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淬火工艺对M390刀具钢力学性能的影响

材料热处理学报 2022年第8期43卷 101-109页

作者：庞亚龙车洪艳梁晨刘少尊闫英杰曹睿兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室甘肃兰州730050 兰州理工大学材料科学与工程学院甘肃兰州730050 中国钢研科技集团有限公司安泰科技股份有限公司北京100081 河北省热等静压工程技术研究中心河北涿州072750

采用X射线衍射(XRD)和扫描电镜(SEM)等研究了经不同工艺淬火后M390刀具钢的物相、显微组织、硬度及拉伸性能。结果表明:随淬火温度从1100℃升高到1200℃,M390刀具钢的基体组织依次由铁素体为主转变为马氏体为主,再到马氏体与残留奥氏体... 详细信息

采用X射线衍射(XRD)和扫描电镜(SEM)等研究了经不同工艺淬火后M390刀具钢的物相、显微组织、硬度及拉伸性能。结果表明:随淬火温度从1100℃升高到1200℃,M390刀具钢的基体组织依次由铁素体为主转变为马氏体为主,再到马氏体与残留奥氏体的混合,而晶粒尺寸未发生明显变化,碳化物类型均为M_(7)C_(3)和M_(23)C_(6);1150℃保温30 min水淬后基体组织以马氏体为主,含有少量的残留奥氏体,相连碳化物占比与圆度值均最小,硬度达到峰值62.38 HRC,抗拉强度与断裂应变总量分别为1121.88 MPa和3.25%,强韧性匹配最优。

关键词： M390钢淬火显微组织硬度强度

呼吸链影响光化学反应过程中细胞外ATP调控作用的研究

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西北师范大学学报（自然科学版） 2022年第1期58卷 77-83页

作者：冯汉青王建荷张悦婧李颖庞海龙西北师范大学生命科学学院甘肃兰州730070

细胞外ATP(eATP)是调节植物多种生理生化反应的信号分子.文中以野生型(WT)和eATP受体缺失突变(dorn-1)拟南芥(Arabidopsis thaliana)为实验材料,分析了呼吸链抑制剂水杨基氧肟酸(SHAM)影响植物光化学反应过程中eATP的调控作用.结果表明,... 详细信息

细胞外ATP(eATP)是调节植物多种生理生化反应的信号分子.文中以野生型(WT)和eATP受体缺失突变(dorn-1)拟南芥(Arabidopsis thaliana)为实验材料,分析了呼吸链抑制剂水杨基氧肟酸(SHAM)影响植物光化学反应过程中eATP的调控作用.结果表明,SHAM能够显著降低交替呼吸途径的容量.在WT叶片中,SHAM处理能够引起光系统Ⅱ(PSⅡ)实际光化学效率(Y(Ⅱ))、相对电子传递速率(R_(ET))、光化学猝灭(q_(p))和PSⅡ处非调节性能量耗散的量子产量(Y(NO))的显著降低,同时使得非光化学猝灭(Q_(NP))和PSⅡ处调节性能量耗散的量子产量(Y(NPQ))显著上升;而在dorn-1叶片中,SHAM对Y(Ⅱ),R_(ET),qp,Q_(NP),Y(NPQ)和Y(NO)均无显著性影响.进一步研究发现,对WT叶片添加外源ATP可显著缓解SHAM所导致的Y(Ⅱ),R_(ET)和q_(p)的下降及Y(NPQ)的上升,而对DORN1叶片添加外源ATP则无类似效应.以上结果表明,eATP可通过受体蛋白DORN1对呼吸链抑制引起的光化学活性的下降进行调控.

关键词：拟南芥 DORN1 细胞外ATP 交替氧化酶途径光系统Ⅱ

Screened peptides from one-bead one-compound technique extend half-life of peptide drugs in circulation through binding to albumin

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Chinese Chemical Letters 2024年第3期35卷 384-388页

作者： Yi-Jing Li Lingze Zhang Ming-Hao pang Pei-Pei Yang Lu-Ming Guo Kuo Zhang Da-Yong Hou Lei Wang Hao Wang Hui Cao State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Peptide drugs are known for their high biological ***,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in ***,inspired by the long circulation of albumin in blood,we screened albumin binding peptides(ABPs)from a one-bead one-compound(OBOC)peptide library to increase the half-life of peptide *** displaying random peptides were screened using fluorescent labeled human serum *** beads with specific binding to albumin were isolated for *** selected ABPs can effectively bind to albumin,thus possessing the long circulation of *** dissociation constant(K_(D))of ABPs to albumin is up to 1×10^(-8)mol/*** one of ABPs(ABP2)was coupled to triptorelin,the circulation half-life of triptorelin in mice was significantly prolonged to 263.50 h much longer than that of triptorelin alone(179.07 h).In addition,the combination therapy using ABP-conjugated triptorelin and doxorubicin(DOX)can effectively inhibit the proliferation of tumor cells in *** OBOC screening strategy and resulting ABPs showed great potential for enhancing the delivery efficiency of peptide drugs.

关键词： One-bead one-compound Combinatorial library Albumin binding Drug delivery Triptorelin

Plasma secreted frizzled-related protein 5（SFRP5） levels in obstructive sleep apnea/hypopnea syndrome

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Plasma secreted frizzled-related protein 5（SFRP5） levels i...

2017全国睡眠呼吸障碍学术大会暨睡眠呼吸疾患新进展学...

作者： Dong-mei Zhang Xing-long pang Rong Huang Feng-ying Gong Xu Zhong Yi Xiao Department of Respiratory Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences &Peking Union Medical College Department of Endocrinology Key Laboratory of Endocrinology of Ministry of HealthThe Translational Medicine CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Background:Obstructive sleep apnea-hypopnea syndrome（OSAHS）is closely associated with obesity,inflammation and insulin *** frizzled-related protein 5（SFRP5）is a recently discovered adipokine,which is involved in inflammation and insulin resistance in *** study aim to evaluate levels of plasma SFRP5 in overweighted or obese（Body mass index,BMI＞24kg/m2）OSAHS patients and examine their potential correlation with sleep characteristics and several biochemical ***:Adult male nondiabetic patients with OSAHS（Apnea Hypopnea Index,AHI＞15/h,n=35）and controls（AHI＜5/h,n=20）,examined with polysomnography,underwent a biochemical analysis to estimate fasting blood glucose,lipid profile,and hypersensitive C-reactive *** the plasma SFRP5 concentrations were also determined after nasal continuous positive airway pressure（nCPAP）***:The two groups were matched for age and *** OSAHS patients,SFRP5 levels correlated positively with triglyceride levels（r=0.490,p=0.003）and negatively with LDL cholesterol levels and HDL cholesterol levels（r=-0.580 and p＜0.001;r=-0.423 and p=0.011;respectively）.However,no association was found between visfatin levels and fast bloodglucose,AHI or nocturnal hypoxia *** SFRP5 levels didn’t have significantly change after overnight nCPAP treatment as well（P=0.148）.Conclusions:In nondiabetic OSAHS patients,SFPR5 levels are associated with lipid ***,there is no correlation between SFRP5 and fast blood glucose（FBG）,sleep architecture or nocturnal hypoxia.

关键词： Secreted frizzled-related protein 5(SFRP5) Obstructive sleep apnea-hypopnea syndrome(OSAHS) Insulin resistance Obesity

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家具供应链碳减排的影响因素

中南林业科技大学学报 2024年第3期44卷 159-166,178页

作者：龙晨庞燕王擎天王忠伟中南林业科技大学湖南长沙410004 岳阳职业技术学院岳阳现代物流产业发展研究院湖南岳阳414000 湖南中南智能装备有限公司湖南长沙410116

【目的】家具作为木材供应链的终端产品积累了最主要的碳流,为减轻家具制造业高污染环节对环境造成的极大负担,分析家具供应链碳减排的关键影响因素,构建家具供应链碳减排影响因素结构层次模型,为推动家具产业降碳减排提供决策支持。【... 详细信息

【目的】家具作为木材供应链的终端产品积累了最主要的碳流,为减轻家具制造业高污染环节对环境造成的极大负担,分析家具供应链碳减排的关键影响因素,构建家具供应链碳减排影响因素结构层次模型,为推动家具产业降碳减排提供决策支持。【方法】运用文献研究法筛选家具供应链碳减排关键影响因素,运用决策实验室方法和解释结构模型组合方法开展影响因素分析,分析各影响因素之间关联,确定影响因素层级。【结果】1)低碳能源供给、低碳材料供给、低碳设备供给、低碳生产技术位于家具供应链碳减排影响因素结构层次模型第一层,为直接影响因素,对家具供应链碳减排产生直接影响。2)政府技术补贴、低碳运输位于家具供应链碳减排影响因素结构层次模型第二层,低碳产品设计、低碳产品促销、回收策略、低碳包装位于结构层次第三层,均为中间影响因素,通过影响直接因素间接对家具供应链碳减排产生影响。3)低碳产品宣传、低碳产品偏好、消费补贴、回收渠道建设位于家具供应链碳减排影响因素结构层次模型第四层,为深层影响因素,对家具供应链碳减排产生根本影响。【结论】家具供应链涉及众多行业,碳减排不止受到单一因素作用,需从供应链整体视角综合考虑供应链碳减排措施。建议从家具供应链碳减排影响因素深层因素入手,构建再制造闭环供应链运作模式,优化废弃家具回收渠道。同时推动家具供应链间协同减排,构建供应链降碳协调契约,引入区块链等降碳新技术,推动家具供应链绿色高效发展。

关键词：家具供应链供应链碳减排影响因素识别 DEMATEL-ISM

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林道网规划决策因素及方法研究进展

世界林业研究 2024年第2期37卷 27-32页

作者：龙晨庞燕王擎天王忠伟中南林业科技大学长沙410004 湖南中南智能装备有限公司长沙410000 岳阳职业技术学院岳阳现代物流产业发展研究院湖南岳阳414000

林道网作为连接森林各个部分和提供资源利用通道的网络结构,对于森林管理、生态保护和可持续发展具有重要作用。近年来,林道网的研究受到多个学科领域的关注,为应对森林管理及森林保护面临的挑战提供了新的视角和方法。文中基于林道网... 详细信息

林道网作为连接森林各个部分和提供资源利用通道的网络结构,对于森林管理、生态保护和可持续发展具有重要作用。近年来,林道网的研究受到多个学科领域的关注,为应对森林管理及森林保护面临的挑战提供了新的视角和方法。文中基于林道网理论发展及规划维度,梳理了国内外学者关于林道网规划决策变量及规划方法的研究成果,规划决策因素包括技术指标、环境指标、经济指标和社会指标,规划方法包括空间多准则方法、精确式算法规划方法和启发式算法规划方法;从林道网与碳密度的关系、区分林种的林道网规划、林区道路可持续规划、林道网多功能集聚4个方面对未来研究进行展望,为新时代林业发展背景下的林道网规划提供理论支持。

关键词：林道网道路网络规划林道网密度空间多准则方法

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复合型生物絮凝剂处理低温低浊水影响因素

哈尔滨工业大学学报 2009年第8期41卷 42-45页

作者：孟路杨基先马放庞长泷金超哈尔滨工业大学城市水资源与水环境国家重点实验室哈尔滨150090

为探讨复合型生物絮凝剂(CBF)在处理低温低浊水源水过程中的影响因素,采用实验室静态试验方法,考察投加量、pH、阳离子絮凝剂等因素对絮凝效果的影响.结果表明:在单独使用CBF时,当投药量范围在5～17.5mg/L以内,CBF可有效地去除水中浊度... 详细信息

为探讨复合型生物絮凝剂(CBF)在处理低温低浊水源水过程中的影响因素,采用实验室静态试验方法,考察投加量、pH、阳离子絮凝剂等因素对絮凝效果的影响.结果表明:在单独使用CBF时,当投药量范围在5～17.5mg/L以内,CBF可有效地去除水中浊度与高锰酸盐指数(CODMn),最佳投加量为7.5mg/***在弱碱性条件下絮凝率较高,最佳pH为8.0.在混凝过程中投加阳离子絮凝剂可有效提高CBF对低温低浊水的处理效果并减少投药量.在与聚合氯化铝铁(PAFC)复配使用时,最佳投药量分别为4mg/L和10mg/L,此时浊度去除率为73.0%,CODMn去除率为60.7%.

关键词：低温低浊水复合型生物絮凝剂聚合氯化铝铁混凝

miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1- containing AMPA receptors in a mouse model of Alzheimer’s disease

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Acta Pharmaceutica Sinica B 2024年第2期14卷 635-652页

作者： Man Luo Yayan pang Junjie Li Lilin Yi Bin Wu Qiuyun Tian Yan He Maoju Wang Lei Xia Guiqiong He Weihong Song Yehong Du Zhifang Dong Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Anatomy Basic Medical CollegeChongqing Medical UniversityChongqing 400016China Townsend Family Laboratories Department of PsychiatryThe University of British ColumbiaVancouver BC V6T 1Z3Canada Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Institute of AgingKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceZhejiang Clinical Research Center for Mental DisordersSchool of Mental Health and the Affiliated Kangning HospitalWenzhou Medical UniversityWenzhou 325000China Institute for Brain Science and Disease of Chongqing Medical University Chongqing 400016China

Alzheimer ’s disease(AD) is a leading cause of dementia in the ***-activated protein kinase phosphatase 1(MKP-1) plays a neuroprotective role in ***,the molecular mechanisms underlying the effects of MKP-1 on AD have not been extensively ***(miRNAs) regulate gene expression at the post-transcriptional level,thereby repressing mRNA ***,we reported that the microRNA-429-3p(miR-429-3p) was significantly increased in the brain of APP23/PS45 AD model mice and N2AAPPAD model *** further found that miR-429-3p could downregulate MKP-1 expression by directly binding to its 3’-untranslated region(3’ UTR).Inhibition of miR-429-3p by its antagomir(A-miR-429) restored the expression of MKP-1 to a control level and consequently reduced the amyloidogenic processing of APP and Aβ *** importantly,intranasal administration of A-miR-429 successfully ameliorated the deficits of hippocampal CA1 long-term potentiation and spatial learning and memory in AD model mice by suppressing extracellular signal-regulated kinase(ERK1/2)-mediated GluAl hyperphosphorylation at Ser831 site,thereby increasing the surface expression of GluAl-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors(AMPARs).Together,these results demonstrate that inhibiting miR-429-3p to upregulate MKP-1 effectively improves cognitive and synaptic functions in AD model mice,suggesting that miR-429/MKP-1 pathway may be a novel therapeutic target for AD treatment.

关键词： Alzheimer's disease MKP-1 miR-429-3p AMPAreceptor Learning and memory long-term potentiation

BaMgAl_(10)O_(17):Eu^(2+),Mn^(2+)中Eu^(2+)→Mn^(2+)的能量传递

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光谱实验室 2006年第5期23卷 918-920页

作者：庞彦龙河北大学国有资产管理处河北省保定市071002

在还原气氛下采用高温固相法合成了BaMgAl_(10)O_(17)Mn^(2+),BaMgAl_(10)O_(17)Eu^(2+),BaMgAl_(10)O_(17)Eu^(2+),Mn^(2+)粉末样品,测量并研究了它们的激发光谱和发射光谱性质。结果表明BaMgAl_(10)O_(17)Eu^(2+),Mn^(2+)中,Eu^(2+)的发射光谱和Mn^(2+)的吸收光谱之间的光谱交叠范围较大,两种离子之间发生了明显的交叉弛豫过程,即有较强的共振能量传递过程,导致在紫外光的激发下,样品BaMgAl_(10)O_(17)Eu^(2+),Mn^(2+)发射光谱中以蓝光和绿光为主。

关键词： BaMgAl10O17 能量传递交叉弛豫