A Self-assembled Nanoparticle Platform Based on Amphiphilic Oleanolic Acid Polyprodrug for Cancer Therapy

作     者：Ying-Sa Wang Gui-Liang Li Shang-Bin Zhu Fan-Chen Jing Run-Dong Liu Sai-Sai Li Jing He Jian-Du Lei Ying-Sa Wang;Gui-Liang Li;Shang-Bin Zhu;Fan-Chen Jing;Run-Dong Liu;Sai-Sai Li;Jing He;Jian-Du Lei

作者机构：Beijing Key Laboratory of Lignocellulosic ChemistryEngineering Research Center of Forestry Biomass Materials and Bioenergy(Ministry of Education)Beijing Forestry UniversityBeijing 100083China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2020年第38卷第8期

页      面：819-829,I0006页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 0817[工学-化学工程与技术] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学] 0702[理学-物理学] 

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.21576029) National Key R&D Program of China(No.2017YFD0601205) 

主　　题：Self-assemble Nanoparticle Oleanolic acid Amphiphilic polyprodrug Drug delivery 

摘      要：Oleanolic acid(OA)is a pentacyclic triterpenoid compound with extensive biological effects,such as anti-inflammatory and anticancer ***,the application of OA in chemotherapy is hampered by its poor solubility and severe adverse *** solve the problems,we developed a self-assembled nanoparticle platform based on amphiphilic oleanolic acid polyprodrug,poly[oligo(ethylene glycol)methyl ether methacrylate]-b-poly(oleanolic acid methacrylate)(POEGMA-b-POAMA),encapsulating 10-hydroxycamptothecin(HCPT)to achieve efficient cancer *** polyprodrug was prepared via reversible addition-fragmentation chain transfer polymerization(RAFT),and could selfassemble to prepare POEGMA-b-POAMA/HCPT nanoparticles(NPs).The obtained nanoparticles exhibited appropriate particle size,excellent drug stability,good drug loading capacity,and high drug loading *** vitro drug release indicated that the drug release was prolonged to 132 *** POEGMA-b-POAMA/HCPT NPs enhanced cell cytotoxicity in 4T1 cells and MCF-7 cells and could be efficiently uptaken by 4T1 ***,in vivo antitumor efficiency showed that the POEGMA-b-POAMA/HCPT NPs had great antitumor efficiency with considerably low adverse effects in the treatment of the 4T1 mouse breast tumor xenograft ***,POEGMA-b-POAMA/HCPT NPs provide great potential as a platform for drug delivery applications.