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Improved Non-Covalent Biofunctionalization of Multi-Walled Carbon Nanotubes Using Carbohydrate Amphiphiles with a Butterfly-Like Polyaromatic Tail

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Nano Research 2010年第11期3卷 764-778页

作者： Mohyeddin Assali Manuel Pernía Leal Inmaculada Fernández pablo romero-Gomez Rachid Baati Noureddine Khiar Instituto de Investigaciones Químicas C.S.I.C-Universidad de Sevillac/.Américo Vespucio49Isla de la CartujaSevilla 41092Spain Departamento de Química Orgánica y Farmacéutica Facultad de FarmaciaUniversidad de SevillaSevilla 41012Spain Instituto de Ciencias de Materiales de Sevilla C.S.I.C-Universidad de Sevillac/.Américo Vespucio49Isla de la CartujaSevilla 41092Spain Universitéde Strasbourg Facultéde Pharmacie CNRS/UMR 7199 Laboratoire des Systèmes Chimiques Fonctionnels BP 6002474 route du Rhin67400 IllkirchFrance

We have developed an efficient strategy for the non-covalent functionalization of multi-walled carbon nanotubes(MWCNTs)which allows a biomimetic presentation of carbohydrates on their surface byπ-πstacking *** strategy is based on the use of sugar-based amphiphiles functionalized with tetrabenzo[a,c,g,i]fluorene(Tbf),a polyaromatic compound with a topology that resembles a butterfly with open *** new carbohydrate-tethered Tbf amphiphiles have been synthesized in a straightforward manner using click *** reported method has been developed in order to improve the rather low ability of pyrene-based systems to exfoliate MWCNTs in *** means of thermogravimetric analysis(TGA),ultraviolet(UV),infrared(IR),and fluorescence spectroscopies the interaction between MWCNTs and the Tbf group has been found to be stronger than those involving pyrene-based amphiphilic *** resulting aggregates with a multivalent sugar exposition on their surface are able to engage in specific ligand-lectin interactions similar to glycoconjugates on a cell membrane.

关键词： Carbon nanotubes non-covalent functionalization tetrabenzo[a c g i]fluorene carbohydrates click chemistry biocompatible system

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Intermittent chaos for ergodic light trapping in a photonic fiber plate

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Light(Science & Applications) 2016年第1期5卷 209-215页

作者： Marina Mariano Gregory Kozyreff Luis G Gerling pablo romero-Gomez Joaquim Puigdollers Jorge Bravo-Abad Jordi Martorell ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)08860Spain Département de Physique UniversitéLibre de Bruxelles(ULB)Campus de la PlaineBruxelles B-1050Belgium Departament Enginyeria Electrònica Universitat Politècnica de CatalunyaBarcelona 08034Spain Departamento de Física Teórica de la Materia Condensada and Condensed Matter Physics Center(IFIMAC) Universidad Autónoma de MadridMadrid 28049Spain Departament de Física Universitat Politècnica de CatalunyaTerrassa 08222Spain

Extracting the light trapped in a waveguide,or the opposite effect of trapping light in a thin region and guiding it perpendicular to its incident propagation direction,is essential for optimal energetic performance in illumination,display or light harvesting *** we demonstrate that the paradoxical goal of letting as much light in or out while maintaining the wave effectively trapped can be achieved with a periodic array of interpenetrated fibers forming a photonic fiber *** entering perpendicular to that plate may be trapped in an intermittent chaotic trajectory,leading to an optically ergodic *** fabricated such a photonic fiber plate and showed that for a solar cell incorporated on one of the plate surfaces,light absorption is greatly *** this,we found the unexpected result that a more chaotic photon trajectory reduces the production of photon scattering entropy.

关键词： chaos ergodicity fiber light-guiding plate light harvesting light trapping

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Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier Martin-Broto Jeronimo Martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa Javier Martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas pablo romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

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Navigating medial patellotibial ligament reconstruction:Clinical perspectives and surgical strategies

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World Journal of Clinical Cases 2025年第1期13卷 6-10页

作者： Juan pablo Zicaro Ignacio Garcia-Mansilla Division of Knee Hospital Italiano de Buenos AiresBuenos Aires 1109Argentina

The surgical approach for patellar instability usually refers to reconstruction of the medial patellofemoral ligament associated with an osteotomy of the tibial tuberosity or a trochleoplasty when *** medial patellotibial ligament and the medial patellomeniscal ligament are secondary stabilizers of the *** this,both the medial patellotibial and patellofemoral ligaments aid in patellar rotation and tilt when the knee is flexed beyond 45°.The medial patellotibial ligament plays a particularly important role in the final stages of stretching in extension and between 40 degrees to 90 degrees of *** clinical relevance and surgical indications for medial patellotibial ligament reconstruction associated with medial patellofemoral ligament reconstruction are still *** editorial explores the surgical indications and clinical results for medial patellotibial ligament reconstruction to improve readers’understanding of this technique,especially because reported clinical outcomes have remained sparse.

关键词： Medial patellotibial ligament Patellar instability Reconstruction Surgical

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Manipulation of bicarbonate concentration in sperm capacitation media improves in vitro fertilisation output in porcine species

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Journal of Animal Science and Biotechnology 2019年第2期10卷 375-389页

作者： Cristina Soriano-úbeda Jon romero-Aguirregomezcorta Carmen Matás pablo E.Visconti Francisco A.García-Vázquez Department of Physiology Faculty of Veterinary ScienceInternational Excellence Campus for Higher Education and Research“Campus Mare Nostrum”University of Murcia30100 MurciaSpain Institute for Biomedical Research of Murcia(IMIB-Arrixaca) MurciaSpain Department of Physiology Faculty of Medicine and NursingUniversity of the Basque Country UPV/EHULeioaBizkaiaSpain.4Department of Veterinary and Animal SciencesUniversity of MassachusettsAmherstMAUSA.

Background: The in vivo concentration of bicarbonate(HCO3-), one of the essential sperm capacitating effectors,varies greatly in the different environments sperm go through from cauda epididymis to the fertilisation site. On the contrary, porcine in vitro sperm capacitation and fertilisation media usually contains a standard concentration of25 mmol/L, and one of the main problems presented is the unacceptable high incidence of polyspermy. This work hypothesised that by modifying the HCO3-concentration of the medium, the output of in vitro sperm capacitation and fertilisation could be ***: Once exposed to the capacitation medium, the intracellular pH(pHi) of spermatozoa increased immediately even at low concentrations of HCO3-, but only extracellular concentrations of and above 15 mmol/L increased the substrates protein kinase A phosphorylation(pPKAs). Although with a significant delay, 15 mmol/L of HCO3-stimulated sperm linear motility and increased other late events in capacitation such as tyrosine phosphorylation(Tyr-P) to levels similar to those obtained with 25 mmol/L. This information allowed the establishment of a new in vitro fertilisation(IVF)system based on the optimization of HCO3-concentration to 15 mmol/L, which led to a 25.3% increment of the viable zygotes(8.6% in the standard system vs. 33.9%).Conclusions: Optimising HCO3-concentrations allows for establishing an IVF method that significantly reduced porcine polyspermy and increased the production of viable zygotes. A concentration of 15 mmol/L of HCO3-in the medium is sufficient to trigger the in vitro sperm capacitation and increase the fertilisation efficiency in porcine.

关键词： Adcy10 Boar Monospermy PKA

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Main environmental variables influencing the abundance of plant species under risk category

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Journal of Forestry Research 2022年第4期33卷 1209-1217页

作者： pablo Antúnez División de Estudios de Posgrado Universidad de la Sierra Juárez68725 Oax.México

Determining climatic and physiographic variables in Mexico’s major ecoregions that are limiting to biodiversity and species of high conservation concern is essential for their ***,at the national level to date,few studies have been performed with large data sets and crossconfirmation using multiple statistical ***,we used 25 endemic,rare and endangered species from 3610 sampling points throughout Mexico and 25 environmental attributes,including average precipitation for different seasons of the year,annual dryness index,slope of the terrain;and maximum,minimum and average temperatures to test our hypothesis that these species could be assessed with the same weight among all variables,showing similar indices of *** results using principal component analysis,covariation analysis by permutations,and random forest regression showed that summer precipitation,length of the frost-free period,spring precipitation,winter precipitation and growing season precipitation all strongly influence the abundance of tropical *** contrast,annual precipitation and the balance at different seasons(summer and growing season)were the most relevant variables on the temperate region *** dry areas,the minimum temperature of the coldest month and the maximum temperature of the warmest month were the most significant *** these different associations in different climatic regions could support a more precise management and conservation plan for the preservation of plant species diversity in forests under different global warming scenarios.

关键词： Correlative models Climate change Effect of topography Endemic species IUCN list Machine learning algorithms

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On the interaction of a donepezil-huprine hybrid with synthetic membrane models

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Neural Regeneration Research 2023年第2期18卷 333-334页

作者： pablo Zambrano Max Planck Institute of Biochemistry Cellular and Molecular BiophysicsMunichGermany

Alzheimer's disease is the most prevalent type of dementia today,discovered and described by Alois Alzheimer in *** to the World Alzheimer Report 2021,75%of people with dementia worldwide are undiagnosed,equivalent to 41 million people(Gauthier et al.,2021).With each passing year,the number of people affected by these diseases is increasing,and the estimates of suffering from them in the future are growing.

关键词： Alzheimer diseases

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Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy

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World Journal of Gastroenterology 2021年第28期27卷 4639-4652页

作者： Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez pablo Salgado Gustavo romero Sección Hepatología Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoFacultad de MedicinaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina Instituto de Investigaciones en Salud Pública Facultad de OdontologíaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1122Argentina Unidad Clínica Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoInvestigador Asociado del Gobierno de la Ciudad Autónoma de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina

This review summarizes the safety and efficacy of statins in patients with *** to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in *** most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver *** is the most serious and potentially life-threatening *** has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle ***,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle *** to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something *** these effects,statins could prevent liver-related morbidity and mortality in cirrhotic *** studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and *** few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic *** large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival *** these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies ***,it is advisable to per

关键词： Cirrhosis Liver disease Statins Safety Efficiency

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Chemokines and Chemokine Receptors:Their Manifold Roles in Homeostasis and Disease

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Cellular & Molecular Immunology 2004年第2期1卷 95-104页

作者： pablo Iribarren Laboratory of Molecular Immunoregulation Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMarylandUSA

Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and *** recent years,it has become clear that the function of chemokines extends well beyond the role in leukocyte *** participate in organ development,angiogenesis/angiostasis,leukocyte trafficking and homing,tumorigenesis and metastasis,as well as in immune responses to microbial ***, chemokines and their receptors are important targets for modulation of host responses in pathophysiologicai conditions and for therapeutic intervention of human *** & Molecular Immunology.2004;1(2): 95-104.

关键词： chemokine receptor development leukocyte homing angiogenesis metastasis

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