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THE　STRUCTURAL　ELUCIDATION　AND　ABSOLUTE　CONFIGURATIONS　OF　TWO　NEW　POLYOXYGENATED　CYCLOHEXENES　FROM　UVARIA　GRANDIFLORA　ROXB．

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Chinese Chemical Letters 1996年第3期7卷 241-244页

作者： pan. xp Yu, DQ Lee, KH BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA UNIV N CAROLINA SCH PHARMNAT PROD LABDIV MED CHEM & NAT PRODCHAPEL HILLNC 27599 CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA

Two new polyoxygenated cyclohexenes,named uvarigranol E (I) andF(VII),were isolated from the rhizome of Uvaria grandiflora. On the basis ofspectral analysis and chemical derivatizations, including preparation of Mosheresters,the structures of I and VII were established as IR-acetoxymethyl-l,2Sdihydroxy-3 R,6S-dibenzoyloxy-cyclohex-4-ene and IR-hydroxymethyl-l,2Sdihydroxy-3R,6S-dibenzoyloxy cyclohex-4-ene.

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X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway

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World Journal of Diabetes 2024年第6期15卷 1299-1316页

作者： Ming-Wei Du Xin-Lin Zhu Dong-Xing Zhang Xian-Zhen Chen Li-Hua Yang Jin-Zhou Xiao Wen-Jie Fang Xiao-Chun Xue Wei-Hua pan.Wan-Qing Liao Tao Yang Institute of Cardiovascular Disease Shanghai Key Laboratory of Traditional Chinese Clinical MedicineShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Dermatology Shanghai Key Laboratory of Molecular Medical MycologySecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Dongshan HospitalMeizhou 514000Guangdong ProvinceChina Department of Dermatology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Emergency Naval Hospital of Eastern TheaterZhoushan 316000Zhejiang ProvinceChina Department of Pharmacy 905th Hospital of People’s Liberation Army of China(PLA)NavyShanghai 200052China

BACKGROUND Diabetic foot ulcers(DFU),as severe complications of diabetes mellitus(DM),significantly compromise patient health and carry risks of amputation and *** To offer new insights into the occurrence and development of DFU,focusing on the therapeutic mechanisms of X-Paste(xp)of wound healing in diabetic *** Employing traditional Chinese medicine ointment preparation methods,xp combines various medicinal ***-performance liquid chromatography(HPLC)identified xp’s main *** streptozotocin(STZ)-induced diabetic,we aimed to investigate whether xp participated in the process of diabetic wound ***-sequencing analyzed gene expression differences between xp-treated and control *** docking clarified xp’s treatment mechanisms for diabetic wound *** umbilical vein endothelial cells(HUVECs)were used to investigate the effects of Andrographolide(Andro)on cell viability,reactive oxygen species generation,apoptosis,proliferation,and metastasis in vitro following exposure to high glucose(HG),while NF-E2-related factor-2(Nrf2)knockdown elucidated Andro’s molecular *** xp notably enhanced wound healing in mice,expediting the healing ***-sequencing revealed Nrf2 upregulation in DM tissues following xp *** identified 21 primary xp components,with Andro exhibiting strong Nrf2 *** mitigated HG-induced HUVECs proliferation,metastasis,angiogenic injury,and inflammation *** alleviates HG-induced HUVECs damage through Nrf2/HO-1 pathway activation,with Nrf2 knockdown reducing Andro’s proliferative and endothelial protective *** xp significantly promotes wound healing in STZ-induced diabetic *** xp’s key component,Andro activates the Nrf2/HO-1 signaling pathway,enhancing cell proliferation,tubule formation,and inflammation reduction.

关键词： Words:Diabetes mellitus Wound healing NF-E2-related factor-2/HO-1 signaling pathway Andrographolide

Creep rate sensitivities of materials by a depth-sensing indentation technique

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Journal of University of Science and Technology Beijing 2006年第4期13卷 308-312页

作者： Yang Gao Shengping Wen Feng pan Laboratory of Advanced Materials Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

The strain rate sensitivity to creep of single crystal Cu（110）, metal tantalum, and 128°Y-X LiNbO3 piezoelectric single crystal were measured at room temperature by MTS Nanoindenter xp. Among the three kinds of materials studied, Cu showed the highest degree of resistance to creep-induced deformation, which is followed by Ta, while the LiNbO3 single crystal deformed more readily than the others. The values of the steady-state strain rate sensitivities determined by the indentation methods are in the range of 0.002-0.006, 0.02-0.06 and 0.02-0.03 for Cu, Ta, and LiNbO3, respectively. The mechanisms for the indentation-induced creeping behavior and the factors that influenced the creeping are discussed.

关键词： indentation creep strain rate sensitivity copper tantalum LiNbO3 piezoelectric single crystal

Lineage-specific positive selection on ACE2 contributes to the genetic susceptibility of COVID-19

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National Science Review 2022年第9期9卷 155-165页

作者： Yuwen pan.pan.ong Liu Fang Wang Peng Wu Fanjun Cheng Xin Jin Shuhua Xu Key Laboratory of Computational Biology Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences The Third People’s Hospital of Shenzhen National Clinical Research Center for Infectious Disease The Second Affiliated Hospital of Southern University of Science and Technology Cancer Biology Research Center (Key Laboratory of the Ministry of Education) Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Gynecologic Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology School of Medicine South China University of Technology Department of Liver Surgery and Transplantation Liver Cancer Institute Zhongshan Hospital Fudan University State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and Development Center for Evolutionary Biology School of Life Sciences Fudan University Human Phenome Institute Zhangjiang Fudan International Innovation Center and Ministry of Education Key Laboratory of Contemporary Anthropology Fudan University School of Life Science and Technology ShanghaiTech University Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

The Angiotensin-Converting Enzyme-2(ACE2) gene,located on xp22.2, attracts a great deal of attention because the protein it encodes is believed to be the functional cellular receptor for the new coronavirus(SARS-CoV-2).However,recent studies are controversial,especially concerning the intrinsic link between ACE2 diversity and COVID-19 ***,we conduct a population genetic study on ACE2 in6354 individuals representing 210 present-day populations and 5 329 individuals of ancient or archaic *** dissected the genetic architecture ofACE2 and identified two major haplogroups(hg) in East Asians,***2-hgl(43%) and ACE2-hg2(53%),while other populations harbor more diverse A ***,there was a significant loss of ACE2 common variations in East Asians in contrast to the X-chromosome-wide and genome-wide ***,association analysis between ACE2-hgs and COVID-19 severity in 1229 Han Chinese individuals with various levels of COVID-19 severity showed a higher risk ofACE2-hgl(odds ratio=1.56,P pan.emics might have been potential driving forces,which consequently contributed to the genetic susceptibility to COVID-19 within and between populations.

关键词： ACE2 COVID-19 genetic susceptibility genetic diversity natural selection East Asia

自制椎板钩分散椎弓根螺钉系统应力作用的有限元分析

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中国组织工程研究与临床康复 2007年第22期11卷 4292-4295页

作者：汪宇潘滔刘先银周希平东莞市人民医院骨科广东省东莞市523018 中山大学附属第一医院骨科广东省广州市510080 华南理工大学交通学院力学实验中心广东省广州市510641

目的:观察加用自制椎板钩对分散椎弓根螺钉系统应力的作用。方法:实验于2005-10-20在华南理工大学交通学院力学实验中心完成。①建立自行设计的新型椎板钩钉系统有限元模型:椎弓根螺钉长度为40mm,圆棒长度120mm,二者直径均为6mm,椎板钩... 详细信息

目的:观察加用自制椎板钩对分散椎弓根螺钉系统应力的作用。方法:实验于2005-10-20在华南理工大学交通学院力学实验中心完成。①建立自行设计的新型椎板钩钉系统有限元模型:椎弓根螺钉长度为40mm,圆棒长度120mm,二者直径均为6mm,椎板钩高度为9mm,长度为22mm。②有限元模型建立:根据以上参数,应用ANSYS8.0软件,按实际大小和结构以二维线梁单元BEAM188建立新型椎板钩钉系统有限元模型,约束尾侧椎弓根螺钉和尾侧椎板钩内表面,垂直于头侧椎弓根螺钉进行加载。③应力测量:前屈扭矩5N·m状态下,对椎弓根螺钉系统不加与加用椎板钩时,整个系统各处的应力变化进行评估。结果:加钩后整个系统受力点增加,受力更加均匀。临床上容易发生断钉的部位应力显著降低。头、尾侧椎弓根钉根部加钩后轴向应力显著降低,以尾侧钉为著,降低37.08%。头、尾侧钉棒连接处加钩后剪切应力下降明显,头侧下降44.02%,尾侧下降60.71%。结论:椎板钩使得椎弓根螺钉系统应力分散,以尾侧椎弓根钉根部及钉棒连接处为著,从而减少椎弓根螺钉断钉的发生。

关键词：椎弓根螺钉椎板钩有限元分析

Time-Delay Signature of Chaotic Vertical-Cavity Surface-Emitting Lasers with Polarization-Rotated Optical Feedback

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Chinese Physics Letters 2011年第1期28卷 98-101页

作者： XIANG Shui-Ying pan.Wei YAN Lian-Shan LUO Bin ZOU Xi-Hua JIANG Ning WEN Kun-Hua Center for Information Photonics and Communications Southwest Jiaotong University Chengdu 610031

To quantitatively evaluate the time-delay （TD） signatures of chaotic signals generated by vertical-cavity surface- emitting lasers （VCSELs） with polarization-rotated optical feedback （PROF）, we propose four cases of resolution coefficients R based on correlation functions. The resolution coefficient characteristics for the x-polarization （xp） mode, g-polarization （YP） mode and the total output are considered. The dependences of R on the feedback strength and feedback delay are discussed and compared carefully. The two-dimensional maps of R show that the TD signatures for the single polarization mode （i.e., xp or YP mode） are much more difficult to retrieve than those for the total output in the entire parameter space. Thus, by using single polarization mode as a chaotic carrier, the TD signatures are extremely difficult to be identified, which contributes a lot in the security-enhanced VCSELs-based chaotic optical communication systems.

关键词： Optics quantum optics and lasers

Freestanding MXene-based macroforms for electrochemical energy storage applications

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SusMat 2023年第4期3卷 471-497页

作者： Qiongqiong Lu Congcong Liu Yirong Zhao Wengao pan.Kun Xie Pengfei Yue Guoshang Zhang Ahmad Omar Lixiang Liu Minghao Yu Daria Mikhailova Institute of Materials Henan Key Laboratory of Advanced Conductor MaterialsHenan Academy of SciencesZhengzhouHenanChina Leibniz Institute for Solid State and Materials Research(IFW)Dresden e.V. DresdenGermany School of Physical Science and Technology Lanzhou UniversityLanzhouChina School of Engineering Westlake UniversityHangzhouZhejiangChina Faculty of Chemistry and Food Chemistry&Center for Advancing Electronics Dresden Technische Universität DresdenDresdenGermany

Freestanding MXene-based macroforms have gained significant attention as versatile components in electrochemical energy storage applications owing to their interconnected conductive network,strong mechanical strength,and customizable surface chemistries derived from MXene *** comprehensive review article encompasses key aspects related to the synthesis of MXene nanosheets,strategies for structure design and surface medication,surface modification,and the diverse fabrication methods employed to create freestanding MXene-based macroform *** review also delves into the recent advancements in utilizing freestanding MXene macroforms for electrochemical energy storage applications,offering a detailed discussion on the significant progress achieved thus ***,the correlation between the macroform’s structural attributes and its performance characteristics is thoroughly explored,shedding light on the critical factors influencing efficiency and *** the remarkable development,the review also highlights the existing challenges and presents future perspectives for freestanding MXenebased macroforms in the realms of high-performance energy storage *** addressing these challenges and leveraging emerging opportunities,the potential of freestanding MXene-based macroforms can be harnessed to enable groundbreaking advancements in the field of energy storage.

关键词： batteries electrochemical energy storage freestanding macroforms MXenes supercapacitors

Effects of Ethyl Acetate Extract of Phyllanthus reticulatus Leaves on Autophagy-related Proteins Beclin-1,ATG5 and LC3 in Nude Mice Xenograft Model of HCC

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Medicinal Plant 2022年第3期13卷 43-47,52页

作者： Zhipeng XU Chenyan LIANG Cuiliu pan.Yunli TANG Jianfang FENG Tong HE Guangxi University of Chinese Medicine Nanning 530020 China Chengdu University of Traditional Chinese Medicine Chengdu 611137 China Wuxuan County Maternal and Child Health Care Hospital Laibin 545900 China

[Objectives]To explore the effects of ethyl acetate extract of Phyllanthus reticulatus leaves on autophagy-related proteins Beclin-1,ATG5 and LC3 by immunohistochemistry,and to preliminarily explore their effects on autophagy.[Methods]BEL-7404 Hepatocellular Carcinoma(HCC)nude mice model was established,and blank group(same volume of pure water),positive control group(20 mg/kg fluorouracil),high dose drug group(600 mg/kg),and medium dose drug group(300 mg/kg),and low dose drug group(150 mg/kg)were set *** 2 weeks of intragastric administration,the nude mice were sacrificed,and the tumor tissues were taken out,processed by immunohistochemistry,and then made into paraffin *** were taken under an optical microscope(10×40),and evaluation and analysis were performed with the aid of the Image-Pro Plus 6.0 image analysis *** were calculated using SPSS 20.0 *** effects of drugs on autophagy-related proteins LC3,Beclin-1 and ATG5 were observed.[Results]Compared with the blank group,the medium and high dose groups of ethyl acetate extract of *** leaves had the effect of promoting the increase of autophagy-related proteins LC3,Beclin-1 and ATG5(P0.05).[Conclusions]The ethyl acetate extract of *** leaves has a promoting effect on autophagy-related proteins LC3,Beclin-1,and ATG5.

关键词： Ethyl acetate extract of Phyllanthus reticulatus leaves Autophagy Hepatocellular Carcinoma(HCC) Nude mice

3种机用单支锉镍钛系统对弯曲根管中心定位能力的比较

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上海交通大学学报（医学版） 2022年第5期42卷 690-694页

作者：李婷婷潘悦萍上海交通大学医学院附属第九人民医院牙体牙髓科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海200011

目的·比较3种机用单支锉镍钛器械系统VDW Reciproc Blue(简称Blue)、FKG xp-endo shaper(简称xp)及M3-L platinum(简称M3)在预备弯曲根管时维持根管原有弯曲度的能力(即中心定位能力)。方法·选择30个树脂模拟弯曲单根管,随机分为3组(B... 详细信息

目的·比较3种机用单支锉镍钛器械系统VDW Reciproc Blue(简称Blue)、FKG xp-endo shaper(简称xp)及M3-L platinum(简称M3)在预备弯曲根管时维持根管原有弯曲度的能力(即中心定位能力)。方法·选择30个树脂模拟弯曲单根管,随机分为3组(Blue组、xp组和M3组),分别用Blue、xp和M3进行根管预备。预备前后的根管内分别注入红色、蓝黑色墨水并在口腔科手术显微镜下拍摄照片。将预备前后的照片进行重叠,以预备前的根尖为圆心,半径从1 mm开始,每增加1 mm做一同心圆,依次递增至10 mm,使其与重叠图像相交成10条弧线,即10个测量位点,记录根管内外侧10个测量位点的去除量差值的绝对值,对3组之间的差异进行统计分析。预备根管后,用口腔科手术显微镜观察锉体有无拉伸形变。结果·M3组与Blue组之间、M3组与xp组之间根管内外侧去除量差值的绝对值的差异均有统计学意义(P=0.0031,P=0.0020),Blue组和xp组之间根管内外侧去除量差值的绝对值的差异无统计学意义(P=0.3502)。xp组锉体在口腔科手术显微镜下观察到出现解螺旋形变,放置于热水内未恢复原形态,M3组与Blue组锉体未观察到有形变。结论·3种单支镍钛锉对弯曲根管进行预备时均能良好地维持根管原有弯曲度,但Blue和xp较M3有更好地维持弯曲根管原始走向的能力。xp在预备树脂根管时容易出现器械形变,临床上应适当减少xp的使用次数。

关键词：根管预备中心定位能力热处理镍钛锉弯曲根管单支锉镍钛系统