检索结果-南通市图书馆

Interplay between metabolic dysfunction-associated fatty liver disease and chronic kidney disease:Epidemiology,pathophysiologic mechanisms,and treatment considerations

引用

World Journal of Gastroenterology 2022年第39期28卷 5691-5706页

作者： panagiotis Theofilis Aikaterini Vordoni Rigas G Kalaitzidis Center for Nephrology“G.Papadakis ”General Hospital of Nikaia-Piraeus“Agios Panteleimon”Nikaia 18454Greece

The recently proposed nomenclature change from non-alcoholic fatty liver disease to metabolic dysfunction-associated fatty liver disease(MAFLD)has resulted in the reappraisal of epidemiological trends and associations with other chronic *** this context,MAFLD appears to be tightly linked to incident chronic kidney disease(CKD).This association may be attributed to multiple shared risk factors including type 2 diabetes mellitus,arterial hypertension,obesity,dyslipidemia,and insulin ***,similarities in their molecular pathophysiologic mechanisms can be detected,since inflammation,oxidative stress,fibrosis,and gut dysbiosis are highly prevalent in these pathologic *** the same time,lines of evidence suggest a genetic predisposition to MAFLD due to gene polymorphisms,such as the PNPLA3 rs738409 G allele polymorphism,which may also propagate renal *** their management,available treatment considerations for obesity(bariatric surgery)and novel antidiabetic agents(glucagon-like peptide 1 receptor agonists,sodiumglucose co-transporter 2 inhibitors)appear beneficial in preclinical and clinical studies of MAFLD and CKD ***,alternative approaches such as melatonin supplementation,farnesoid X receptor agonists,and gut microbiota modulation may represent attractive options in the *** a look to the future,additional adequately sized studies are required,focusing on preventing renal complications in patients with MAFLD and the appropriate management of individuals with concomitant MAFLD and CKD.

关键词： Metabolic dysfunction-associated fatty liver disease Chronic kidney disease Hepatic steatosis inflammation Type 2 diabetes mellitus Obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Helicobacter pylori infection and inflammatory bowel disease: Is there a link?

引用

World Journal of Gastroenterology 2014年第21期20卷 6374-6385页

作者： Konstantinos Papamichael panagiotis Konstantopoulos Gerassimos J Mantzaris First Gastroenterology Clinic Evaggelismos Hospital10676 AthensGreece

Helicobacter pylori(***)infection is one of the most widely spread infectious diseases in *** can cause chronic gastritis,peptic ulcer disease and gastric malignancies and has been associated with extra-gastric *** elicit a chronic systemic inflammatory response which,under certain conditions,may trigger autoimmune reactions and may be implicated in the pathogenesis of autoimmune *** the pathogenesis of inflammatory bowel disease(IBD)is unknown,it is thought to result from complex interactions between environmental factors and microbiota in the gut of individuals who are genetically *** bacterial and viral agents have been implicated in the aetiology of *** theory,*** infection could be involved in the pathogenesis of IBD by inducing alterations in gastric and/or intestinal permeability or by causing immunological derangements resulting in absorption of antigenic material and autoimmunity via various immunological *** mechanisms may also be responsible for the co-existence of IBD with other autoimmune diseases and/or extra-intestinal ***,the epidemiological data fail to support this ***,various studies indicate that the prevalence of *** infection is low in patients with IBD,suggesting a protective role for this infection in the development of *** this report,we aim to shed light on proposed mechanisms and confounding factors underlying the potential link between *** infection and IBD.

关键词： Helicobacter pylori Inflammatory bowel disease Ulcerative colitis Crohn’ s disease Colorectal cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermal Energy Storage Contribution to the Economic Dispatch of Island Power Systems

引用

CSEE Journal of Power and Energy Systems 2020年第1期6卷 100-110页

作者： panagiotis Romanos Emmanouil Voumvoulakis Christos N.Markides Nikos Hatziargyriou School of Electrical and Computer Engineering National Technical University of Athens(NTUA)Zografou 15780Greece Hellenic Electricity Distri-bution Network Operator S.A.(HEDNO) Athens 11743Greece Clean Energy Processes(CEP)Laboratory Depart-ment of Chemical EngineeringImperial College LondonLondon SW72AZU.K.

In this paper the provision of flexible generation is investigated by extracting steam from Rankine-cycle power stations during off-peak demand in order to charge thermal tanks that contain suitable phase-change materials(PCMs);at a later time when this is required and/or is economically effective,these thermal energy storage(TES)tanks can act as the heat sources of secondary thermal power plants in order to generate power,for example as evaporators of,e.g.,organic Rankine cycle(ORC)plants that are suitable for power generation at reduced temperatures and smaller *** type of solution offers greater flexibility than TES-only technologies that store thermal energy and release it back to the base power station,since it allows both derating but also over-generation compared to the base power-station *** solution is applied in a case study of a 50-MW rated oil-fired power station unit at the autonomous system of *** optimal operation of the TES system is investigated,by solving a modified Unit Commitment-Economic Dispatch optimization problem,which includes the TES operating *** results indicate that for most of the scenarios the discounted payback period is lower than 12 years,while in few cases the payback period is 5 years.

关键词： Economic dispatch energy-management energy storage flexibleenergysystem flexiblegeneration generation integrated energystorage phasechangematerials smartgrids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Methodology for Online Identification of Dynamic Behavior of Power Systems with an Increased Amount of Power Electronics Interface Units

引用

CSEE Journal of Power and Energy Systems 2019年第2期5卷 171-180页

作者： panagiotis N.Papadopoulos Jovica V.Milanovic School of Electrical and Electronic Engineering The University of ManchesterManchesterM601QDU.K.

A methodology for online and offline dynamic stabil-ity assessment,suitable for power systems with high penetration of power electronics interface units is presented in this *** increasing penetration of renewable energy resources as well as changing market operations,new types of loads and storage technologies,are causing significant changes to power systems dynamic *** generator groups and generators exhibiting poorly damped oscillatory behavior are identified online,opening the possibility to corrective control actions in order to stabilize the ***,statistical analysis of the abundant data from simulations provides information on the overall impact of power electronics interface units on system stability.

关键词： Decision trees dynamicsecurityassessment probabilistictransientstability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nutrients in litterfall,forest floor and mineral soils in two adjacent forest ecosystems in Greece

引用

Journal of Forestry Research 2020年第1期31卷 291-301页

作者： panagiotis Michopoulos Kostas Kaoukis George Karetsos Theodoros Grigoratos Constantini Samara H.A.O.DEMETER-Institute of Mediterranean Forest Ecosystems Terma Alkmanos11528 AthensGreece Department of Chemistry Environmental Pollution Control LaboratoryAristotle University Thessaloniki54124 ThessalonikiGreece Sustainable Transport Unit(STU) Institute for EnergyTransport and Climate Change(IETC)Joint Research Centre(JRC)Via E Fermi 274921027 IspraItaly

The fluxes of masses and the nutrients Ca,Mg,K,N,P and S were determined in the litterfall of two adjacent forest ecosystems of Hungarian oak(Quercus frainetto L.)and European beech(Fagus sylvatica L.)in a mountainous area of northeastern Greece in 2010–*** foliar litterfall for both species reached about 70%of the total litterfall,and was significantly higher from the other two fractions(woody and rest litterfall).The fluxes of masses and nutrients were compared between ecosystems for each fraction *** one significant statistical difference was found,that of K in the woody *** addition,the stocks of masses and nutrients were calculated in the forest floors and mineral soils of the two ***,the stocks of nutrients in the forest floors and mineral soils were compared between *** the L horizon of the forest floors,statistical differences,as a result of species effect,were found for the stocks of Ca and *** the FH horizons,the masses and all the nutrient stocks differed significantly,as the beech plot had much higher quantities of organic matter and *** higher quantities were probably due to low soil temperatures(microclimate)and high acidity in the beech plot(species effect)that slowed down *** the mineral soils,the propagation of random error derived from random errors of the individual soil layers was an important factor in the statistical *** of the soil acidity in the beech plot,the stocks of exchangeable base cations were significantly higher in the oak plot,whereas the other nutrient stocks did not differ.

关键词： Beech Oak Litterfall Forest floor Mineral soil Nutrients

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The interplay of cell cycle and DNA repair gene alterations in upper tract urothelial carcinoma:predictive and prognostic implications

引用

Precision Clinical Medicine 2020年第3期3卷 153-160页

作者： panagiotis J.Vlachostergios Department of Medicine Division of Hematology and Medical OncologyWeill Cornell MedicineNew YorkNY 10065USA Department of Medicine Division of Hematology and Medical OncologyNew York Presbyterian Brooklyn Methodist HospitalBrooklynNY 11215USA

Upper tract urothelial carcinoma(UTUC)is rare but can occur sporadically outside the context of Lynch *** these cases,knowing whether non-mismatch repair(MMR),DNA damage response and repair(DDR),and cell cycle gene alterationsmay predict responses to chemotherapy orimmunotherapy and survival is of clinical *** study examined the germline and somatic mutational landscape of two UTUC patients with differential responses to programmed death 1(PD-1)/PD-ligand 1(PD-L1)immune checkpoint inhibitors and queried three independent UTUC cohort studies for co-occurrence of key cell cycle and DDR genes,as well as for their associations with overall survival(OS).TP53 and RB1 emerged as potential determinants of shorter OS in UTUC cohort patients,regardless of concurrent DDR alterations,and if prospectively assessed in larger studies they might also explain resistance to PD-1/PD-L1 blockade despite PD-L1 expression.

关键词： upper tract urothelial carcinoma DNA damage response and repair cell cycle genetic testing genomics mutations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomic and mitochondrial evidence of ancient isolations and extreme introgression in the four-lined snake

引用

Current Zoology 2020年第1期66卷 99-111页

作者： Evanthia THANOU panagiotis KORNILIOS Petros LYMBERAKIS Adam D.LEACHE Department of Biology University of WashingtonSeattleWAUSA The Molecular Ecology Backshop LoutrakiGreece Institute of Evolutionary Biology(CSIC-Universitat Pompeu Fabra) BarcelonaSpain Natural History Museum of Crete University of CreteIrakleioGreece

Comparing mitochondrial and genomic phylogenies is an essential tool for investigating speciation processes,because each genome carries different inheritance properties and evolutionary ***,mitonuclear discordance may arise from ecological adaptation,historic isolation,population size changes,and sex-biased *** related taxa are expected to experience gene flow;however,this may not be true for insular populations or populations isolated in *** four-lined snake Elaphe quatuorlineata has a fragmented distribution,separating populations of the Italian and Balkan Peninsulas,whereas several insular Aegean populations of significantly smaller body size(Cyclades island group and Skyros Island,Greece)are currently considered distinct *** constructed the species-tree phylogeny of this species utilizing genome-wide single nucleotide polymorphisms and a gene-tree based on complete cytochrome b sequences,aiming to detect convergence and discrepancies between biparentally and maternally inherited *** structuring,phylogenetic patterns and migration events among geographically defined lineages supported our hypothesis of isolation in multiple *** biogeographical barriers did not restrict subsequent dispersal,extensive genetic exchange occurred between mainland Balkan *** process has led to the mitochondrial sweep of an ancestral mitolineage that survived only in peripheral(East Greece)and insular populations(North Cyclades and Skyros).The Central Cyclades represent an ancient lineage for both molecular markers that emerged almost 3.3 *** their distinct morphology,insular *** populations should be the future focus of an extensive sampling,especially since the mitonuclear discordance observed in this species could be related to ecological adaptations,such as the island-dwarfism phenomenon.

关键词： Aegean Islands Elaphe quatuorlineata species-tree genome-wide SNPs mitochondrial introgression phylogeography refugia within refugia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current concepts in the surgical treatment of skeletal metastases

引用

World Journal of Orthopedics 2020年第7期11卷 319-327页

作者： Jessica Ehne panagiotis Tsagozis Department of Orthopedic Surgery Karolinska University HospitalSolna 17176Sweden

Symptomatic metastatic bone disease affects a large proportion of patients with malignant tumours and significantly impairs patients’quality of *** are still controversies regarding both surgical indications and methods,mainly because of the relatively few high-quality studies in this ***,prosthetic reconstruction has been shown to result in fewer implant failures and should be preferred in patients with a good *** estimation tools should be used as part of preoperative *** treatment,which relies on radiotherapy and inhibition of osteoclast function may also offer symptomatic relief and prevent implant *** this review we discuss the epidemiology,indications for surgery,preoperative planning,surgical techniques and adjuvant treatment of metastatic bone disease.

关键词： Pathological fracture Bone cancer Adjuvant radiotherapy Survival analysis Fracture fixations Fixation devices Orthopaedic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A combined risk-based and condition monitoring approach:developing a dynamic model for the case of marine engine lubrication

引用

Transportation Safety and Environment 2022年第3期4卷 74-87页

作者： Nikolaos P.Ventikos panagiotis Sotiralis Emmanouil Annetis School of Naval Architecture and Marine Engineering National Technical University of Athens9 Iroon Politechneiou St15773ZografouGreece.

This paper focuses on the creation of a dynamic probabilistic model which simulates deterioration trends of a marine engine lubricationsystem. The approach is based on risk and the implementation is achieved through a dynamic Bayesian network (dBN).Risk can be useful for decision making, while dBNs are a powerful tool for risk modelling and prediction models. The model takesinto account deterioration of engine components, oil degradation and the off-line condition monitoring technique of oil analysis, inthe context of predictive maintenance. The paper aims to efficiently predict probability evolution for main engine lubrication failureand to decide upon the most beneficial schemes from a variety of lubrication oil analysis interval schemes by introducing monetarycosts and producing the risk model. Real data and respective analysis, along with expert elicitation, are utilized for achieving modelquantification, while themodel is materialized through a code in the Matlab environment. Results from the probabilistic model showa realistic simulation for the system and indicate the obvious, that with more frequent oil analyses and respective maintenance orrepairs, the probability of failure drops significantly. However, the results from the risk model highlight that the costs can redefinescheme suggestions, as they can correspond to low probabilities of failure but also to higher costs. A two-month interval scheme issuggested, in contrast to the most preferred practice among shipping companies of a three-month interval. The developed model isin general identified as a failure prediction tool focusing on marine engine lubrication failure.

关键词： Risk modelling dynamic Bayesian networks(dBNs) condition monitoring predictive maintenance marine engine lubrication oil analysis deterioration model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Graft choices for anterolateral ligament knee reconstruction surgery: Current concepts

引用

World Journal of Clinical Cases 2022年第24期10卷 8463-8473页

作者： Byron Chalidis Charalampos Pitsilos Dimitrios Kitridis panagiotis Givissis 1^(st)Orthopaedic Department Aristotle University of ThessalonikiSchool of MedicineThessaloniki 57010Greece 2^(nd)Orthopaedic Department Aristotle University of ThessalonikiSchool of MedicineThessaloniki 54635Greece

The anterolateral ligament(ALL)is a primary structure of the anterolateral complex of the knee that contributes to internal rotational stability of the *** of the ALL is commonly associated with rupture of the anterior cruciate *** left untreated,ALL lesions may lead to residual anterolateral rotational instability of the knee after anterior cruciate ligament reconstruction,which is a common cause of anterior cruciate ligament graft *** function of the ALL can be restored by lateral extraarticular tenodesis or anterolateral ligament reconstruction(ALLR).In the lateral extraarticular tenodesis procedure,a strip of the iliotibial band is placed in a non-anatomical position to restrain the internal rotation of the tibia,while in ALLR,a free graft is fixed at the insertion points of the native *** and semitendinosus grafts have mainly been utilized for ALLR,but other autografts have also been ***,allografts and synthetic grafts have been applied to minimize donor-site morbidity and maximize the size and strength of the ***,there has been no strong evidence to fully support one method over another thus *** present review presents a detailed description of the graft choices for ALLR and the current literature available in regard to the effectiveness and outcomes of published surgical techniques.

关键词： Anterolateral ligament Reconstruction Lateral extraarticular tenodesis Anterior cruciate ligament Hamstrings Gracilis Semitendinosus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：