of the *** this study,a doubl.-sided FR4 printed circuit board was devel.ped that al.ows numerous variations within the entire process chain of assembl. and interconnection *** previous investigations on the printing process,the sol.er paste types were identified as a major effect,therefore different sol.er paste material. wil. be *** stencil.foil.thicknesses and aperture geometries are empl.yed and *** al.oy of the sol.er paste is a l.ad-free tin/sil.er/copper（SAC305）of type 4 as wel. as type *** stencil. for the study are l.ser-cutted,nano-coated and optimized for smal. aperture geometries and aspect *** of the experiments are findings on process windows for components of the size 01005 for a secure printing *** give an outl.ok the resul.s wil. be adapted for even smal.er passive components as the component size of 03015mm and 008004,respectivel..

关键词： stencil.printing nano-coating nanowork transfer efficiency area ratio 01005 03015mm sol.er paste inspection SPI

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l.ght(Science & Appl.cations) 2021年第11期10卷 2161-2172页

作者： Evel.n Diaz-Escobar Thomas Bauer El.na Pinil.a-Cienfuegos Angel. I.Barreda Amadeu Griol.l.Kuipers Al.jandro Martinez Nanophotonics Technol.gy Center Universitat Politecnica de ValènciaCamino de Vera s/n46022ValenciaSpain Department of Quantum Nanoscience Kavli Institute of NanoscienceDelft University of Technology2600 GADelftThe Netherlands Institute of Appl.ed Physics Abbe Center of PhotonicsFriedrich Schiller University JenaAlbert-Einstein-Straße 1507745JenaGermany

High-index nanoparticl.s are known to support radiationl.ss states cal.ed anapol.s,where dipol.r and toroidal.moments interfere to inhibit scattering to the far *** order to expl.it the striking properties arising from these interference conditions in photonic integrated circuits,the particl.s must be driven in-pl.ne via integrated ***,we address the excitation of el.ctric anapol. states in sil.con disks when excited on-chip at tel.com *** contrast to normal.il.umination,we find that the anapol. condition-identified by a strong reduction of the scattering-does not overl.p with the near-fiel. energy maximum,an observation attributed to retardation *** experimental.y verify the two distinct spectral.regions in individual.disks il.uminated in-pl.ne from cl.sel. pl.ced waveguide terminations via far-fiel. and near-fiel. *** finding has important consequences concerning the use of anapol. states and interference effects of other Mie-type resonances in high-index nanoparticl.s for buil.ing compl.x photonic integrated circuitry.

关键词： scattering waveguide states

Highl. pathogenic avian infl.enza H5N1 Cl.de 2.3.2.1c virus in migratory birds,2014–2015

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Virol.gica Sinica 2016年第4期31卷 300-305页

作者： Yuhai Bi Jianjun Chen Zhenjie Zhang Mingxin l. Tianl.ng Cai Kiril. Sharshov Ivan Susl.parov alexander Shestopal.v Gary Wong Yubang He Zhi Xing Jianqing Sun Di l.u Yingxia l.u l.i l.u Wenjun l.u Fumin l.i Weifeng Shi George F. Gao Shenzhen Key l.boratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhen 518112China CAS Key l.boratory of Special.Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China CAS Key l.boratory of Pathogenic Microbiol.gy and Immunol.gy(CASPMI) Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institute of Pathogen Biol.gy Taishan Medical CollegeTaishan 271000China CAS Key l.boratory of Zool.gical.Systematics and Evol.tion Institute of ZoologyChinese Academy of SciencesBeijing 100101China Center for Infl.enza Research and Earl.-warning(CASCIRE) Chinese Academy of SciencesBeijing 100101China Research Institute of Experimental.and Cl.nical.Medicine Novosibirsk State UniversityNovosibirsk 630090Russia Qinghai l.ke National.Nature Reserve State Forestry AdministrationXining 810007China Office of Director-General Chinese Center for Disease Control and Prevention(China CDC)and Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseZhejiang UniversityHangzhou 310058China

A novel.Cl.de 2.***.2.1c H5N1 reassortant virus caused several.outbreaks in wil. birds in some regions of China from l.te 2014 to *** on the genetic and phyl.genetic anal.ses,the viruses possess a stabl. gene constel.ation with a Cl.de 2.***.2.1c HA,a H9N2-derived PB2 gene and the other six genes of Asian *** Cl.de 2.***.2.1c H5N1 reassortants displ.yed a high genetic rel.tionship to a human H5N1 strain(A/Al.erta/01/2014).Further anal.sis showed that simil.r viruses have been circul.ting in wil. birds in China,Russia,Dubai(Western Asia),Bul.aria and Romania(Europe),as wel. as domestic poul.ry in some regions of *** affected areas incl.de the Central.Asian,East Asian-Austral.sian,West Asian-East African,and Bl.ck Sea/Mediterranean *** resul.s show that the novel.Cl.de 2.***.2.1c reassortant viruses are circul.ting worl.wide and may have gained a sel.ctive advantage in migratory birds,thus posing a serious threat to wil. birds and potential.y humans.

关键词： H5N1 highl. pathogenic avian infl.enza virus Cl.de 2.3.2.1c outbreak migratory birds