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From conventional two-stage hepatectomy to AlPPS:Fifteen years of experience in a hepatobiliary surgery unit

Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 542-550页

作者： Javier Maupoey Ibáñez Eva María MontalváOrón Andrea BoscàRobledo Alonso Camacho Ramírez Ana Hernando Sanz pablo Granero Castro Alberto Alegre Delgado Rafael lópez-Andújar Hepatobiliary Surgery and Transplant Unit La Fe University and Polytechnic HospitalValenciaSpain Department of Radiology La Fe University and Polytechnic HospitalValenciaSpain

Background:Hepatectomy in patients with large tumor load may result in postoperative liver failure and associated complications due to excessive liver parenchyma *** two-stage hepatectomy(TSH)and associating liver partition and portal vein ligation for staged hepatectomy(AlPPS)technique are possible solutions to this *** liver metastases(CRlM)is the most frequent indication,and there is a need to assess outcomes for both techniques to improve surgical and long-term oncological outcomes in these ***:A single-center retrospective study was designed to compare TSH with AlPPS in patients with initially unresectable bilateral liver tumors between January 2005 and January *** was performed from January 2012 onwards as the technique of ***-term overall survival(OS)and disease-free survival(DFS)were evaluated as primary outcome in CRlM *** morbidity,mortality and liver growth in all patients were also ***:A total of 38 staged hepatectomies were performed:17 TSH and 21 *** resection rate was 76.5%(n=13)in the TSH group and 85.7%(n=18)in the AlPPS group(P=0.426).Overall major morbidity(Clavien-Dindo≥3 a)(stage 1+stage 2)was 41.2%(n=7)in TSH and 33.3%(n=7)in AlPPS patients(P=0.389),and perioperative 90-day mortalities were 11.8%(n=2)vs.19.0%(n=4)in each group,respectively(P=0.654).Intention-to-treat OS rates at 1 and 5 years in CRlM patients for TSH(n=15)were 80%and 33%,and for AlPPS(n=17)76%and 35%,*** rates at 1 and 5 years were 36%and 27%in the TSH group vs.33%and 27%in the AlPPS group,***:AlPPS is an effective alternative to TSH in bilateral affecting liver tumors,allowing higher resection rate,but patients must be carefully *** CRlM patients similar long-term OS and DFS can be achieved with both techniques.

关键词： AlPPS Two-stage hepatectomy Colorectal liver metastases Posthepatectomy liver failure

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Central nervous system stimulation therapies in phantom limb pain:a systematic review of clinical trials

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Neural Regeneration Research 2022年第1期17卷 59-64页

作者： M.Ángeles García-Pallero Diana Cardona lola Rueda-Ruzafa Miguel Rodriguez-Arrastia pablo Roman Hospital Universitario Central de Asturias AsturiasSpain Department of Nursing Science Physiotherapy and MedicineUniversity of AlmeríaAlmeríaSpain Department of Functional Biology and Health Sciences Faculty of Biology-CINBIOUniversity of VigoVigoPontevedraSpain Faculty of Health Sciences Pre-Department of NursingJaume I UniversityCastello de la PlanaSpain Research Group CYS Faculty of Health SciencesJaume I UniversityCastello de la PlanaSpain

Phantom limb pain is a chronic pain syndrome that is difficult to cope *** neurostimulation treatment is indicated for refractory neuropathic pain,there is scant evidence from randomized controlled trials to recommend it as the treatment ***,a systematic review was performed to analyze the efficacy of central nervous system stimulation therapies as a strategy for pain management in patients with phantom limb pain.A literature search for studies conducted between 1970 and September 2020 was carried out using the MEDlINE and Embase *** of The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline were *** were a total of 10 full-text articles retrieved and included in this *** brain stimulation,repetitive transcranial magnetic stimulation,transcranial direct current stimulation,and motor cortex stimulation were the treatment strategies used in the selected clinical *** transcranial magnetic stimulation and transcranial direct current stimulation were effective therapies to reduce pain perception,as well as to relieve anxiety and depression symptoms in phantom limb pain ***,invasive approaches were considered the last treatment option as evidence in deep brain stimulation and motor cortex stimulation suggests that the value of phantom limb pain treatment remains ***,the findings on use of these treatment strategies in other forms of neuropathic pain suggest that these invasive approaches could be a potential option for phantom limb pain patients.

关键词： central nervous system stimulation neuromodulation neuropathic pain phantom limb pain systematic review

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Hepatocellular carcinoma in non-alcoholic fatty liver disease from a clinical and public health perspective

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 755-758页

作者： luis Antonio Díaz Marco Arrese Juan pablo Arab Departamento de Gastroenterología Escuela de MedicinaPontificia Universidad Católica de ChileSantiagoChile Division of Gastroenterology Department of MedicineSchulich School of MedicineWestern University&London Health Sciences CentreLondonONCanada Alimentiv LondonONCanada

Non-alcoholic fatty liver disease(NAFlD)is the leading cause of chronic liver disease in the western world(1).Currently,the global prevalence of NAFlD is estimated at 30%and is notably higher in South America and the Middle East(1).NAFlD prevalence has been rising during the last decades,and cases of decompensated NAFlD cirrhosis could increase by 168%in 2030(Figure 1A)(2).These trends are probably explained by several factors including the decrease in viral hepatitis incidence and the increasing prevalence of obesity and type 2 diabetes mellitus(T2DM)among the general population(2).

关键词： prevalence NAFlD liver

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Cardiovascular prevention in elderly patients

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Journal of Geriatric Cardiology 2022年第5期19卷 377-392页

作者： Clara Bonanad Rosa Fernández-Olmo Sergio García-Blas Jose Antonio Alarcon pablo Díez-Villanueva Carmen Rus Mansilla Héctor García-Pardo pablo Toledo Ana Ayesta Eva Pereira Antoni Carol Almudena Castro-Conde Carmen de pablo-Zarzoso Manuel Martínez-Sellés Vicente Arrarte Raquel Campuzano Albert Ariza-Solé Servicio de Cardiología Hospital Clínico Universitario de ValenciaValenciaSpain Instituto de Investigación Sanitaria INClIVA ValenciaSpain Servicio Cardiología Hospital Universitario de Jaén Spain Servicio Cardiología Hospital de Donosti Spain Servicio de Cardiología Hospital Universitario La Princesa de MadridSpain Servicio de Cardiología Hospital Alto Gudalquivir de AndújarJaénSpain Servicio de Cardiología Hospital Rio Hortega de ValladolidSpain Servicio Cardiología Hospital Clínico San Cecilio de Granada Spain Servicio de Cardiología Hospital Universitario Central de AsturiasSpain Servicio de Cardiologia Hospital de LugoSpain Servicio de Cardiología Hospital Moisés Broggi de BarcelonaSpain Servicio de Cardiología Hospital Universitario de la Paz de Madrid Spain Servicio de Cardiología Hospital Ramón y Cajal de MadridSpain Department of Cardiology.Hospital Universitario Gregorio Marañón CIBERCV.Universidad EuropeaUniversidad Compluten Servicio de Cardiología del Hospital General de Alicante Spain Servicio de Cardiología Hospital Universitario Fundación de Alcorcón de MadridSpain Servicio de Cardiología Hospital Bellvitge de BarcelonaBioheartGrup de Malalties CardiovascularsInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatBarcelonaSpain

In recent decades,life expectancy has been increasing *** this scenario,health interventions are ne-cessary to improve prognosis and quality of life of elderly with cardiovascular risk factors and cardiovascular ***,the number of elderly patients included in clinical trials is low,thus current clinical practice guidelines do not include specific *** document aims to review prevention recommendations focused in patients≥75 years with high or very high cardiovascular risk,regarding objectives,medical treatment options and also including physical exercise and their inclusion in cardiac rehabilitation ***,we will show why geriatric syndromes such as frailty,dependence,cognitive impair-ment,and nutritional status,as well as comorbidities,ought to be considered in this population regarding their important pro-gnostic impact.

关键词： prevention patients cardiovascular

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Peridynamic State-Based Models and the Embedded-Atom Model

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Communications in Computational Physics 2014年第1期15卷 179-205页

作者： pablo Seleson Michael l.Parks Max Gunzburger Institute for Computational Engineering and Sciences 201 East 24th StStop C0200AustinTexas 78712-1229USA. Sandia National laboratories Computing Research CenterP.O.Box 5800MS 1320AlbuquerqueNM 87185-1320USA. Department of Scientific Computing 400 Dirac Science LibraryFlorida State UniversityTallahasseeFL 32306-4120USA.

We investigate connections between nonlocal continuum models and molecular dynamics.A continuous upscaling of molecular dynamics models of the form of the embedded-atom model is presented,providing means for simulating molecular dynamics systems at greatly reduced *** are presented for structured and structureless material models,supported by computational *** nonlocal continuum models are shown to be instances of the state-based peridynamics *** relating multibody peridynamic models and upscaled nonlocal continuum models are derived.

关键词： Peridynamics multibody potentials embedded-atom molecular dynamics.

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Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression

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World Journal of Gastroenterology 2017年第29期23卷 5266-5281页

作者： maría l bacigalupo pablo carabias maría f troncoso Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológicas (IQUIFIB) Consejo Nacional de lnvestigaciones Científicas y Técnicas Universidad de Buenos Aires

Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies.

关键词： Galectin-1 胃的癌症 Hepatocellular 癌 Colorectal 癌胰腺的癌症 1 6-N-acetylglucosaminyltransferase V

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Participation of Auxin Transport in the Early Response of the Arabidopsis Root System to Inoculation with Azospirillum brasilense

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Phyton-International Journal of Experimental Botany 2022年第11期91卷 2383-2401页

作者： Elizabeth Carrillo-Flores Jonanci Arreola-Rivera DenníMariana pazos-Solís Moisés Bocanegra-Mondragón Grisel Fierro-Romero MaElena Mellado-Rojas Elda Beltrán-Peña laboratorio de Transducción de Señales Edificio B3Instituto de Investigaciones Químico-Biológicas de la Universidad Michoacana de San Nicolás de HidalgoCiudad UniversitariaMorelia58030México Tecnológico de Monterrey School of Engineering and SciencesCampus QuerétaroSan PabloQuerétaro76130México School of the Environment Florida A&M UniversityTallahassee32307USA

The potential of Plant Growth Promoting Rhizobacteria(PGPR)has been demonstrated in the case of plant inoculation with bacteria of the genus Azospirillum which improves *** produces a wide variety of molecules,including the natural auxin indole-3-acetic acid(IAA),as well as other ***,several studies have suggested that auxin induces changes in plant development during their interaction with the *** effects of *** Sp245 on the development of Arabidopsis thaliana root were investigated to help explain the molecular basis of the *** results obtained showed a decrease in primary root length from the first day and remained so throughout the exposure,accompanied by a stimulation of initiation and maturation of lateral root primordia and an increase of lateral *** enhanced auxin response was evident in the vascular tissue and lateral root meristems of inoculated ***,after five days of bacterization,the response disappeared in the primary root *** role of polar auxin transport(PAT)in auxins relocation involved the PGP1,AXR4-1,and BEN2 proteins,which apparently mediated ***-induced root branching of Arabidopsis seedlings.

关键词： Auxin Azopirillum brasilense Arabidopsis auxin transport lateral roots

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Relationships between soil pollution by heavy metals and melanin-dependent coloration of a fossorial amphisbaenian reptile

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Integrative Zoology 2022年第4期17卷 596-607页

作者： JoséMARTÍN pablo RECIO Gonzalo RODRÍGUEZ-RUIZ Isabel BARJA Eduardo GUTIÉRREZ luis VGARCÍA Departamento de Ecología Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain Departamento de Zoología Facultad de BiologíaUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain Departamento de Biogeoquímica Ecología Vegetal y MicrobianaInstituto de Recursos Naturales y Agrobiología de SevillaCSICSevillaSpain

Melanin is the basis of coloration in many animals,and although it is often used in communication,thermoregulation,or camouflage,melanin has many other physiological *** example,in polluted habitats,melanin can have a detoxifying *** coloration would help to sequester in the skin the heavy metal contaminants from inside the body,which will be expelled to the exterior when the skin is ***,animals should have evolved more melanic colorations in more polluted habitats(“industrial melanism”hypothesis).We examined whether the fossorial amphisbaenian reptile,Trogonophis wiegmanni,is able to eliminate heavy metals,derived from soil pollution by seagull depositions,through sloughing its *** results suggest a covariation between levels of soil pollution by heavy metals and the concentration of heavy metals in the sloughed skins of *** suggests that amphisbaenians may expel heavy metals from their bodies when they slough the *** also tested whether amphisbaenians inhabiting soils with higher levels of heavy metal pollution had darker(melanin-dependent)body ***,contrary to predictions from the“industrial melanization”hypothesis,we found a negative relationship between soil pollution and proportions of melanic *** contradictory result could,however,be explained because heavy metals have endocrine disruption effects that increase physiological stress,and higher stress levels could result in decreased *** suggest that although amphisbaenians might have some detoxifying mechanism linked to melanin in the skin,this process might be negatively affected by stress and result ineffective under conditions of high soil pollution.

关键词： amphisbaenians coloration fossorial reptiles heavy metals melanin soil pollution

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Chemokines and Chemokine Receptors:Their Manifold Roles in Homeostasis and Disease

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Cellular & Molecular Immunology 2004年第2期1卷 95-104页

作者： pablo Iribarren laboratory of Molecular Immunoregulation Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMarylandUSA

Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and *** recent years,it has become clear that the function of chemokines extends well beyond the role in leukocyte *** participate in organ development,angiogenesis/angiostasis,leukocyte trafficking and homing,tumorigenesis and metastasis,as well as in immune responses to microbial ***, chemokines and their receptors are important targets for modulation of host responses in pathophysiologicai conditions and for therapeutic intervention of human *** & Molecular Immunology.2004;1(2): 95-104.

关键词： chemokine receptor development leukocyte homing angiogenesis metastasis

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Interleukin 6 and interferon gamma haplotypes are related to cytokine serum levels in dogs in an endemic leishmania infantum region

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Infectious Diseases of Poverty 2023年第1期12卷 62-70页

作者： luisÁlvarez pablo-Jesús Marín-García Pilar Rentero-Garrido Celia Pilar Martinez-Jimenez lola llobat Department of Animal Production and Health Public Health and Food Science and TechnologyVeterinary Medicine FacultyFacultad de VeterinariaUniversidad Cardenal Herrera-CEUCEU UniversitiesValenciaSpain Precision Medicine Unit INCLIVA Biomedical Research InstituteValenciaSpain Helmholtz Pioneer Campus(HPC) Helmholtz Zentrum MünchenNeuherbergGermany

Background The Ibizan Hound is a canine breed native to the Mediterranean region,where leishmaniasis is an endemic *** studies indicate a low prevalence of this disease in Ibizan Hound dogs,whereas other canine breeds present a high ***,the underlying molecular mechanisms still remain *** aim of this work is to analyse the relationship between serum levels of cytokines and the genomic profiles in two canine breeds,Ibizan Hound(resistant canine breed model)and Boxer(susceptible canine breed model).Methods In this study,we analyse the haplotypes of genes encoding cytokines related to immune response of leishmania infantum infection in twenty-four Boxers and twenty-eight Ibizan Hounds apparently healthy using CanineHD DNA Analysis BeadChip including 165,480 mapped *** *** extension of *** was used to perform a General linear Model(GlM)regression to estimate the magnitude of individual haplotype effects within each *** Mean levels of interferon gamma(IFN-γ),interleukin 2(Il-2)and Il-18 in Boxer dogs were 0.19±0.05 ng/ml,46.70±4.54 ng/ml,and 36.37±30.59 pg/ml,whereas Ibizan Hound dogs present 0.49±0.05 ng/ml,64.55±4.54 ng/ml,and 492.10±31.18 pg/ml,*** GlM regression shows fifteen haplotypes with statistically significant effect on the cytokine serum levels(Plevant are Il6-CGAAG and IFNG-GCA haplotypes,which increase and decrease the Il-2,Il-8 and IFN-γserum levels,*** Haplotypes in the IFNG and Il6 genes have been correlated to serum levels of IFN-γ,Il-2 and Il-18,and a moderate effect has been found on Il8 haplotype correlated to Il-8 and Il-18 serum *** results indicate that the resistance to *** infection could be a consequence of certain haplotypes with a high frequency in the Ibizan Hound dog breed,while susceptibility to the disease would be related to other specific haplotypes,with high frequency in *** studies are nee

关键词： Cytokine Haplotype Dog Immune response Regulatory mechanism Resistance Susceptibility

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