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Potential role of the microbiome in liver injury during COVID-19: Further research is needed

World Journal of Gastroenterology 2023年第3期29卷 503-507页

作者： Marcos Roberto Tovani-Palone paolo pedersini Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical Sciences(SIMATS)Chennai 600077India IRCCS Fondazione Don Carlo Gnocchi Milan 20148Italy

Although different studies have associated coronavirus disease 2019(COVID-19)with the occurrence of liver injury,the hepatic injury route during the COVID-19 course is not yet fully understood.In order to better understand the mechanisms of the disease,the human gut microbiota has been the subject of extensive discussion in the context of COVID-19 pathophysiology.However,many questions remain,including the risks of liver injury due to COVID-19 specific populations.Further research in this field could allow the discovery of new personalized treatment strategies aimed at improving the microbiota composition,thereby reducing COVID-19 severity and its complications in different populations.In this article,we discussed basic mechanisms of severe acute respiratory syndrome coronavirus 2 infection and recent evidence on the relationship between COVID-19,the gut microbiome and liver injury as well as proposed recommendations for further research.

关键词： COVID-19 Gut microbiota Coronavirus Gut microbial-host-immune axis Gut-lung axis Liver injury

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Inequity in the global distribution of monkeypox vaccines

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World Journal of Clinical Cases 2023年第19期11卷 4498-4503页

作者： Marcos Roberto Tovani-Palone Neel Doshi paolo pedersini Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India Department of Medicine Pravara Institute of Medical SciencesAhmednagar 413736India IRCCS Fondazione Don Carlo Gnocchi Milan 20148Italy

Monkeypox(mpox)has been a public health emergency of international concern that emerged in mid-2022 and has spread to 110 countries.The clinical findings of the disease vary according to the seriousness of the cases.Although its case fatality risk has not been high,a significant percentage of patients require hospitalization.In this context,local initiatives were taken to extend the limited supply of vaccines against the disease;however,such measures have not been sufficient to contain the spread of cases and ensure an equitable distribution of health resources.As a result,endemic regions of low-income countries continue to have insufficient access to mpox vaccination.Despite this and considering the global scope of the disease,there is still little discussion in the literature about the difficulties in achieving adequate vaccination coverage rates for the target population of interest.In this article,we briefly discussed general aspects of the disease,including its surveillance,the current global context of challenges for mpox vaccination,and issues on global allocation of health resources as well as proposed related recommendations.

关键词： Monkeypox Smallpox vaccine Health inequities Vaccination coverage Vaccination hesitancy Healthcare financing

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