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The incidence rate and histological characteristics of intimal hyperplasia in elastase-induced experimental abdominal aortic aneurysms in mice

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Animal Models and Experimental Medicine 2024年第3期7卷 388-395页

作者： Meng Li panpan wei Kexin Li Haole Liu Naqash Alam Haiwen Hou Jie Deng Baohui Xu Enqi Liu Sihai Zhao Yankui Li Laboratory Animal Center Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery The Second Hospital of Tianjin Medical UniversityTianjinChina Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery Stanford University School of MedicineStanfordCaliforniaUSA

Intimal hyperplasia(IH)is a negative vascular remodeling after arterial *** occasionally occurs in elastase-induced abdominal aortic aneurysm(AAA)mouse *** study aims to clarify the incidence and histological characteristics of IH in aneurysmal mice.A retrospective study was conducted by including 42 male elastaseinduced mouse AAA *** IH incidence,aortic diameters with or without IH,and hyperplasia lesional features of mice were *** 42 elastase-induced AAA mouse models,10 mice developed mild IH(24%)and severe IH was found in only 2 mice(5%).The outer diameters of the AAA segments in mice with and without IH did not show significant *** mild and severe IH lesions show strong smooth muscle cell positive staining,but endothelial cells were occasionally observed in severe IH *** was obvious macrophage infiltration in the IH lesions of the AAA mouse models,especially in mice with severe ***,only a lower numbers of T cells and B cells were found in the IH *** cell-secreted matrix metalloproteinases(MMP)2 was highly expressed in all IH lesions,but MMP9 was only overexpressed in severe *** conclusion,this study is the first to demonstrate the occurrence of aneurysmal IH and its histological characteristics in an elastaseinduced mouse AAA *** will help researchers better understand this model,and optimize it for use in AAA-related research.

关键词： abdominal aortic aneurysms animal model histology intimal hyperplasia

Kunming mouse strain is less susceptible to elastase-induced abdominal aortic aneurysms

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Animal Models and Experimental Medicine 2022年第1期5卷 72-80页

作者： Haole Liu Kangli Tian Congcong Xia panpan wei Boyu Xu weilai Fu Yankui Li Yafeng Li Liang Bai Rong Wang weirong Wang Baohui Xu Enqi Liu Sihai Zhao Institute of Cardiovascular Science School of Basic Medical SciencesXi'an Jiaotong University Health Science CenterXi'anChina Laboratory Animal Center Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery The Second Hospital of Tianjin Medical UniversityTianjinChina Pain Rehabilitation Department of TCM Orthopedic Center Xi'an Honghui HospitalXi'anChina Department of Vascular Surgery Stanford University School of MedicineStanfordCaliforniaUSA

Background:Porcine pancreatic elastase(PPE)is successfully used to induce abdominal aortic aneurysm(AAA)in ***,differences between mouse strains in susceptibility to PPE induction have been *** mouse is one of the most frequently used strains in China but whether it is suitable for induction of AAA by PPE application remains ***:PPE infusion(1.5 units/ml)in temporary controlled aorta was performed to induce AAAs in both C57BL/6J and Kunming *** saline(PBS)application was used as vehicle *** aorta diameters of all mice were measured at days 0 and 14 after surgery to evaluate the AAA ***:After 14 days of PPE or PBS infusion,all mice were sacrificed and aorta tissues were collected for histological staining *** the 14th day after infusion,PPE successfully induced aortic dilation in Kunming mice and typical AAA in C57BL/6J *** aorta diameter increased by 0.23 mm in Kunming mice after PPE infusion,while it was 0.72 mm in the C57BL/6J *** induced mild elastin degradation,smooth muscle cell(SMC)depletion and mural leucocyte infiltration in Kunming mice,but in PPE-sensitive C57BL/6J mice,it induced total loss of SMCs,elastin disappearance and diffused infiltrated leucocytes in aortic aneurysmal *** effects of PPE in inducing angiogenesis and upregulating matrix metalloproteinase 2 and 9 expression in Kunming mice were also weaker than that in C57BL/6J ***:At the reported dose of PPE,Kunming mouse is not as susceptible to AAA formation as C57BL/6J *** failure of PPE to induce AAA formation in Kunming mice may be associated to its inability to boost a strong inflammatory response.

关键词： abdominal aortic aneurysms C57BL/6J histology Kunming strain

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao wei panpan Zhao Yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

手持终端小型MIMO智能天线阵列的优化设计

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固体电子学研究与进展 2021年第3期41卷 203-209页

作者：魏盼盼王峰文舸一南京信息工程大学应用电磁学研究中心南京210044

提出了一种工作在3.3~3.5 GHz频段的手持终端八单元MIMO智能天线阵列。该阵列由两个对称的四单元子阵列组成,分别放置在移动终端的两个长边偏上位置。四单元子阵总尺寸为45 mm×5 mm×3 mm,仅占基板长边约三分之一。先引入地面隔离槽,使... 详细信息

提出了一种工作在3.3~3.5 GHz频段的手持终端八单元MIMO智能天线阵列。该阵列由两个对称的四单元子阵列组成,分别放置在移动终端的两个长边偏上位置。四单元子阵总尺寸为45 mm×5 mm×3 mm,仅占基板长边约三分之一。先引入地面隔离槽,使MIMO接收系统获得良好的隔离和包络相关系数;再基于最大功率传输效率法,获得指定辐射方向的发射天线阵列的最优激励,并保证在该方向上获得最大增益;最后利用自行研发的波束成形控制器实现最优激励分布,从而将天线波束偏转到指定方向。天线阵列工作在3.45 GHz时,在x、z方向上增益分别为4.1 dBi和5.9 dBi。

关键词： MIMO智能天线阵列最大功率传输效率法最优激励波束成形控制器

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探究钢筋套筒灌浆连接施工质量控制

山西建筑 2019年第7期45卷 127-129页

作者：卫盼盼河南五建建设集团有限公司河南郑州450000

分析了钢筋套筒灌浆连接施工中存在的质量问题,从钢筋套筒灌浆连接施工中各主要的阶段,对影响质量的因素进行了研究,并给出了相关的解决方案,从而保证钢筋套筒灌浆连接施工质量。

关键词：钢筋工程灌浆质量控制

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领导理论发展的研究综述

商业经济 2014年第6期 24-26页

作者：蔚盼盼新疆财经大学工商管理学院新疆乌鲁木齐830012

领导理论是研究领导有效性的理论。自20世纪40年代以来,西方学者从不同角度对领导问题进行大量研究,先后形成了三个不同的发展阶段:领导特性理论、领导行为理论和领导权变理论。20世纪80年代以来,经济的不断发展和企业的不断增加促使越... 详细信息

领导理论是研究领导有效性的理论。自20世纪40年代以来,西方学者从不同角度对领导问题进行大量研究,先后形成了三个不同的发展阶段:领导特性理论、领导行为理论和领导权变理论。20世纪80年代以来,经济的不断发展和企业的不断增加促使越来越多的学者及实践工作者从其它角度对领导行为进行研究,推动了领导理论的发展。具有代表性的领导理论主要有:领导归因理论;魅力型领导理论;交易—变革型领导理论;团队领导。

关键词：领导理论理论发展研究综述

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烟叶物理特性与打叶风分工艺参数的关系

烟草科技 2014年第8期47卷 5-9页

作者：卫盼盼吴祚友安银立马建勋华环国际烟草有限公司安徽省凤阳县门台工业园233121

为缩短打叶复烤调试时间,采用逐步回归、偏相关、通径分析和聚类分析法研究了烟叶物理指标与打叶风分工艺参数的关系。结果表明:1物理指标与打叶风分工艺参数间的逐步回归方程达到显著水平。2二润后烟叶温度越高,一打所需打辊转速越大;... 详细信息

为缩短打叶复烤调试时间,采用逐步回归、偏相关、通径分析和聚类分析法研究了烟叶物理指标与打叶风分工艺参数的关系。结果表明:1物理指标与打叶风分工艺参数间的逐步回归方程达到显著水平。2二润后烟叶温度越高,一打所需打辊转速越大;烟叶含水率越大,四打所需打辊转速越小,三打则越大;烟叶越厚,一打所需打辊转速越大,四打则越小;烟叶越宽,二打所需打辊转速越大;烟叶长度与打辊转速无关。3二润后烟叶含水率越大,各级风分风速越大;烟叶越厚,二打一分风速越大。4根据回归分析得出的物理指标,结合打辊转速和风分风速,通过聚类分析将19个样品中的15个分为4类,每类样品具有相似的打叶工艺参数,其余4个样品的参数各不相同。

关键词：烟叶物理指标打叶风分逐步回归分析聚类分析

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换热站标准化建设与节能管理

超声引导下内热针治疗肩背肌筋膜炎患者的效果分析

中国科技纵横 2022年第4期 25-27页

作者：魏盼盼河南商丘商都大道中电(商丘)热电有限公司河南商丘 476000

目前,节能已经成为城市发展的主要基调,本文从城市集中供热换热站的角度进行分析,对标准化换热站的相关问题进行阐述,从而有助于实现节能建设目标.

关键词：换热站节能优化探讨

来源：博看期刊评论

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中国伤残医学 2024年第15期32卷 40-43页

作者：魏盼盼山东省昌邑市人民医院麻醉科山东潍坊261300

目的:探讨超声引导下内热针治疗肩背肌筋膜炎患者的效果及应用价值。方法:选取2023年3—11月昌邑市人民医院收治的92例肩背肌筋膜炎患者为研究对象,按随机数字表法将其分为对照组和研究组,各46例。对照组采用体外冲击波治疗,研究组在对... 详细信息

目的:探讨超声引导下内热针治疗肩背肌筋膜炎患者的效果及应用价值。方法:选取2023年3—11月昌邑市人民医院收治的92例肩背肌筋膜炎患者为研究对象,按随机数字表法将其分为对照组和研究组,各46例。对照组采用体外冲击波治疗,研究组在对照组基础上采用超声引导下竖脊肌间隙内热针治疗。比较两组症状积分、日常活动能力、炎症水平及临床疗效。结果:研究组治疗总有效率为97.83%,高于对照组的84.78%,差异有统计学意义(P<0.05)。治疗后,两组压痛、肿胀、功能障碍症状积分、白细胞介素-6、C反应蛋白水平均较治疗前降低,且研究组均低于对照组,差异均有统计学意义(P<0.05)。治疗1、2、4周后,两组改良Barthel指数(MBI)评分均较治疗前升高,且治疗2、4周后研究组MBI评分均高于对照组,差异均有统计学意义(P<0.05)。结论:肩背肌筋膜炎患者采用超声引导下内热针疗法,能够提升治疗的总有效率,改善压痛、肿胀、功能障碍等症状,提高日常生活能力,缓解体内炎症反应。

关键词：肩背肌筋膜炎内热针超声引导疗效