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Esophago-gastro-duodenoscopy could be an important tool in the diagnostic dilemma inherent in perforated peptic ulcer: A case report

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 82-84页

作者： pankaj prasoon Giridhar Hanumappa Devadasar Tun Aung Kyaw Mohd.Akthar Ansari Mulky Damodar Kamath Chean Leung Chong Department of General Surgery Suri Seri Begawan HospitalKuala Belait Negara Brunei DarussalamBrunei

Acute abdomen is a common and sometimes dramatic clinical condition,which can be fatal if diagnosis is not made in *** peptic ulcer is a cause of an acute abdomen,which can be diagnosed by imaging ***,erect chest X-ray and CT scan may not always establish the *** we report a case of a patient with acute abdomen,where radiological imaging and CT scan were not able to provide a clear *** patient was diagnosed with perforated peptic ulcer by esophago-gastro-duodenoscopy,and underwent laparotomy to repair the anterior wall duodenal perforation with an omental *** endoscopic evaluation seems to be an essential tool for upper gastrointestinal evaluation in acute abdomen cases with inconclusive imaging results.

关键词： Perforated peptic ulcer Esophago-gastro-duodenoscopy Acute abdomen

Synchronous intraoperative radiofrequency ablation for multiple liver metastasis and resection of giant solid pseudopapillary tumors of the pancreas

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Chinese Medical Journal 2012年第9期125卷 1661-1663页

作者： LI Jia-xin WU Hong HUANG Ji-wei pankaj prasoon ZENG Yong Department of Hepato-bilio-pancreatic Surgery West China HospitalSichuan UniversityChengduSichuan 610041China

The solid pseudopapillary tumors of the pancreas （SPTP） are rare tumors, which are commonly found in adolescent women. Radical surgical resection of the primary tumor or metastases is the standard treatment for SPTP and could achieve long-term survival. We reported a case of a 20-year-old female with multiple liver metastases of SPTP, and performed surgical resection for primary tumor 14 cm in diameter and 2 major liver metastases （both 5 cm in diameter）, radiofrequency ablation （RFA） for small lesions and one major liver metastase 6 cm in diameter successfully. No evidence of recurrence in situ or in the liver was found by computed tomography （CT） scan 3 months after the operation. RFA is a safe and effective treatment for unresectable multiple liver metastases of SPTP.

关键词： radiofrequency ablation resection solid pseudopapillary tumors of the pancreas liver metastases

The EORTC QLQ-C30 and QLQ-CR29 may play a complementary role to LARS score in evaluating the quality of life for patients following laparoscopic and robotic rectal cancer surgery

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第3期4卷 79-84页

作者： Weifeng Lao pankaj prasoon Yangtao Pan Yiming Lv Lian Tat Tan Department of Colorectal Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of General Surgery RIPAS HospitalBandar Seri BegawanBrunei Darussalam

Objective:To analyze whether the European Organisation for Treatment and Research of Cancer(EORTC)Quality of Life Questionnaires(QLQ-C30 and QLQ-CR29)complement the low anterior resection of rectum syndrome(LARS)score in evaluating the quality of life of patients who underwent laparoscopic or robotic rectal cancer ***:Initially,335 patients who underwent laparoscopic or robotic rectal cancer surgery were randomly selected at Sir Run Run Shaw Hospital,Zhejiang University School of Medicine from June 2013 to September *** the patients took the questionnaires of LARS score,QLQ-C30 and ***,questionnaires filled out by 224 patients were qualified after *** were divided into three groups according to LARS score:No LARS group(score 0-20),minor LARS group(score 21-29)and major LARS group(score 30-42).The scores of QLQ-C30 as well as QLQ-CR29 among the three groups were ***:Major,minor and no LARS groups had 140 cases,40 cases and 44 cases *** the scales of QLQ-C30,significant differences were discovered in global quality of life,physical function,role function,emotional function,cognitive function,social function,fatigue,pain,dyspnea,sleep disturbance,constipation and diarrhea between the no and major LARS groups(p<0.05).While the differences were only found in global quality of life and diarrhea between the minor and major LARS groups(p<0.05).In QLQ-CR29,scales of urinary frequency,blood and mucus in stool,body image,flatulence,fecal incontinence,sore skin,stool frequency,embarrassment,impotence,abdominal pain,buttock pain,bloating,dry mouth,hair loss,taste,anxiety and weight,had significant differences between the no and major LARS groups(p<0.05).Only six scales,ie blood and mucus in stool,flatulence,fecal incontinence,stool frequency,embarrassment and dysuria had significant differences between the minor and major LARS groups(p<0.05).Conclusion:For patients following laparoscopic or robotic low anal sp

关键词： Laparoscopic Robotic LARS score EORTC QLQ-C30 EORTC QLQ-CR29

Hemi-portocaval shunt： A simple salvage maneuver for small-for-size graft during living donor liver transplantation： a case report

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Chinese Medical Journal 2011年第14期124卷 2231-2233页

作者： HUANG Ji-wei YAN Lu-nan CHEN Zhe-yu WU Hong LU Qiang XU Ying-long pankaj prasoon ZENG Yong Department of Hepato-Biliary-Pancreatic Surgery West China Hospital Sichuan University Chengdu Sichuan 610041 China

Since the fast expansion of living donor liver transplantation （LDLT） over last few decades, small-for-size syndrome （SFSS） has emerged as a tough problem. Herein the first case of LDLT combined hemi-portocaval shunt in the mainland of China was reported. Portal venous overperfusion was well modulated and the recipient recovered uneventfully. LDLT combined hemi-portocaval shunt was a feasible procedure for preventing SFSS in LDLT.

关键词： liver transplantation small-for-size syndrome hepatocellular carcinoma

Surgical vs percutaneous radiofrequency ablation for hepatocellular carcinoma in dangerous locations

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World Journal of Gastroenterology 2011年第1期17卷 123-129页

作者： Ji-Wei Huang Roberto Hernandez-Alejandro Kristopher P Croome Lu-Nan Yan Hong Wu Zhe-Yu Chen pankaj prasoon Yong Zeng Department of Hepato-Biliary-Pancreatic Surgery Division of Liver Transplantation West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Surgery University of Western Ontario Hepatobiliary and Liver Transplant Surgery London Health Sciences Centre London Ontario N6A 4S2 Canada

AIM:To compare the long-term outcome of percutaneous vs surgical radiofrequency ablation(RFA) for hepatocellular carcinoma(HCC) in dangerous ***:One hundred and sixty-two patients with HCC in dangerous locations treated with percutaneous or surgical RFA were enrolled in this *** patients were divided into percutaneous RFA group and surgical RFA *** the patients were regularly followed up for a long time,their curative rate,hospital stay time,postoperative complications and 5-year local tumor progression were compared and ***:No significant difference was observed in curative rate between the two groups(91.3% vs 96.8%,P = 0.841).The hospital stay time was longer and more analgesics were required while the incidence of bile duct injury and RFA-related hemorrhage was lower in surgical RFA group than in percutaneous RFA group(P < 0.05).The local progression rate of HCC in dangerous locations was significantly lower in surgical RFA group than in percutaneous RFA group(P = 0.05).The relative risk of local tumor progression was 14.315 in percutaneous RFA ***:The incidence of severe postoperative complications and local tumor progression is lower after surgical RFA than after percutaneous RFA.

关键词：手术治疗射频消融危险地点肝癌 VS RFA 肝细胞癌治愈率

Risk factors for incomplete polyp resection during colonoscopy

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第4期4卷 105-110页

作者： Weifeng Lao pankaj prasoon Gaoyang Cao Lian Tat Tan Sheng Dai Giridhar Hanumappa Devadasar Xuefeng Huang Department of Colorectal Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of General Surgery RIPAS HospitalBandar Seri BegawanBrunei Department of General Surgery SSBH HospitalKuala BelaitBrunei

Colonoscopic polypectomy is extremely effective in protecting against colorectal cancers,and recognition of adenomas by colonoscopy is of paramount importance in preventing colorectal cancer(CRC)and CRC-associated *** polyp resection(IPR)occurs routinely in medical practice following *** conducted a comprehensive literature search to identify studies that reported on the potential risk factors for IPR using MEDLINE,EMBASE,and *** time was limited between January 2004 and July *** search revealed assessments of the position,morphology,and histologic variation of the polypsdas well as the relevant skills that may interfere with *** included studies showed that colonic polyps with a diameter>20 mm and proximal in location should be dealt with *** smaller polyps,cold-snare polypectomy appeared to be the most effective method used to accomplish comprehensive polyp *** addition,endoscopist experience in narrow-band imaging in polyp detection were also associated with ***,polypectomy should be performed cautiously if the polyp growth is expected to be cancerous and situated in the proximal portion of the colon or rectum,and modalities should be standardized so as to lower the potential risk for IPR.

关键词： Colon cancer Incomplete resection of polyp Incomplete endomucosal resection Colorectal polyps Colonoscopic polypectomy

Autologous bone marrow transplantation in decompensated liver: Systematic review and meta-analysis

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World Journal of Gastroenterology 2015年第28期21卷 8697-8710页

作者： prasoon pankaj Qi Zhang Xue-Li Bai Ting-Bo Liang Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital Zhejiang University School of Medicine

AIM:To evaluate the efficacy of autologous bone marrow mononuclear cell transplantation in decompensated liver ***:Medline,EMBASE,PubMed,Science Direct,and the Cochrane Library were searched for relevant *** case-control studies were included along with randomized clinical *** was performed in line with recommendations from the Cochrane Collaboration software review *** was assessed using a randomeffects ***:Four randomized controlled trials and four retrospective studies were *** transplantation increased serum albumin level by 1.96 g/L(95%CI:0.74-3.17;P = 0.002],2.55 g/L(95%CI:0.32-4.79;P= 0.03),and 3.65 g/L(95%CI:0.76-6.54;P = 0.01)after 1,3,and 6 mo,*** who had undergone cell transplantation also had a lower level of total bilirubin[mean difference(MD):-1.37 mg/dL;95%CI:-2.68-(-0.06);P = 0.04]after 6 *** decreased after 1 year when compared to standard treatment(MD:-1.26;95%CI:-2.48-(-0.03);P =0.04].A temporary decrease in alanine transaminase and aspartate transaminase were significant in the cell transplantation ***,after 6 mo treatment,patients who had undergone cell transplantation had a slightly longer prothrombin time(MD:5.66 s,95%CI:0.04-11.28;P = 0.05).Changes in the model for endstage liver disease score and Child-Pugh score were not statistically ***:Autologous bone marrow transplantation showed some benefits in patients with decompensated liver ***,further studies are still needed to verify its role in clinical treatment for end-stage liver disease.

关键词： Autologous transplantation Bone marrow Cirrhosis Decompensated liver disease

''Sandwich'' treatment for diospyrobezoar intestinal obstruction: A case report

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World Journal of Gastroenterology 2014年第48期20卷 18503-18506页

作者： Yi-Xiong Zheng pankaj prasoon Yan Chen Liang Hu Li Chen Department of Gastrointestinal Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Department of Hepato-Biliary-Pancreatic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Department of Gastrointestinal Medicine The Second Affiliated Hospital Zhejiang University School of Medicine

Intestinal obstruction is a common clinical entity encountered in surgical *** objective of this report is to corroborate an atypical scenario of intestinal obstruction in a Chinese patient and to focus on the diagnosis and treatment.A 27-year-old male presented with a history of gastric pain combined with nausea and abdominal distension that had been present for 5 *** presence of a foreign body was detected by computed tomography and observed as an abnormal density within the stomach.A diospyrobezoar was revealed during gastroscopy,the extraction of which was preventeddue to its size and *** endoscopic holmium laser joined with a snare was used to fragment the obstruction,which was followed by management with a conservative"sandwich"treatment strategy involving intestinal decompression with an ileus tube and Coca-Cola lavage between endoscopic lithotripsy fragmentation *** strategy resulted in the successful removal of the diospyrobezoar along with multiple small bowel *** patient was discharged after abatement of *** case presented here demonstrates the implementation of a conservative,yet successful,treatment as an alternative to conventional surgical removal of intestinal obstructions.

关键词： Small bowel obstruction Diospyrobezoar Ileus tube

Immunotherapy for hepatocellular carcinoma: From basic research to clinical use

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World Journal of Hepatology 2015年第7期7卷 980-992页

作者： Yu-Peng Hong Zi-Duo Li pankaj prasoon Qi Zhang Department of Oncology Zhejiang Provincial People’s Hospital Department of Oncology Shijitan Hospital Capital Medical University Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital Zhejiang University School of Medicine Key Laboratory of Cancer Prevention and Intervention National Ministry of Education

Hepatocellular carcinoma(HCC) is a common cancer worldwide with a poor prognosis. Few strategies have been proven efficient in HCC treatment, particularly for those patients not indicated for curative resection or transplantation. Immunotherapy has been developed for decades for cancer control and is attaining more attention as a result of encouraging outcomes of new strategies such as chimeric antigen receptor T cells and immune checkpoint blockade. Right at the front of the new era of immunotherapy, we review the immunotherapy in HCC treatment, from basic research to clinical trials, covering anything from immunomodulators, tumor vaccines and adoptive immunotherapy. The mechanisms, efficacy and safety as well as the approach particulars are unveiled to assist readers to gain a concise but extensive understanding of immunotherapy of HCC.

关键词：干扰素 Chemokine 肿瘤疫苗采纳免疫疗法妄想的抗原受体检查点封锁