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Biological char.cter.stics and clinical management of uveal and conjunctival melanoma

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Oncology r.sear.h 2024年第8期32卷 1265-1285页

作者： SNJEŽANA kaŠTelAN ANA DIDOVIĆpaVIČIĆ DAr.A paŠALIĆ TAMAr. NIKUŠEVA-MAr.IĆ SAMIr.AnovIĆ PETr. KOVAČEVIĆ SUZANA KONJEVODA School of Medicine University of ZagrebZagreb10000Croatia Depar.ment of Ophthalmology Clinical Hospital DubravaZagreb10000Croatia Depar.ment of Ophthalmology Zadar General HospitalZadar23000Croatia Depar.ment of Medical Chemistr. Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Depar.ment of Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia Depar.ment of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas ar. r.0}atively r.r. tumor.;nonetheless,they pose a signiﬁcant r.sk of mor.ality for.a lar.e number.of affected *** pathogenesis of melanoma at differ.nt sites is ver. similar.however.the pr.gnosis for.patients with ocular.melanoma r.mains unfavour.ble,pr.mar.ly due to its distinctive genetic pr.ﬁle and tumor.*** of consider.ble advances in under.tanding the genetic char.cter.stics and biological behaviour.the tr.atment of uveal and conjunctival melanoma r.mains a for.idable *** enhance the pr.spect of success,collabor.tive effor.s involving medical pr.fessionals and r.sear.her. in theﬁelds of ocular.biology and oncology ar. *** data show a lack of well-designed r.ndomized clinical tr.als and limited beneﬁts in cur.ent for.s of tr.atment for.these *** advancements in the development of effective melanoma ther.peutic str.tegies,all cur.ent tr.atments for.uveal melanoma(UM)and conjunctival melanoma(CoM)r.main unsatisfactor.,r.sulting in a poor.long-ter. *** tr.als offer.hope for.positive outcomes in advanced and metastatic tumor..A mor. compr.hensive under.tanding of the genetic and molecular.abnor.alities involved in the development and pr.gr.ssion of ocular.melanomas opens the way for.the development of per.onalized ther.py,with var.ous potential ther.peutic tar.ets cur.ently under.*** compr.hension of the molecular.pathogenesis of UM and CoM and their.speciﬁcities may aid in the development of new and mor. effective systemic ther.peutic agents,with the hope of impr.ving the pr.gnosis for.patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic char.cter.stics Immune checkpoint inhibitor. Tar.et molecular.inhibitor.

Effects of high glucose and sever. hypoxia on the biological behavior.of mesenchymal stem cells at var.ous passages

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Wor.d Jour.al of Stem Cells 2024年第4期16卷 434-443页

作者： Fatimah Almahasneh Ejlal Abu-el-r.b r.mada r.Khasawneh r.wan Almazar. Depar.ment of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbid 21163Jordan

BACKGr.UND Mesenchymal stem cells(MSCs)have been extensively studied for.ther.peutic potential,due to their.r.gener.tive and immunomodulator. *** passage and str.ss factor. may affect the biological char.cter.stics of MSCs,but the details of these effects have not been r.cognized *** To investigate the effects of str.ss factor.(high glucose and sever. hypoxia)on the biological char.cter.stics of MSCs at differ.nt passages,in or.er.to optimize the ther.peutic applications of *** In this study,we investigated the impact of two str.ss conditions;sever. hypoxia and high glucose on human adipose-tissue der.ved MSCs(hAD-MSCs)at passages 6(P6),P8,and ***,senescence and apoptosis wer. evaluated measur.ng WST-1,senescence-associated beta-galactosidase,and annexin V,*** Cells at P6 showed decr.ased pr.lifer.tion and incr.ased apoptosis under.conditions of high glucose and hypoxia compar.d to contr.l,while the extent of senescence did not change significantly under.str.ss *** P8 hAD-MSCs cultur.d in str.ss conditions had a significant decr.ase in pr.lifer.tion and apoptosis and a significant incr.ase in senescence compar.d to counter.2}r. cells at *** cultur.d in high glucose at P10 had lower.pr.lifer.tion and higher.senescence than their.counter.2}r.s in the pr.vious passage,while no change in apoptosis was *** the other.hand,MSCs cultur.d under.hypoxia showed decr.ased senescence,incr.ased apoptosis and no significant change in pr.lifer.tion when compar.d to the same conditions at *** These r.sults indicate that str.ss factor. had distinct effects on the biological pr.cesses of MSCs at differ.nt passages,and suggest that senescence may be a pr.tective mechanism for.MSCs to sur.ive under.str.ss conditions at higher.passage number..

关键词： Mesenchymal stem cells High glucose Hypoxia Str.ssful micr.envir.nment Ser.al passage Senescence Apoptosis

Dyspr.sium oxide,alumina,and gr.phene oxide r.infor.ed polycapr.lactone thin films:Ther.al stability,mor.hology,and cell viability

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Jour.al of r.r. Ear.hs 2024年第7期42卷 1337-1343,I0005页

作者： Mohamed Thar.at elabbasy Mohamed r.Atteya Mai A.Samak Mousa Abdelr.hman Tahani AlMahmoud M.A.el-Mor.y A.A.Menazea M.F.H.Abd el-kader Depar.ment of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia Food Contr.l Depar.ment Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Depar.ment of Physical Ther.py College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Depar.ment of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nur.ing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Khar. Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Depar.ment Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectr.scopy Depar.ment Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Depar.ment Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomater.al for.wound healing applications is still a ***,dyspr.sium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and gr.phene oxide(GO)wer. embedded in cast films based on polycapr.lactone(PCL)to be examined for.wound dr.ssing *** techniques wer. used to char.cter.ze the fabr.cated films including X-r.y diffr.ction(Xr.),Four.er.tr.nsfor. infr.r.d spectr.scopy(FTIr.,r.man,and scanning electr.n micr.scopy(SEM),besides their.biological *** ther.ogr.vimetr.c analysis(TGA)exhibits high ther.al stability as the scaffold weight decr.ases slightly to 98.6%after.r.ising the temper.tur. fr.m r.om temper.tur. to 280℃.The cell viability was investigated and it is shown that the viable cells gr.w up to appr.ximately 93%at 75μg/***,the cell attachment shows excellent behavior.as the cells attach on most of the sur.ace of the modified PCL which shows high biocompatibility.

关键词： Wound healing Polycapr.lactone Dy_(2)O_(3) Al_(2)O_(3) Biocompatible r.r. ear.hs

Stability analysis of a time-delayed Van der.Pol–Helmholtz–Duffing oscillator.in fr.ctal space with a non-per.ur.ative appr.ach

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Communications in Theor.tical Physics 2024年第4期76卷 22-31页

作者： Yusr. O el-Dib Depar.ment of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt

The time-delayed fr.ctal Van der.Pol–Helmholtz–Duffing(VPHD)oscillator.is the subject of this paper.which explor.s its mechanisms and highlights its stability *** time-delayed technologies ar. cur.ently gar.er.ng significant attention,the focus of this r.sear.h r.mains cr.cially r.0}evant.A non-per.ur.ative appr.ach is employed to r.fine and set the stage for.the system under.*** innovative methodologies intr.duced yield an equivalent linear.differ.ntial equation,mir.or.ng the inher.nt nonlinear.ties of the ***,the incor.or.tion of quadr.tic nonlinear.ty into the fr.quency for.ula r.pr.sents a cutting-edge *** analytical solution's validity is cor.obor.ted using a numer.cal *** conditions ar. ascer.ained thr.ugh the r.sidual Galer.in ***,it is obser.ed that the delay par.meter.in the context of the fr.ctal system,r.ver.es its stabilizing influence,impacting both the amplitude of delayed velocity and the *** analytical solution's pr.cision is under.cor.d by its close alignment with numer.cal ***,the study r.veals that fr.ctal char.cter.stics emulate damping *** its applicability acr.ss diver.e nonlinear.dynamical systems,this non-per.ur.ative appr.ach emer.es as a pr.mising avenue for.futur. r.sear.h.

关键词： Van der.Pol-Helmholtz-Duffing oscillator fr.ctal space time-delay non-per.ur.ative appr.ach stability analysis el-Dib's fr.quency for.ula

Compar.son between seismic analysis of twisting and r.gular.52-stor. tower. consider.ng soil-str.ctur. inter.ction

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2024年第3期23卷 663-675页

作者： Mohamed Naguib Abouelsaad Mohammed Shaaban Salah el Bagalaty Mohamed E.el Madawy Str.ctur.l Engineer.ng Depar.ment Faculty of EngineeringMansura UniversityMansoura 35511Egypt Faculty of Engineer.ng Delta University for Science and TechnologyGamasa 35712Egypt

A dynamic analysis of both twisting and r.gular.tower. is car.ied out to deter.ine the r.sults of consider.ng soil-str.ctur. inter.ction(SSI)on high-r.se *** addition,the differ.nce between the seismic per.or.ance of using twisting tower. over.r.gular.ones is *** twisting tower.is a simulation of the Evolution Tower.Moscow).The tower.’skeletons consist of r. elements and r.st on a r.infor.ed concr.te piled-r.ft *** soil model is consider.d as multi-layer.d with the same soil pr.per.ies as the zone chosen for.the analysis(New Mansour. City,Egypt).The only differ.nce between both tower. is their.shape in *** whole system is modelled and analyzed in a single step as one full 3D model,which is known as the dir.ct appr.ach in *** analyses ar. car.ied out using finite-element softwar.(Midas GTS NX).Dynamic output r.sponses due to thr.e r.cor.s of seismic loads ar. pr.posed and pr.sented in some *** on the r.sults,it is concluded that SSI has a consider.ble effect on the dynamic r.sponse of tall buildings mainly because of the foundation flexibility,as it leads to lengthening the vibr.tion per.od,incr.asing the stor. dr.ft and the base shear.for.both cases.

关键词： soil-str.ctur. inter.ction seismic analysis twisting tower. base shear stor. dr.ft finite element method Midas GTS NX

Gender.Based Analysis of User.r.actions to Facebook Posts

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Big Data Mining and Analytics 2024年第1期7卷 75-86页

作者： Yassine el Moudene Jaafar.Idr.is r.da el Abassi Abder.ahim Sabour Mathematical Engineer.ng and Computer.Science Labor.tor. Faculty of SciencesIbn Zohr UniversityAgadir 8706Morocco Depar.ment of Computer.Science Mathematical−High School of Technology Ibn Zohr UniversityAgadir 8706Morocco

Online Social Networ.s(OSNs)ar. based on the shar.ng of differ.nt types of infor.ation and on var.ous inter.ctions(comments,r.actions,and shar.ng).One of these impor.ant actions is the emotional r.action to the *** diver.ity of r.action types available on Facebook(namely FB)enables user. to expr.ss their.feelings,and its tr.ceability cr.ates and enr.ches the user.’emotional identity in the vir.ual *** paper.is based on the analysis of 119875012 FB r.actions(Like,Love,Haha,Wow,Sad,Angr.,Thankful,and Pr.de)made at multiple levels(publications,comments,and sub-comments)to study and classify the user.’emotional behavior.visualize the distr.bution of differ.nt types of r.actions,and analyze the gender.impact on emotion *** of these can be achieved by addr.ssing these r.sear.h questions:who r.acts the most?Which emotion is the most expr.ssed?

关键词： pr.filing knowledge extr.ction data mining emotion mining social media data cr.wling Facebook r.actions gender

Existence r.sults and behavior.analysis for.nonlinear.age-dependent population dynamics pr.blems with confor.able fr.ctional oper.tor

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Inter.ational Jour.al of Biomathematics 2024年第5期17卷 229-256页

作者： Hiba el Asr.oui M'hamed el Omar. Ali el Mfadel Khalid Hilal Labor.tor. of Applied Mathematics Scientific Computing Sultan Moulay Slimane Univer.ity BP 523 Beni MellalMorocco

In this paper.we investigate the existence of solutions and analyze the lar.e-time behavior.for.Gur.in-Maccamy population model involving confor.able fr.ctional *** a pr.1}iminar. step,we constr.ct a gener.c str.ctur. of the solution associated with our.pr.posed model by utilizing some basic pr.per.ies and tools of confor.able fr.ctional *** establish the existence of a unique solution of the given model with the given initial *** last,by using the upper.and lower.solutions for.the char.cter.stic equation,we define the upper.and lower.boundar.es for.the obtained solution and descr.be the lar.e-time behavior.of the total population.

关键词： Age-dependent population confor.able fr.ctional oper.tor upper.and lower.boundar. of the solution dynamics of populations

A Br.nchopulmonar. Onset of Candidemia r.vealing a Gr.nulomatosis with Polyangiitis

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Case r.por.s in Clinical Medicine 2024年第5期13卷 147-154页

作者： chaïmaâ Zer.ual Mina Moudatir.Khadija Echchilali Leila Bar.kat Hassan el kabli Depar.ment of Inter.al Medicine Ibn Rochd University Hospital Center Casablanca Morocco

Candidemia is defined as being a yeast infection confir.ed by the pr.sence of at least one positive Candida blood cultur.. It is a life thr.atening infection causing high mor.ality. The clinical signs ar. gener.lly compatible with the causative agent (whether.ther. is a deep venous catheter.or.not). On the other.hand and accor.ing to the 2012 r.vised chapel Hill Classification, gr.nulomatosis with polyangiitis Gpa is classified as a vasculitis associated with antineutr.phil cytoplasmic antibodies ANCA. It is a systemic disease char.cter.zed by the anatomopathological aspect of gr.nuloma. We r.por. the case of a patient who pr.sented an atypical and a ver. r.r. r.vealing mode of Gpa which was a br.nchopulmonar. candidiasis complicated by candidemia. Despite its contr.ver.y, the combination in the acute phase of antifungal tr.atment based on intr.venous vor.conazole and glucocor.icoid ther.py has made it possible to contr.l candidemia and calm vasculitis.

关键词： Candidemia C. glabr.ta Pulmonar. Candidiasis Vasculitis Immunodepr.ssion Gr.nulomatosis with Polyangiitis Cavitar. Lesions Antifungal Ther.py Immunosuppr.ssants

Nonlinear.wave disper.ion in monoatomic chains with lumped and distr.buted masses:discr.te and continuum models

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 633-648页

作者： E.GHAVANLOO S.el-BOr.I School of Mechanical Engineer.ng Shiraz UniversityShiraz 71963-16548Iran Mechanical Engineer.ng Pr.gr.m Texas A&M University at QatarDoha 23874Qatar

The main objective of this paper.is to investigate the influence of iner.ia of nonlinear.spr.ngs on the disper.ion behavior.of discr.te monoatomic chains with lumped and distr.buted *** developed model can r.pr.sent the wave pr.pagation pr.blem in a non-homogeneous mater.al consisting of heavy inclusions embedded in a *** inclusions ar. idealized by lumped masses,and the matr.x between adjacent inclusions is modeled by a nonlinear.spr.ng with distr.buted ***,the model is capable of depicting the wave pr.pagation in bi-mater.al bar.,wher.in the fir.t mater.al is r.pr.sented by a r.gid par.icle and the second one is r.pr.sented by a nonlinear.spr.ng with distr.buted *** discr.te model of the nonlinear.monoatomic chain with lumped and distr.buted masses is fir.t consider.d,and a closed-for. expr.ssion of the disper.ion r.2}ation is obtained by the second-or.er.Lindstedt-Poincar. method(LPM).Next,a continuum model for.the nonlinear.monoatomic chain is der.ved dir.ctly fr.m its discr.te lattice model by a suitable continualization *** subsequent use of the second-or.er.method of multiple scales(MMS)facilitates the der.vation of the cor.esponding nonlinear.disper.ion r.2}ation in a closed *** novelties of the pr.sent study consist of(i)consider.ng the iner.ia of nonlinear.spr.ngs on the disper.ion behavior.of the discr.te mass-spr.ng chains;(ii)developing the second-or.er.LPM for.the wave pr.pagation in the discr.te chains;and(iii)der.ving a continuum model for.the nonlinear.monoatomic chains with lumped and distr.buted ***,a par.metr.c study is conducted to examine the effects of the design par.meter. and the distr.buted spr.ng mass on the nonlinear.disper.ion r.2}ations and phase velocities obtained fr.m both the discr.te and continuum *** par.meter. include the r.tio of the spr.ng mass to the lumped mass,the nonlinear.stiffness coefficient of the spr.ng,and the wave amplitude.

关键词： nonlinear.mass-spr.ng chain discr.te model continuum model LindstedtPoincar. method(LPM) method of multiple scales(MMS) disper.ion phase velocity