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The translational revolution in atopic dermatitis:the paradigm shift from pathogenesis to treatment

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Cellular & Molecular Immunology 2023年第5期20卷 448-474页

作者： paola Facheris Jane Jeffery Ester Del Duca Emma Guttman-Yassky Laboratory of Inflammatory Skin Diseases Department of DermatologyIcahn School of Medicine at Mount SinaiNew YorkNYUSA Humanitas Clinical and Research Center Department of DermatologyRozzanoMilanoItaly Duke University School of Medicine DurhamNCUSA Department of Dermatology Icahn School of Medicine at Mount SinaiNew YorkNYUSA.

Atopic dermatitis(AD)is the most common inflammatory skin disease,and it is considered a complex and heterogeneous *** phenotypes of AD,defined according to the patient age at onset,race,and ethnic background;disease duration;and other disease characteristics,have been recently described,underlying the need for a personalized treatment *** advancements in understanding AD pathogenesis resulted in a real translational revolution and led to the exponential expansion of the therapeutic *** study of biomarkers in clinical studies of emerging treatments is helping clarify the role of each cytokine and immune pathway in AD and will allow addressing the unique immune fingerprints of each AD *** medicine will be the ultimate goal of this targeted translational *** this review,we discuss the changes in the concepts of both the pathogenesis of and treatment approach to AD,highlight the scientific rationale behind each targeted treatment and report the most recent clinical efficacy data.

关键词： Atopic dermatitis translational revolution biomarkers eczema

Immortalized hippocampal astrocytes from 3xTg-AD mice,a new model to study disease-related astrocytic dysfunction:a comparative review

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Neural Regeneration Research 2023年第8期18卷 1672-1678页

作者： Laura Tapella Giulia Dematteis Armando A Genazzani Massimiliano De paola Dmitry Lim Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Department of Neuroscience Mario Negri Institute for Pharmacological Research IRCCSMilanoItaly

Alzheimer's disease(AD)is characterized by complex etiology,long-lasting pathogenesis,and celltype-specific ***,there is no cure for AD,emphasizing the urgent need for a comprehensive understanding of cell-specific ***,principal homeostatic cells of the central nervous system,are key players in the pathogenesis of neurodegenerative diseases,including *** models greatly facilitate the investigation of cell-specific pathological alterations and the dissection of molecular mechanisms and ***-derived and immortalized astrocytic cell lines,alongside the emerging technology of adult induced pluripotent stem cells,are widely used to study cellular dysfunction in ***,no stable cell lines were available from genetic mouse AD ***,we established immortalized hippocampal astroglial cell lines from amyloid-βprecursor protein/presenilin-1/Tau triple-transgenic(3xTg)-AD mice(denominated as wild type(WT)-and 3Tg-iAstro cells)using retrovirus-mediated transduction of simian virus 40 large T-antigen and propagation without clonal selection,thereby maintaining natural heterogeneity of primary *** groups have successfully used 3Tg-iAstro cells for single-cell and omics approaches to study astrocytic AD-related alterations of calcium signaling,mitochondrial dysfunctions,disproteostasis,altered homeostatic and signaling support to neurons,and blood-brain barrier *** we provide a comparative overview of the most used models to study astrocytes in vitro,such as primary culture,tumor-derived cell lines,immortalized astroglial cell lines,and induced pluripotent stem cell-derived *** conclude that immortalized WT-and 3Tg-iAstro cells provide a noncompetitive but complementary,low-cost,easy-to-handle,and versatile cellular model for dissection of astrocyte-specific AD-related alterations and preclinical drug discovery.

关键词： Alzheimer's disease astrocytes immortalization astroglial Alzheimers's disease model blood-brain barrier calcium signaling central nervous system homeostasis disproteostasis endoplasmic reticulum-mitochondria contacts induced pluripotent stem cell-derived astrocytes protein synthesis

Antiseptic Efficacy of A Soap Made from Biosurfactants Isolated from Bacillus and Lactobacillus against Pathogenic Bacteria

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Advances in Microbiology 2024年第1期14卷 31-58页

作者： Frédéric Yannick Okouakoua Christian Aimé Kayath Nicaise Saturnin Mokémiabeka Varelle Bervanie Ngala Elenga Digne Nedjea N’goma-Mona Ndelani Nkalla Lambi Sandra paola Elenga Wilson Christ Dieuveil Bayakissa Malanda Rodinet Tsana Junior Patrick Sergy Bissoko1 Moïse Doria Kaya-Ongoto Duchel Jeanedvi Kinavouidi Etienne Nguimbi Laboratoire de Biologie Cellulaire et Molé culaire (BCM) Facult&eacute des Sciences et Techniques Universit&eacute Marien N’gouabi Brazzaville Congo Institut National de Recherche en Sciences Exactes et Naturelles (IRSEN) Avenue de l’Auberge Gascogne Brazzaville Congo

The aim of our study was to use a biosurfactant produced by Bacillus and Lactobacillus isolates as an antiseptic in the formulation of local soap. A total of 60 isolates were characterized by microbiological techniques (30 Bacillus and 30 Lactobacillus) and the ability to produce biosurfactants was demonstrated by a hydrocarbon emulsification index (E24). The emulsification indexes (E24) varied from 9% to 100% for Bacillus and from 33% to 100% for Lactobacillus as well. The antagonistic assay showed that biosurfactants were able to inhibit the formation of biofilms and growth of pathogens such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Salmonella typhirium, Shigella boydii and Proteus mirabilis. The biosurfactant consortium (BioC) from Bacillus consortium and from Lactobacillus was able to inhibit biofilm formation and the pathogens growth. The BioC was stable to alkaline pH and the temperatures stability of Biosurfactant was ranging from 50°C to 90°C. The soap was made by the cold saponification process using one biosurfactant consortium formulated. This soap has a pH of 10 and showed good cleaning power and good foam stability. Similarly, the soap showed good antiseptic power and disinfection power against all pathogens tested. Handwashing is critical to preventing disease transmission. The persistence of pathogens in waste water was evaluated. The BioS produced showed good disinfection power against all pathogens tested. The valor of reduction on the hands and in the waste water was significantly more than compared to the control soaps used. This soap could be used in the prevention, fighting, and treatment of bacterial and viral infections.

关键词： Antiseptic Soap Biosurfactants Bacillus Lactobacillus Disinfection Pathogens bacteria

Type 2 diabetes and bone fragility in children and adults

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World Journal of Diabetes 2022年第11期13卷 900-911页

作者： Maria Felicia Faienza paola Pontrelli Giacomina Brunetti Department of Biomedical Sciences and Human Oncology Pediatric UnitUniversity of Bari Aldo MoroBari 70124Italy Division of Nephrology Department of Emergency and Organ TransplantationUniversity of Bari Aldo MoroBari 70124Italy Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity of Bari Aldo MoroBari 70125Italy

Type 2 diabetes(T2D)is a global epidemic *** prevalence of T2D in adolescents and young adults is increasing *** mechanisms leading to T2D in young people are similar to those in older ***,the severity of onset,reduced insulin sensitivity and defective insulin secretion can be different in subjects who develop the disease at a younger age.T2D is associated with different complications,including bone fragility with consequent susceptibility to *** purpose of this systematic review was to describe T2D bone fragility together with all the possible involved *** studies have reported that patients with T2D show preserved,or even increased,bone mineral density compared with *** apparent paradox can be explained by the altered bone quality with increased cortical bone porosity and compromised mechanical ***,reduced bone turnover has been described in T2D with reduced markers of bone formation and *** findings prompted different researchers to highlight the mechanisms leading to bone fragility,and numerous critical altered pathways have been identified and *** detail,we focused our attention on the role of microvascular disease,advanced glycation end products,the senescence pathway,the Wnt/β-catenin pathway,the osteoprotegerin/receptor-activator of nuclear factor kappa B ligand,osteonectin and fibroblast growth factor *** understanding of type 2 myeloid bone fragility is an important issue as it could suggest possible interventions for the prevention of poor bone quality in T2D and/or how to target these pathways when bone disease is clearly evident.

关键词： Type 2 diabetes Bone remodeling Cytokines Bone fragility Bone mineral density Chronic kidney disease

Relation between skeletal muscle volume and prognosis in rectal cancer patients undergoing neoadjuvant therapy

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 423-433页

作者： paola De Nardi Alessandro Giani Giulia Maggi Marco Braga Department of Gastrointestinal Surgery IRCCS San Raffaele Scientific InstituteMilano 20132Italy Department of Surgery School of MedicineUniversity of Milano-BicoccaMilan ItalyMonza 20900Italy Department of Oncologic Surgery Policlinico CasilinoRome 00169Italy Department of Surgery San Gerardo HospitalUniversity Milano BicoccaMonza 20900Italy

The prognostic role of body composition indexes,and specifically sarcopenia,has recently been explored in different cancer ***,conflicting results have been *** in cancer type,cancer stage or oncological treatments,as well as different methodology and definition of sarcopenia,could be accounted for different conclusions retrieved from *** focusing on colorectal cancer,it clearly appears that colon and rectal cancers are often treated as a single entity though they have different behaviors and ***,patients with advanced rectal cancer represent a peculiar group of patients that according to current guidelines are treated with neoadjuvant chemotherapy and radiotherapy followed by radical *** review was restricted to a homogeneous group of patients with advanced lower rectal cancer and the aim of exploring whether there is a correlation between skeletal muscle depletion and *** was searched for articles related to patients with advanced rectal cancer undergoing neoadjuvant chemo-radiotherapy(NCRT)followed by radical surgery,in whom muscle mass and/or change in muscle mass during neoadjuvant treatment were *** full-text articles were selected and included in the present *** main findings of our review were:(1)The majority of the studies defined sarcopenia as muscle mass alone over muscle strength or physical performance;(2)There was a great deal of heterogeneity in the definition and measures of sarcopenia,in the definition of cut-off values,and in the method to measure change in muscle mass;(3)There was not full agreement on the association between sarcopenia at baseline and/or after chemoradiotherapy and prognosis,and only few studies found a significance in the multivariate analysis;and(4)It seems that a loss in skeletal muscle mass during NCRT is associated with the worst outcomes in terms of disease-free *** conclusion,analysis of muscle mass might provid

关键词： Advanced rectal cancer Sarcopenia Neoadjuvant treatment Chemoradiotherapy Surgery Muscle mass change Prognosis Survival Review

Photocatalytic activity of Eu-doped ZnO prepared by supercritical antisolvent precipitation route:When defects become virtues

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Journal of Materials Science & Technology 2022年第17期112卷 49-58页

作者： Olga Sacco paola Franco Iolanda De Marco Vincenzo Vaiano Emanuela Callone Riccardo Ceccato Francesco Parrino Department of Chemistry and Biology“A.Zambelli” University of Salernovia Giovanni Paolo II13284084 Fisciano SalernoItaly Department of Industrial Engineering Univerisity of SalernoVia Giovanni Paolo II 13284084 Fisciano SalernoItaly Department of Industrial Engineering University of TrentoVia Sommarive 930123 TrentoItaly

The aim of this work is to determine the structural and optical properties of Eu-doped ZnO powders prepared by supercritical antisolvent precipitation route(SAS)and to correlate the physico-chemical features with the photocatalytic activity under UV *** and EPR spectroscopy highlight the introduction of novel defects(mainly singly and doubly ionized oxygen vacancies,and oxygen interstitials)on the Eu-doped ZnO samples,which confer higher hydrophilicity to the doped samples with respect to bare ZnO,as evidenced by FT-IR ***,photoluminescence spectra show that the presence of Eu^(3+) totally quenches the visible light emission typical of bare ZnO,which mainly results from the recombination of photogenerated holes at defective *** prepared samples were tested both for the photocatalytic degradation of crystal violet dye(CV)and for the partial oxidation of ferulic acid under UV *** photocatalytic activity results evidence of a higher ability of Eu-doped photocatalysts to degrade CV and ferulic acid,while higher selectivity values towards vanillin are obtained in the presence of bare *** higher activity of Eu-doped ZnO photocatalysts is linked to the stabilization of photogenerated holes and to their higher hydrophilicity,both brought by the generation of defective sites induced by the presence of Eu^(3+) ions within the ZnO lattice.

关键词： Europium doped ZnO Supercritical antisolvent precipitation Crystal violet Vanillin Photocatalysis UV light Defective sites

Evolutionary importance of the relationship between cytogeography and climate:New insights on creosote bushes from North and South America

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Plant Diversity 2022年第5期44卷 492-498页

作者： Romina Vidal-Russell Mariana Tadey Romana Urfusova Tomás Urfus Cintia paola Souto Laboratorio Ecotono-INIBIOMA(CONICET-UNComahue) Quintral1250BarilocheRío NegroArgentina Department of Botany Faculty of ScienceCharles UniversityBenátská212800PragueCzech Republic

Relationships between genome size and environmental variables suggest that DNA content might be adaptive and of evolutionary importance in *** genus Larrea provides an interesting system to test this hypothesis,since it shows both intra-and interspecific variation in genome *** has an amphitropical distribution in North and South American deserts,where it is most *** tridentata in North America shows a gradient of increasing autopolyploidy;while three of the four studied South American species are diploids,Larrea divaricata,Larrea nitida,Larrea ameghinoi,and the fourth is an allopolyploid,Larrea *** downloaded available focal species’georeferenced records from seven data *** used these records to extract biologically relevant environmental variables from WorldClim at 30 arc seconds scale,to have a broad characterization of the variable climatic conditions of both regions,and a climatic envelope for each *** estimated relative DNA content index and relative monoploid genome values,by flow cytometry,of four most abundant Larrea species throughout their respective *** we winnow the bioclimatic dataset down to uncorrelated variables and sampled locales,to analyse the degree of association between both intra-and interspecific relative DNA content and climatic variables that are functionally relevant in arid environments using Pearson correlations,general linear and mixed effects *** the genus Larrea,relative DNA content increases with rising temperature and decreases with rising *** the intraspecific level,all four species show relative DNA content variation across climatic *** is a genus that shows genome size variation correlated with *** results are also consistent with the hypothesis that extreme environmental pressures may have facilitated repeated whole genome duplication events in North America,while in South America,reticulate evolution,as allopolyploidizati

关键词： DNA content Drylands Genome size Jarilla Larrea Zygophyllaceae

Robust estimation of time-dependent precision matrix with application to the cryptocurrency market

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Financial Innovation 2022年第1期8卷 1313-1337页

作者： paola Stolfi Mauro Bernardi Davide Vergni Institute for Applied Mathematics“Mauro Picone”(IAC)-National Research Council of Italy Via dei Taurini 1900185 RomeItaly Department of Statistical Sciences University of PadovaVia C.Battisti24135121 PaduaItaly

Most financial signals show time dependency that,combined with noisy and extreme events,poses serious problems in the parameter estimations of statistical ***,when addressing asset pricing,portfolio selection,and investment strategies,accurate estimates of the relationship among assets are as necessary as are delicate in a time-dependent *** this regard,fundamental tools that increasingly attract research interests are precision matrix and graphical models,which are able to obtain insights into the joint evolution of financial *** this paper,we present a robust divergence estimator for a time-varying precision matrix that can manage both the extreme events and time-dependency that affect financial time ***,we provide an algorithm to handle parameter estimations that uses the“maximization–minimization”*** apply the methodology to synthetic data to test its ***,we consider the cryptocurrency market as a real data application,given its remarkable suitability for the proposed method because of its volatile and unregulated nature.

关键词： Time-varying models Robust methods Kernel estimation Precision matrix Divergence

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BIOCELL 2022年第12期46卷 2525-2530页

作者： MONICA SAVIO VALENTINA MINOIA paola FULGHIERI LUCIA ANNA STIVALA VIRGINIE SOTTILE Department of Molecular Medicine University of PaviaPavia27100Italy

The nutraceutical resveratrol is associated with a range of biological effects,from antibiotic to antiinflammatory *** major axis of research has sought to harness its anti-tumour potential,with promising preclinical results and early clinical trials.A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell *** is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in *** we evoke novel developments in the field that could lead to more reliable conditions for the translational use of resveratrol-based compounds.

关键词： Resveratrol Nutraceutical Cancer Cell Differentiation Dihydroxystilbene