Overview of clinical trials for nasopharyngeal carcinoma(in the English literature)

作     者：Anne W.M.Lee 

作者机构：Department of Clinical OncologyPamela Youde Nethersole Eastern Hospital 

出 版 物：《Chinese Journal of Cancer》 (CHINESE JOURNAL OF CANCER)

年 卷 期：2010年第29卷第8期

页      面：709-714页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：鼻咽癌 英文文献 临床试验 治疗方式 技术进步 强度调制 RT技术 高剂量 

摘      要：Megavoltage radiation therapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). Treatment results have been steadily improving with rapid technological advances and better knowledge on optimization of dose fractionation. During the past decade, RT techniques have evolved from conventional 2-dimensional (2D) to 3-dimensional (3D) complex technique with multiple conformal fields and intensity-modulation. There is little controversy that intensity-modulated technique (IMRT) is recommended if resources permit, dosimetric studies show clear improvement in dose distribution, with conformity of high dose to concave tumor targets and sharp dose gradient for adequate tumor coverage and better protection of adjacent normal tissues.