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Liver abnormalities following SARS-CoV 2 infection in children 1 to 10 years of age

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Family Medicine and Community Health 2024年第1期12卷 28-35页

作者： Pauline Terebuh Veronica R Olaker Ellen K Kendall David C Kaelber Rong Xu pamela b.davis Center for Artificial Intelligence in Drug Discovery Case Western Reserve UniversityClevelandOHUSA The Center for Clinical Informatics Research and Education The MetroHealth SystemClevelandOHUSA Department of Medicine PediatricsDepartment of Population and Quantitative Health SciencesCase Western Reserve UniversityClevelandOHUSA Center for Community Health Integration Case Western Reserve UniversityClevelandOHUSA

Objective beginning in October 2021 in the USA and elsewhere,cases of severe paediatric hepatitis of unknown aetiology were identified in young *** the adenovirus and adenovirus-associated virus have emerged as leading aetiological suspects,we attempted to investigate a potential role for SARS-CoV 2 in the development of subsequent liver *** We conducted a study using retrospective cohorts of deidentified,aggregated data from the electronic health records of over 100 million patients contributed by US healthcare *** Compared with propensity score matched children with other respiratory infections,children aged 1-10 years with COVID-19 had a higher risk of elevated transaminases(HR(95%CI)2.16(1.74 to 2.69))or total bilirubin(HR(95%CI)3.02(1.91 to 4.78)),or new diagnoses of liver diseases(HR(95%CI)1.67(1.21 to 2.30))from 1 to 6 months after *** with pre-existing liver abnormalities,liver abnormalities surrounding acute infection,younger age(1-4 years)or illness requiring hospitalisation all had similarly elevated *** who developed liver abnormalities following COVID-19 had more pre-existing conditions than those who developed abnormalities following other *** These results indicate that SARS-CoV 2 may prime the patient for subsequent development of liver infections or non-infectious liver *** rare(~1 in 1000),SARS-CoV 2 is a risk for subsequent abnormalities in liver function or the diagnosis of diseases of the liver.

关键词： elevated diagnosis subsequent

Pregnancy stressors and postpartum symptoms of depression and anxiety:the moderating role of a cognitivebehavioural therapy(CbT)intervention

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General Psychiatry 2024年第1期37卷 112-121页

作者： Yunxiang Sun Soim Park Abid Malik Najia Atif Ahmed Zaidi Atif Rahman pamela J Surkan Department of International Health Johns Hopkins University Bloomberg School of Public HealthBaltimoreMarylandUSA Department of Public Mental Health Health Services AcademyIslamabadPakistan Human Development Research Foundation RawalpindiPakistan Department of Primary Care and Mental Health Institute of Population HealthUniversity of LiverpoolLiverpoolUK

background Little is known about the association between stressors(especially positive stressors)during pregnancy and postpartum depression and *** We investigated the association between positive and negative stress events during different stages of pregnancy and postpartum mental health outcomes among low-income pregnant women with symptoms of anxiety in Pakistan and evaluated whether an intervention based on cognitive behavioural therapy(CbT)had a regulatory *** Participants were 621 pregnant Pakistani women with mild *** the Pregnancy Experience Scale-brief Version,six scores were created to assess positive and negative *** performed a multivariate linear regression to examine whether these six scores,measured both at baseline and in the third trimester,were associated with postpartum anxiety and depressive *** effect of the intervention on this relationship was examined by adding an interaction term to the regression *** Hassles frequency measured in the third trimester was positively associated with depression(b=0.22,95%confidence interval(Cl):0.09 to 0.36)and anxiety(b=0.19,95%Cl:0.08to 0.30).At the same timepoint,uplifts intensity was negatively associated with symptoms of depression(b=-0.82,95%Cl:1.46 to-0.18)and anxiety(b=-0.70,95%Cl:-1.25 to-0.15),whereas hassles intensity was positively related to symptoms of depression(b=1.02,95%Cl:0.36 to 1.67)and anxiety(b=0.90,95%Cl:0.34 to 1.47).The intensity ratio of hassles to uplifts reported in the third trimester was positively related to both depression(b=1.40,95%Cl:0.59 to 2.20)and anxiety(b=1.26,95%Cl:0.57 to 1.96).The intervention strengthened the overall positive effects of uplfts and the negative effects of *** experiences at baseline during early pregnancy to mid-pregnancy were not associated with mental health *** Stressors in the third trimester but not earlier in pregnancy were associated with postpartum symptoms

关键词： postpartum stress behaviour

Pleistocene glaciation advances the cryptic speciation of Stellera chamaejasme *** a major biodiversity hotspot

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Journal of Integrative Plant biology 2024年第6期66卷 1192-1205页

作者： Santosh Kumar Rana Hum Kala Rana Jacob bLandis Tianhui Kuang Juntong Chen Hengchang Wang Tao Deng Charles C.davis Hang Sun CAS Key Laboratory for Plant Diversity and biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Arkansas biosciences Institute Arkansas State UniversityJonesboroArkansas 72401USA School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA bTI Computational biology Center Boyce Thompson InstituteIthacaNew York 14853USA CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of SciencesWuhan Botanical GardenWuhan 430074China Department of Organismic and Evolutionary biology HerbariaHarvard UniversityCambridgeMassachusetts 02138USA

The mountains of Southwest China comprise a significant large mountain range and biodiversity hotspot imperiled by global climate *** high species diversity in this mountain system has long been attributed to a complex set of factors,and recent large-scale macroevolutionary investigations have placed a broad timeline on plant diversification that stretches from 10 million years ago(Mya)to the *** our increasing understanding of the temporal mode of speciation,finer-scale populationlevel investigations are lacking to better refine these temporal trends and illuminate the abiotic and biotic influences of cryptic *** is largely due to the dearth of organismal sampling among closely related species and populations,spanning the incredible size and topological heterogeneity of this *** study dives into these evolutionary dynamics of speciation using genomic and ecomorphological data of Stellera chamaejasme *** identified four previously unrecognized cryptic species having indistinct morphological traits and large metapopulation of evolving lineages,suggesting a more recent diversification(~2.67-0.90 Mya),largely influenced by Pleistocene glaciation and biotic *** factors likely influenced allopatric speciation and advocated cyclical warming–cooling episodes along elevational gradients during the *** study refines the evolutionary timeline to be much younger than previously implicated and raises the concern that projected future warming may influence the alpine species diversity,necessitating increased conservation efforts.

关键词： cryptic speciation glacial-interglacial Hengduan Mountains north-south migration Stellera chamaejasme

Association of COVID- 19 with respiratory syncytial virus (RSV) infections in children aged 0-5 years in the USA in 2022: a multicentre retrospective cohort study

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Family Medicine and Community Health 2023年第4期11卷 45-55页

作者： Lindsey Wang pamela b.davis Nathan berger David C Kaelber Nora Volkow Rong Xu Center for Science Healthand SocietyCase Western Reserve UniversityClevelandOhioUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA The Center for Clinical Informatics Research and Education and the Departments ofInternal Medicine Pediatricsand Population and Quantitative Health SciencesMetroHealth Medical CenterClevelandOhioUSA National Institute on Drug Abuse National Institute of HealthBethesdaMarylandUSA Center for AI in Drug Discovery Case Western Reserve University School of MedicineClevelandOhioUSA

Objective To investigate whether COVID-19 infection was associated with increased risk for incident respiratory syncytial virus(RSV)infections and associated diseases among young children that might have contributed to the 2022 surge of severe paediatric RSV cases in the *** This is a retrospective population-based cohort *** outcomes were examined,including overall RSV infection,positive lab test-confirmed RSV infection,clinically diagnosed RSV diseases,RSV-associated bronchiolitis and unspecified *** ratio(RR)and 95%CI of the outcomes that occurred during the 2022 and 2021 RSV seasons were calculated by comparing propensity-score matched *** Nationwide multicentre database of electronic health records(EHRs)of 61.4million patients in the USA including 1.7million children 0–5 years of age,which was accessed through TriNetX Analytics that provides web-based and secure access to patient EHR data from hospitals,primary care and specialty treatment *** The study population consisted of 228940 children of 0–5 years with no prior RSV infection who had medical encounters in October *** were replicated in a separate study population of 370919 children of 0–5 years with no prior RSV infection who had medical encounters in July 2021–August 2021 during a non-overlapping time *** For the 2022 study population(average age 2.4 years,46.8%girls,61%white,16%black),the risk for incident RSV infection during October 2022–December 2022 was 6.40%for children with prior COVID-19 infection,higher than 4.30%for the matched children without COVID-19(RR 1.40,95%CI 1.27 to 1.55);and among children aged 0–1year,the overall risk was 7.90%for those with prior COVID-19 infection,higher than 5.64%for matched children without(RR 1.40,95%CI 1.21 to 1.62).For the 2021 study population(average age 2.2 years,46%girls,57%white,20%black),the risk for incident RSV infection during July 2021–December 2021 was 4.85%for childre

关键词： infections matched centre

Time trend and seasonality in medically attended respiratory syncytial virus (RSV) infections in US children aged 0-5 years, January 2010-January 2023

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Family Medicine and Community Health 2023年第4期11卷 36-44页

作者： Lindsey Wang Nathan berger pamela b.davis David C Kaelber Nora Volkow Rong Xu Center for Science Healthand SocietyCase Western Reserve UniversityClevelandOhioUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA The Center for Clinical Informatics Research and Education and the Departments ofInternal Medicine Pediatricsand Population and Quantitative Health SciencesMetroHealth Medical CenterClevelandOhioUSA National Institute on Drug Abuse National Institute of HealthBethesdaMarylandUSA Center for Artificial Intelligence in Drug Discovery Case Western Reserve University School of MedicineClevelandOhioUSA

Objective The long-term time trend and seasonality variations of first-time medically attended respiratory syncytial virus(RSV)infections among young children are *** aim to examine the time trend of medically attended first-time RSV infections among young children in the USA from January 2010 through January *** This is a population-based cohort study using electronic health records(EHRs).Monthly incidence rate of medically attended first-time RSV infection(cases per 10000000 person-days).A time-series regression model was used to model and predict time trends and *** Multicenter and nationwide TriNetX Network in the *** The study population comprised children aged 0–5 years who had medical visits during the period of January 2010 to January *** The data included 29013937 medical visits for children aged 0–5 years(46.5%girls and 53.5%boys)from January 2010 through January *** 2010 through 2019,the monthly incidence rate of first-time medically attended RSV infection in children aged 0–5 years followed a consistent seasonal *** patterns of medically attended RSV infections were significantly disrupted during the COVID-19 *** 2020,the seasonal variation disappeared with a peak incidence rate of 20 cases per 1000000 person-days,a decrease of 97.4%from the expected peak rate(rate ratio or RR:0.026,95%CI 0.017 to 0.040).In 2021,the seasonality returned but started 4 months earlier,lasted for 9 months,and peaked in August at a rate of 753 cases per 1000000 person-days,a decrease of 9.6%from the expected peak rate(RR:0.90,95%CI 0.82 to 0.99).In 2022,the seasonal pattern is similar to prepandemic years but reached a historically high rate of 2182 cases per 10000000 person-days in November,an increase of 143%from the expected peak rate(RR:2.43,95%CI 2.25 to 2.63).The time trend and seasonality of the EHR-based medically attended RSV infections are consistent with those of RSV-associated hospital

关键词： infections trend attended

Pelage color of red bats Lasiurus borealis varies with body size:An image analysis of museum specimens

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Current Zoology 2010年第4期56卷 401-405页

作者： Andrew K.davis Steven b.CASTLEbERRY D.b. Warnell School of Forestry and Natural Resources The University of Georgia

Mammalian pelage color can vary among individuals of many species, although this intraspecific variation is oftenoverlooked by researchers, perhaps because of its sometimes subtle nature and difficulty in assessing it quantitatively. Thus, suchvariation is rarely studied in mammals, and this is especially true within the order Chiroptera, where there has been very little empiricalresearch. We examined museum specimens of red bats (Lasiurus borealis, family Vespertilionidae) from Georgia, USA, todetermine the extent of sexual dimorphism in pelage color and to explore possible associations between body size and pelagecolor. We photographed 54 specimens under uniform lighting, and used an image analysis program to measure pelage hue on theuropatagium region, which is fully furred in members of the genus Lasiurus. Statistical analyses of pelage hue scores showedmales had significantly redder pelage than females when considered alone, but when examined together with effects of body sizeand collection year, sex was not significant, and collection year and body size were. More recent specimens tended to be less redthan older specimens, which might indicate a wearing of the buffy tips of hairs from older specimens, and smaller bats of bothsexes tended to be more red. These interesting findings are encouraging and we suggest that future explorations into intraspecificvariation in pelage color of bats using this or similar approaches are warranted to clarify the significance of the patterns. Thisstudy also demonstrated that care must be taken in analyses of mammalian pelage color from older museum skins, or at least thatresearchers must take into account the age of the specimens .

关键词： Pelage color Sexual dimorphism Red bats Lasiurus borealis Image analysis

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序——贺《信息系统学报》创办

信息系统学报 2007年第1期 6-7页

作者：任明张楠 Gordon b.davis 清华大学明尼苏达大学卡尔森管理学院

我很荣幸能够为《信息系统学报》作序。每当回想起我们创立管理信息系统(MIS)学科以来所发生的巨大变化,以及课程设置上的相应改变时,我总是惊叹不已。1967年,我和我的同事们在明尼苏达创立了第一个MIS专业。当时,计算机已经开始被用于...

我很荣幸能够为《信息系统学报》作序。每当回想起我们创立管理信息系统(MIS)学科以来所发生的巨大变化,以及课程设置上的相应改变时,我总是惊叹不已。1967年,我和我的同事们在明尼苏达创立了第一个MIS专业。当时,计算机已经开始被用于组织中的日常数据处理,如工资管理、库存管理、生产进度控制等。设立这一学科的初衷在于我们和这个领域中的许多领导者都意识到计算机技术在提升组织管理能力方面的巨大潜能,具体表现在为组织中的各级决策者提供更好的、及时的、以决策为导向的信息。我们意识到在计

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危险的体征——胸膜摩擦音

国际护理学杂志 1988年第6期 268-274页

作者： NANCY b.davis ,任真年

对疾病的正确估计和发现,重要的是在危险体征出现之前。你熟悉这些危险体征吗?遇到危险情况,你知道怎样做出反应吗?本文就从病人的胸膜摩擦音谈起。一男性患者,35岁,建筑工人,因股骨骨折而住院,牵引使他感到不舒适,昨日自述小夹板压迫... 详细信息

对疾病的正确估计和发现,重要的是在危险体征出现之前。你熟悉这些危险体征吗?遇到危险情况,你知道怎样做出反应吗?本文就从病人的胸膜摩擦音谈起。一男性患者,35岁,建筑工人,因股骨骨折而住院,牵引使他感到不舒适,昨日自述小夹板压迫疼痛。“你感到怎么样?”护士通过监护系统问道。“我感到呼吸困难。”患者回答道。“我正要给你检查小夹板呢。”患者躺在床上看电视。他呼吸急促表情痛苦。应升高患者床头45°,以利呼吸。脉搏,有力而不浅细,116次/分;呼吸,浅快,28次/分。要询问患者,“你胸痛吗?”“是的,”患者回答道,“我去年患胸膜炎时也有这样的感觉。”

关键词：摩擦音疼痛擦音胸膜小夹板体征

Iron,the endolysosomal system and neuroinflammation:a matter of balance

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Neural Regeneration Research 2022年第5期17卷 1003-1004页

作者： Daniel A.bórquez pamela J.Urrutia Marco T.Núñez Center for biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile Department of biology Faculty of SciencesUniversidad de ChileSantiagoChile

Iron accumulation and neuroinflammation are cardinal features of many neurodegenerative diseases(Urrutia et al.,2021).However,the hierarchy in the pathogenic mechanisms and the molecular connections between these proc... 详细信息

关键词： Iron system showing