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t.anscranial elect.ical st.mulat.on in neurological disease

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Neural Regenerat.on Research 2022年第10期17卷 2221-2222页

作者： Gregory l.Brown Michael t.Brown Neurished HersheyPAUSA

Increased lifespan is one of societ.’s great.st.achievement.,but.t.is longevit. increases t.e prevalence of diseases of aging,such as neurological ***,neurological disorders are t.e leading cause of disabilit. and t.e second leading cause of deat.s(Feigin et.al.,2019).Furt.ermore,t.ese diseases affect.people in low-,medium-,and high-income count.ies(Feigin et.al.,2019).Current.t.chnology t. modify neurological burden is scarce,which poses numerous challenges for healt.care,global policy,and economic st.bilit.(Feigin et.al.,2019).t. face t.ese challenges,brain st.mulat.on t.chnology,such as t.anscranial elect.ical st.mulat.on(t.S),has displayed excit.ng *** et.al.(2017)provide a det.iled overview of t.e safet. and applicat.on of ***,elect.odes are at.ached t. t.e head and a weak current.e.g.,1-2 mA)is applied t.rough t.e scalp,skull,and int. t.e brain for 10-30 minut.s t. act.vat. neurons(Ant.l et.al.,2017).t.e t.chnique is ext.emely safe wit. no serious adverse effect. report.d from t.ousands of sessions(Ant.l et.al.,2017).t.e most.common side effect. are a t.ngling/it.hing sensat.on or redness at.t.e st.mulat.on sit.(Ant.l et.al.,2017).However,t.ese side effect. can be minimized by reducing t.e elect.ode-skin impedance,slowly ramping up and ramping down t.S,or using t.pical analgesics(Ant.l et.al.,2017).t.e development.of t.S may repair neural dysfunct.on and st.m t.e oncoming incidence of neurodegenerat.ve disease.

关键词： st.mulat.on sensat.on elect.ical

Get.ing physical wit. medical educat.on:Exercise based virt.al anat.my review classes for medical st.dent.

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World Journal of Met.odology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe t.niya S Nagpal Michele l Barbeau Charys M Mart.n Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Facult. of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anat.my and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Depart.ent.of Anat.my and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

t.e benefit. of regular physical act.vit. are well ***,few st.dies have examined t.e effect.veness of int.grat.ng physical act.vit.(pa)int. curricula wit.in a post.secondary *** invest.gat. t.e incorporat.on of pa int. medical curriculum,we developed a series of opt.onal exercise-based review sessions designed t. reinforce musculoskelet.l(MSK)anat.my course *** synchronous sessions were co-t.ught.by a group fit.ess inst.uct.r and an anat.my *** fit.ess inst.uct.r would lead st.dent. t.rough bot. st.engt. and yoga st.le exercises,while t.e anat.my inst.uct.r asked quest.ons about.relevant.anat.mical st.uct.res relat.d t. course mat.rial previously *** t.e sessions,part.cipant. were asked t. evaluat. t.e classes on t.eir self-report.d exam preparedness in improving MSK anat.my knowledge,pa.levels,and ment.l *** part.cipant. complet.d surveys;a majorit. agreed t.at.t.e classes increased underst.nding of MSK concept.(90.0%)and act.vit. levels(97.7%).Many(70.0%)felt.t.at.t.e classes helped reduce *** majorit. of respondent.(90.0%)agreed t.at.t.e classes cont.ibut.d t. increased feelings of social ***,medical st.dent. saw benefit.in pa based int.rvent.ons t. supplement.MSK course *** wit. increasing act.vit. levels and promot.ng healt. behaviours,int.grat.ng pa int. medical curriculum may improve comprehension of learning mat.rial,alleviat. st.ess and fost.r social connect.vit. among medical st.dent..

关键词： Medical educat.on Musculoskelet.l Anat.my Exercise Online learning

t.e Effect. of Ant.biot.cs, Met.ls, and Biot.c Int.ract.ons on t.e Assembly of t.xonomically Diverse Single and Mixed Species Biofilms

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Advances in Microbiology 2020年第12期10卷 623-646页

作者： Roshan Angosht.ri Kim t. Scribner t.rence l. Marsh Depart.ent.of Microbiology and Molecular Genet.cs Michigan State University East Lansing MI USA Depart.ent.of Fisheries and Wildlife Michigan State University East Lansing MI USA

t. bet.er underst.nd t.e assembly of t.e st.rgeon egg microbiome, we purified six bact.rial isolat.s from eggs and charact.rized t.eir abilit. t. form biofilms under t.e st.ess of t.bramycin, wit. and wit.out.exogenous prot.in. In experiment. wit. single species biofilms, t.bramycin reduced t.e met.bolic act.vit. of all isolat.s and increased biofilm biomass of t.ree. t.e addit.on of exogenous prot.in t. t.e assay count.red t.e inhibit.on of biofilm and met.bolic act.vit. by t.bramycin of Pseudomonas sp., Brevundimonas sp., Flavobact.rium columnare and mixed biofilms of Pseudomonas-F. columnare and Brevundimonas-Hydrogenophaga. t.o of t.e isolat.s (Pseudomonas spp.) t.at.produced ant.microbial act.vit., were effect.ve at.reducing biofilm format.on by Brevundimonas, but.enhanced biofilm format.on in ot.er isolat.s. Increasing concent.at.ons of Mg2+ had no effect.on biofilm format.on but.Ca2+ enhanced biofilm format.on of Pseudomonas aeruginosa pa01 (posit.ve cont.ol) and Brevundimonas. Biofilm assembly by t.ese t.o bact.ria was inhibit.d by low concent.at.ons of Ni2+. Mixed biofilms of Brevundimonas and Hydrogenophage consist.nt.y produced more robust.biofilm t.an t.e st.ains in isolat.on, suggest.ng synergism. Est.blished Brevundimonas biofilm appeared adept.at.recruit.ng pelagic Acidovorax and Hydrogenophaga int. biofilm, suggest.ng t.at.it.plays an import.nt.role in t.e select.on of species int. t.e microbiome.

关键词： Biofilm Assembly Ant.microbial Resist.nce t.bramycin Met.bolic Act.vit. Met.l Resist.nce

Real-t.me Measurement. and Modelling on Dynamic Behaviour of SonoVue Bubbles Based on light.Scat.ering t.chnology

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Chinese Physics let.ers 2008年第1期25卷 172-175页

作者：屠娟 GUANJ.F. MAt.lA t.J. Crum l.A. 魏荣爵 Key laborat.ry of Modern Acoust.cs (Minist.y of Educat.on) Nanjing University Nanjing 210093 Cent.r for Indust.ial and Medical Ult.asound Applied Physics Laboratory University of Washington Seattle WA 98105 USA

t.e dynamic behaviour of SonoVue microbubbles, a new generat.on ult.asound cont.ast.agent. is invest.gat.d in real t.me wit. light.scat.ering met.od. Highly dilut.d SonoVue microbubbles are inject.d int. a dilut.d gel made of xant.an gum and wat.r. t.e responses of individual SonoVue bubbles t. driven ult.asound pulses are measured. Bot. linear and nonlinear bubble oscillat.ons are observed and t.e result. suggest.t.at.SonoVue microbubbles can generat. st.ong nonlinear responses. By fit.ing t.e experiment.l dat. of individual bubble responses wit. Sarkar＇s model, t.e shell coat.ng paramet.r of t.e bubbles and dilat.t.onal viscosit. is est.mat.d t. be 7.0 nm-s-pa.

关键词： MICROBUBBlE CONt.ASt.AGENt. CRIt.CAl-ANGlE Ult.ASOUND MICROSPHERES BACKSCAt.ER WAt.R

Effect.ve dat. sampling st.at.gies and boundary condit.on const.aint. of physics-informed neural net.orks for ident.fying mat.rial propert.es in solid mechanics

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Applied Mat.emat.cs and Mechanics(English Edit.on) 2023年第7期44卷 1039-1068页

作者： W.WU M.DANEKER M.A.JOllEY K.t.t.RNER l.lU Depart.ent.of Anest.esiology and Crit.cal Care Medicine Children's Hospital of PhiladelphiaPhiladelphiaPA 19104U.S.A. Division of Pediat.ic Cardiology Children's Hospital of PhiladelphiaPhiladelphiaPA 19104U.S.A. Depart.ent.of Chemical and Biomolecular Engineering University of PennsylvaniaPhiladelphiaPA 19104U.S.A. Depart.ent.of Mechanical Engineering and Applied Mechanics University of PennsylvaniaPhiladelphiaPA 19104U.S.A.

Mat.rial ident.ficat.on is crit.cal for underst.nding t.e relat.onship bet.een mechanical propert.es and t.e associat.d mechanical ***,mat.rial ident.ficat.on is a challenging t.sk,especially when t.e charact.rist.c of t.e mat.rial is highly nonlinear in nat.re,as is common in biological *** t.is work,we ident.fy unknown mat.rial propert.es in cont.nuum solid mechanics via physics-informed neural net.orks(PINNs).t. improve t.e accuracy and efficiency of PINNs,we develop efficient.st.at.gies t. nonuniformly sample observat.onal *** also invest.gat. different.approaches t. enforce Dirichlet.t.pe boundary condit.ons(BCs)as soft.or hard ***,we apply t.e proposed met.ods t. a diverse set.of t.me-dependent.and t.me-independent.solid mechanic examples t.at.span linear elast.c and hyperelast.c mat.rial *** est.mat.d mat.rial paramet.rs achieve relat.ve errors of less t.an 1%.As such,t.is work is relevant.t. diverse applicat.ons,including opt.mizing st.uct.ral int.grit. and developing novel mat.rials.

关键词： solid mechanics mat.rial ident.ficat.on physics-informed neural net.ork(PINN) dat. sampling boundary condit.on(BC)const.aint

Sedent.ry behavior and physical act.vit. predict.ng depressive sympt.ms in adolescent. beyond at.ribut.s of healt.-relat.d physical fit.ess

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Journal of Sport.and Healt. Science 2018年第4期7卷 489-496页

作者： gene l.farren t.o zhang xiangli gu kat.erine t.t.omas Depart.ent.of Kinesiology Health Promotionand RecreationUniversity of North TexasDentonTX 76203USA Corresponding aut.or.E-mail address：Gene.Farren@unt.edu

Background： Sedent.ry behavior （SB）, physical act.vit. （pa）, and at.ribut.s of physical fit.ess have been shown t. be relat.d t. depressive sympt.ms in adolescent.. t.e purpose of t.e present.st.dy was t. invest.gat. whet.er SB and fit.ess-producing act.vit. predict.d depression in act.ve adolescent. over and above gender and fit.ess at.ribut.s. Met.ods： part.cipant. were 249 adolescent. （age： 12.85 ± 0.89 years, mean ± SD） from 3 public middle schools who wore Act.cal acceleromet.rs t. assess t.eir SB and pa. part.cipant. also complet.d t.e FIt.ESSGRAM healt.-relat.d fit.ess assessment.and a brief depression quest.onnaire. A 3-st.p hierarchical regression analysis was conduct.d wit. gender and fit.ess at.ribut.s （i.e., body mass index （BMI）, maximal volume oxygen upt.ke （VO2max）, curlups, and pushups）, moderat.- and vigorous-int.nsit. act.vit., and SB ent.red in respect.ve st.ps. Result.： Regression analysis indicat.d act.vit. variables （i.e., moderat.- and vigorous-int.nsit. act.vit.） significant.y predict.d depression （△R^2= 0.12, p 〈 0.01） beyond gender and fit.ess at.ribut.s. Overall, gender, fit.ess at.ribut.s, act.vit. variables, SB explained 31% of t.e variance in depression. St.uct.re coefficient. revealed VO2max （rs= -0.77）, moderat.-int.nsit. act.vit. （rs= -0.67）, vigorous-int.nsit. act.vit. （rs = -0.81）, and SB （rs = 0.57） were subst.nt.ally correlat.d wit. t.e crit.rion variable; t.us, t.ey were t.e st.ongest.predict.rs of depression. Conclusion： t.e findings of t.e current.st.dy indicat.d SB and pa were bot. significant.predict.rs of depression; however, sufficient.fit.ess-producing act.vit. and adequat. cardiorespirat.ry fit.ess may nullify t.e negat.ve influence of SB on depressive sympt.ms in act.ve adolescent..2018 Published by Elsevier B.V. on behalf of Shanghai Universit. of Sport. t.is is an open access art.cle under t.e CC BY-NC-ND license. （ht.p：//***/licenses/by-nc-nd/4.0/）.

关键词： Acceleromet.rs Adolescent.healt. Cardiorespirat.ry fit.ess FIt.ESSGRAM Ment.l healt. Moderat.-t.-vigorous-int.nsit. act.vit.

Frequency synt.esis of forced opt.-elect.onic oscillat.rs at.t.e X-band

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Chinese Opt.cs let.ers 2017年第1期15卷 40-44页

作者： t. Sun li. Zhang A. K. Poddar U. l. Rohde A. S. Daryoush Depart.ent.of ECE Drexel University Philadelphia PA 19104 USA Synergy Microwave Corp. Paterson NJ 07504 USA

Ult.a-low phase noise performance is required for frequency agile local oscillat.rs, which are t.e core for high resolut.on imagers, spect.um analyzers, and high speed dat. communicat.ons. A forced opt.-elect.onic oscillat.r （OEO） benefit. from frequency st.bilizat.on t.chniques for realizing a clean and low phase noise source at.micro- wave and millimet.r wave frequencies. Forced oscillat.on t.chniques of self-inject.on locking and self-phase lock loop are combined t. provide an ult.a-low oscillat.r phase noise bot. close-in and far-away from t.e carrier frequency, while a t.nable yt.rium iron garnet.microwave filt.r combined wit. a wavelengt. t.ned t.ansversal filt.r are employed t. implement.bot. coarse and fine frequency t.ning for a t.nable X-band OEO. A phase noise of -137 dBc/Hz at.an offset.frequency of 10 kHz is achieved covering t.e frequencies of 9 t. 11 GHz wit. a fine frequency t.ning resolut.on of 44 Hz/pm and coarse t.ning of 25 MHz/mA. Moreover, t.e long t.rm st.bilit. of t.e out.ut.signal is t.st.d, and a maximum frequency drift.of 2 kHz is measured wit.in 60 min for t.e X-band synt.esizer.

关键词： Fiber opt.cs links and subsyst.ms Radio frequency phot.nics Oscillat.rs

Segment.boundaries of t.e adult.rat.epididymis limit.int.rst.t.al signaling by pot.nt.al paracrine fact.rs and segment. lose different.al gene expression aft.r efferent.duct.ligat.on

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Asian Journal of Andrology 2007年第4期9卷 565-573页

作者： t.rry t. t.mer Daniel S. Johnst.n Scot. A. Jelinsky Jose l. t.msig Joshua N. Finger Depart.ent.of Urology University of Virginia Health Science System Charlottesville VA 22908 US Cell Biology University of Virginia Health Science System Charlottesville VA 22908 US Cont.acept.on Women＇s Health and Musculoskeletal Biology Wyeth Research Collegeville PA 19426 USA Biological t.chnologies Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA

t.e epididymis is divided int. caput. corpus and cauda regions, organized int. int.aregional segment. separat.d by connect.ve t.ssue sept. （Ct.）. In t.e adult.rat.and mouse t.ese segment. are highly different.at.d. Regulat.on of t.ese segment. is by endocrine, lumicrine and paracrine fact.rs, t.e relat.ve import.nce of which remains under invest.gat.on. Here, t.e abilit. of t.e Ct. t. limit.signaling in t.e int.rst.t.al compart.ent.is reviewed as is t.e effect.of 15 days of unilat.ral efferent.duct.ligat.on （EDl） on ipsilat.ral segment.l t.anscript.onal profiles. Int.r-segment.l microperifusions of epidermal growt. fact.r （EGF）, vascular endot.elial growt. fact.r （VEGFA） and fibroblast.growt. fact.r 2 （FGF2） increased phosphorylat.on of mit.gen act.vat.d prot.in kinase （MAPK） in segment. 1 and 2 of t.e rat.epididymis and t.e effect. of all fact.rs were limit.d by t.e Ct. separat.ng t.e segment.. Microan＇ay analysis of segment.l gene expression det.rmined t.e effect.of 15 days of unilat.ral EDl on t.e t.anscript.me-wide gene expression of rat.segment. 1-4. Over 11 000 genes were expressed in each of t.e four segment. and over 2 000 t.anscript. in segment.1 responded t. deprivat.on of t.st.cular lumicrine fact.rs. Segment. 1 and 2 of cont.ol t.ssues were t.e most.t.anscript.onally different.and EDl had it. great.st.effect. t.ere. In t.e absence of lumicrine fact.rs, all four segment. regressed t. a t.anscript.onally undifferent.at.d st.t., consist.nt.wit. t.e less different.at.d hist.logy. Deprivat.on of lumicrine fact.rs could st.mulat. an individual gene＇s expression in some segment. yet.suppress it.in ot.ers. Such result. reveal a higher complexit. of t.e regulat.on of rat.epididymal segment. t.an t.at.is generally appreciat.d. （Asian J Androl 2007 July; 9： 565-573）

关键词： efferent.duct.ligat.on dedifferent.at.on proximal epididymis

Hepat.t.s A vaccine associat.d wit. aut.immune hepat.t.s

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World Journal of Gast.oent.rology 2007年第15期13卷 2238-2239页

作者： pa Berry G Smit.-laing Medway Marit.me Hospit.l Windmill Road GillinghamKentUnited Kingdom

t. describe a case of probable relapsing aut.immune hepat.t.s associat.d wit. vaccinat.on against.hepat.t.s A virus （HAV）. A case report.and review of lit.rat.re were writ.en concerning aut.immune hepat.t.s in associat.on wit. hepat.t.s A and ot.er hepat.t.opic viruses. Soon a^er t.e administ.at.on of formalin-inact.vat.d hepat.t.s A vaccine, a man who had recent.y recovered from an uncharact.rized but.self-limit.ng hepat.t.c illness, experienced a severe det.riorat.on （ASt.1687 U/l, INR 1.4）. Ant.-nuclear ant.bodies were det.ct.ble, and liver biopsy was compat.ble wit. aut.immune hepat.t.s. t.e observat.on support. t.e role of HAV as a t.igger of aut.immune hepat.t.s. St.dies in helper t.cell act.vit. and ant.body expression against.hepat.c prot.ins in t.e cont.xt.of hepat.t.s A infect.on are summarized, and t.e concept.of molecular mimicry wit. regard t. ot.er forms of viral hepat.t.s and aut.immunit. is briefly explored.

关键词： Hepat.t.s A virus Vaccine Aut.immune hepat.t.s Helper t.cell Molecular mimicry