Autologous bone marrow transplantation in decompensated liver: Systematic review and meta-analysis
Autologous bone marrow transplantation in decompensated liver: Systematic review and meta-analysis作者机构：Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital Zhejiang University School of Medicine
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2015年第21卷第28期
页 面：8697-8710页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by National Natural Science Foundation of China(No.81171884 and No.81401954) Innovation and HighLevel Talent Training Program of the Department of Health of Zhejiang Province,China
主 题：Autologous transplantation Bone marrow Cirrhosis Decompensated liver disease
摘 要：AIM:To evaluate the efficacy of autologous bone marrow mononuclear cell transplantation in decompensated liver ***:Medline,EMBASE,PubMed,Science Direct,and the Cochrane Library were searched for relevant *** case-control studies were included along with randomized clinical *** was performed in line with recommendations from the Cochrane Collaboration software review *** was assessed using a randomeffects ***:Four randomized controlled trials and four retrospective studies were *** transplantation increased serum albumin level by 1.96 g/L(95%CI:0.74-3.17;P = 0.002],2.55 g/L(95%CI:0.32-4.79;P= 0.03),and 3.65 g/L(95%CI:0.76-6.54;P = 0.01)after 1,3,and 6 mo,*** who had undergone cell transplantation also had a lower level of total bilirubin[mean difference(MD):-1.37 mg/dL;95%CI:-2.68-(-0.06);P = 0.04]after 6 *** decreased after 1 year when compared to standard treatment(MD:-1.26;95%CI:-2.48-(-0.03);P =0.04].A temporary decrease in alanine transaminase and aspartate transaminase were significant in the cell transplantation ***,after 6 mo treatment,patients who had undergone cell transplantation had a slightly longer prothrombin time(MD:5.66 s,95%CI:0.04-11.28;P = 0.05).Changes in the model for endstage liver disease score and Child-Pugh score were not statistically ***:Autologous bone marrow transplantation showed some benefits in patients with decompensated liver ***,further studies are still needed to verify its role in clinical treatment for end-stage liver disease.
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