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Sensitivity analysis of borehole thermal energy storage: examining key factors for system optimization

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Energy Storage and Saving 2024年第3期3卷 218-230页

作者： Piyush kumar Kumawat Haiyan Zhou Kevin Kitz John McLennan Kody Powell Milind Deo palash Panja Department of Chemical Engineering University of UtahSalt Lake CityUT 84112USA Energy&Geoscience Institute University of UtahSalt Lake CityUT 84108USA RESPEC Company LLC Rapid CitySD 57703USA Kitzworks LLC BoiseID 83717USA

Borehole thermal energy storage(BTES)systems have garnered significant attention owing to their efficacy in storing thermal energy for heating and cooling *** modeling is paramount for ensuring the precise design and operation of BTES *** study conducts a sensitivity analysis of BTES modeling by employing a comparative investigation of five distinct parameters on a wedge-shaped model,with implications extendable to a cylindrical *** parameters examined included two design factors(well spacing and grout thermal conductivity),two operational variables(charging and discharging rates),and one geological attribute(soil thermal conductivity).Finite element simulations were carried out for the sensitivity analysis to evaluate the round-trip efficiency,both on a per-cycle basis and cumulatively over three years of operation,serving as performance *** results showed varying degrees of sensitivity across different models to changes in these *** particular,the round-trip efficiency exhibited a greater sensitivity to changes in spacing and volumetric flow ***,this study underscores the importance of considering the impact of the soil and grout-material thermal conductivities on the BTES-system performance over *** optimized scenario is modelled and compared with the base case,over a comparative assessment based on a 10-year *** analysis revealed that,at the end of the 10-year period,the optimized BTES model achieved a cycle efficiency of 83.4%.This sensitivity analysis provides valuable insights into the merits and constraints of diverse BTES modeling methodologies,aiding in the selection of appropriate modeling tools for BTES system design and operation.

关键词： Borehole thermal energy storage(BTES) Outlet temperature Round-trip efficiency Heating and cooling modes Well spacing Grout thermal conductivity Charging and discharging rates Soil thermal conductivity

Novel insights on oral squamous cell carcinoma management using long non-coding RNAs

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Oncology Research 2024年第10期32卷 1589-1612页

作者： SUBHAYAN SUR DIMPLE DAVRAY SOUMYA basu SUPRIYA KHEUR JAYANTA kumar PAL SHUCHI NAGAR AVINASH SANAP BHIMAPPA MRUDAGI SAMIR GUPTA Cancer and Translational Research Centre Dr.D.Y.Patil Biotechnology and Bioinformatics InstituteDr.D.Y.Patil VidyapeethTathawadePune411033India Bioinformatics Centre Dr.D.Y.Patil Biotechnology and Bioinformatics InstituteDr.D.Y.Patil VidyapeethPune411033India Department of Oral Pathology and Microbiology Dr.D.Y.Patil Dental College&HospitalDr.D.Y.Patil VidyapeethPune411018India Department of Surgical Oncology Dr.D.Y.Patil Medical CollegeHospital&Research CentreDr.D.Y.Patil VidyapeethPune411018India

Oral squamous cell carcinoma(OSCC)is one of the most prevalent forms of head and neck squamous cell carcinomas(HNSCC)with a poor overall survival rate(about 50%),particularly in cases of ***-based cancer biomarkers are a relatively advanced concept,and non-coding RNAs currently have shown promising roles in the detection and treatment of various *** review underlines the function of long non-coding RNAs(lncRNAs)in the OSCC and its subsequent clinical ***,a class of non-coding RNAs,are larger than 200 nucleotides and resemble mRNA in numerous ***,unlike mRNA,lncRNA regulates multiple druggable and non-druggable signaling molecules through simultaneous interaction with DNA,RNA,proteins,or microRNAs depending on concentration and localization in *** of oncogenic lncRNAs and downregulation of tumor suppressor lncRNAs are evident in OSCC tissues and body fluids such as blood and saliva indicating their potential as valuable *** inhibition of candidate oncogenic lncRNAs or overexpression of tumor suppressor lncRNAs showed potential therapeutic roles in in-vivo animal *** types of lncRNAs that are expressed differentially in OSCC tissue and bodily fluids have been systematically documented with specificity and *** review thoroughly discusses the biological functions of such lncRNAs in OSCC cell survival,proliferation,invasion,migration,metastasis,angiogenesis,metabolism,epigenetic modification,tumor immune microenvironment,and drug ***,we addressed the diagnostic and therapeutic importance of lncRNAs in OSCC pre-clinical and clinical systems,providing details on ongoing research and outlining potential future directions for advancements in this *** essence,this review could be a valuable resource by offering comprehensive and current insights into lncRNAs in OSCC for researchers in fundamental and clinical domains.

关键词： Oral squamous cell carcinoma(OSCC) Head and neck cancer Non-coding RNA Long non-coding RNA(lncRNA) Cancer diagnosis

Control of Non-Deterministic Systems With μ-Calculus Specifications Using Quotienting

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IEEE/CAA Journal of Automatica Sinica 2021年第5期8卷 953-970页

作者： Samik basu Ratnesh kumar the Department of Computer Science Iowa State UniversityIowa 50011-3060 USA the Department of Electrical and Computer Engineering Iowa State UniversityIowa 50011-3060 USA

The supervisory control problem for discrete event system(DES) under control involves identifying the supervisor, if one exists, which, when synchronously composed with the DES,results in a system that conforms to the control specification. In this context, we consider a non-deterministic DES under complete observation and control specification expressed in action-based propositional μ-calculus. The key to our solution is the process of quotienting the control specification against the plan resulting in a new μ-calculus formula such that a model for the formula is the supervisor. Thus the task of control synthesis is reduced a problem of μ-calculus satisfiability. In contrast to the existing μ-calculus quotienting-based techniques that are developed in deterministic setting, our quotienting rules can handle nondeterminism in the plant models. Another distinguishing feature of our technique is that while existing techniques use a separate μ-calculus formula to describe the controllability constraint(that uncontrollable events of plants are never disabled by a supervisor), we absorb this constraint as part of quotienting which allows us to directly capture more general state-dependent controllability constraints. Finally, we develop a tableau-based technique for verifying satisfiability of quotiented formula and model generation. The runtime for the technique is exponential in terms of the size of the plan and the control specification. A better complexity result that is polynomial to plant size and exponential to specification size is obtained when the controllability property is state-independent. A prototype implementation in a tabled logic programming language as well as some experimental results are presented.

关键词： Discrete event systems(DES) non-deterministic plant μ-calculus supervisory control

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Transition metal-based single-atom catalysts(TM-SACs);rising materials for electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2022年第7期31卷 444-471,I0012页

作者： Bishnupad Mohanty Suddhasatwa basu Bikash kumar Jena Materials Chemistry Department CSIR-Institute of Minerals and Materials TechnologyBhubaneswar 751013India Academy of Scientific&Innovative Research(AcSIR) Ghaziabad 201002India

The continuous increase of global atmospheric CO_(2) concentrations brutally damages our environment. A series of methods have been developed to convert CO_(2) to valuable fuels and value-added chemicals to maintain the equilibrium of carbon cycles. The electrochemical CO_(2) reduction reaction(CO_(2)RR) is one of the promising methods to produce fuels and chemicals, and it could offer sustainable paths to decrease carbon intensity and support renewable energy. Thus, significant research efforts and highly efficient catalysts are essential for converting CO_(2) into other valuable chemicals and fuels. Transition metal-based single atoms catalysts(TM-SACs) have recently received much attention and offer outstanding electrochemical applications with high activity and selectivity opportunities. By taking advantage of both heterogeneous and homogeneous catalysts, TM-SACs are the new rising star for electrochemical conversion of CO_(2) to the value-added product with high selectivity. In recent years, enormous research effort has been made to synthesize different TM-SACs with different M–Nxsites and study the electrochemical conversion of CO_(2) to CO. This review has discussed the development and characterization of different TMSACs with various catalytic sites, fundamental understanding of the electrochemical process in CO_(2) RR,intrinsic catalytic activity, and molecular strategics of SACs responsible for CO_(2)RR. Furthermore, we extensively review previous studies on 1 st-row transition metals TM-SACs(Ni, Co, Fe, Cu, Zn, Sn) and dual-atom catalysts(DACs) utilized for electrochemical CO_(2) conversions and highlight the opportunities and challenges.

关键词： CO_(2)RR Single-atom catalyst SACs Dual-atom catalyst DACs Transition metals Support catalysts

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Broadband, High Gain, Narrow Width Rectangular Dielectric Resonator Antenna with Air Gap

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Journal of Electronic Science and Technology 2019年第1期17卷 90-96页

作者： Ankit kumar Roy Sukla basu Kalyani Government Engineering College

The broadband, narrow width, rectangular dielectric resonator antenna(RDRA) of aluminum nitride(εr=8.6) was designed and the effect of inclusion of air gap at the bottom of the dielectric resonator antenna(DRA),above the ground plane, was investigated. Gain around 7 dBi was obtained for DRA with air gap(DRAAG) over a broad bandwidth in upper X, Ku, and K bands. Further enhancement in gain could be obtained by placing a metal wall parallel to the length of DRA. However, due to the presence of metal wall, bandwidth was reduced. These structures with the metal wall are capable of operating over a wide band extending from Ku band to lower K band with the gain of around 10 dBi. CST Microwave Studio Software was used to simulate all these *** parameters of DRA with air gap were compared with several broadband DRA structures reported in recent literature. The proposed DRAAG with the metal wall in this paper is capable of operating over a wide bandwidth along with a significant gain.

关键词： Dielectric resonator antenna(DRA) rectangular dielectric resonator antenna(RDRA) wide band dielectric resonator antenna X Ku and K bands dielectric resonator antenna

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The evolution of graphene-based electronic devices

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International Journal of Smart and Nano Materials 2010年第3期1卷 201-223页

作者： Joydeep basu Jayanta kumar basu Tarun Kanti Bhattacharyya Department of Electronics and Electrical Communication Engineering Department of Chemical Engineering Indian Institute of TechnologyKharagpur 721302India

Successful isolation of single-layer graphene,the two-dimensional allotrope of carbon from graphite,has fuelled a lot of interest in exploring the feasibility of using it for fabrication of various electronic devices,particularly because of its exceptional electronic *** is poised to save Moore’s law by acting as a successor of silicon-based *** article reviews the success story of this allotrope with a focus on the structure,properties and preparation of graphene as well as its various device applications.

关键词： electronic device FET field effect graphene nanoelectronics

Chaperone-assisted E3 ligase CHIP:A double agent in cancer

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Genes & Diseases 2022年第6期9卷 1521-1555页

作者： Sunny kumar Malini basu Mrinal K.Ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatSouth 24 ParaganasWest Bengal 743372India

The carboxy-terminus of Hsp70-interacting protein(CHIP)is a ubiquitin ligase and co-chaperone belonging to Ubox family that plays a crucial role in the maintenance of cellular homeostasis by switching the equilibrium of the folding-refolding mechanism towards the proteasomal or lysosomal degradation *** links molecular chaperones ***70,HSP70 and HSP90 with ubiquitin proteasome system(UPS),acting as a quality control *** contains charged domain in between N-terminal tetratricopeptide repeat(TPR)and C-terminal Ubox *** domain interacts with the aberrant client proteins via chaperones while Ubox domain facilitates the ubiquitin transfer to the client proteins for ***,CHIP is a classic molecule that executes ubiquitination for degradation of client ***,CHIP has been found to be indulged in cellular differentiation,proliferation,metastasis and ***,CHIP can play its dual role as a tumor suppressor as well as an oncogene in numerous malignancies,thus acting as a double ***,in this review,we have reported almost all substrates of CHIP established till date and classified them according to the hallmarks of *** addition,we discussed about its architectural alignment,tissue specific expression,sub-cellular localization,folding-refolding mechanisms of client proteins,E4 ligase activity,normal physiological roles,as well as involvement in various diseases and tumor ***,we aim to discuss its importance in HSP90 inhibitors mediated cancer ***,this report concludes that CHIP may be a promising and worthy drug target towards pharmaceutical industry for drug development.

关键词： Chaperones(HSC70/HSP70&HSP90) CHIP Oncogene Therapy Tumor suppressor Ubiquitin proteasome system(UPS)

COVID-19 therapeutics:Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

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Genes & Diseases 2023年第4期10卷 1402-1428页

作者： Sunny kumar Malini basu Pratyasha Ghosh Uttam Pal Mrinal K.Ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatWest Bengal 743372India Department of Economics Bethune CollegeUniversity of CalcuttaKolkata 700006India

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes the compli-cated disease *** are continuously facing huge problems in the treatment of patients,as COVID-19-specific drugs are not available,hence the principle of drug repurpos-ing serves as a one-and-only ***,the repurposing of many drugs is underway;few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical *** in this review,our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs,the potential mechanism of actions,and the current clinical trial status of various drugs which are under repurposing since early *** last,we briefly proposed the probable phar-macological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines.

关键词： Clinical trials COVID-19 Drug discovery Pharmacology Repurposing of drugs SARS-CoV-2

Growth and Approximation of Generalized Bi-Axially Symmetric Potentials

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Journal of Mathematical Research with Applications 2015年第6期35卷 613-624页

作者： Devendra kumar Anindita basu Department of Mathematics Faculty of Science Al-Baha University Department of Mathematics Dr.Bhupendra Nath Dutta Smriti MahavidyalayaBurdwan P.O Box- 713407 West Bengal India

The paper deals with growth estimates and approximation(not necessarily entire) of solutions of certain elliptic partial differential equations. These solutions are called generalized bi-axially symmetric potentials(GBASP’s). To obtain more refined measure of growth, we have defined q-proximate order and obtained the characterization of generalized q-type and generalized lower q-type with respect to q-proximate order of a GBASP in terms of approximation errors and ratio of these errors in sup norm.

关键词： generalized bi-axially symmetric potentials q-proximate order Jacobi polynomials generalized q-type generalized lower q-type approximation errors