检索结果-南通市图书馆

A nanotherapeutic strategy to target drug-tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer

引用

Cancer Communications 2023年第4期43卷 503-507页

作者： Tatiana Shaurova Lingyue Yan Yafei Su Laurie James Rich Vui King Vincent-Chong Hannah Calkins Saraswati Pokharel Martin Petkovich Mukund Seshadri Yun Wu pamela anne hershberger Department of Pharmacology and Therapeutics Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Department of Biomedical Engineering University at Buffalothe State University of New YorkBuffaloNew YorkUSA Cell Stress and Biophysical Oncology Graduate Program Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Fujifilm-Visual Sonics Corporation TorontoOntarioCanada Department of Oral Oncology Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Department of Pathology Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Cancer Research Institute School of MedicineQueens UniversityKingstonOntarioCanada

Dear Editor,For patientswith epidermal growth factor receptor(EGFR)mutant non-small cell lung cancer(NSCLC),EGFR tyrosine kinase inhibitors(TKIs)are used as the first-line treatment[1,2].Despite initial therapeutic responses,patients invariably experience disease progression due to acquired drug resistance[3].Resistance arises,in part,because a subset of cancer cells undergoes epithelial-mesenchymal transition(EMT)and remains viable despite exposure to EGFR TKI concentrations that eliminate the bulk population[4].The surviving cells can be re-sensitized to treatment by prolonged culture in the absence of EGFR TKIs,indicating a transient.

关键词： therapeutic viable resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Overview of clinical trials for nasopharyngeal carcinoma(in the English literature)

引用

Chinese Journal of Cancer 2010年第8期29卷 709-714页

作者： anne W.M.Lee Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital

Megavoltage radiation therapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). Treatment results have been steadily improving with rapid technological advances and better knowledge on optimization of dose fractionation. During the past decade, RT techniques have evolved from conventional 2-dimensional (2D) to 3-dimensional (3D) complex technique with multiple conformal fields and intensity-modulation. There is little controversy that intensity-modulated technique (IMRT) is recommended if resources permit, dosimetric studies show clear improvement in dose distribution, with conformity of high dose to concave tumor targets and sharp dose gradient for adequate tumor coverage and better protection of adjacent normal tissues.

关键词：鼻咽癌英文文献临床试验治疗方式技术进步强度调制 RT技术高剂量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Maintenance therapy in advanced non-small cell lung cancer： a prime-time for change？

引用

Chinese Medical Journal 2013年第12期126卷 2390-2398页

作者： Oscar Siu Hong Chan Rebecca Mei WanYeung anne Wing Mui Lee Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China

Lung cancer is the leading cancer in terms of incidence and mortality in China and its incidence in China is predicted to increase in the next 20 years.1 The majority of the lung cancer patients are diagnosed with advanced stage disease,for which chemotherapy or targeted therapies are the mainstay palliative *** the identification of single-driver mutations,like the epidermal growth factor receptor （EGFR） mutation,platinum-based doublet was the standard first line treatment for advanced stage nonsmall cell lung cancer （NSCLC） patients with a good performance status （PS）.However,patient prognosis remains poor and the modest treatment efficacy seems to have reached a plateau despite newer generation of platinum doublets.2 The recommendation for the duration of first line platinum doublet treatment is 4-6 cycles.3 The paradigm was based on the fact that a protracted course of chemotherapy did not prolong survival but introduced cumulative toxicities.4,5 The use of maintenance therapy （MT）,defined by Grossi et al6 as the prolongation of chemotherapy with the administration of additional drugs at the end of a defined number of initial chemotherapy cycles after achieving maximum tumor response,was not considered as a standard option in the past.

关键词： non-small cell lung cancer chemotherapy maintenance therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

分享知识——一种全新的在线支持和培训方法帮助Raytheon办公室的用户更好地工作

引用

Windows IT Pro Magazine（国际中文版） 2006年第7期 22-23页

作者： anne Grubb 臧铁军(译者)

IT人员的主要工作之一是向用户培训关于Microsoft Office和其它应用程序的基础知识。但是这类培训能够把完成特定工作并不是一般任务时所需的正确知识传授给他们吗？按照pamela Leal，Raytheon公司的信息知识与管理主管的说法，对于Rayt... 详细信息

IT人员的主要工作之一是向用户培训关于Microsoft Office和其它应用程序的基础知识。但是这类培训能够把完成特定工作并不是一般任务时所需的正确知识传授给他们吗？按照pamela Leal，Raytheon公司的信息知识与管理主管的说法，对于Raytheon公司的用户来说，这个问题的答案是肯定的。但是3年前，pamela和Raytheon公司IT管理部门的其他同事都意识到用户在使用像Microsoft Excel、Word和Power Point一类的Office应用软件时并没有充分发挥它们的效率。

关键词：用户培训基础知识 Raytheon公司 Microsoft 办公室 Office 管理部门 Excel Power

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Philippine retinoblastoma initiative multi-eye center study 2010-2020

引用

International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John V.Mercado Patricia E.Cabrera Paulita pamela P.Astudillo Rolando Enrique D.Domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(P<0.02)and those from the Visayas(P<0.003).Based on the International Retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：