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世界儿科杂志:英文版 2016年第3期12卷 347-352页

作者： Yong-Hong Sun Xiao-Yan Lei Yi-pa sai Jun-Hui Chen Yuan-Chun Sun Xia Gao Department of Pediatrics People's Hospital of Gansu ProvinceLanzhouGansuChina

background:Hepatitis b virus-associated glomerulonephritis(HbV-GN)is one of the extrahepatic manifestations after HbV infection,which would cause great clinical harm to *** present study was undertaken to investigate the HbV-GN genotypes and its clinical relevance in Chinese ***:A total of 41 HbV-infected children diagnosed with HbV-GN were enrolled in the *** patients underwent liver and kidney *** genotypes and cccDNA were detected in their serum samples to analyze the relationship between HbV genotypes and clinical characteristics,cccDNA,and ***:Among the 41 children with HbV-GN,29(70.7%)had genotype C,10(24.4%)had genotype b,2(4.9%)had genotype b/C,and none of them had genotype non-b/*** children had genotypes b or C;moreover,the genotype C was the most frequent *** incidence of hematuria and albuminuria,reduction in complement C3,increase in serum alanine aminotransferase levels and renal insufficiency in the children with genotype C were signifi cantly higher than those in the children with genotype b(Ppatomegaly(P>0.05).The frequency of HbV cccDNA positive in the genotype C group was significantly higher than that in the genotype b group(72.4%vs.30.0%,Pbserved in hepatic inflammation grades and stages of fibrosis between the two groups(P>0.05).Conclusion:Genotype C was the most frequent genotype in the described group of patients with HbV-GN,and the liver and kidney damage indicators were more likely to occur in patients with genotype C.

关键词： cccDNA genotypes glomerulonephritis hepatitis b virus pathology

Selective silencing of 2Cys and type-Ⅱb Peroxiredoxins discloses their roles in cell redox state and stress signaling

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Journal of Integrative Plant biology 2015年第6期57卷 591-601页

作者： patrícia Vidigal Ana Montserrat Martin-Hernandez Cèlia Guiu-Aragonés sara Amncio Luísa Carvalho Departamento de Recursos Naturais Ambiente e Território (DRAT)/Centro de Botanica Aplicada à Agricultura (CBAA)Institute of AgronomyUniversity of Lisbon Institut de Recercai Tecnologia Agroalimentàries (IRTA) Centre for Research in Agricultural Genomics (CSIC-IRTA-UAB-UB) Campus Universitat Autonoma de Barcelona (UAB)Edificio Center for Research in Agricultural Genomics (CRAG)

Peroxiredoxins （Prx） catalyse the reduction of hydrogen peroxide （H2O2） and, in association with catalases and other peroxidases, may participate in signal transduction by regulating intercel ular H2O2 concentration that in turn can control gene transcription and cel signaling. Using virus-induced-gene-silencing （VIGS）, 2-Cys Peroxiredoxin （2CysPrx） family and type-II Peroxiredoxin b （PrxI b） gene were silenced in Nicotiana benthamiana, to study the impact that the loss of function of each Prx would have in the antioxidant system under control （22℃） and severe heat stress conditions （48 ℃）. The results showed that both Prxs, although in different organel es, influence the regeneration of ascorbate to a significant extent, but with different purposes. 2CysPrx affects abscisic acid （AbA） biosynthesis through ascorbate, while PrxIIb does it probably;through the xanthophyl cycle. Moreover, 2CysPrx is key in H2O2 scavenging and in consequence in the regulation of AbA signal-ing downstream of reactive oxygen species and PrxIIb provides an important assistance for H2O2 peroxisome scavenges.

关键词： 2-Cys Peroxiredoxin abscisic acid ascorbate heat stress hydrogen peroxide peroxisome type-Ⅱ Peroxiredoxin b

基于双浮标连续监测资料分析大亚湾西南部海域水体环境变化特征及其影响因素

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热带海洋学报 2024年第4期43卷 153-164页

作者：奚琛林宗轩萨如拉邓玺刘强倪亮罗来才马腾谢智杰陈思若陈松泽中广核研究院有限公司广东深圳518000 海洋地球古菌组学重点实验室南方科技大学广东深圳518055 广东省深圳生态环境监测中心站广东深圳518049 深圳市朗诚科技股份有限公司广东深圳518000 哈尔滨工程大学黑龙江哈尔滨150001 海洋科学与工程系南方科技大学广东深圳518055

水质环境监测对了解海洋生态系统变化至关重要。本文利用2022—2023年期间位于大亚湾西南部海域的2个浮标的连续监测数据,分析了水质环境的时间序列变化。结果表明,大亚湾西南部海域的温度、盐度可能受太阳辐射与降水的影响,具有明显的... 详细信息

水质环境监测对了解海洋生态系统变化至关重要。本文利用2022—2023年期间位于大亚湾西南部海域的2个浮标的连续监测数据,分析了水质环境的时间序列变化。结果表明,大亚湾西南部海域的温度、盐度可能受太阳辐射与降水的影响,具有明显的季节性差异,即夏季温度高、盐度低,冬季温度低、盐度较高;而Chl a具有明显的昼夜节律,溶解氧和pH存在相似的日变化模式。在夏、秋季,大鹏澳较杨梅坑海域呈现出高温、低盐、低溶解氧、低pH和高Chl a的特点。Pearson相关性分析表明,夏、秋季的温度、盐度、溶解氧、pH和Chl a之间存在显著的相关性,且存在区域差异,湾口附近,海浪、上升流等水体运动可能是主要影响因素;近岸,径流输入可能是导致水质环境变化的主导因素。此外,本文还记录了远距离台风引起的海浪及降水事件,继而对大亚湾海域环境造成影响。解析沿海环境参数时间序列的变化特征,对海洋生态系统的演变特征研究具有重要指示作用。

关键词：大亚湾近岸海域环境参数在线监测分布特征

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A new series of environment-friendly reddish inorganic pigments based on AFeO_(3)(A=Ln,Y) with high NIR solar reflectance

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Journal of Materiomics 2021年第5期7卷 1061-1073页

作者： Maria Fortuño-Morte pablo Serna-Gallén Héctor beltrán-Mir Eloísa Cordoncillo Departamento de Química Inorgánica y Orgánica Universitat Jaume IAv.Sos Baynat s/n12071Castellóde la PlanaSpain

Environment-friendly pigments based on AFeO_(3)(A=La,Pr,Nd,Sm,Gd,Tb,Y or Yb)with high nearinfrared(NIR)reflectance were synthesised by a coprecipitation method at 1200℃.The Rietveld refinement analysis showed single-phase orthorhombic perovskite for all *** pigments,which showed reddish hues,offered good colour stability after mixing these pigments in powder form with siloxane transparent paint and two different *** powderepaint mixtures produced with GdFeO_(3),TbFeO_(3) and YFeO_(3) pigments have the highest NIR solar reflectance,reaching values of R=50%.The temperature shielding studies conducted using TbFeO_(3) pigmentepaint mixture for a roof coating yielded a reduction of 3.2℃ in comparison to a commercial ***,the glazes that were pigmented using GdFeO_(3),TbFeO_(3) and YFeO_(3) compositions also presented the most intense reddish colours.A study of the thermal and chemical stability of the pigment with the highest NIR solar reflectance showed good stability in both *** reddish pigments that were prepared can therefore be good candidates for use in different applications such as cool pigments or pigments for ceramic glazes at high temperatures.

关键词： High NIR reflectance Cool pigment Reddish pigment Environment-friendly Coprecipitation

The effect of severe plastic deformation on the Mg properties after CEC deformation

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Journal of Magnesium and Alloys 2020年第3期8卷 761-768页

作者： b.Suikowski M.Janoska G.boczkal R.Chulist M.Mroczkowski P.paika Department of Non-Ferrous Metals Engineering Faculty of Non-Ferrous MetalsAGH University of Science and Technology30 Mickiewicza Av.Krakow 30-059Poland Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta St.Krakow 30-059Poland

In this study,the effect of severe plastic deformation on the Mg grain refinement and recovery mechanism was *** pure magnesium was deformed at room temperature by cycling extrusion-compression(CEC)process up to large *** steps of deformation have been used by applying 1,2 and 4 passes of CEC giving a total effective plastic strain ofε=*** and structural properties of Mg in initial state and the states after successive steps of deformation were *** mechanical properties were determined by microhardness and compression tests at room *** structural investigations involved light microscope observations,electron back scattered diffraction and texture measurements by X-ray *** was found that the CEC process refines the grain size down to 6.4μm and reduces strong rolling texture ***,only the first two passes had a strong effect on mechanical properties while a larger number of CEC cycles(above 4)led to failure of the samples with a small effect on *** observation correlates with texture evolution indicating a more random orientation distribution that slows down the typical for hep metals rapid work *** was found that the CEC process activated twin dynamic recrystallization in deformed *** process led to the formation of new randomly oriented grains inside the twinned areas and as a consequence it reduced the strong rolling texture components.

关键词： Magnesium Cyclic extrusion compression Texture Microhardness

A new endophytic insect-associated Daldinia species, recognised from a comparison of secondary metabolite profiles and molecular phylogeny

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Fungal Diversity 2013年第3期60卷 107-123页

作者： Sylvie pažoutová Stefanie Follert Jens bitzer Matthias Keck Frank Surup PetrŠrůtka Jaroslav Holuša Marc Stadler Institute of Microbiology of the ASCR v.v.i.Vídeňská108314220 Prague 4Czech Republic Department Microbial Drugs Helmholtz-Zentrum für Infektionsforschung GmbHInhoffenstrasse 738124 BraunschweigGermany IMD Natural Solutions GmbH Otto-Hahn-Strasse 1544227 DortmundGermany Faculty of Forestry and Wood Sciences Czech University of Life SciencesKamýcká12916521 Prague 6Czech Republic

Xylariaceous endophytes are commonly encountered in plants,and it has recently been found out that insect vectors play a major role in their life cycle,as well as in the apparent host-specificity of the fungal *** this study,a new insect-associated,endophytic anamorph species of Daldinia is recognised from a comparison of (a)morphological and ecological data;(b)molecular phylogenetic data based on rDNA,alpha-actin and beta-tubulin genes;and (c)secondary metabolite profiles based on high performance liquid chromatography/diode array/mass spectrometry(HPLC-DAD/MS)and gas chromatography/mass spectrometry(GC-MS)in comparison with authentic strains of Daldinia and other *** new species,Daldinia hawksworthii,is a symbiont of the willow woodwasp,Xiphydria prolongata,which is in turn preferentially associated with salix.A comparison of HPLCDAD/MS profiles from standardised cultures revealed the presence of a specific compound,which was not encountered in any of the ca.250 Daldinia strains studied for *** compound was isolated after fermentation of the fungus in 10 l scale by preparative *** elucidation by NMR spectroscopy revealed a novel pyrone,for which the name dalsymbiopyrone is *** compound showed weak antimicrobial and cytotoxic effects and might be a signal molecule involved in the trilateral ecological interaction between the host plant,the insect,and its fungal symbiont.

关键词： Fungi Endophytes Evolution Xylariales bioactive metabolites Natural products Alpha-pyrones

Identification of the unknown shielding parameters with gammaray spectrum using a derivative-free inverse radiation transport model

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Nuclear Science and Techniques 2018年第5期29卷 75-81页

作者： Ying Chen Lian-Ping Zhang sa Xiao Lun-Qiang Wu Shan-Li Yang bing-Yuan Xia Jian-Min Hu Institute of materials China Academy of Engineering Physics

Identifying the unknown geometric and material information of a multi-shield object by analyzing the radiation signature measurements is always an important problem in national and global security. In order to identify the unknown shielding layer thicknesses of a source/shield system with gamma-ray spectra, we have developed a derivative-free inverse radiation transport model based on a differential evolution algorithm with global and local neighbourhoods(IRT-DEGL). In the present paper, the IRT-DEGL model is further extended for estimating the unknown thicknesses with random initial guesses and material mass densities of multi-shielding layers as well as their combinations. Using the detected gamma-ray spectra,the illustration of inverse studies is implemented and the main influence factors for inverse results are also analyzed.

关键词： Inverse problem Derivative-free inverse radiation transport model Gamma-ray spectrum Multishielding layers

3D uniform nitrogen-doped carbon skeleton for ultra-stable sodium metal anode

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Nano Research 2020年第8期13卷 2136-2142页

作者： ben Liu Danni Lei Jin Wang Qingfei Zhang Yinggan Zhang Wei He Hongfei Zheng baisheng sa Qingshui Xie Dong-Liang Peng baihua Qu Pen-Tung sah Institute of Micro-Nano Science and Technology Fujian Key Laboratory of Materials GenomeCollege of MaterialsXiamen UniversityXiamen361005China State Key Laboratory of Optoelectronic Materials and Technologies School of Materials Science and EngineeringSun Yat-Sen(Zhongshan)UniversityGuangzhou510275China Multiscale Computational Materials Facility College of Materials Science and EngineeringFuzhou UniversityFuzhou350100China

Sodium metal batteries are arousing extensive interest owing to their high energy density,low cost and wide ***,the practical development of sodium metal batteries is inherently plagued by the severe volume expansion and the dendrite growth of sodium metal anode during long cycles under high current ***,a simple electrospinning method is applied to construct the uniformly nitrogen-doped porous carbon fiber skeleton and used as three-dimensional(3D)current collector for sodium metal anode,which has high specific surface area(1,098 m^2/g)and strong binding to sodium *** a result,nitrogen-doped carbon fiber current collector shows a low sodium deposition overpotential and a highly stable cyclability for 3,500 h with a high coulombic effciency of 99.9%at 2 mA/cm^2 and 2 mAh/cm^***,the full cells using carbon coated sodium vanadium phosphate as cathode and sodium pre-plated nitrogen-doped carbon fiber skeleton as hybrid anode can stably cycle for 300 *** results illustrate an effective strategy to construct a 3D uniformly nitrogen-doped carbon skeleton based sodium metal hybrid anode without the formation of dendrites,which provide a prospect for further development and research of high performance sodium metal batteries.

关键词： sodium metal anode porous carbon skeleton nitrogen-doping sodium affinity ultra-stable cyclability

A Self-assembled Nanoparticle Platform based on Amphiphilic Oleanolic Acid Polyprodrug for Cancer Therapy

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Chinese Journal of Polymer Science 2020年第8期38卷 819-829,I0006页

作者： Ying-sa Wang Gui-Liang Li Shang-bin Zhu Fan-Chen Jing Run-Dong Liu sai-sai Li Jing He Jian-Du Lei beijing Key Laboratory of Lignocellulosic Chemistry Engineering Research Center of Forestry Biomass Materials and Bioenergy(Ministry of Education)Beijing Forestry UniversityBeijing 100083China

Oleanolic acid(OA)is a pentacyclic triterpenoid compound with extensive biological effects,such as anti-inflammatory and anticancer ***,the application of OA in chemotherapy is hampered by its poor solubility and severe adverse *** solve the problems,we developed a self-assembled nanoparticle platform based on amphiphilic oleanolic acid polyprodrug,poly[oligo(ethylene glycol)methyl ether methacrylate]-b-poly(oleanolic acid methacrylate)(POEGMA-b-POAMA),encapsulating 10-hydroxycamptothecin(HCPT)to achieve efficient cancer *** polyprodrug was prepared via reversible addition-fragmentation chain transfer polymerization(RAFT),and could selfassemble to prepare POEGMA-b-POAMA/HCPT nanoparticles(NPs).The obtained nanoparticles exhibited appropriate particle size,excellent drug stability,good drug loading capacity,and high drug loading *** vitro drug release indicated that the drug release was prolonged to 132 *** POEGMA-b-POAMA/HCPT NPs enhanced cell cytotoxicity in 4T1 cells and MCF-7 cells and could be efficiently uptaken by 4T1 ***,in vivo antitumor efficiency showed that the POEGMA-b-POAMA/HCPT NPs had great antitumor efficiency with considerably low adverse effects in the treatment of the 4T1 mouse breast tumor xenograft ***,POEGMA-b-POAMA/HCPT NPs provide great potential as a platform for drug delivery applications.

关键词： Self-assemble Nanoparticle Oleanolic acid Amphiphilic polyprodrug Drug delivery

基于随机森林的川崎病诊断关键实验室指标预测研究

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检验医学与临床 2024年第19期21卷 2887-2891,2897页

作者：王爱琼萨日娜张巧丽柴利娜李爱月内蒙古自治区鄂尔多斯市中心医院儿科内蒙古鄂尔多斯017000 内蒙古迪安丰信医疗科技有限责任公司内蒙古呼和浩特010000

目的通过随机森林算法构建诊断模型,分析不完全川崎病区别于完全川崎病的关键实验室指标,以提高不完全川崎病的诊断率及降低其误诊率。方法选取2018年1月至2023年6月就诊于鄂尔多斯市中心医院儿科确诊为完全川崎病或不完全川崎病的患儿... 详细信息

目的通过随机森林算法构建诊断模型,分析不完全川崎病区别于完全川崎病的关键实验室指标,以提高不完全川崎病的诊断率及降低其误诊率。方法选取2018年1月至2023年6月就诊于鄂尔多斯市中心医院儿科确诊为完全川崎病或不完全川崎病的患儿145例,其中不完全川崎病34例(不完全组),完全川崎病111例(完全组)。比较两组红细胞计数、血红蛋白、红细胞沉降率、血钠、白细胞计数、血小板计数、平均血小板体积、中性粒细胞计数、中性粒细胞百分比、淋巴细胞计数、淋巴细胞百分比、C反应蛋白、丙氨酸转氨酶、总蛋白、清蛋白、总胆红素、天冬氨酸转氨酶、降钙素原(PCT)、肌酸激酶、肌酸激酶M多肽(CK-M)、N末端b型钠尿肽前体(NT-probNP)、凝血酶原时间、凝血酶时间、D-二聚体、尿白细胞计数的差异,利用随机森林算法构建诊断模型,分析不完全川崎病区别于完全川崎病的实验室指标。结果模型结果显示,贡献度前5位的实验室指标依次为血小板计数(0.381)、尿白细胞计数(0.372)、淋巴细胞百分比(0.260)、凝血酶时间(0.255)及中性粒细胞百分比(0.163),在区分川崎病类型方面具有重要的指示意义。构建的诊断模型ROC曲线下面积为0.864,灵敏度为1.00,特异度为0.74。结论通过随机森林算法得出,血小板计数、尿白细胞计数、淋巴细胞百分比、凝血酶时间以及中性粒细胞百分比可作为诊断不完全川崎病的关键实验室指标,这为患儿的诊断与及时治疗提供理论依据。

关键词：随机森林不完全川崎病实验室指标早期诊断完全川崎病

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