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Paleo-glacial reconstruction of the Thajwas glacier in the Kashmir Himalaya using 10Be cosmogenic radionuclide dating

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Geoscience Frontiers 2022年第6期13卷 30-40页

作者： Omar Jaan paul Shakil Ahmad Romshoo Reyaz Ahmad Dar Pankaj kumar Soumya Prakash Dhal Sundeep Chopra Department of Earth Sciences University of KashmirSrinagarIndia Islamic University of Science and Technology(IUST) KashmirIndia Inter-University Accelerator Centre(IUAC) New DelhiIndia Department of Geoinformatics University of KashmirSrinagarIndia

Quantitative glacial chronologies of past glaciations are sparse in the Himalaya, and mostly absent in the Kashmir Himalaya. We used cosmogenicBe exposure dating, and geomorphological mapping to reconstruct glacial advances of the Thajwas Glacier(TG) in the Great Himalayan Range of the Kashmir Himalaya. FromBe exposure dating of ten moraine boulders, four glacial stages with ages ~20.77 ±2.28 ka, ~11.46 ± 1.69 ka, ~9.12 ± 1.39 ka and ~4.19 ± 0.78 ka, were identified. The reconstructed cosmogenic radionuclide ages confirmed the global Last Glacial Maximum(g LGM), Younger Dryas, Early Holocene, and Neoglaciation episodes. As per area and volume change analyses, the TG has lost 51.1 km~2 of its area and a volume of 2.64 km~3 during the last 20.77 ± 2.28 ka. Overall, the results suggested that the TG has lost 64% of area and 73% of volume from the Last glacial maximum to Neoglaciation and about 85.74% and 87.67% of area and volume, respectively, from Neoglaciation to the present day. The equilibrium line altitude of the TG fluctuated from 4238 m a.s.l present to3365 m a.s.l during the g LGM(20.77 ± 2.28 ka). The significant cooling induced by a drop in mean ambient temperature resulted in a positive mass balance of the TG during the g LGM. Subsequently the melting accelerated due to the continuing rise of the global ambient temperature. Paleo-glacial history reconstruction of the Kashmir Himalaya, with its specific geomorphic and climatic setting, would help close the information gap about the chronology of past regional glacial episodes.

关键词： Glacier reconstruction Cosmogenic 10Be gLGM Kashmir Himalaya Equilibrium Line Altitude

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Identification,synthesis and characterization of an unknown process related impurity in eslicarbazepine acetate active pharmaceutical ingredient by LC/ESI-IT/MS,~1H,^(13)C and ~1H-~1H COSY NMR

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Journal of Pharmaceutical Analysis 2014年第5期4卷 339-344页

作者： Saji Thomas Saroj kumar paul Subhash Chandra Joshi Vineet kumar Ashutosh Agarwal Dharam Vir Analytical Research Department Jubilant Life Sciences Ltd.R&D CentreC-26Sector-59NoidaUttar Pradesh 201301India Chemical Research Department Jubilant Life Sciences Ltd.R&D CentreC-26Sector-59NoidaUttar Pradesh 201301India

A new impurity was detected during high performance liquid chromatographic （HPLC） analysis of eslicarbazepine acetate active pharmaceutical ingredient. The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer （LC/ESI-IT/MS） analysis. Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using 1H, 13C nuclear magnetic resonance spectrometry （NMR）, 1H-1H correlation spectro-scopy （COSY） and infrared spectroscopy （IR）. Based on the spectroscopic and spectrometric data, unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl propionate.

关键词： Eslicarbazepine acetate Characterization LC/ES I-IT/MS NMR Impurity

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Single polarization photonic crystal fiber filter based on surface plasmon resonance

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Frontiers of Optoelectronics 2019年第2期12卷 157-164页

作者： Md. Nazmul HOSSEN Md. FERDOUS Kawsar AHMED Md. Abdul KHALEK Sujan CHAKMA Bikash kumar paul Department of Information and Communication Technology(ICT) Mawlana Bhashani Science and Technology University(MBSTU)SantoshTangail 1902Bangladesh Group of Biophotomatix SantoshTangail 1902Bagladesh Department of Software Enineering(SWE) Daffodil International UniversityShukrabadDhaka 1207Bangladesh

In this paper,we propose a photonic crystal fiber(PCF)polarization filter based on surface plasmon resonance(SPR)*** nanowire is used as the active plasmonic *** into silica core becomes coupled to gold nanowire stimulating SPR. It soplits light into two orthogonal(x-polarization and y-polarization)polarization in the second order of surface plasmon *** investigations of the proposed PCF filter is finite element method(FEM).By position,the performance of the propsed PCF filter is inspected *** of any polarization can be obtained by properly placing the metal *** maximum cnfinement loss of x-polarization is 692.25dB/cm and y-polarization is 1.13dB/cm offers at resonance position 1.42μ*** a confinement loss difference between two orthogonal polarizations makes PCF a talented candidate to filter ***,the recommended PCF structure is useful for polarization device.

关键词： photonic crystal fiber (PCF) surface plasmon resonance (SPR) perfectly match layer polarization filter

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Outbreak of an emerging zoonotic Nipah virus:An emerging concern

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Journal of Biosafety and Biosecurity 2023年第2期5卷 57-59页

作者： Diptanu paul Aroop Mohanty Abhishek Shah Bijaya kumar Padhi Ranjit Sah Department of Microbiology AIIMS BhubaneswarIndia Department of Microbiology AIIMS GorakhpurIndia B.P.Koriala Institute of Health Sciences DharanNepal Department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and ResearchIndia Tribhuvan University Teaching Hospital Institute of MedicineKathmanduNepal Department of Microbiology Dr.D.Y.Patil Medical CollegeHospital and Research CentreDr.D.Y.Patil VidyapeethPuneMaharashtraIndia Department of Public Health Dentistry Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia

The Nipah virus(NiV)infection is one of the newly emerging deadly zoonotic diseases which carries a significant weightage of mortality among its *** to the relatively recent history of its emergence and only a few known outbreaks,we cannot predict but foresee its potential to create havoc,which can be far more dreadful than the current ongoing COVID-19 *** we have tried to depict the fatal potential of the virus and the increased propensity with which it can spread to rest of the world.

关键词： Nipah Virus Bangladesh Outbreak

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Synaptosome microRNAs:emerging synapse players in aging and Alzheimer’s disease

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Neural Regeneration Research 2023年第6期18卷 1275-1276页

作者： Subodh kumar Center of Emphasis in Neuroscience Department of Molecular and Translational Medicine paul L.Foster School of Medicine Texas Tech University Health Sciences CenterEl PasoTXUSA

Synaptosome:Synapses are the most critical portion of neuron connections,necessary for cellular organization of the *** integrity is uttermost important for healthy brain *** perturbation in the synapse structure and/or function initiates neurological *** are the prime targets that are smashed in almost all neurodegenerative *** vital components of synapse are essential for neurotransmission,synaptic plasticity and overall synapse *** dysfunctions are well studied in Alzheimer’s disease(AD)and other neurodegenerative diseases(Gowda et al.,2021).The best way to study the synapse dysfunctions in neurological diseases is the biochemical analysis of“synaptosome”.

关键词： Alzheimer diseases

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Dual-wavelength all-fiber Q-switched fiber laser using bismuth-doped fiber as saturable absorber

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Optoelectronics Letters 2024年第3期20卷 147-151页

作者： Aruna Ghosh Abdulkadir Mukhtar Diblawe Uttam kumar Samanta Moh Yasin Sulaiman Wadi Harun Mukul Chandra paul Fiber Optics and Photonics Division CSIR-Central Glass and Ceramic Research InstituteKolkata 700032India Physics Department Jadavpur UniversityKolkata 700032India Photonics Engineering Laboratory Department of Electrical EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia Department of Physics Faculty of Science and TechnologyAirlangga UniversitySurabayaIndonesia

A passively Q-switched all-fiber laser is demonstrated using a 10-cm-long bismuth-doped fiber(BDF) as a saturable absorber(SA). The dual-wavelength operation was obtained due to the nonlinear effect inside the fabricated BDF, which has a high germanium content. Stable Q-switched pulses were obtained at the dual synchronous wavelengths of 1 530.1 nm and 1 531.1 nm. When the pump power is tuned from 105.3 mW to 191.0 mW, the repetition rate can be varied from 82.6 kMz to 117.6 kHz. The maximum pulse energy and average output power were 83.4 nJ and 9.8 mW, respectively while the minimum pulse width was 8.5 μs at the maximum pump power of 191.0 mW. Our results indicate that BDF could be a promising alternative optical modulator for pulsed fiber laser application.

关键词： fiber switched pump

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Silica Induced Early Fibrogenic Reaction in Lung of Mice Ameliorated by Nyctanthes arbortristis Extract

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Biomedical and Environmental Sciences 2002年第3期15卷 215-222页

作者： BHOLA NATH paul ANAND PRAKASH SIRISH kumar AJAY KYADAV UMANI ASHOK KSAXENA ANAND PRAKASH SAHU KEWAL LAL KALYAN KDUTTA Immunobiology Laboratory Industrial Toxicology Research CentreM.G.MargLucknow 226001U.P.India Inhalation Toxicology Laboratory Industrial Toxicology Research CentreM.G.MargLucknow 226001U.P.India Preventive Toxicology Laboratory Industrial Toxicology Research CentreM.G.MargLucknow 226001U.P.India

Objective To investigate the pharmacological effect of Nyctanthes arbortristis (NAT) leaf extract in the prevention of lung injury induced by silica particles. Method Lung injury was induced in Swiss mice through inhalation exposure to silica particles (<5m) using a Flow Past Nose Only Inhalation Chamber at the rate of -10 mg/m3 respirable mass for 5 h. Lung bronchoalveolar lavage (BAL) fluid collected between 48 and 72 h was subjected to protein profiling by electrophoresis and cytokine evaluation by solid phase sandwich ELISA. Lung histopathology was performed to evaluate lung injury. Results Inhalation of silica increased the level of tumor necrosis factor-a (TNF-a), and of the 66 and 63 kDa peptides in the BAL fluid in comparison to sham-treated control. Pre-treatment of silica exposed mice with NAT leaf extract significantly prevented the accumulation of TNF-a in the BAL fluid, but the 66 and 63 kDa peptides remained unchanged. The extract was also effective in the prevention of silica-induced early fibrogenic reactions like congestion, edema and infiltration of nucleated cells in the interstitial alveolar spaces, and thickening of alveolar septa in mouse lung. Conclusion NAT leaf extract helps in bypassing silica induced initial lung injury in mice.

关键词： Nyctanthes arbortristis Lung-injury Silica Mice prevention

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Optical Spectroscopy of Classical Be Stars in Old Open Clusters

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Research in Astronomy and Astrophysics 2023年第3期23卷 16-24页

作者： Madhu Kashyap Jagadeesh Blesson Mathew K.T.paul Gourav Banerjee Suman Bhattacharyya R.Anusha Pramod kumar S. Department of Physics and Electronics CHRIST(Deemed to be University)Hosur Main RoadBengaluruIndia Department of Physics and Astronomy University of Western OntarioON N6A 3K7Canada Indian Institute of Astrophysics KoramangalaBengaluruIndia

We performed the optical spectroscopy of 16 classical Be stars in 11 open clusters older than 100 *** is the first spectroscopic study of classical Be stars in open clusters older than 100 *** found that the Hαemission strength of most of the stars is less than 40?,in agreement with previous *** analysis further suggests that one of the stars,[KW97]35–12,might be a weak Hαemitter in nature,showing Hαequivalent width of-0.5?.Interestingly,we also found that the newly detected classical Be star LSⅢ+4737b might be a component of the possible visual binary system LSⅢ+4737,where the other companion is also a classical Be ***,the present study indicates the possible detection of a binary Be ***,it is observed that all 16 stars exhibit a lesser number of emission lines compared to classical Be stars younger than 100 ***,the spectral type distribution analysis of B-type and classical Be stars for the selected clusters points out that the existence of CBe stars can depend on the spectral type distribution of B-type stars present in these clusters.

关键词： clusters showing spectroscopic

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Role of fibrinogen,albumin and fibrinogen to albumin ratio in determining angiographic severity and outcomes in acute coronary syndrome

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World Journal of Cardiology 2023年第1期15卷 13-22页

作者： Kunaal Makkar Yash paul Sharma Akash Batta Juniali Hatwal Prashant kumar Panda Department of Cardiology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Cardiology Dayanand Medical College and HospitalLudhiana 141001PunjabIndia Department of Internal Medicine Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

BACKGROUND Coronavirus disease 2019(COVID-19)pandemic unmasked the huge deficit in healthcare resources *** highlighted the need for efficient risk stratification in management of cardiovascular *** To study the applicability of the old,available and affordable nonconventional biomarkers:albumin and fibrinogen in their ability to predict angiographic severity and clinical outcomes in patients with acute coronary syndrome(ACS).METHODS In this prospective,observational study,166 consecutive patients with ACS were ***,albumin and their ratio were determined from *** with underlying chronic liver disease,active malignancy,autoimmune disease,active COVID-19 infection and undergoing thrombolysis were *** Mean age of the population was 60.5±1.5 years,74.1%being *** elevation myocardial infarction(STEMI)was most common presentation of ACS seen in 57%*** albumin ratio(FAR)≥19.2,had a sensitivity of 76.9%and specificity of 78.9%[area under the receiver operating characteristic curves(AUROC)=0.8,P=0.001]to predict≤thrombolysis in myocardial infarction(TIMI)1 flow in culprit artery in STEMI *** in non-STEMI patients,FAR≥18.85 predicted the same with 80%sensitivity and 63%specificity(AUROC=0.715,P=0.006).CONCLUSION Novel biomarkers,with their high cost,lack of availability and long turn over time are impractical for real-world ***≤TIMI 1 flow in the culprit artery has significant impact of management and *** study has shown that readily available biomarkers like fibrinogen and albumin can help identify these high-risk patients with good *** allows risk-stratification and individualization of treatment in ACS.

关键词： Acute coronary syndrome Albumin Fibrinogen Fibrinogen to albumin ratio Total occlusion of culprit artery

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Developing Strong and Hybrid Formulation for the Single Stage Single Period Multi Commodity Warehouse Location Problem: Theoretical Framework and Empirical Investigation

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American Journal of Operations Research 2015年第3期5卷 112-128页

作者： R. R. K. Sharma parag Tyagi Vimal kumar Ajay Jha Department of Industrial & Management Engineering IIT Kanpur India

We note that the Single Stage Single Period Multi Commodity Warehouse Location Problem (SSSPMCWLP) has been first attempted by Geoffrion and Graves [1], and that they use the weak formulation (in context of contribution of this paper). We give for the first time “strong” formulation of SSSPMCWLP. We notice advantages of strong formulation over weak formulation in terms of better bounds for yielding efficient Branch and Bound solutions. However, the computation time of “strong” formulation was discovered to be higher than that of the “weak” formulation, which was a major drawback in solving large size problems. To overcome this, we develop the hybrid strong formulation by adding only a few most promising demand and supply side strong constraints to the weak formulation of SSSPMCWLP. So, the formulations developed were put to test on various large size problems. Hybrid formulation is able to give better bound than the weak and takes much less CPU time than the strong formulation. So, a kind of trade off is achieved allowing efficiently solving large sized SSSPMCWLP in real times using hybrid formulation.

关键词： SSUWLP SSSPMCWLP Strong and Weak Constraints Hybrid Formulation RMIP

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