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The Analysis and Remediation Technology of the Pollution of the Groundwater Environment in Longkou Plain, China

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Journal of Environmental Science and Engineering(A) 2021年第2期10卷 45-51页

作者： panpan meng Geological Environment Monitoring Station of Yantai City Yantai 264005China

In order to study the groundwater environment in the Longkou plain,48 groups of water samples are collected,consisting of 7 groups of surface water samples and 41 groups of groundwater *** quality of groundwater in the Longkou Plain is poor,with class V water quality accounting for more than 90%,and no class I,II water quality,sporadic distribution of Class III and IV water *** influencing factors of water quality are mainly inorganic indicators such as nitrate,total hardness,chloride,salinity and sulfate,the detection rate of heavy metals is *** is the main pollution index in this area,and the increase of nitrate content is closely related to the construction of underground *** on the characteristics of groundwater pollution in the Longkou Plain,the in-situ chemical remediation of groundwater pollution is proposed.

关键词： Groundwater environment quality assessment pollution analysis remediation technology.

Zebrafish for thrombocytopoiesis-and hemostasis-related researches and disorders

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Blood Science 2020年第2期2卷 44-49页

作者： panpan meng Liangliang Wu Qing Lin Yiyue Zhang Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes Department of Developmental BiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515P.R.China Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhou 510006P.R.China

Platelets play vital roles in hemostasis,inflammation,and vascular *** are also active participants in the immune *** vertebrates,zebrafish have a highly conserved hematopoietic system in the developmental,cellular,functional,biochemical,and genetic levels with *** in zebrafish are functional homologs of mammalian ***,we summarized thrombocyte development,function,and related research techniques in zebrafish,and reviewed available zebrafish models of platelet-associated disorders,including congenital amegakaryocytic thrombocytopenia,inherited thrombocytopenia,essential thrombocythemia,and blood coagulation disorders such as gray platelet *** elegant zebrafish models and methods are crucial for understanding the molecular and genetic mechanisms of thrombocyte development and function,and provide deep insights into related human disease pathophysiology and drug development.

关键词： Animal models Platelet-associated diseases Thrombocytopoiesis Zebrafish

Impact of Energy Efficiency and Financial Support on Green Upgrading in China’s Industrial Sector

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Proceedings of Business and Economic Studies 2023年第6期6卷 24-29页

作者： Yingying Zhou Ning Yang panpan meng Xiaoqian Jing Fengran Lu School of Economics and Management China University of Mining and TechnologyXuzhou 221116China

The report from the 20th National Congress of China emphasizes the importance of focusing on the clean,low-carbon,and efficient use of energy,increasing financial support,and promoting green upgrading within the industrial *** paper,based on annual data,employs the entropy weight method to construct a comprehensive index reflecting the impact of green upgrading in industrial *** delve deeper,it utilizes the DEA model to measure energy efficiency and its subdivision BCC model to break down energy efficiency into technical and scale *** financial support landscape is examined from the vantage points of both direct and indirect *** a multivariate time series model,this paper thoroughly investigates the influence of energy efficiency and financial support on the green upgrading of the industrial *** findings reveal a significant positive impact of both energy efficiency and financial support on green upgrading in industrial ***,scale efficiency emerges as the primary driver of energy ***,indirect financing proves to be more effective in promoting financial support than direct *** empirical results retain their robustness even after substituting explanatory *** study concludes by contextualizing the research findings within the current real-world scenario,offering practical insights,and proposing specific recommendations.

关键词： Energy efficiency Financial support Industrial green upgrading DEA-BCC model

Identification and characterization of human hematopoietic mesoderm

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Science China(Life Sciences) 2024年第2期67卷 320-331页

作者： Yuqi Wen Jingjing Zhao Runqing Zhang Fan Liu Xiaoyuan Chen Dan Wu mengge Wang Cuicui Liu Pei Su panpan meng Yiyue Zhang Xin Gao Lu Wang Hongtao Wang Jiaxi Zhou State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative MedicineTianjin 300020China Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhou 510006China

The embryonic mesoderm comprises heterogeneous cell subpopulations with distinct lineage *** is unclear whether a bias for the human hematopoietic lineage emerges at this early developmental *** this study,we integrated single-cell transcriptomic analyses of human mesoderm cells from embryonic stem cells and embryos,enabling us to identify and define the molecular features of human hematopoietic mesoderm(HM)cells biased towards hematopoietic *** discovered that BMP4 plays an essential role in HM specification and can serve as a marker for HM ***,BMP4 acts as a downstream target of HDAC1,which modulates the expression of BMP4 by deacetylating its *** of HDAC significantly enhances HM specification and promotes subsequent hematopoietic cell *** conclusion,our study identifies human HM cells and describes new mechanisms for human hematopoietic development.

关键词： hematopoietic mesoderm human pluripotent stem cells human embryos BMP4 HDAC1

Magnetically-responsive phase change thermal storage materials:Mechanisms,advances,and beyond

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Journal of Energy Chemistry 2025年第2期101卷 485-510页

作者： Yan Gao Yang Li Jinjie Lin panpan Liu Xiao Chen Ge Wang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule & Structure Construction School of Materials Science and Engineering University of Science and Technology Beijing School of Physics and Astronomy Beijing Normal University Shunde Graduate School University of Science and Technology Beijing

Rapid advances in thermal management technology and the increasing need for multi-energy conversion have placed stringent energy efficiency requirements on next-generation shape-stable composite phase change materials(PCMs).Magnetically-responsive phase change thermal storage materials are considered an emerging concept for energy storage systems,enabling PCMs to perform unprecedented functions(such as green energy utilization,magnetic thermotherapy,drug release,etc.).The combination of multifunctional magnetic nanomaterials and PCMs is a milestone in the creation of advanced multifunctional composite ***,a timely and comprehensive review of composite PCMs based on magnetic nanoparticle modification is still ***,we furnish an exhaustive exposition elucidating the cutting-edge advancements in magnetically responsive composite *** delve deeply into the multifarious roles assumed by distinct nanoparticles within composite PCMs of varying dimensions,meticulously scrutinizing the intricate interplay between their architectures and thermophysical ***,we prognosticate future research trajectories,delineate alternative stratagems,and illuminate prospective *** review is intended to stimulate broader academic interest in interdisciplinary fields and provide valuable insights into the development of next-generation magnetically-responsive composite PCMs.

关键词： Magnetic nanoparticles Magnetic-thermal conversion Phase change materials Response mechanism Thermal energy storage

外生性环境对农户宅基地流转意愿的影响机制研究——基于需求层次的中介效应

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农林经济管理学报 2024年第4期23卷 527-536页

作者：范胜龙孟盼盼福建农林大学公共管理学院福建福州350002

基于福建省845份实地调研数据,采用聚类分析法对农户宅基地需求层次进行界定,借助中介效应模型,探究外生性环境、需求层次对流转意愿的影响机制。结果表明:外生性环境显著影响流转意愿,交易市场的子变量流转案例对流转意愿的促进作用最... 详细信息

基于福建省845份实地调研数据,采用聚类分析法对农户宅基地需求层次进行界定,借助中介效应模型,探究外生性环境、需求层次对流转意愿的影响机制。结果表明:外生性环境显著影响流转意愿,交易市场的子变量流转案例对流转意愿的促进作用最为强烈;需求层次在政策激励、交易市场影响流转意愿中发挥中介作用,在社会环境影响流转意愿中发挥遮掩效应;外生性环境对流转意愿的影响在需求层次上具有异质性,生活类需求层次的农户流转宅基地更易受政策的激励,而情感类需求层次的农户更易受社会环境的影响。据此,建议探索侧重住宅用地属性的宅基地管理方式,落实农户资格权延期兑换制度,扩展宅基地基层治理网络,以全面推进宅基地流转工作。

关键词：农村宅基地流转意愿外生性环境需求层次中介效应

A mitochondria targeting Ir(Ⅲ)complex triggers ferroptosis and autophagy for cancer therapy:A case of aggregation enhanced PDT strategy for metal complexes

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Chinese Chemical Letters 2025年第1期36卷 374-380页

作者： panpan Wang Hongbao Fang mengmeng Wang Guandong Zhang Na Xu Yan Su Hongke Liu Zhi Su Jiangsu Collaborative Innovation Center of Biomedical Functional Materials College of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

Metal complexes hold significant promise in tumor diagnosis and ***,their potential applications in photodynamic therapy(PDT)are hindered by issues such as poor photostability,low yield of reactive oxygen species(ROS),and aggregation-induced ROS *** address these challenges,we present a molecular self-assembly strategy utilizing aggregation-induced emission(AIE)conjugates for metal *** a proof of concept,we synthesized a mitochondrial-targeting cyclometalated Ir(Ⅲ)photosensitizer *** approach significantly enhances the photodynamic effect while mitigating the dark toxicity associated with AIE ***-TPE readily self-assembles into nanoaggregates in aqueous solution,leading to a significant production of ROS upon light *** Ir-TPE triggers multiple modes of death by excessively accumulating ROS in the mitochondria,resulting in mitochondrial DNA *** damage can lead to ferroptosis and autophagy,two forms of cell death that are highly cytotoxic to cancer *** aggregation-enhanced photodynamic effect of Ir-TPE significantly enhances the production of ROS,leading to a more pronounced cytotoxic *** vitro and in vivo experiments demonstrate this aggregation-enhanced PDT approach achieves effective in situ tumor *** study not only addresses the limitations of metal complexes in terms of low ROS production due to aggregation but also highlights the potential of this strategy for enhancing ROS production in PDT.

关键词： Metal complex AIEgens Mitochondria targeting Enhanced photodynamic therapy Anticancer agent

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei panpan Zhao Yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

Deciphering the role of mtH_(2)O_(2) in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding panpan Li Bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China

Hepatic ischemia-reperfusion injury(HIRI)is characterized by mitochondrial dysfunction and oxidative *** mitochondrial hydrogen peroxide(mtH_(2)O_(2))levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during ***,low-background fluorogenic probes have been overlooked in the context of super-resolution *** this study,we developed a low-background fluorogenic probe(MitoWG)with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH_(2)O_(2)in *** of the desirable fluorescence properties of the probe by mtH_(2)O_(2)was confirmed using structural illumination microscopy(SIM),enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH_(2)O_(2)levels were successfully observed in both cellular and rat models of ***,we associated the decline in mitochondrial redox homeostasis with accelerated mtH_(2)O_(2)production during HIRI,which triggered mitophagy deficiency and led to cell *** conclusion,Mito-WG possesses excellent photophysical and low-background properties for SIM imaging,making it a promising tool for mtH_(2)O_(2)tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH_(2)O_(2)-activatable super-resolution imaging fluorogenic probe