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Theoretical Analysis on effect of Adding Argon to Hydrogen Plasma

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Plasma Science and Technology 2004年第2期6卷 2204-2212页

作者：胡纯栋 e.Speth Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China Max-Planck-Institut fiir Plasmaphysik EURATOM-Association 85748 Garching Germany

An increased of H ion beam current whenever argon gas is added has been observed. The physics behind argon effect is that in the production of more H atoms, a part of H atoms will be converted to H2*(v>4) to increase H- density. Increase of nH depends on the rate of added Ar η %, primary filling pressure P, electron density neAr and recombination coefficient 7 of H atom. Adding 25% Ar is optimal, although there have been assumed various parameters. Increase of nH depends on decreased recombination coefficient 7, and increased primary filling pressure P. The increase of nH is small when the pressure P pa. Optimized volume size l/R^2 is optimal for obtaining a maximum Ar effect.

关键词： H- ion beam Ar effect neutral beam injection

不同口腔感觉训练对脑卒中后吞咽障碍患者功能恢复的促进效果比较

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首都食品与医药 2024年第15期31卷 25-27页

作者：郑慧荣唐娥湖南省祁阳市人民医院湖南永州426100

目的探索不同口腔感觉训练对脑卒中后吞咽障碍患者功能恢复的促进效果.方法选取祁阳市人民医院口腔科104例脑卒中后吞咽障碍患者,随机分组,即可分为对照组(n=52)与观察组(n=52),对照组采用传统口腔训练,观察组联合口腔感觉训练干预,对... 详细信息

目的探索不同口腔感觉训练对脑卒中后吞咽障碍患者功能恢复的促进效果.方法选取祁阳市人民医院口腔科104例脑卒中后吞咽障碍患者,随机分组,即可分为对照组(n=52)与观察组(n=52),对照组采用传统口腔训练,观察组联合口腔感觉训练干预,对比两组患者吞咽功能、营养状况及生活状况.结果干预后,观察组患者洼田饮水试验、VFSS评估结果优于对照组(PlB、pa含量、改良Barthel指数与SWAl-QOl评分均高于对照组,PG-SGA评分低于对照组(P<0.05).结论针对脑卒中后吞咽障碍患者应用口腔感觉训练,可有效改善其吞咽功能,进而提升其营养及生活状况.

关键词：口腔感觉训练脑卒中后吞咽障碍功能恢复

Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity

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Acta Pharmaceutica Sinica B 2023年第1期13卷 204-212页

作者： Benjamin l.Prather Shuyue Ji Yue Zhao Femil Joseph Shajan Mi Zhao Zakey Yusuf Buuh Robert Maloney Rui Zhang Carson Cohen Rongsheng e.Wang Department of Chemistry Temple UniversityPhiladelphiaPA 19122USA

Chemicals possessing reactive electrophiles can denature innate proteins leading to undesired toxicity,and the overdose-induced liver injury by drugs containing electrophiles has been one of the major causes of non-approval and withdraw by the US Food and Drug Administration(FDA).elucidating the associated proteins could guide the future development of therapeutics to circumvent these drugs’toxicities,but was largely limited by the current probing tools due to the steric hindrance of chemical tags including the common“click chemistry”*** the widely used non-steroidal anti-inflammatory drug acetaminophen(ApaP)as an example,we hereby designed and synthesized an ApaP analogue using fluorine as a steric-free *** toxicity studies indicated our analogue has similar activity to the parent *** analogue was applied to the mouse hepatocellular proteome together with the corresponding desthiobiotinSH probe for subsequent fluorine-thiol displacement reactions(FTDRs).This set of probes has enabled the labeling and pull-down of hepatocellular target proteins of the ApaP metabolite as validated by Western *** preliminary validation results supported the interaction of ApaP with the thioredoxin protein,which is an important redox protein for normal liver *** results demonstrated that our probes confer minimal steric perturbation and mimic the compounds of interest,allowing for global profiling of interacting *** fluorine-thiol displacement probing system could emerge as a powerful tool to enable the investigation of drug-protein interactions in complex biological environments.

关键词： Acetaminophen(ApaP) liver Hepatotoxicity Bioorthogonal Click chemistry Fluorinedisplacement Fluorinethiol displacementreaction FTDR

甲基化酶抑制剂5氮杂-2-脱氧胞苷对瘢痕疙瘩成纤维细胞TGF-β／smad信号通路的影响

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中华整形外科杂志 2013年第4期29卷 285-289页

作者：邹崎葩杨娥张恒术重庆医科大学附属第一医院整形美容外科重庆400016

目的探讨甲基化酶抑制剂5-氮杂-2-脱氧胞苷对瘢痕疙瘩成纤维细胞TGF-β／smad信号通路的影响。方法收集瘢痕疙瘩及正常皮肤组织各15例，免疫组化检测磷酸化smad2（P-smad2）和磷酸化smad3（p-smad3）在瘢痕疙瘩和正常皮肤中的阳性表达... 详细信息

目的探讨甲基化酶抑制剂5-氮杂-2-脱氧胞苷对瘢痕疙瘩成纤维细胞TGF-β／smad信号通路的影响。方法收集瘢痕疙瘩及正常皮肤组织各15例，免疫组化检测磷酸化smad2（P-smad2）和磷酸化smad3（p-smad3）在瘢痕疙瘩和正常皮肤中的阳性表达率；将瘢痕疙瘩分为实验组和对照组，实验组以5，氮杂-2-脱氧胞苷（5×10^-5mmol／l）干预，对照组用等量的DMeM培养液，采用组织块法培养人瘢痕疙瘩成纤维细胞，流式细胞仪分析5-氮杂-2-脱氧胞苷（5×10^-5mol／l）对瘢痕疙瘩成纤维细胞周期及凋亡的影响；Westernblot检测各组p-smad2、p-smad3、TGF-β1和smad7的表达变化；细胞免疫荧光染色法观察各组瘢痕疙瘩成纤维细胞内p-smad2和p-smad3蛋白的影响。结果瘢痕疙瘩组织中p-smad2和p-smad3阳性表达率明显高于正常皮肤组织中p-smad2和P-smad3阳性表达。流式细胞仪显示5-氮杂-2-脱氧胞苷干预瘢痕疙瘩成纤维细胞后，细胞停滞于G0／G1期比例增加并且细胞凋亡率增加，瘢痕疙瘩成纤维细胞中p-smad2和p-smad3蛋白的表达减少，同时，TGF—β1蛋白表达减少，smad7蛋白表达回升。此外，5-氮杂-2-脱氧胞苷抑制smad2和smad3磷酸化及核转移。结论甲基化酶抑制剂5-氮杂-2-脱氧胞苷可抑制瘢痕疙瘩成纤维细胞的增殖及促进其凋亡，其作用机制可能与抑制TGF-β／srnad信号通路有关。

关键词：瘢痕疙瘩成纤维细胞 5-氮杂-2-脱氧胞苷 TGF-β smad通路

DNA甲基转移酶1在人瘢痕疙瘩成纤维细胞中的表达及意义

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中华整形外科杂志 2013年第2期29卷 117-120页

作者：杨娥邹崎葩张恒术重庆医科大学附属第一医院整形美容科重庆400016

目的探讨DNA甲基转移酶1（DNA methyltransferase1，DNMT1）在瘢痕疙瘩的不同生长期和不同部位的成纤维细胞表达及其意义。方法收集53例瘢痕疙瘩患者手术切除的瘢痕疙瘩标本，并按生长期分为A（〈6个月）、B（6～12个月）、C（1～2年）... 详细信息

目的探讨DNA甲基转移酶1（DNA methyltransferase1，DNMT1）在瘢痕疙瘩的不同生长期和不同部位的成纤维细胞表达及其意义。方法收集53例瘢痕疙瘩患者手术切除的瘢痕疙瘩标本，并按生长期分为A（〈6个月）、B（6～12个月）、C（1～2年）、D（〉2年）4组；免疫组织化学法检测各组标本正常皮肤、浸润部、增生部及老化部成纤维细胞DNMT1的表达并比较差异；RT-PCR法检测各组标本及不同部位成纤维细胞DNMT1mRNA的表达。结果DNMT1在成纤维细胞中主要分布于细胞核内；瘢痕疙瘩成纤维细胞DNMT1蛋白阳性表达率（72％）及DNMT1mRNA表达均高于正常皮肤成纤维细胞（8％，P=0．001）；瘢痕疙瘩生长期较短组成纤维细胞DNMT1阳性表达率（100％，评分：10．47±1．85）及DNMT1mRNA表达均高于生长期较长组（45％，评分：7．71±1．80，P=0．007）；瘢痕疙瘩浸润部（100％，评分：10．47±1．85）成纤维细胞DNMT1阳性表达率及DNMT1mRNA表达均高于增生部（78％，评分：6．63±1．75）与老化部（38％，评分：5．53±1．55，P=0．001）。结论DNMT1在瘢痕疙瘩发病中具有重要作用；随着瘢痕疙瘩生长期的延长，DNMT1的表达有降低趋势；随着瘢痕疙瘩中央成纤维细胞老化，DNMT1表达降低。提示DNMT1在瘢痕疙瘩生长过程中起着重要的作用，并且与瘢痕疙瘩浸润生长密切相关。

关键词：瘢痕疙瘩 DNA甲基转移酶1 成纤维细胞

Olfactory Dysfunction as an early Biomarker in parkinson's Disease

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Neuroscience Bulletin 2017年第5期33卷 515-525页

作者： Michelle e.Fullard James F.Morley John e.Duda parkinson's Disease Research Education and Clinical Center Corporal Michael J. Crescenz VA Medical CenterPhiladelphia PA 19104 USA Department of Neurology University of Pennsylvania School of Medicine Philadelphia PA 19104 USA

Olfactory dysfunction is common in parkinson＇s disease （PD） and often predates the diagnosis by years, reflecting early deposition of lewy pathology, the histo- logic hallmark of PD, in the olfactory bulb. Clinical tests are available that allow for the rapid characterization of olfactory dysfunction, including tests of odor identification, discrimination, detection, and recognition thresholds, memory, and tests assessing the build-up of odor intensity across increasing suprathreshold stimulus concentrations. The high prevalence of olfactory impairment, along with the ease and low cost of assessment, has fostered great interest in olfaction as a potential biomarker for PD. Hyposmia may help differentiate PD from other causes of parkinsonism, and may also aid in the identification of ＂pre-motor＂ PD due to the early pathologic involvement of olfactory pathways. Olfactory function is also correlated with other non-motor features of PD and may serve as a predictor of cognitive decline. In this article, we summarize the existing literature on olfaction in PD, focusing on the potential for olfaction as a biomarker for early or differential diagnosis and prognosis.

关键词： Olfaction · parkinson's disease · Biomarker ·parkinsonism · pathology

Oligodendrocyte pathology in fetal alcohol spectrum disorders

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Neural Regeneration Research 2022年第3期17卷 497-502页

作者： Nune Darbinian Michael e.Selzer Center for Neural Repair and Rehabilitation(Shriners Hospitals Pediatric Research Center) Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

The pathology of fetal alcohol syndrome and the less severe fetal alcohol spectrum disorders includes brain *** studies have shed light on the molecular mechanisms underlying these white matter *** models of fetal alcohol syndrome and human studies have shown suppressed oligodendrocyte differentiation and apoptosis of oligodendrocyte precursor *** exposure led to reduced expression of myelin basic protein and delayed myelin basic protein expression in rat and mouse models of fetal alcohol syndrome and in human histopathological *** studies have reported increased expression of many chemokines in dysmyelinating disorders in central nervous system,including multiple sclerosis and fetal alcohol *** ethanol exposure reduced levels of the neuroprotective insulin-like growth factor-1 in fetal and maternal sheep and in human fetal brain tissues,while ethanol increased the expression of tumor necrosis factor α in mouse and human *** matter lesions have been induced in the developing sheep brain by alcohol exposure in early *** fetal alcohol syndrome models have shown reduced axon diameters,with thinner myelin sheaths,as well as reduced numbers of oligodendrocytes,which were also morphologically aberrant *** of markers for mature myelination,including myelin basic protein,also were *** accumulating knowledge concerning the mechanisms of ethanol-induced dysmyelination could lead to the development of strategies to prevent dysmyelination in children exposed to ethanol during fetal *** studies using fetal oligodendrocyte-and oligodendrocyte precursor cell-derived exosomes isolated from the mother's blood may identify biomarkers for fetal alcohol syndrome and even implicate epigenetic changes in early development that affect oligodendrocyte precursor cell and oligodendrocyte function in *** combining various imaging modalities with mo

关键词： alcohol development dysmyelination ethanol fetal alcohol syndrome fetal brain myelin basic protein neurodegeneration oligodendrocyte injury oligodendrocyte precursor cells

Scoping review of cochlear implantation in Susac’s syndrome

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第9期7卷 126-132页

作者： Philip l.Perez Andrew A.McCall Barry e.Hirsch Department of Otolaryngology University of PittsburghPittsburghPA15213USA

Objective:Scoping review of published literature to establish clinical characteris tics and audiologic outcomes in patients diagnosed with Susac’s Syndrome(SS)who have undergone cochlear implantation(CI).Data sources:All published studies of CI in SS and contribution of two of our own patients who have not been reported ***:A comprehensive search of MeDlINe(via PubMed)was carried out in March 2020 using the following keywords and related entry terms:Susac's Syndrome,Cochlear ***:Our search identified a total of five case reports of CI in *** the addition of our two patients reported here,we analyzed characteristics and outcomes in seven *** age at implantation was 30 years old(range 19-46),with six women and one man *** time from onset of hearing loss to implantation was 17 months(range three months to four years).Best reported postoperative speech understanding was reported via different metrics,with six of seven patients achieving open set speech scores of 90% or better,and one subject performing at 68%.Vestibular symptoms were present preoperatively in four of seven patients(57%),with vestibular testing reported in two patients,and showing vestibulopathy in one *** complications were reported following cochlear ***:Cochlear implantation is a viable option for hearing rehabilitation in patients with SS,with levels of attainment of open set speech comparable to other populations of CI candidates.

关键词： Susac's syndrome Cochlear implantation Scoping review

Sub-stand diameter distribution types vary along an old-growth Douglas-fir chronosequence into the horizontal diversification development stage

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Journal of Forestry Research 2023年第2期34卷 415-424页

作者： Jerilynn e.Peck eric K.Zenner Department of ecosystem Science and Management The Pennsylvania State UniversityUniversity ParkPA 16802USA

Managing mature Douglas-fir[Pseudotsuga menziesii(Mirb.)Franco]stands to emulate the structural complexity of natural old-growth forest requires identifying structural targets at the sub-stand level at which neighborhood dynamics and patchy disturbance shape *** therefore sought to describe the archetypal shapes of predominant sub-stand diameter distribution types(DDTs)observed in natural tree neighborhoods in stands comprising a chronosequence(ca.120-450+yrs)encompassing mature,vertical diversification,and horizontal diversification development *** ten 1.0 ha stands are located in the southcentral Oregon Cascades,*** on the known spatial position of each tree,natural tree neighborhoods were identified using the floating neighborhood approach based on spatial tessellation connecting neighboring trees at the first-(mean 61 m2)through fifth-(mean 2058 m2)order *** analysis was then used to objectively identify the most predominant DDTs among the relative tree size distributions observed in the trans-scale neighborhoods within each *** measures regression was used to classify each DDT to one of six observed archetypal shapes:negative exponential,unimodal,rotated sigmoid,bimodal,concave,or *** three of the 81 observed DDTs deviated bye stand average,while every stand had at least one DDT that deviated by>50%(maximum 83%).Within each stand,five to ten predominant DDTs were observed,which deviated from the stand average by 30-48%and were characterized by two to five different archetypal ***,in some stands the majority of tree neighborhoods were best characterized by a different shape from that assigned at the stand *** from the stand average increased from the youngest stand in the mature development stage through the middle stands in the vertical diversification stage to the oldest stands in the horizontal diversification *** complexity of DDT shapes tended to increas

关键词： Diameter distribution type Floating neighborhood Restoration silviculture Small-scale Structural complexity