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Native and transplant kidney histopathological manifestations in association with COVID-19 infection: A systematic review

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World Journal of Transplantation 2021年第11期11卷 480-502页

作者： Vishnu Jeyalan Joshua Storrar Henry H L Wu Arvind ponnusamy Smeeta Sinha Philip A Kalra Rajkumar Chinnadurai Department of Renal Medicine Royal Preston HospitalPreston PR29HTUnited Kingdom Department of Renal Medicine Salford Care OrganisationNorthern Care Alliance NHS Foundation TrustSalford M68HDUnited Kingdom Faculty of Biology Medicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can result in clinically significant multi-system disease including involvement in the *** underlying histopathological processes were unknown at the start of the *** case reports and series have been published describing the underlying renal histopathology from kidney biopsies,we have started to gain an insight into the renal manifestations of this novel *** To provide an overview of the current literature on the renal histopathological features and mechanistic insights described in association with coronavirus disease 2019(COVID-19)*** A systematic review was performed by conducting a literature search in the following websites-‘PubMed’,‘Web of Science’,‘Embase’and‘Medline-ProQuest’with the following search terms-“COVID-19 AND kidney biopsy”,“COVID-19 AND renal biopsy”,“SARS-CoV-2 AND kidney biopsy”and“SARS-CoV-2 AND renal biopsy”.We have included published data up until February 15,2021,which includes kidney biopsies(native,transplant and postmortem)from patients with *** on clinical presentation,histopathological features,management and outcome was extracted from the reported *** The total number of biopsies reported on here is 288,of which 189 are postmortem,84 native and 15 *** results are varied and show underlying pathologies ranging from collapsing glomerulopathy and acute tubular injury(ATI)to anti-nuclear cytoplasmic antibody associated vasculitis and pigment *** was variation in the specific treatment used for the various renal conditions,which included steroids,hydroxychloroquine,eculizumab,convalescent plasma,rituximab,anakinra,cyclophosphamide and renal replacement therapy,amongst *** pathological process which occurs in the kidney following COVID-19 infection and leads to the described biopsy findings has been hypothesized in some conditions but not others(for example,sepsis related hypoperf

关键词： COVID-19 Histopathology Kidney biopsy Transplant SARS-CoV-2

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调和函数的Lipschitz型空间和Landau-Bloch型定理

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数学学报（中文版） 2017年第6期60卷 1025-1036页

作者：陈少林 Miodrag MATELJEVIC Saminathan ponnusamy 王仙桃衡阳师范学院数学与统计学院衡阳421008 University of Belgrade Faculty of MathematicsStudentski Trg 16 Belgrade11000 Serbia Indian Statistical Institute Chennai CentreSETSMGR Knowledge CityCIT Campus Chennai600113 India 汕头大学数学系汕头515063

主要研究调和函数和Poisson方程的解的性质.讨论了调和函数的Lipschitz型空间,建立了调和函数的Schwarz-Pick型引理,并利用所得结果证明了与调和Hardy空间有关的一个Landau-Bloch型定理.最后,还利用正规族理论讨论了与Poisson方程的解... 详细信息

主要研究调和函数和Poisson方程的解的性质.讨论了调和函数的Lipschitz型空间,建立了调和函数的Schwarz-Pick型引理,并利用所得结果证明了与调和Hardy空间有关的一个Landau-Bloch型定理.最后,还利用正规族理论讨论了与Poisson方程的解有关的Landau-Bloch型定理的存在性.

关键词： Schwarz—Pick型引理调和函数 Lipschitz型空间 Poisson方程

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多重调和映射的等周型和Fejer-Riesz型不等式

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中国科学：数学 2014年第2期44卷 127-138页

作者：陈少林 ponnusamy Saminathan 王仙桃衡阳师范学院数学与计算科学系衡阳421008 Indian Statistical Institute(ISI) Chennai CentreChennai 600113India 湖南师范大学数学与计算机科学学院长沙410081

本文讨论多重调和映射的等周型和Fejer-Riesz型不等式.首先,本文改进Kalaj和Meˇstrovi′c的相应结果,并将其结果推广到多重调和映射.其次,本文证明Pavlovi′c和Dostani′c的相应结果对于多重调和映射也是成立的.最后,本文建立关于多重... 详细信息

本文讨论多重调和映射的等周型和Fejer-Riesz型不等式.首先,本文改进Kalaj和Meˇstrovi′c的相应结果,并将其结果推广到多重调和映射.其次,本文证明Pavlovi′c和Dostani′c的相应结果对于多重调和映射也是成立的.最后,本文建立关于多重调和映射的Fejer-Riesz型不等式.

关键词：多重调和映射等周型不等式 Hardy类

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Gromov双曲Holder区域的边界性质

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数学学报（中文版） 2023年第4期66卷 651-662页

作者：周青山李浏兰李希宁 SAMINATHAN ponnusamy 佛山科学技术学院数学与大数据学院佛山528000 衡阳师范学院衡阳421001 中山大学数学系珠海510970 Indian Institute of Technology Madras India 600036 Department of Mathematics Petrozavodsk State UniversityLenina 33185910 PetrozavodskRussia

设Ω■R^(n)是一个满足拟双曲边界条件的Gromov双曲区域.通过使用直径型的Gehring-Hayman不等式和Bonk-Heinonen-Koskela的一致化过程,我们在此文中建立了Ω的内直径边界和Gromov边界的双边H?lder对应关系.作为应用,我们不仅可以得到拟... 详细信息

设Ω■R^(n)是一个满足拟双曲边界条件的Gromov双曲区域.通过使用直径型的Gehring-Hayman不等式和Bonk-Heinonen-Koskela的一致化过程,我们在此文中建立了Ω的内直径边界和Gromov边界的双边H?lder对应关系.作为应用,我们不仅可以得到拟共形映射的内直径边界连续性,也可以得到关于拟双曲度量的拟等距映射在内直径边界的连续性.

关键词： Holder区域 Gromov双曲区域 Holder连续性拟双曲度量

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A Complete DFT, TD-DFT and Non-Linear Optical Property Study on 6-Amino-2-Methylpyridine-3-Carbonitrile

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Computational Chemistry 2017年第3期5卷 129-144页

作者： Durai Sakthi Madhu Prakasam Annamalai Prakasam Santhanam Sivakumar ponnusamy Munusamy Anbarasan Department of Physics Periyar University Salem India Centre for Nanoscience and Nanotechnology Periyar University Salem India Department of Physics Thiruvalluvar Government Arts College Rasipuram Namakkal India Department of Chemistry E.R.K. Arts & College Dharmapuri India

The optimized geometric structure and photophysical properties of 6-Amino-2-methylpyridine-3-carbonitrile dye have been studied by using Density Functional Theory (DFT). The lowest singlet excited state geometry optimized using Time-Dependent Density Functional Theory (TD-DFT). On the basis of ground and excited state geometries, the absorption spectra have been calculated using the DFT and TD-DFT method in gas phase and acetonitrile medium. To understand the Non-Linear Optical properties of 6-Amino-2-methylpyridine-3-carbonitrile dye, we computed dipole moment (μ), electronic polarizability (α), and first hyperpolarizability (β0) and second order hyperpolarizability (γ) using B3LYP density functional theory method in conjunction with 6-311++G(d) basis set.

关键词： Vibrational Spectra DFT Natural Bond Orbitals HOMO-LUMO Electronic and Absorption Spectra

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Cost and outcomes of postacute care after primary hip and knee arthroplasty

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中华物理医学与康复杂志 2017年第7期39卷 542-542页

作者： ponnusamy KE Naseer Z El Dafrawy MH

BACKGROUND AND OBJECTIVE With the aging of the population of the United States,significant increases are expected in cases of total hip arthroplasty(THA)and total knee arthroplasty(TKA).Joint arthroplasty is now the largest Medicare procedural cost,at 6.3%.This study examined the duration of care,charges and readmission rates after primary THA or *** Data were obtained from the Medicare Provider Analysis and Review(medPAR)database for individuals undergoing primary TKA(n=136,842)or THA(n=329,233)in *** collected included subsequent inpatient rehabilitation,extended-care facility

关键词：膝关节髋关节置换护理成本医疗保险老龄化费用

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Circulating Th17 and Tc17 Cells and Their Imbalance with Regulatory T Cells Is Associated with Myocardial Infarction in Young Indian Patients

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World Journal of Cardiovascular Diseases 2015年第12期5卷 373-387页

作者： Thiruvelselvan ponnusamy Komarlu Venkatachala Srikanth Ramanjappa Manjunatha Vijay V. Kakkar Lakshmi Mundkur Research Scholar Manipal University at Thrombosis Research Institute Bangalore India Narayana Institute of Cardiac Sciences Bangalore India Clinical Research Unit Thrombosis Research Institute Bangalore India Mary and Gary Western and Tata Molecular Immunology Unit Thrombosis Research Institute Bangalore India Molecular Immunology Unit Thrombosis Research Institute London United Kingdom

Background: Activated inflammatory cells are found in coronary plaques as well as peripheral circulation in patients with acute coronary syndrome. We explored the circulating T cell profile, their reactivity to self-antigens and plasma cytokine levels in Indian patients with Myocardial Infarction. Methods and Results: Intracellular expression of interferon-γ Interleukin (IL)-4, IL-17, IL-10 and Foxp3 were determined in CD4+ and CD8+ T cells using flow cytometry in patients with ST elevated myocardial infarction (STEMI) (N = 79) and controls (N = 80). Cytokines were measured using Milliplex kit and T cell reactivity was studied by CFSE dilution. Statistical analysis was performed using SPSS software. Patients with myocardial infarction showed higher proportion of IL-17 expressing CD4+ and CD8+ T cells (Th17 and Tc17) and elevated levels of IL-6 and IL-17 in plasma with significant reduction in circulating Tregs. Th1, Th2 and CD4+CD28null cells were not significantly different in patients compared to healthy individuals. The ratio of Th17 and Tc17 to Tregs showed an independent association with STEMI with an adjusted odds ratio of 2.92 (95% CI: 1.73 - 4.92), P + and CD8+ T cells secreting IL-17 and Tregs is associated with acute myocardial infarction. HSP60 and Ox-LDL may contribute to this response and pathogenesis of AMI in Indian population.

关键词： T Lymphocytes Adaptive Immunity Coronary Artery Disease Myocardial Infarction Cytokines Auto-Antigens

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维生素B12缺乏症

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英国医学杂志中文版 2019年第9期22卷 537-542页

作者： Nithya Sukumar ponnusamy Saravanan 永丰(译者) Department of Populations Evidence and Technologies Warwick Medical School University of Warwick Coventry CV4 7AL UK Department of Diabetes Endocrinology and Metabolism George Eliot Hospital Nuneaton UK 中华医学杂志编辑部

一名44岁女性,因嗜睡2年到全科门诊就诊,嗜睡导致其无法继续小学教师的工作。数年前患者曾有贫血史,但除混合避孕药外,未规律服用治疗贫血的相关药物。患者母亲患有甲状腺功能减退症并服用左旋甲状腺素;家庭其他成员病史不详。体格检查... 详细信息

一名44岁女性,因嗜睡2年到全科门诊就诊,嗜睡导致其无法继续小学教师的工作。数年前患者曾有贫血史,但除混合避孕药外,未规律服用治疗贫血的相关药物。患者母亲患有甲状腺功能减退症并服用左旋甲状腺素;家庭其他成员病史不详。体格检查无特殊。近期血液生化检查显示,血红蛋白110g/L(参考范围115~160g/L),平均红细胞容积102fL(80~100fL)。

关键词：维生素B12缺乏症甲状腺功能减退症平均红细胞容积左旋甲状腺素血液生化检查门诊就诊小学教师相关药物

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Alphabet Strategy for diabetes care: A multi-professional, evidence-based, outcome-directed approach to management

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World Journal of Diabetes 2015年第6期6卷 874-879页

作者： James D Lee ponnusamy Saravanan Vinod Patel Diabetes and Endocrinology Centre George Eliot Hospital NHS Trust Warwick Medical School University of Warwick CV4 7AL Coventry United Kingdom

With the rising global prevalence in diabetes, healthcare systems are facing a growing challenge to provide efficient and effective diabetes care management in the face of spiralling treatment costs. Diabetes is a major cause of premature mortality and associated with devastating complications especially if managed poorly. Although diabetes care is improving in England and Wales, recent audit data suggests care remains imperfect with wide geographical variations in quality. Diabetes care is expensive with a sizeable amount of available expenditure used for treating the complications of diabetes. A target driven, long-term, multifactorial intervention in patients with type 2 diabetes has been shown to reduce mortality and morbidity. The alphabet strategy is a novel approach to effective diabetes care provision, aiming to address patient education and empowerment, provide consistent comprehensive care delivered in a timely fashion, and allowing multidisciplinary team work.

关键词： Alphabet strategy Diabetes care management Checklist Multifactorial intervention Chronicdisease management

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Adaptive Polling Rate for SNMP for Detecting Elusive DDOS

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Journal of Cyber Security 2022年第1期4卷 17-28页

作者： Yichiet Aun Yen-Min Jasmina Khaw Ming-Lee Gan Vasaki ponnusamy Faculty of Information Communication and Technology Kampar31900Malaysia

Resilient network infrastructure is pivotal for business entities that are growing reliance on the *** Denial-of-Service(DDOS)is a common network threat that collectively overwhelms and exhausts network resources using coordinated botnets to interrupt access to network services,devices,and *** is typically deployed to detect DDOS based on Snort *** being fairly accurate,IDS operates on a computeintensive packet inspection technique and lacks ***,SNMP is a comparably lightweight countermeasure for fast ***,this SNMP trigger is often circumvented if the DDOS burst rate is coordinated to flood the network smaller than theSNMPpolling ***,SNMP does not scale well if the poll rate is set extremely fine for improved detection *** this paper,a lightweight 3D SNMP scaling method is proposed to optimize the SNMP poll rate forDDOSmitigation *** 3D-SNMP uses horizontal scaling to dynamically adjust the optimal poll rate through random packet inspection that is *** a sign of DDOS is detected,3D-SNMP scales down the poll rate for finer *** DDOS subsides,3D-SNMP scales the poll rate up for faster DDOS *** equilibrium between scalability and accuracy is determined on the fly depending on the types of DDOS variants.3D-SNMP also adds a vertical scaling to detect non-salient DDOS that falls below the detection *** experimental results showed that 3D-SNMP achieved DDOS detection of 92%while remaining scalable to different DDOS variants and volumes.

关键词： SNMP DDOS poll rate network security threat detection

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