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Friction 2024年第9期12卷 2126-2138页

作者： Ainhoa GUINEA Andrea AGINAGALDE Wilson TATO Iñigo LLAVORI pablo garcia Leire ARRAIAGO Alaitz ZABALA Mechanical and Industrial Production Department Mondragon UnibertsitateaMondragon 20500Spain Orona EIC Orona IdeoHernani 20120Spain

The coefficient of friction(CoF)between the deflection pulley and rope in a lift strongly affects the life span of the *** surface roughness is a key factor affecting the metallic pulley–rope CoF,its effect on polymeric pulleys is *** present study analyses the effect of roughness and working conditions on cast polyamide 6(PA6G)deflection pulley–thermoplastic polyurethane(TPU)-coated rope *** statistical analysis revealed that the effect of surface roughness on the CoF for low-load tests was *** present study contributes significantly to parameter selection in deflection pulley machining to minimise friction between the pulley and rope.

关键词： polymer-on-polymer friction roughness dry sliding

Pleiotrophin fights Brd2 for neuronal differentiation

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Neural Regeneration Research 2015年第4期10卷 544-546页

作者： pablo garcia-Gutierrez Mario garcia-Dominguez Stem Cells Department Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) (Consejo Superior de Investigaciones Cientificas (CSIC)Junta de AndalucíaUniversidad de SevillaUniversidad Pablo de Olavide).Av.Americo Vespucio s/n41092 SevilleSpain

Bromodomain containing 2 （Brd2） protein belongs to the Bromodomains and Extra Terminal domain （BET） family of chromatin adaptors characterized by the presence of two N-terminal tandem bromodomains and an exclusive C-terminal extra terminal domain （ET）（Belkina and Denis, 2012; Shi and Vakoc, 2014）. Bromodomains are involved in recognizing acetylated histone tails and other acetylated proteins while the ET domain has been implicated in protein-protein interaction.

关键词： Pleiotrophin fights Brd2 for neuronal differentiation cycle

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“这是历史性的时刻”

环球财经 2024年第6期 108-108页

作者： pablo Ruiz garcia(图) 不详

当地时间2024年5月10日晚,西班牙Los Urrosde Liencres坎塔布里亚海岸上空的极光,极光一般只在地球南北两极的高纬度地区出现,但是由于今年由太阳耀斑引发了近20年以来最强的地磁暴,导致西班牙、美国密歇根州、中国北京等低纬度地区也... 详细信息

当地时间2024年5月10日晚,西班牙Los Urrosde Liencres坎塔布里亚海岸上空的极光,极光一般只在地球南北两极的高纬度地区出现,但是由于今年由太阳耀斑引发了近20年以来最强的地磁暴,导致西班牙、美国密歇根州、中国北京等低纬度地区也出现了极光极光在这些低纬度地区呈现罕见的粉红色和红色,而不是更常见的绿色和蓝色,这与太阳耀斑的强度、它们撞击地球大气层的哪一部分。

关键词：太阳耀斑地磁暴极光地球大气层密歇根州低纬度地区高纬度地区南北两极

A GIS-based methodology for the appraisal of historical,architectural,and social values in historic urban cores

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Frontiers of Architectural Research 2020年第4期9卷 900-913页

作者： Juan A.garcia-Esparza pablo Altaba Tena Department of Mechanical Engineering and Construction Universitot Jaume I12071Castello de la PlanaSpain

Historic environments represent the evolution of materials and techniques that have been used for the construction these environments over the *** into the study of this field entails working not only on the crafts that have constructed these environ ments but also on the people who made,used,and reinterpreted them by learning about the craftsmen and the idiosyncrasies of the *** study has adopted several methodologies as referenee to examine the material and cultural reality of the rural region of Valencia,*** the adaptation of in ter national methodologies,researchers have carried out a digital database that compiles and maps out the results of the Local Character Assessment of ten Histotiric Urban Cores by incorporating the historical,architectural,and social values to reinforce the Territorial Heritage Action *** of the critical innovations adopted by this form of assessment is the compulsory integration of tangible and intangible heritage through the active involvement of users and *** innovation is to understand the values behind the dynamism and transformation of historic ***,this study advances theory and practice on the transmission of knowledge among artisans,researchers,and the population and how con temporary practices help acquire new meani ngs that overlap the past ones.

关键词： Historic environment Local Character Assessme nt Digital heritage GIS for heritage Heritage values

Landscape genetics reveals inbreeding and genetic bottlenecks in the extremely rare short-globose cacti Mammillaria pectinifera (Cactaceae) as a result of habitat fragmentation

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Plant Diversity 2017年第1期39卷 13-19页

作者： Reyna Maya-garcia Santiago Arizaga pablo Cuevas-Reyes Juan Manuel Penaloza-Ramirez Victor Rocha Ramirez Ken Oyama Facultad de Biologia Universidad Michoacana de San Nicolas de Hidalgo Mexico Escuela Nacional-de Estudios Superiores Unidad Morelia UNAM Antigua Carretera a Pdtzcuaro 8701 Colonia Ex-Hacienda de SanJose de la Huerta58190 Morelia Michoacan Mexico

Mammillaria pectinifera is an endemic, short-globose cactus species, included in the IUCN list as a threatened species with only 18 remaining populations in the Tehuacfin-Cuicatlan Valley in central Mexico. We evaluated the population genetic diversity and structure, connectivity, recent bottlenecks and population size, using nuclear microsatellites. M. pectinifera showed high genetic diversity but some evidence of heterozygote deficiency （F15）, recent bottlenecks in some populations and reductions in population size. Also, we found low population genetic differentiation and high values of connectivity for M. pectinifera, as the result of historical events of gene flow through pollen and seed dispersal. M. pectinifera occurs in sites with some degree of disturbance leading to the isolation of its populations and decreasing the levels of gene flow among them. Excessive deforestation also changes the original vegetation damaging the natural habitats. This species will become extinct if it is not properly preserved. Furthermore, this species has some ecological features that make them more vulnerable to disturbance such as a very low growth rates and long life cycles. We suggest in situ conservation to prevent the decrease of population sizes and loss of genetic diversity in the natural protected areas such as the Tehuacan-Cuicatlan Biosphere Reserve. In addition, a long-term ex situ conservation program is need to construct seed banks, and optimize seed germination and plant establishment protocols that restore disturbed habitats. Furthermore, creating a supply of living plants for trade is critical to avoid further extraction of plants from nature.

关键词： MammiUaria pectiniferaNuclear SSRGenetic diversityRecent bottlenecksEffective population size

Planetary Gear Profile Modification Design Based on Load Sharing Modelling

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 810-820页

作者： IGLESIAS Miguel FERNáNDEZ DEL RINCóN Alfonso DE-JUAN Ana Magdalena garcia pablo DIEZ Alberto VIADERO Fernando Mechanical Engineering Research Group University of Cantabria

In order to satisfy the increasing demand on high performance planetary transmissions, an important line of research is focused on the understanding of some of the underlying phenomena involved in this mechanical system. Through the development of models capable of reproduce the system behavior, research in this area contributes to improve gear transmission insight, helping developing better maintenance practices and more efficient design processes. A planetary gear model used for the design of profile modifications ratio based on the levelling of the load sharing ratio is presented. The gear profile geometry definition, following a vectorial approach that mimics the real cutting process of gears, is thoroughly described. Teeth undercutting and hypotrochoid definition are implicitly considered, and a procedure for the incorporation of a rounding arc at the tooth tip in order to deal with corner contacts is described. A procedure for the modeling of profile deviations is presented, which can be used for the introduction of both manufacturing errors and designed profile modifications. An easy and flexible implementation of the profile deviation within the planetary model is accomplished based on the geometric overlapping. The contact force calculation and dynamic implementation used in the model are also introduced, and parameters from a real transmission for agricultural applications are presented for the application example. A set of reliefs is designed based on the levelling of the load sharing ratio for the example transmission, and finally some other important dynamic factors of the transmission are analyzed to assess the changes in the dynamic behavior with respect to the non-modified case. Thus, the main innovative aspect of the proposed planetary transmission model is the capacity of providing a simulated load sharing ratio which serves as design variable for the calculation of the tooth profile modifications.

关键词： transmission planetary gear load sharing relief profile modification

Overview of the anterolateral complex of the knee

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World Journal of Clinical Cases 2022年第24期10卷 8474-8481页

作者： Ignacio garcia-Mansilla Juan pablo Zicaro Ezequiel Fernando Martinez Juan Astoul Carlos Yacuzzi MatiasCosta-Paz Knee Surgery Hospital Italiano de Buenos AiresBuenos Aires 1199Argentina

In the last few years,much more information on the anterolateral complex of the knee has become *** has now been demonstrated how it works in conjunction with the anterior cruciate ligament(ACL)controlling anterolateral rotatory *** studies have shown that the anterolateral complex(ALC)has a role as a secondary stabilizer to the ACL in opposing anterior tibial translation and internal tibial *** is of utmost importance that surgeons comprehend the intricate anatomy of the entire anterolateral aspect of the *** most studies have only focused on the anterolateral ligament(ALL),the ALC of the knee consists of a functional unit formed by the layers of the iliotibial band combined with the anterolateral joint *** interest has also been given to imaging evaluation using magnetic resonance and several studies have targeted the evaluation of the ALC in the setting of ACL *** are inconsistent with a lack of association between magnetic resonance imaging evidence of injury and clinical *** ACL reconstruction may not always reestablish knee rotatory stability in patients with associated ALC *** such cases,additional procedures,such as anterolateral reconstruction or lateral tenodesis,may be *** are several techniques available for ALL *** options include the iliotibial band,gracilis or semitendinosus tendon autograft,or allograft.

关键词： Anterolateral complex Knee instability Anterolateral ligament Anterior cruciate ligament reconstruction

Has platelet-rich plasma any role in partial tears of the anterior cruciate ligament?Prospective comparative study

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World Journal of Orthopedics 2021年第6期12卷 423-432页

作者： Juan pablo Zicaro Ignacio garcia-Mansilla Andres Zuain Carlos Yacuzzi Matias Costa-Paz Knee Division Hospital Italiano de Buenos AiresBuenos Aires 1181Argentina

BACKGROUND Partial tears of the anterior cruciate ligament(ACL)are frequent,and there is still considerable controversy surrounding their diagnosis,natural history and *** To examine patient-reported outcomes,physical examination and magnetic resonance imaging(MRI)findings of partial ACL tears treated with an intraarticular injection of platelet-rich plasma(PRP)compared to a control *** From January 2015 to November 2017,consecutive patients from a single institution with partial ACL tears treated nonoperatively were prospectively *** tears were defined as a positive Lachman test with a clear endpoint,a negative pivot-shift and less than 3 mm of side-to-side difference using the KT1000 *** in group 1 were treated with one intraarticular injection of PRP and specific physical therapy *** group consisted of patients treated only with physical *** analyzed data included physical examination,Tegner activity level and Lysholm and International Knee Documentation Committee *** MRI findings and at 6 mo follow-up were *** was defined as those patients with clinical instability at follow-up that required a subsequent ACL *** A total of 40 patients where included,21 treated with PRP injection with a mean follow-up of 25 mo[standard deviation(SD):3.6]and 19 in the control group with a mean follow-up of 25 mo(SD:5.68).Overall failure rate was 32.0%(n=13).No significant differences were observed between groups regarding subjective outcomes,return to sport and failure *** findings revealed an improvement in the ACL signal in half of the patients of both ***,we did not find a significant relationship between MRI findings and clinical *** Overall,95.0%of patients returned to sports at a mean follow-up of 25 *** time to return to sports was 4 *** of these patients,almost 30.0%in each group had a new episode of instability

关键词： Anterior cruciate ligament Partial tears Platelet-rich plasma Non-operative treatment

Failure rate,return-to-sports and magnetic resonance imaging after meniscal repair:119 patients with 7 years mean follow up

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世界骨科杂志:英文版 2023年第8期14卷 612-620页

作者： Juan pablo Zicaro Nicolas Garrido Ignacio garcia-Mansilla Carlos Yacuzzi Matias Costa-Paz Department of Knee Hospital Italiano de Buenos AiresBuenos Aires 1109Argentina

BACKGROUND One of the most important factors to consider in relation to meniscal repair is the high failure rate reported in the existing *** To evaluate failure rates,return to sports(RTS)rate,clinical outcomes and magnetic resonance image(MRI)evaluation after meniscus suture repair for longitudinal tears at a minimum *** We conducted a retrospective review of meniscal repairs between January 2004 and December *** patients treated for longitudinal tears associated or not with an anterior cruciate ligament reconstruction(ACL-R)were *** ramp lesions,radial and root tears,associated with multiligament injuries,tibial fracture and meniscal allograft transplants were *** details and failure rate,defined as symptomatic patients who underwent a revision surgery,were *** isolated bucket handle tears(BHTs)were usually associated with higher failure rates,we compared BHTs and not BHTs associated or not with an *** 2014,the inside-out technique using cannulas and suture needles with 2-0 Tycron began to *** addition,the number of stitches per repair was *** view of differences in surgical technique,we compared two different cohorts:before and after *** recorded the RTS according to the level achieved and the time to *** and IKDC scores were *** were studied with x-rays and MRI as standard postoperative *** One hundred and nineteen patients were included with a mean follow up of 7 years(SD:4.08).Overall failure rate was 20.3%at a mean 20.1 *** statistically significant differences were found when comparing failure for medial and lateral meniscal repair(22.7%and 15.3%,P=0.36),BHTs and not BHTs(26%and 17.6%,P=0.27),isolated or associated with an ACL-R(22.9%and 18%,P=0.47),or when comparing only BHTs associated with an ACL-R(23%and 27.7%,P=0.9)or *** comparing cohorts before and after 2014,we found a significant decrease in the overall f

关键词： Meniscus repair Bucket handle tears Meniscal suture Failure rate Longitudinal meniscus tears

Revision anterior cruciate ligament reconstruction:Return to sports at a minimum 5-year follow-up

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World Journal of Orthopedics 2022年第9期13卷 812-824页

作者： Ezequiel Ortiz Juan pablo Zicaro Ignacio garcia Mansilla Carlos Yacuzzi Matias Costa-Paz Knee Division Hospital Italiano de Buenos AiresCiudad Autónoma 1181Buenos AiresArgentina

BACKGROUND Between 43%and 75%of patients who undergo primary anterior cruciate ligament(ACL)surgery return to sport ***,after a revision ACL reconstruction(ACLR)the rate of return to sports is variable.A few publications have reported returns to sports incidence between 56%to 100%after revision *** To determine return to sports and functional outcomes after a single-stage revision ACLR with a 5-year minimum follow-up at a single *** All patients operated between 2010 and 2016 with a minimum 5 years of followup were *** of sport,intensity,frequency,expectation,time to return to sport and failure rate were ***,Tegner and International Knee Documentation Committee forms were evaluated prior to the first ACLR surgery,at 6 mo after primary surgery and after revision ACLR at 5 years minimum of *** stability was tested with the knee arthrometer test(KT-1000 knee arthrometer,Medmetric Corp).RESULTS A total of 41 patients who underwent revision ACLR during that period of time were contacted and available for *** patient age at time of revision was 29 years old[interquartile range(IQR):24.0-36.0],and 39(95.0%)were *** median time from revision procedure to follow-up was 70 mo(IQR:58.0-81.0).Regarding return to sports,16(39.0%)were at the same level compared to preinjury period,and 25 patients(61.0%)returned at a lower ***-three percent categorized the sport as very important and 37.0%as *** patient(2.4%)failed with a recurrent ACL *** preoperative Lysholm and(SD)16]and 50(SD 11),*** follow-up,mean Lysholm and subjective International Knee Documentation Committee scores were 89(SD 8)and 82(SD 9)(P=0.0001).Mean Tegner score prior to primary ACLR was 6.7(SD 1.3),5.1(1.5 SD)prior to revision ACLR and 5.6(1.6 SD)at follow-up(P=0.0002).Overall,knee arthrometer test measurement showed an average of 6 mm(IQR:4.0-6.0)side-to-side difference of displacement pri

关键词： Return to sport Revision anterior cruciate ligament Arthroscopy Knee Functional outcome