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The incidence rate and histological characteristics of intimal hyperplasia in elastase-induced experimental abdominal aortic aneurysms in mice

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Animal Models and Experimental Medicine 2024年第3期7卷 388-395页

作者： Meng Li panpan wei Kexin Li Haole Liu Naqash Alam Haiwen Hou Jie Deng Baohui Xu Enqi Liu Sihai Zhao Yankui Li Laboratory Animal Center Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery The Second Hospital of Tianjin Medical UniversityTianjinChina Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery Stanford University School of MedicineStanfordCaliforniaUSA

Intimal hyperplasia(IH)is a negative vascular remodeling after arterial *** occasionally occurs in elastase-induced abdominal aortic aneurysm(AAA)mouse *** study aims to clarify the incidence and histological characteristics of IH in aneurysmal mice.A retrospective study was conducted by including 42 male elastaseinduced mouse AAA *** IH incidence,aortic diameters with or without IH,and hyperplasia lesional features of mice were *** 42 elastase-induced AAA mouse models,10 mice developed mild IH(24%)and severe IH was found in only 2 mice(5%).The outer diameters of the AAA segments in mice with and without IH did not show significant *** mild and severe IH lesions show strong smooth muscle cell positive staining,but endothelial cells were occasionally observed in severe IH *** was obvious macrophage infiltration in the IH lesions of the AAA mouse models,especially in mice with severe ***,only a lower numbers of T cells and B cells were found in the IH *** cell-secreted matrix metalloproteinases(MMP)2 was highly expressed in all IH lesions,but MMP9 was only overexpressed in severe *** conclusion,this study is the first to demonstrate the occurrence of aneurysmal IH and its histological characteristics in an elastaseinduced mouse AAA *** will help researchers better understand this model,and optimize it for use in AAA-related research.

关键词： abdominal aortic aneurysms animal model histology intimal hyperplasia

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Role of long non-coding RNAs in normal and malignant hematopoiesis

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Science China(Life Sciences) 2013年第10期56卷 867-875页

作者： wei panpan HAN Bowei CHEN YueQin Key Laboratory of Gene Engineering of Ministry of Education State Key Laboratory for BiocontrolSchool of Life ScienceSun Yat-sen University

Long non-coding RNAs(lncRNAs)are defined as a class of nonprotein-coding transcripts greater than 200 nucleotides in length,which have diverse functions in development and diseases including *** advances have revealed that lncRNAs regulate hematopoietic development at almost every stage,including differentiation of the myelocyte,lymphocyte,and *** regulation of the lncRNAs may block aspects of blood development,which can lead to different types of hematopoietic *** findings highlight the role of lncRNAs as potential therapeutic tools in malignant *** this review,we summarize recent progress in the study of functional lncRNAs associated with blood development,as well as dysregulated lncRNAs involved in diverse blood diseases by interacting with crucial susceptibility genes in different *** addition,we discuss genome-wide studies on lncRNAs,which are helpful for genome screening and in-depth functional study of lncRNAs associated with blood development and disease.

关键词： long non-coding RNA (IncRNA) hematopoiesis blood disease susceptibility gene

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不同人工孵化模式对青海湖裸鲤孵化效果的影响

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科学养鱼 2024年第4期 22-24页

作者：魏盼盼丰朝晖俞录贤祁洪芳董在杰青海湖裸鲤救护中心青海省青海湖裸鲤繁育与保护重点实验室青海西宁810016 中国水产科学研究院淡水渔业研究中心农业农村部淡水渔业与种质资源利用重点实验室江苏无锡214081

在最初的青海湖裸鲤人工孵化过程中,采用传统的平列槽流水孵化模式,该法占地面积大、耗能高,且因受精卵为沉性卵,具有微黏性的特征,在孵化过程中卵粒易粘连结块,造成死亡,孵化率很难进一步提升。2013年,青海湖裸鲤救护中心将孵化模式逐... 详细信息

在最初的青海湖裸鲤人工孵化过程中,采用传统的平列槽流水孵化模式,该法占地面积大、耗能高,且因受精卵为沉性卵,具有微黏性的特征,在孵化过程中卵粒易粘连结块,造成死亡,孵化率很难进一步提升。2013年,青海湖裸鲤救护中心将孵化模式逐渐改进为立体式流水孵化与圆缸淋浴转动孵化联合使用的模式,在提升孵化率的基础上,实现了优化空间、节水增效的目的(俞录贤等,2016)。但是在实际生产中,立体式孵化器与圆缸配套使用的模式,程序较为繁琐,且人力需求和生产成本较高。

关键词：孵化过程孵化效果人工孵化占地面积节水增效青海湖裸鲤卵粒孵化率

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Effect of tubastatin A on NLRP3 inflammasome activation in macrophages under hypoxia/ reoxygenation conditions

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World Journal of Emergency Medicine 2024年第4期15卷 289-296页

作者： Hao Li Chang Liu Ying Cui panpan Chang wei Chong Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Trauma Medicine Center Peking University People's HospitalBeijing 100871China Key Laboratory of Trauma and Neural Regeneration Peking UniversityBeijing 100871China National Center for Trauma Medicine of China Beijing 100871China

BACKGROUND:There are currently no effective drugs to mitigate the ischemia/reperfusion injury caused by fluid resuscitation after hemorrhagic shock(HS).The aim of this study was to explore the potential of the histone deacetylase 6(HDAC6)-specific inhibitor tubastatin A(TubA)to suppress nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation in macrophages under hypoxia/reoxygenation(H/R)***:The viability of RAW264.7 cells subjected to H/R after treatment with different concentrations of TubA was assessed using a cell-counting kit-8(CCK8)***,2.5μmol/L TubA was used with RAW264.7 cells under H/R ***264.7 cells were divided into three groups,namely the control,H/R,and TubA *** levels of reactive oxygen species(ROS)in the cells were detected using fluorescence *** protein expression of HDAC6,heat shock protein 90(Hsp90),inducible nitric oxide synthase(iNOS),NLRP3,gasdermin-D(GSDMD),Caspase-1,GSDMD-N,and Caspase-1 p20 was detected by western *** levels of interleukin-1β(IL-1β)and IL-18 in the supernatants were detected using enzyme-linked immunosorbent assay(ELISA).RESULTS:HDAC6,Hsp90,and iNOS expression levels were significantly higher(P<0.01)in the H/R group than in the control group,but lower in the TubA group than in the H/R group(P<0.05).When comparing the H/R group to the control group,ROS levels were significantly higher(P<0.01),but significantly reduced in the TubA group(P<0.05).The H/R group had higher NLRP3,GSDMD,Caspase-1,GSDMD-N,and Caspase-1 p20 expression levels than the control group(P<0.05),however,the TubA group had significantly lower expression levels than the H/R group(P<0.05).IL-1βand IL-18 levels in the supernatants were significantly higher in the H/R group compared to the control group(P<0.01),but significantly lower in the TubA group compared to the H/R group(P<0.01).CONCLUSION:TubA inhibited the expression of HDAC6,Hsp90,and iNOS in macrophages

关键词： Hemorrhagic shock Hypoxia/reoxygenation Macrophage NLRP3 Tubastatin A

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弹性蛋白酶诱导的小鼠腹主动脉瘤消退期组织学特征观察

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西安交通大学学报（医学版） 2024年第1期45卷 119-125页

作者：李濛刘浩乐魏盼盼李可心吴海滨侯海雯刘恩岐李艳奎赵四海天津医科大学第二医院血管外科天津300211 西安交通大学医学部实验动物中心陕西西安710061

目的确定猪胰弹性蛋白酶(PPE)诱导的腹主动脉瘤(AAA)到达消退期的时间点,观察AAA消退期的组织学特征。方法选用C57BL/6J小鼠,手术游离腹主动脉,进行血管腔内输注PPE诱导AAA。测量小鼠术前、术后14 d(AAA到达平台期的时间点)和术后56 d(... 详细信息

目的确定猪胰弹性蛋白酶(PPE)诱导的腹主动脉瘤(AAA)到达消退期的时间点,观察AAA消退期的组织学特征。方法选用C57BL/6J小鼠,手术游离腹主动脉,进行血管腔内输注PPE诱导AAA。测量小鼠术前、术后14 d(AAA到达平台期的时间点)和术后56 d(AAA消退期时间点)腹主动脉直径,比较分析术后14 d和术后56 d动脉瘤病变部位组织学特征。结果与正常腹主动脉相比,PPE输注14 d组和56 d组,腹主动脉直径均显著增加(直径增长率分别为147%和155%)。PPE输注后14 d,动脉瘤病变部位显微镜镜下可见弹性纤维断裂、平滑肌耗竭和炎症细胞弥散浸润等典型的AAA特征。在PPE输注后56 d组,虽然动脉直径没有明显变化,但组织学可见弹力纤维部分修复,新生平滑肌细胞补充至损伤的中膜,浸润的炎症细胞明显消退,外膜新生血管减少,呈现出疾病消退期的显著特征。结论在PPE诱导的小鼠AAA模型中,术后56 d是观察动脉瘤消退的合适时间点,动脉瘤病变消退的组织学特征明显。

关键词：腹主动脉瘤消退弹性蛋白酶小鼠组织学

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对比增强能谱乳腺摄影用于非肿块样强化乳腺癌的诊断价值

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国际医学放射学杂志 2024年第3期47卷 321-327页

作者：陈军葛金丹魏盼盼杨光华蓓王勇荣小翠全冠民河北医科大学第四医院放射科石家庄050011 河北医科大学第一医院放射与核医学科河北医科大学第二医院影像科

目的探讨对比增强能谱乳腺摄影(CESM)影像特征对非肿块样强化(NME)乳腺导管癌不同组织学类型与腋窝淋巴结(ALN)转移的诊断价值。方法回顾性纳入完成CESM检查的NME乳腺癌女性病人63例,经病理确诊为导管原位癌(DCIS)或浸润性导管癌(IDC)... 详细信息

目的探讨对比增强能谱乳腺摄影(CESM)影像特征对非肿块样强化(NME)乳腺导管癌不同组织学类型与腋窝淋巴结(ALN)转移的诊断价值。方法回顾性纳入完成CESM检查的NME乳腺癌女性病人63例,经病理确诊为导管原位癌(DCIS)或浸润性导管癌(IDC)。根据组织学类型分为DCIS组(32例)和IDC组(31例);根据有无微浸润将32例DCIS病人分为单纯DCIS组(18例)和DCIS伴微浸润(DCIS-MI)组(14例);根据ALN转移情况分为转移阳性组(19例)和转移阴性组(44例)。采用t检验、Mann-Whitney U检验、χ^(2)检验比较各分组的CESM影像特征的差异。将筛选出来有统计学意义的CESM影像特征行多因素Logistic回归分析,确定IDC、DCIS-MI及ALN转移的独立预测因素。绘制受试者操作特征(ROC)曲线,计算并比较ROC曲线下面积(AUC)、敏感度、特异度。结果DCIS与IDC间在内部强化方式、头足位减影影像相对强化比值(%RSCC)及时间信号强化曲线(TIC)类型存在统计学差异(均P3.42%和集簇/簇环强化是IDC的独立预测因素(均P2.47%和最大截面面积大于4.37 cm2是DCIS-MI的独立预测因素(均P2.71%和集簇/簇环强化是ALN转移的独立预测因素(均P<0.05),其AUC值分别为0.717、0.786。结论在CESM上测得的%RSCC、最大截面面积、TIC、形态分布特征及内部强化特征对于非肿块型乳腺导管癌组织学类型及ALN转移具有一定的诊断价值,可为临床医生决策及病人预后提供参考依据。

关键词：非肿块型乳腺病变对比增强能谱乳腺摄影导管原位癌浸润性导管癌

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云南景谷基地C3F烟叶质量特点与稳定性分析

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种业导刊 2024年第4期 12-16页

作者：王战义綦世飞左伟标毕乐乐卫盼盼安银立王松峰华环国际烟草有限公司中国农业科学院烟草研究所

分析云南景谷基地中橘三（C3F）烟叶内、外在质量，掌握烟叶质量特点和稳定性，以期为提升基地高端原料生产提供技术支持。分别采集景谷基地永平镇、威远镇、勐班乡、半坡乡和碧安乡共5个有代表性乡镇2020—2022年C3F烟叶，通过对烟叶... 详细信息

分析云南景谷基地中橘三（C3F）烟叶内、外在质量，掌握烟叶质量特点和稳定性，以期为提升基地高端原料生产提供技术支持。分别采集景谷基地永平镇、威远镇、勐班乡、半坡乡和碧安乡共5个有代表性乡镇2020—2022年C3F烟叶，通过对烟叶外观质量、物理特性、化学成分和感官质量分析，初步明确了景谷基地C3F烟叶主要特点。C3F烟叶表现为颜色橘黄，成熟度较好，叶片结构疏松，身份中等，有油分，色度强；叶长、叶宽和单叶质量等物理特性指标适中；化学成分呈现出高糖、低两糖比，氯和钾氯比年际间差异大；清香型风格特征明显。外观和感官质量综合得分逐年提升；除拉力外，物理特性各指标变异较小；除氯和钾氯比外，各化学成分变异不大；不同年度和区域样品间，质量稳定性较好。景谷基地应控制烟叶总糖含量、适当提高还原糖含量，有助于烟叶品质的提升，部分植烟区域应加强土壤和烟叶中氯的动态监测，在土壤和烟叶氯含量均偏低的区域，精准补氯，以稳定烟叶中氯含量。

关键词：烟叶质量特点外观质量物理特性化学成分感官质量稳定性景谷基地

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Chlorofullerene C60Cl6 Enables Efficient and Stable Tin-Based Perovskite Solar Cells

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Energy & Environmental Materials 2024年第1期7卷 180-187页

作者： Jingfu Chen Chengbo Tian Chao Sun panpan Yang Wenjing Feng Lingfang Zheng Liu Yang Enlong Hou Jiefeng Luo Liqiang Xie Zhanhua wei Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and Engineering Huaqiao University

Tin-based perovskite solar cells（TPSCs） have received great attention due to their eco-friendly properties and high theoretical ***,the fast crystallization feature of tin-based perovskites leads to poor film quality and limits the corresponding device ***,a chlorofullerene,C60Cl6,with six chlorine attached to the C60cage,is applied to modulate the crystallization process and passivate grain boundary defects of the perovskite film.

关键词： crystallization regulation defect passivation fullerene derivative perovskites solar cell tin-based perovskite

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Kunming mouse strain is less susceptible to elastase-induced abdominal aortic aneurysms

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Animal Models and Experimental Medicine 2022年第1期5卷 72-80页

作者： Haole Liu Kangli Tian Congcong Xia panpan wei Boyu Xu weilai Fu Yankui Li Yafeng Li Liang Bai Rong Wang weirong Wang Baohui Xu Enqi Liu Sihai Zhao Institute of Cardiovascular Science School of Basic Medical SciencesXi'an Jiaotong University Health Science CenterXi'anChina Laboratory Animal Center Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery The Second Hospital of Tianjin Medical UniversityTianjinChina Pain Rehabilitation Department of TCM Orthopedic Center Xi'an Honghui HospitalXi'anChina Department of Vascular Surgery Stanford University School of MedicineStanfordCaliforniaUSA

Background:Porcine pancreatic elastase(PPE)is successfully used to induce abdominal aortic aneurysm(AAA)in ***,differences between mouse strains in susceptibility to PPE induction have been *** mouse is one of the most frequently used strains in China but whether it is suitable for induction of AAA by PPE application remains ***:PPE infusion(1.5 units/ml)in temporary controlled aorta was performed to induce AAAs in both C57BL/6J and Kunming *** saline(PBS)application was used as vehicle *** aorta diameters of all mice were measured at days 0 and 14 after surgery to evaluate the AAA ***:After 14 days of PPE or PBS infusion,all mice were sacrificed and aorta tissues were collected for histological staining *** the 14th day after infusion,PPE successfully induced aortic dilation in Kunming mice and typical AAA in C57BL/6J *** aorta diameter increased by 0.23 mm in Kunming mice after PPE infusion,while it was 0.72 mm in the C57BL/6J *** induced mild elastin degradation,smooth muscle cell(SMC)depletion and mural leucocyte infiltration in Kunming mice,but in PPE-sensitive C57BL/6J mice,it induced total loss of SMCs,elastin disappearance and diffused infiltrated leucocytes in aortic aneurysmal *** effects of PPE in inducing angiogenesis and upregulating matrix metalloproteinase 2 and 9 expression in Kunming mice were also weaker than that in C57BL/6J ***:At the reported dose of PPE,Kunming mouse is not as susceptible to AAA formation as C57BL/6J *** failure of PPE to induce AAA formation in Kunming mice may be associated to its inability to boost a strong inflammatory response.

关键词： abdominal aortic aneurysms C57BL/6J histology Kunming strain

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Inhibition of Heterogeneous Nucleation in Water by Hydrogel Coating

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Research 2024年第2期2023卷 139-147页

作者： Siyang Li panpan Zhu Yaoting Xue Lei Wangg Tuck-Whye Wong Xuxu Yang Haoei Zhou Tiefeng Li We Yang Department of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang UniversityHangzhou 310027China Center for X-Mechanics Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China School of Biomedical Engineering and Health Sciences and Advanced Membrane Technology Research Centre Universiti Teknologi MalaysiaSkudai 81310Malaysia

Heterogeneous nucleation plays a critical role in the phase transition of water,which can cause damage in various ***,we report that heterogeneous nucleation can be inhibited by utilizing hydrogel coatings to isolate solid surfaces and ***,which contain over 90%water when fully swelled,exhibit a high degree of similarity to *** to this similarity,there is a great energy barrier for heterogeneous nucleation along the water-hydrogel ***,hydrogel coatings,which possess polymer networks,exhibit higher fracture energy and more robust adhesion to solid surfaces compared to *** high fracture and adhesion energy acts as a deterrent for fracture nucleation within the hydrogel or along the hydrogel-solid *** a hydrogel layer approximately 100μm thick,the boiling temperature of water under atmospheric pressure can be raised from 100 to 108℃.Notably,hydrogel coatings also result in remarkable reductions in cavitation pressure on multiple solid *** have demonstrated the efficacy of hydrogel coatings in preventing damages resulting from acceleration-induced *** coatings have the potential to alter the energy landscape of heterogeneous nucleation on the water-solid interface,making them an exciting avenue for innovation in heat transfer and fluidic systems.

关键词： fracture cavitation similarity

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