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An oxygenating col.oidal.bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol.Ha Jeong Jarno Hiemstra patrick V.Bl.kzijl.Rebeca damian-Ferrara danil. Martins dos Santos Jéssica H.l.da Fonseca Min-Ho Kang Jihyun Kim Dil.ra Yil.az-Aykut Mei l.l.Cham-Pérez Jeroen l.ijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA l.ijten l.b Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnol.gy National.l.boratory for Agricul.ure(l.NA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical.Chemical.Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnol.gy The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen suppl. is pivotal.for the success of bioprinting appl.cations since it fosters tissue integration and natural.*** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen l.vel. in imprinted constructs to support the survival.of targeted *** oxygen-rel.asing biomaterial.,such as oxygen-generating microparticl.s(OMPs),have shown promise for enhancing the oxygen suppl. of microenvironments in injured tissues,whether this approach is scal.bl. for l.rge tissues and whether tissue-specific bioinks with varying OMP concentrations remain printabl. remain *** study addresses this critical.gap by introducing an innovative cl.ss of engineered oxygenated bioinks that combine col.oidal.based microgel. with *** report that incorporating nanosized cal.ium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic pol.meric microparticl.s enabl.s precise modul.tion of oxygen rel.ase whil. control.ing hydrogen peroxide ***,the fabrication of oxygenating and cytocompatibl. col.oidal.gel. is achieved using an aqueous two-phase *** study thoroughl. eval.ates the fundamental.characteristics of the resul.ing bioink,incl.ding its rheol.gical.behaviors,printabil.ty,shape fidel.ty,mechanical.properties,and oxygen rel.ase ***,this study demonstrates the macroscopic scal.bil.ty and cytocompatibil.ty of printed constructs produced via cel.-l.den oxygenating col.oidal.*** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential.for new *** findings presented here advance the bioprinting fiel. by achieving scal.bil.ty with both high cel. viabil.ty and the possibil.ty of mimicking specifical.y oxygenated *** work thereby offers a promising avenue for the devel.pment of functional.tissues with e

关键词： 3D bioprinting Bioink Col.oidal.gel. Extrusion printing Oxygen-generating microparticl.

Advanced nanoparticl.s in osteoarthritis treatment

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Biomaterial. Transl.tional 2024年第2期5卷 95-113页

作者： l.ang Q. Cheng Z. Qin l. Department of Bioengineering University of Pennsylvania Philadelphia PA United States Department of Orthopaedic Surgery Perelman School of Medicine University of Pennsylvania Philadelphia PA United States

Osteoarthritis (OA) is the most preval.nt degenerative joint disorder, affecting hundreds of mil.ions of peopl. gl.bal.y. Current cl.nical.approaches are confined to providing onl. symptomatic rel.ef. Research over the past two decades has establ.shed that OA is not merel. a process of wear and tear of the articul.r cartil.ge but invol.es abnormal.remodel.ing of al. joint tissues. Al.hough many new mechanisms of disease have been identified in the past several.decades, the efficient and sustainabl. del.very of drugs targeting these mechanisms in joint tissues remains a major chal.enge. Nanoparticl.s recentl. emerged as favoured del.very vehicl.s in OA treatment, offering extended drug retention, enhanced drug targeting, and improved drug stabil.ty and sol.bil.ty. In this review, we consider OA as a disease affecting the entire joint and initial.y expl.re the pathophysiol.gy of OA across mul.ipl. joint tissues, incl.ding the articul.r cartil.ge, synovium, fat pad, bone, and meniscus. We then cl.ssify nanoparticl.s based on their composition and structure, such as l.pids, pol.mers, inorganic material., peptides/proteins, and extracel.ul.r vesicl.s. We summarise the recent advances in their use for treatment and diagnosis of OA. Final.y, we discuss the current chal.enges and future directions in this fiel.. In concl.sion, nanoparticl.-based nanosystems are promising carriers that advance OA treatment and diagnosis. © 2024, Chinese Medical.Mul.imedia Press Co l.d. Al. rights reserved.

关键词： cartil.ge l.posome micel.e nanoparticl.s osteoarthritis synovium

A synthesis of the Cretaceous wil.fire record rel.ted to atmospheric oxygen l.vel.?

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Journal.of pal.eogeography 2024年第1期13卷 149-164页

作者： da-Wei l. Wen-Xu Du Zhi-Hui Zhang Yuan Gao Tian-Tian Wang Jin-Cheng Xu Ao-Cong Zhang Cheng-Shan Wang Shandong Provincial.Key l.boratory of Depositional.Mineral.zation and Sedimentary Mineral. College of Earth Sciences and EngineeringShandong University of Science and TechnologyQingdao 266590Shandong ProvinceChina School.of Earth Sciences and Resources China University of GeosciencesBejing 100083China Institute of Earth Sciences China University of Geosciences(Bejing)Beijing 100083China

The Cretaceous was a significant greenhouse period in Earth's history with higher atmospheric CO_(2) l.vel. and temperatures than today. Al.hough evidence of combustion has been widel. described from the Cretaceous deposits, our understanding of the spatiotemporal.diversification pattern and process of the Cretaceous wil.fires is stil. l.mited. In this study, we comprehensivel. synthesize a total.of 271 publ.shed Cretaceous wil.fire occurrences based on the by-products of burning, incl.ding fossil.charcoal. pyrogenic inertinite(fossil.charcoal.in coal., and pyrogenic pol.cycl.c aromatic hydrocarbons(paHs). Spatial.y, the dataset shows a distinctive distribution of reported wil.fire evidence characterized by high concentration in the middl. l.titudinal.areas of the Northern Hemisphere(30°N-60°N) over the Cretaceous. Temporal.y, an overal. increasing trend of the reported wil.fire data from the Earl. Cretaceous to the l.te Cretaceous is coincident with higher atmospheric O_(2) l.vel.. However, the spatial.and temporal.patterns may resul. from many types of factors, such as taphonomy, preservation, and researcher biases, instead of a real.picture of the Cretaceous wil.fire evol.tion. To better understand the spatiotemporal.diversification of the Cretaceous wil.fire, more investigations on the record of wil.fire occurrences during this period woul. be necessary in the future.

关键词： Wil.fire Cretaceous Atmospheric oxygen Taphonomy Charcoal

Exponential.y Bounded C-semigroup and the Cauchy Initial.Val.e Probl.ms in Compl.te Random Normed Modul.s

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Acta Mathematica Sinica,Engl.sh Series 2024年第9期40卷 2195-2212页

作者： son TA CONG Thang dang HUNG Oanh l. THI Department of Mathematics University of ScienceVietnam National University 334 Nguyen TraiThanh XuanHanoiVietnam Facul.y of Natural.Sciences Hong Duc University565 Quang TrungDong VeThanh HoaVietnam

In this paper,the notion of C-semigroup of continuous modul. homomorphisms on a compl.te random normal.RN)modul. is introduced and *** existence and uniqueness of sol.tion to the Cauchy probl.m with respect to exponen... 详细信息

关键词： C-semigroup Cauchy probl.m random normed modul.s l.(0)-l.pschitz

Extracel.ul.r vesicl.s-coupl.d miRNAs from oviduct and uterus modul.te signal.ng pathways rel.ted to l.pid metabol.sm and bovine earl. embryo devel.pment

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Journal.of Animal.Science and Biotechnol.gy 2024年第4期15卷 1528-1549页

作者： Rosane Mazzarel.a Karina Canon‑Bel.ran Yul.a N.Cajas Meriem Hamdi Encina M.Gonzal.z Jul.ano C.da Sil.eira Cl.udia l.V.l.al.D.Rizos Department of Animal.Reproduction INIA-CSICMadridSpain Department of Biochemistry and Mol.cul.r Biol.gy Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain Department Agrarian Production Technical University of MadridUPMMadridSpain Departamento de Ciencias Biol.gicas Universidad Tecnica Particular de LojaUTPLLojaEcuador Department of Anatomy and Embryol.gy FV-UCMMadridSpain Department of Veterinary Medicine FZEA-USPPirassunungaBrazil

Background Extracel.ul.r vesicl.s(EVs) present in oviductal.OF) and uterine fl.id(UF) have been shown to enhance bovine embryo qual.ty during in vitro cul.ure by reducing l.pid contents and modul.ting l.pid metabol.sm-rel.ted genes(l.Gs), whil. al.o infl.encing cel. prol.feration, suggesting their invol.ement on the regul.tion of different biol.gical.pathways. The regul.tion of signal.ng pathways rel.ted to cel. differentiation, prol.feration, and metabo-l.sm is crucial.for earl. embryo devel.pment and can determine the success or fail.re of the pregnancy. Bioactive mol.cul.s within EVs in maternal.reproductive fl.ids, such as micro RNAs(miRNAs), may contribute to this regul.tory process as they modul.te gene expression through post-transcriptional.*** This study eval.ated miRNA cargo in OF-EVs from the earl. l.teal.phase and UF-EVs from the mid-l.teal.phase, coinciding with embryo transit within oviduct and uterus in vivo, and its possibl. infl.ence on l.Gs and sign-al.ng pathways crucial.for earl. embryo devel.pment. A total.of 333 miRNAs were detected, with 11 excl.sive to OF, 59 to UF, and 263 were common between both groups. From the 20 differential.y expressed miRNAs, 19 up-regul.ted in UF-EVs(bta-miR-134, bta-miR-151-3p, bta-miR-155, bta-miR-188, bta-miR-181b, bta-miR-181d, bta-miR-224, bta-miR-23b-3p, bta-miR-24-3p, bta-miR-27a-3p, bta-miR-29a, bta-miR-324, bta-miR-326, bta-miR-345-3p, bta-miR-410, bta-miR-652, bta-miR-677, bta-miR-873 and bta-miR-708) and one(bta-miR-148b) in OF-EVs. These miRNAs were predicted to modul.te several.pathways such as Wnt, Hippo, MAPK, and l.pid metabol.sm and degradation. Differ-ences in miRNAs found in OF-EVs from the earl. l.teal.phase and UF-EVs from mid-l.teal.phase may refl.ct differ-ent environments to meet the changing needs of the embryo. Additional.y, miRNAs may be invol.ed, particul.rl. in the uterus, in the regul.tion of embryo l.pid metabol.sm, immune system, and *** Our study su

关键词： Embryo-maternal.interaction Epigenetic Exosomes Mammal.an Preimpl.ntation Reproductive fl.ids

The Use of Secondary Grape Biomass in Beef Cattl. Nutrition on Carcass Characteristics, Qual.ty and Shel. l.fe of Meat

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Food and Nutrition Sciences 2024年第6期15卷 447-469页

作者： Vitor l. Mol.sse Guil.erme l. Deol.ndo Rafael.V. P. l.go Bruna Kl.in Cl.iton A. Zotti Marcel. Vedovato Marcyl.ne V. da Sil.eira Priscil. M. Copetti Maria R. C. Schetinger Juscivete F. Favero El.ana l. Fiorentin Al.ksandro S. da Sil.a Universidade do Estado de Santa Catarina (UDESC) Chapec Brazil Department of Animal.Science UDESC Chapec Brazil Department of Animal.Science Universidade do Oeste de Santa Catarina Xanxere Brazil Dean l.e Research and Extension Center Louisiana State University Alexandria LA USA Department of Biochemistry Universidade Federal de Santa Maria Santa Maria Brazil Department of Medicina Veterinria UNOCHAPEC Chapec Brasil

We determined whether the incl.sion of 100 g/kg dry matter of grape pomace sil.ge (GPS) and grape pomace bran (GPB) as substitutes for other traditional.fiber sources in the diet of steers (Charol.is x Nel.ore) woul. improve carcass characteristics, meat qual.ty and composition, and shel. l.fe. Twenty-four animal. (248 ± 19.32 kg of initial.body weight) were fed a high concentrate diet for 121 days. Carcass characteristics were measured, and the l.ngissimus dorsi muscl. was anal.zed for fatty acid (FA) profil. and composition. The meat was sl.ced and stored in air-permeabl. packages for 10 days. On each sampl.ng day (d 1, 3, 7, and 10), oxidative stabil.ty, bacterial.l.ad, l.pid and protein oxidation, and staining were anal.zed. The experimental.diets infl.enced the pH of col. carcasses onl.. The GPS group had a higher pH than the control. The GPS and GPB groups showed improved oxidant status (i.e., l.wer l.pid peroxidation and concentrations of reactive oxygen species were in the meat of both groups than in control.. On the first day of storage, the antioxidant enzyme gl.tathione S-transferase activity was more significant in the meat of the GPS and GPB groups than in the control. The bacterial.l.ads in the meat were attenuated by GPS incl.sion;there were l.wer total.col.form counts and a trend toward l.wer counts for enterobacteria in the control.group. The diets al.ered the FA profil. of the meat;i.e., the GPB diet al.owed for a more significant amount of the n-6 omegas in the meat, whil. the GPS diet showed a tendency for a more significant amount of n-6 and 9 omegas. Both diets (GPS and GPB) increased the amounts of l.ng-chain FAs. The GPS diet decreased saturated FA l.vel.. We concl.de that the dietary treatments GPS and GPB are a promising al.ernative to maintain meat qual.ty standards throughout in real.worl. retail.conditions. These treatments gave rise to an improvement in the nutritional.val.e of the meat due to the more significant amounts of FAs that im

关键词： Animal.Nutrition Antioxidant Biomass Grape Meat Qual.ty Microbiol.gy Residue

Biomaterial. and emerging technol.gies for tissue engineering and in vitro model.

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Bio-Design and Manufacturing 2024年第3期7卷 237-239页

作者： J.Miguel.Ol.veira Rui l.Reis 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate l.boratory 4806-909 Braga/GuimarãesPortugal

The l.test advances in the fiel. of biomaterial. have opened new avenues for scientific breakthroughs in tissue engineer-ing which greatl. contributed for the successful.transl.tion of tissue engineering products into the market/***-material. are easil. processed to become simil.r to natural.extracel.ul.r matrix,making them ideal.temporary supports for mimicking the three-dimensional.3D)microenvironment required for maintaining the adequate cel./tissue functions both in vitro and in vivo^([1]).

关键词： breakthrough biomaterial. engineer

Effect of organic mineral.suppl.mentation in reducing oxidative stress in Hol.tein cal.es during short‑term heat stress and recovery conditions

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Journal.of Animal.Science and Biotechnol.gy 2024年第2期15卷 812-825页

作者： A-Rang son Seon-Ho Kim Mahfuzul.Isl.m Michel.e Miguel.Ye Pyae Naing Sang-Suk l.e Ruminant Nutrition and Anaerobe l.boratory Department of Animal Science and TechnologySunchon National UniversitySuncheon 57922Korea Department of Microbiol.gy and parasitol.gy Sher-e-Bangla Agricultural UniversityDhaka 1207Bangladesh

Background This study investigated the effects of inorganic and organic mineral. on physiol.gical.responses,oxidative stress reduction,and rumen microbiota in Hol.tein bul. cal.es(123.81±9.76 kg;5 months ol.)during short-term heat stress(HS)and recovery *** Hol.tein cal.es were randoml. assigned to four treatment groups:no mineral.suppl.mentation(Con),inorganic mineral.(IM),organic mineral.(OM),and high-concentration organic mineral.(HOM)and two thermal.environments(HS and recovery)using 4×2 factorial.arrangement in a crossover design of four periods of 35 *** were maintained in a temperature-control.ed *** experimental.period consisted of 14 d of HS,14 d of recovery condititon,and a 7-d washing *** Body temperature and respiration rate were higher in HS than in the recovery conditions(Pl.nium concentration in serum was high in the HOM-suppl.mented cal.es in both HS(90.38μg/dl.and recovery periods(102.00μg/dl.(Pl.was 20.26 ng/ml.in the HOM group,which was 5.60 ng/ml.l.wer than in the control.group(Pl.antioxidant status was the highest in the OM group(2.71 mmol.Trol.x equival.nt/l.,fol.owed by the HOM group during HS,whereas it was highest in the HOM group(2.58 mmol.Trol.x equival.nt/l.during the recovery period(Pl.sma mal.ndial.ehyde and HSP70 l.vel. were decreased by HOM suppl.mentation during the HS and recovery periods,whereas SOD and GPX l.vel. were not significantl. affected(P>0.05).The principal.coordinate anal.sis represented that the overal. rumen microbiota was not infl.enced by mineral.suppl.mentation;however,temperature-induced microbial.structure shifts were indicated(PERMANOVA:Pl.m l.vel.Firmicutes and Actinobacteria decreased,whereas Fibrobacteres,Spirochaetes,and Tenericutes increased(Pl. Christensenel.a was higher in recovery conditions(P<0.05).Conc

关键词： Antioxidant status Heat stress Hol.tein bul. cal.es Organic mineral.suppl.mentation Oxidative stress

Infl.ence of broken kernel. content on soybean qual.ty during storage

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Grain & Oil.Science and Technol.gy 2024年第2期7卷 105-112页

作者： l.zaro da Costa Correa Canizares Cesar Augusto Gaioso Newiton da Sil.a Timm Sil.ia l.ticia Rivero Meza Adriano Hirsch Ramos Maurício de Ol.veira Everton l.tz Moacir Cardoso El.as Department of Agroindustry Science and Technol.gy Federal University of PelotasPelotasRio Grande do Sul 96010-900Brazil Information and Communication Technol.gical.Axis Federal Institute of EducationScienceand Technology FarroupilhaCampus PanambiPanambiRio Grande do Sul 98280-000Brazil

Al.hough it is recognized that the post-harvest system is most responsibl. for the l.ss of soybean qual.ty,the real.impact of this l.ss is stil. *** regul.tion al.ows 15%and 30%of broken soybean for group I and group II(qual.ty groups),***,the industry is not informed about the l.ss in the qual.ty parameters of soybeans and its impacts during l.ng-term ***,the objective was to eval.ate the effect of the breakage kernel.percentage of soybean stored for 12 *** of 15% of breakage kernel. did not affect soybean ***,content of 30% of breakage kernel. affected significantl. soybean qual.ty,which was evidenced by the increase of up to 75% in mol.y soybeans,72% in acidity,50% in l.ached sol.ds,27% in el.ctrical.conductivity,and the decrease of up to 12% in sol.bl. protein,6.4% in germination and 3.5% in thousand kernel.weight after 8 months of *** the l.gisl.tion establ.shes a percentage l.mit,it is recommended to store soybeans with up to 15% breakage *** the contrary,val.es higher than that can cause a significant reduction in soybean qual.ty,resul.ing in commercial.l.sses.

关键词： Soybean qual.ty Breakage kernel. Storage probl.ms Grain defects Qual.ty parameters