Role of fibrinogen,albumin and fibrinogen to albumin ratio in determining angiographic severity and outcomes in acute coronary syndrome

作     者：Kunaal Makkar Yash Paul Sharma Akash Batta Juniali Hatwal Prashant Kumar Panda 

作者机构：Department of CardiologyPost Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of CardiologyDayanand Medical College and HospitalLudhiana 141001PunjabIndia Department of Internal MedicinePost Graduate Institute of Medical Education and ResearchChandigarh 160012India 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第1期

页      面：13-22页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：American college of Cardiology,No.3445007 European society of Cardiology,No.1036629 

主　　题：Acute coronary syndrome Albumin Fibrinogen Fibrinogen to albumin ratio Total occlusion of culprit artery 

摘      要：BACKGROUND Coronavirus disease 2019(COVID-19)pandemic unmasked the huge deficit in healthcare resources *** highlighted the need for efficient risk stratification in management of cardiovascular *** To study the applicability of the old,available and affordable nonconventional biomarkers:albumin and fibrinogen in their ability to predict angiographic severity and clinical outcomes in patients with acute coronary syndrome(ACS).METHODS In this prospective,observational study,166 consecutive patients with ACS were ***,albumin and their ratio were determined from *** with underlying chronic liver disease,active malignancy,autoimmune disease,active COVID-19 infection and undergoing thrombolysis were *** Mean age of the population was 60.5±1.5 years,74.1%being *** elevation myocardial infarction(STEMI)was most common presentation of ACS seen in 57%*** albumin ratio(FAR)≥19.2,had a sensitivity of 76.9%and specificity of 78.9%[area under the receiver operating characteristic curves(AUROC)=0.8,P=0.001]to predict≤thrombolysis in myocardial infarction(TIMI)1 flow in culprit artery in STEMI *** in non-STEMI patients,FAR≥18.85 predicted the same with 80%sensitivity and 63%specificity(AUROC=0.715,P=0.006).CONCLUSION Novel biomarkers,with their high cost,lack of availability and long turn over time are impractical for real-world ***≤TIMI 1 flow in the culprit artery has significant impact of management and *** study has shown that readily available biomarkers like fibrinogen and albumin can help identify these high-risk patients with good *** allows risk-stratification and individualization of treatment in ACS.