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Theoretical Study of the AIEt3-Promoted Tandem Reductive Rearrangement of Epoxides

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Chinese Journal of Chemical Physics 2008年第6期21卷 547-554页

作者： Li-dong Zhang hui-jun Guo Yang pan Fei Qi National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 China

The AIEt3-promoted tandem reductive rearrangement reactions of epoxides was studied at B3LYP/6- 31C（d,p） level. For the model compound α-hydroxy epoxides, two possible reaction pathways Ⅰ and Ⅱ were calculated. The main difference is the order of ethylene release and six- to five-member ring rearrangement. The ring contraction rearrangement in pathway Ⅰ is the first step and this step is the rate controlling step with a free energy barrier of 116.62 kJ/mol. For pathway Ⅱ, the ethylene release occurs first, and is followed by a six-member ring opening reaction which is the rate controlling step, and the barrier is 251.38 kJ/mol. The reason for such high barrier is that the ethylene release results in the following reaction being more difficult. The results show that pathway Ⅰ （C-C rearrangement and then ethylene release） is more favorable, which is consistent with experimental results.

关键词： AIEt3 Rearrangement Density functional theory Diol Epoxide

Stem cells： a new strategy for treatment of infections

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医学争鸣 2017年第4期8卷 3-8,13页

作者： xia0 Dang-Sheng FANG hui pan hui- Yun LI Sheng-Jie VIP Ward First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Department of Internal Medicine First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China

Infections by bacteria, fungi, or other microorganisms are common clinical diseases that cause millions of deaths every year. The development of antibiotic resistance in bacteria and other microorganisms presents new challenges for treatment of infectious diseases. Stem cell proliferation and differentiation(SCPD), the key physiological processes in all multicellular organisms, plays crucial roles throughout the development and recovery from infectious diseases in the fight against pathogen invasion in multicellular organisms. Manipulation of SCPD has potentiality as a general method for treatment or prevention of infectious diseases.

关键词：《医学争鸣》期刊经济研究编辑工作英文摘要

Assessment of quality of life for the patients with cervical cancer at different clinical stages

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Chinese Journal of Cancer 2013年第5期32卷 275-282页

作者： Yao Xie Fang-hui Zhao Si-Han Lu He Huang Xiong-Fei pan Chun-xia Yang You-Lin Qiao Department of Epidemiology West China Public Health School Sichuan University Department of Epidemiology Cancer Institute/Hospital Chinese Academy of Medical Sciences

With improved overall survival of cervical cancer patients, the importance of the quality of life (QOL) is increasingly recognized. This study was conducted to compare the QOL of women with different stage cervical cancer before and after treatment to facilitate improved cervical cancer prevention and treatment. We used the generic Medical Outcomes Study Short Form-36 (MOS SF-36) to collect QOL information. Based on SF-36, we interviewed cervical cancer patients at West China Second Affiliated Hospital and Sichuan Cancer Hospital between May 2010 and January 2011. A total of 92 patients with precancerous lesions, 93 with early cancer, and 35 with advanced cancer responded to our survey. Average physical component summary (PCS) scores were significantly different between the three groups at every time point (P < 0.05). Average mental component summary (MCS) scores were significantly different between the three groups after treatment (P < 0.05). Average PCS and MCS scores increased gradually from the pretreatment to posttreatment period for patients with precancerous lesions. However, they reached the lowest at 1 month after treatment for patients with early and advanced cancers and rebounded between 1 and 6 months after treatment. Our results indicate that patients with precancerous lesions and early cervical cancer show better overall QOL than do those with advanced cervical cancer. Additionally, patients with early cancer recover more quickly than do those with advanced cancer in terms of both physical and mental functions. Thus, early detection and treatment initiatives may improve the QOL for patients with precancerous lesions and cervical cancer.

关键词：子宫颈癌癌症患者生活质量质量评估临床肿瘤医院中国西部精神功能

AN EFFICIENT AND STEREOSPECIFIC SYNTHESIS OF 1-PALMITOYL-2-[(z,z,z)-9,12,15-LINOLENOYL]-SNGLYCEROPHOSPHOCHOLINE

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Chinese Chemical Letters 1995年第10期6卷 863-866页

作者： xia, J hui, YZ Chinese Acad Sci Shanghai Inst Organ Chem State Key Lab Bioorgan & Nat Prod Chem Shanghai 200032 Peoples R China

A polyunsaturated mixed-acid phosphatidylcholine,1-palmitoyl-2-linolenoy1 snglycerophosphocholine (1) Prepared from D-mannitol as an optically active starting materialis described.

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Experimental Study of Wave Pressure on a Breakwater Pier

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China Ocean Engineering 1999年第2期14卷 209-216页

作者： pan, SH xia, QY Lin, SQ Xu, LH Hohai Univ Coll Harbour Waterway & Coastal Engn Dept Coastal Engn Nanjing 210098 Peoples R China Fujian Prov Ports & Shipping Adm Bur Fuzhou 350009 Peoples R China

Test studies on the wave pressure on a breakwater pier show that the influence of transmissive wave pressure on the outside wall of the breakwater pier is considerable, when the width of the pier is not very large. The variations of transmissive wave pressure on the breakwater pier with different widths are compared and the relationship is obtained between relative transmitting distance b/L and wave pressure reduction factor K, which may be used in the design of similar breakwater piers.

关键词： wave pressure breakwater pier

Visual field mean deviation and relevant factors in 928 Chinese retinitis pigmentosa patients

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1978-1983页

作者： hui Ye xiao-Ping xia Department of Ophthalmology the Third Affiliated Hospital of Sun Yat-sen University

AIM: To investigate the associations between demographic and clinical factors with the rate of visual field mean derivation(MD) decline in retinitis pigmentosa(RP) ***: Correlations of MDs with the visual acuity and retinal pigmentation were analyzed in 928 RP patients. MD decreasing rate in 10 y and potential influences of gender, age, family history and retinal pigmentation on the rate were explored in 201 RP patients. RESULTS: In the 928 patients, average MD and visual acuity were-14.44±8.61 dB and 0.79±0.35 respectively and when MD was lower than-9.18 dB the visual acuity would be below 1.0(20/20). The average MD medium between eyes with or without retinal pigmentation was-14.82 dB. In 123 non-pigmented eyes, the average MD were lower than the medium but in 153 pigmented eyes it was higher than that. In the 201 patients, the average decreasing value of MD in 10 years’ period was-8.01±3.66 dB and the value were correlated to retinal pigmentation but not to gender, age or RP family history. CONCLUSION: The rate of MD decline in RP eyes is significantly related to retinal pigmentation. Our study demonstrates the quantitative rate of MD decline in RP patients and the value of MD could well reflect the severity of RP.

关键词： retinitis pigmentosa mean deviation of visual field visual acuity retinal pigmentation

Neospora caninum immune mapped protein 1(NcIMP1) is a novel vaccine candidate against neosporosis

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Frontiers of Agricultural Science and Engineering 2015年第1期2卷 66-72页

作者： xia CUI Daoyu YANG Tao LEI hui WANG pan HAO Qun LIU Key Laboratory of Zoonosis of Ministry of Agriculture and National Animal Protozoa Laboratory College of Veterinary Medicine China Agricultural University

The Neospora caninum immune mapped protein 1(Nc IMP1) was identified as a membrane protein,and a previous study indicated that Nc IMP1 could be a promising vaccine candidate against neosporosis. In this study, the immune response and protection efficacy of Nc IMP1 were evaluated. The coding sequence of Nc IMP1 was inserted into the eukaryotic expression vector pc DNA3.1(+), resulting in the recombination plasmid pc DNAIMP1, which was used for the intramuscular immunization of BALB/c mice. After immunization, the immune response was evaluated using a lymphoproliferative assay and cytokine and antibody measurements. Quantification of the cerebral parasite burden of mice challenged with 2106 N. caninum was performed 14 days after the last immunization. The results showed that the mice immunized with pc DNA-IMP1 developed a high level of specific antibody responses against recombinant Nc IMP1,with a mixed Ig G1/Ig G2 a response and a predominance of Ig G2 a production. The cellular immune response was associated with the production of IFN-γ, IL-2, IL-4 and IL-10 cytokines. The experiment was terminated 30 days p.i.,and the cerebral parasite burden in each mouse was assessed by quantitative PCR. The parasite burden was significantly reduced in the pc DNA-IMP1-vaccinated mice. These data suggest that IMP1 is a promising vaccine candidate against neosporosis.

关键词： Neospora caninum immune mapped protein 1(IMP1) vaccine candidate BALB/c mice

Effect of surface morphology on wettability conversion

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Journal of Advanced Ceramics 2016年第4期5卷 284-290页

作者： xia KONG Yawei HU xiaofang WANG Wei pan College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi'an Shaanxi 710021 China State Key Laboratory of New Ceramics and Fine Processing Tsinghua University Beijing 100084 China

A hierarchical structural surface of TiO2 film with reversibly light-switchable wettability between superhydrophobicity and superhydrophilicity on metal substrate was fabricated through simply dip-coating method from TiO2 precursor solution containing TiO2 nanoparticles with the average diameter 25 nm (P25),followed by heat-treatment and modification with fluoroalkylsilane (FAS) *** morphology,phase and crystallographic structure,and chemical composite of the as-prepared TiO2 film were characterized by scanning electron microscopy (SEM),X-ray diffraction (XRD),and X-ray photoelectron spectroscopy (XPS).The wettability of TiO2 film was characterized by a drop shape *** water contact angle of superhydrophobic TiO2 film was up to 165.6°.Under UV irradiation,the water contact angle decreased and the superhydrophobic TiO2 film became superhydrophilic because of hydroxyl groups absorption on the TiO2 ***,the surface morphology of TiO2 film,which resulted from the TiO2 nanoparticles added in TiO2 precursor solution,had a significant effect on the wettability conversion of TiO2 film and enhanced the switch from hydrophobicity to *** wettability could be reversibly switched between superhydrophobicity and superhydrophilicity via alternation of UV exposure and dark storage.

关键词： TiO2 morphology wettability reverse conversion

Development of genomic resources for Wenchengia alternifolia(Lamiaceae)based on genome skimming data

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Plant Diversity 2022年第6期44卷 542-551页

作者： Qi-Yue Zhou hui-xia Cai Zi-Han Liu Lang-Xing Yuan Lei Yang Tuo Yang Bo Li pan Li Laboratory of Systematic&Evolutionary Botany and Biodiversity College of Life SciencesZhejiang UniversityHangzhou310058China Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai201602China Haikou Duotan Wetlands Institute Haikou570100China Orchid Conservation&Research Center of Shenzhen Shenzhen518114China Research Centre of Ecological Sciences College of AgronomyJiangxi Agricultural UniversityNanchang330045China

Wenchengia alternifolia(Lamiaceae),the sole species of the genus Wenchengia is extremely rare and is currently listed as Critically Endangered(CR) on the IUCN Red List. The species had long been considered endemic to Hainan Island,China and was once believed to be extinct until a small remnant population was rediscovered at the type locality in *** more populations were later found on Hainan and in *** order to develop genomic resources for further studies on population genetics and conservation biology of this rare species,we identified infraspecific molecular markers in the present study,using genome skimming data of five individuals collected from two populations on Hainan Island and three populations in Vietnam *** length of plastome of the five individuals varied from 152,961 bp to 150,204 bp,and exhibited a typical angiosperm quadripartite *** plastid hotspot regions with the Pi> 0.01(trnH-psbA,psbA-trnK,rpl22,ndhE,ndhG-ndhI rps15-ycf1),and 1621 polymorphic gSSRs,as well as 1657 candidate SNPs in 237 variant nuclear genes were identified,thereby providing important information for further genetic studies.

关键词： Wenchengia Plastid hotspot Simple sequence repeat(SSR) Single nucleotide polymorphism(SNP)