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Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis

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Military Medical Research 2024年第2期11卷 287-307页

作者： pa. Luo Fu-Qiang Gao Wei Sun jun-You Li Cheng Wang Qing-Yu Zhang Zhi-Zhuo Li Peng Xu Depa.tment of Joint Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an 710054China Depa.tment of Orthopedics China-Japan Friendship HospitalBeijing 100029China Depa.tment of Orthopa.dic Surgery of the Perelman School of Medicine University of PennsylvaniaPhiladelphiaPA 19104USA School of Mechanical Engineering Sungkyunkwan UniversitySuwon 16419South Korea Depa.tment of Orthopa.dic Surgery Peking University Third HospitalPeking UniversityBeijing 100191China Depa.tment of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Rheumatoid arthritis(RA)is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opa.ity and typically leads to serious joint damage and irreversible disability,thus adversely affecting locomotion ability and life ***,good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of *** fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo ***,we review the fluorescent probes developed for the detection and imaging of RA biomarkers,namely reactive oxygen/nitrogen species(hypochlorous acid,peroxynitrite,hydroxyl radical,nitroxyl),pH,and cysteine,and address the related challenges and prospects to inspire the design of novel fluorescent probes and the improvement of their performance in RA studies.

关键词： Rheumatoid arthritis Fluorescent probe Imaging Diagnosis Biomarker

中美战略博弈背景下美澳同盟转型的特征、动因及影响

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太平洋学报 2024年第2期32卷 17-28页

作者：宁团辉中国国际问题研究院北京100005

美澳同盟是美国亚太联盟体系的重要一环,是美国实施地区战略的重要工具。随着美国对华战略竞争的加剧,美澳同盟的转型进程加快。从同盟针对的目标来看,美澳同盟将围绕遏制中国的战略需求进行全面转型;从同盟内部关系来看,澳大利亚对美... 详细信息

美澳同盟是美国亚太联盟体系的重要一环,是美国实施地区战略的重要工具。随着美国对华战略竞争的加剧,美澳同盟的转型进程加快。从同盟针对的目标来看,美澳同盟将围绕遏制中国的战略需求进行全面转型;从同盟内部关系来看,澳大利亚对美澳同盟的引导和塑造能力明显增强;从同盟性质来看,美澳同盟将从防御性同盟转型为进攻性同盟,进攻能力和威慑能力成为双方合作的重点;从同盟合作范围来看,美澳同盟的综合性特征更加明显。美澳同盟转型是美国调动盟友资源、推进“印太战略”部署和强化对华战略竞争的重要措施,同时也适应了澳大利亚缓解战略焦虑和制衡中国影响力的现实需求。这不仅使得两国在战略上深度捆绑,增强了美国对华战略竞争的力量优势,也使得澳大利亚处理对华关系难度加大,并冲击地区和平与合作的进程。

关键词：中美战略博弈美澳同盟联盟转型 “印太战略”

Genomic selection of eight fruit traits in pear

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Horticultural Plant Journal 2024年第2期10卷 318-326页

作者： Manyi Sun Mingyue Zhang Satish Kumar Mengfan Qin Yueyuan Liu Runze Wang Kaijie Qi Shaoling Zhang Wenjing Chang Jiaming Li jun Wu College of Horticulture State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationNanjing Agricultural UniversityNanjingJiangsu 210095China State Key Laboratory of Crop Biology College of Horticulture Science and EngineeringShandong Agricultural UniversityTai'anShandong 271018China The New Zealand Institute for Plant and Food Research Limited Private Bag 1401Havelock North 4157New Zealand Zhongshan Biological Breeding Laboratory NanjingJiangsu 210014China

Genomic selection (GS) has the potential to improve selection efficiency and shorten the breeding cycle in fruit tree breeding. In this study,we evaluated the effect of prediction methods, marker density and the training population (TP) size on pear GS for improving its performance and reducing cost. We evaluated GS under two scenarios:(1) five-fold cross-validation in an interspecific pear family;(2) independent validation. Based on the cross-validation scheme, the prediction accuracy (pa. of eight fruit traits varied between 0.33 (fruit core vertical diameter)and 0.65 (stone cell content). Except for single fruit weight, a slightly better prediction accuracy (pa. was observed for the five pa.ametrical methods compa.ed with the two non-pa.ametrical methods. In our TP of 310 individuals, 2 000 single nucleotide polymorphism (SNP) markers were sufficient to make reasonably accurate predictions. pa. for different traits increased by 18.21%-46.98%when the TP size increased from 50to 100, but the increment was smaller (-4.13%-33.91%) when the TP size increased from 200 to 250. For independent validation, the pa. ranged from 0.11 to 0.45 using rrBLUP method. In summary, our results showed that the TP size and SNP numbers had a greater impa.t on the pa.than prediction methods. Furthermore, relatedness among the training and validation sets, and the complexity of traits should be considered when designing a TP to predict the test pa.el.

关键词： Pear Pyrus Prediction method TP size SNP marker number

PDA/Fe_(3)O_(4)上浆对碳纤维/聚酰胺6热塑性复合材料力学性能的影响

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重庆大学学报 2024年第8期47卷 123-131页

作者：黄焘武肖鹏宁慧铭胡宁重庆大学航空航天学院重庆400044 河北工业大学机械工程学院天津300401

在碳纤维增强热塑性复合材料中,碳纤维(CF)与热塑性树脂基体间的界面强弱对其整体力学性能有巨大的影响。为改善CF与聚酰胺6(pa.)的界面性能,利用多巴胺(DA)的聚合与黏附特性,将纳米相四氧化三铁(Fe_(3)O_(4))引入到CF表面进行协同修饰... 详细信息

在碳纤维增强热塑性复合材料中,碳纤维(CF)与热塑性树脂基体间的界面强弱对其整体力学性能有巨大的影响。为改善CF与聚酰胺6(pa.)的界面性能,利用多巴胺(DA)的聚合与黏附特性,将纳米相四氧化三铁(Fe_(3)O_(4))引入到CF表面进行协同修饰,通过简单的浸渍共沉积,利用DA的氧化自聚合在CF表面构建聚多巴胺/纳米四氧化三铁(PDA/Fe_(3)O_(4))涂层。对CF改性前后表面微观结构与化学特性进行了表征,结果表明PDA/Fe_(3)O_(4)上浆剂能够显著提高CF表面的粗糙度与化学活性,加强纤维与树脂基体的机械啮合作用与化学相互作用。与未改性CF/pa.复合材料相比,制备得到的改性CF/pa.复合材料表现出优异的力学性能,其弯曲强度、层间剪切强度分别提高了30.8%和29.1%。

关键词：碳纤维聚酰胺6 聚多巴胺纳米四氧化三铁界面性能

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Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative pa.ients

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Virologica Sinica 2024年第2期39卷 319-330页

作者： Guixin Li Danli Yang Xin Liu Ting Zhang Hui Liu jun Zou Zimeng Xu Xiangmei Chen Lizhong Dai Hongsong Chen Fengmin Lu Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijing100044China Depa.tment of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking UniversityBeijing100191China Baruch S.Blumberg Institute DoylestownPA18901USA Shenzhen Sanyuansheng Biotechnology Co. LtdShenzhen518000China Precision Medicine Center of Zhengzhou University Academy of Medical SciencesZhengzhou UniversityZhengzhou450001China Peking University-Sansure Biotech Joint Laboratory of Molecular Medicine Sansure Biotech Co.LtdChangsha410205China

Naturally occurred precore(PC,G1896A)and/or basal core promoter(BCP,A1762T/G1764A)mutations are prevalent in chronic HBV-infected pa.ients,especially those under HBeAg-negative ***,the replicative capa.ity of HBV with PC/BCP mutations remains ***,meta-analysis showed that,only under HBeAg-negative status,the serum HBV DNA load in pa.ients with PC mutation was 7.41-fold higher than those without the *** PC mutation alone and BCPþPC mutations promoted HBV replication in cell and hydrodynamic injection mouse *** human hepa.ocyte chimeric mouse model,BCPþPC mutations led to elevated replicative capa.ity and intrahepa.ic core protein ***,preC RNA harboring PC mutation could serve as mRNA to express core and P proteins,and such pgRNA-like function favored the maintenance of cccDNA pool under HBeAg-negative ***,BCPþPC mutations induced more extensive and severe human hepa.ocyte damage as well as activated endoplasmic reticulum stress and TNF signaling pa.hway in livers of chimeric *** study indicates that HBeAg-negative pa.ients should be monitored on HBV mutations regularly and are expected to receive early antiviral treatment to prevent disease progression.

关键词： Hepa.itis B virus Precore mutation Basal core promoter mutations Endoplasmic reticulum stress

General anesthetic agents induce neurotoxicity through astrocytes

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Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： Yanchang Yang Tiantian Liu jun Li Dandan Yan Yuhan Hu Pin Wu Fuquan Fang pa.rick M.McQuillan Wenxin Hang Jianhang Leng Zhiyong Hu Depa.tment of Anesthesiology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Depa.tment of Anesthesiology Ningbo Women and Children’s HospitalNingboZhejiang ProvinceChina Depa.tment of Anesthesiology Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhouZhejiang ProvinceChina Cell Biology Depa.tment Yale UniversityNew HavenCTUSA Depa.tment of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPAUSA Depa.tment of Central Laboratory Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial *** studies,however,have focused on the effects of general anesthetic agents on neuroglia or *** can also be an important target of general anesthetic agents as they exert not only sedative,analgesic,and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive ***,we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes,and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes,in addition to acting on the receptors on their surface,which not only affect Ca^(2+)signaling,inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes,but are even involved in the regulation of the pro-and anti-inflammatory processes of *** would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons,other neuroglia,and vascular *** this review,we summarize how general anesthetic agents act on neurons via astrocytes,and explore potential mechanisms of action of general anesthetic agents on the nervous *** hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents neuron neurotoxicity N-methyl-D-aspa.tate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

Federated Dynamic Client Selection for Fairness Guarantee in Heterogeneous Edge Computing

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Journal of Computer Science & Technology 2024年第1期39卷 139-158页

作者：毛莺池沈莉娟吴俊平萍吴杰 Key Laboratory of Water Big Data Technology of Ministry of Water Resources Hohai UniversityNanjing 211100China College of Computer and Information Hohai UniversityNanjing 211100China Center of Networked Computing Temple UniversityPhiladelphiaPA 19122-6096U.S.A

Federated learning has emerged as a distributed learning pa.adigm by training at each client and aggregat-ing at a pa.ameter *** heterogeneity hinders stragglers from responding to the server in time with huge com-munication *** client grouping in federated learning can solve the straggler problem,the stochastic selection strategy in client grouping neglects the impa.t of data distribution within each ***,current client grouping ap-proaches make clients suffer unfair pa.ticipa.ion,leading to biased performances for different *** order to guaran-tee the fairness of client pa.ticipa.ion and mitigate biased local performances,we propose a federated dynamic client selec-tion method based on data representativity(FedSDR).FedSDR clusters clients into groups correlated with their own lo-cal computational *** estimate the significance of client datasets,we design a novel data representativity evalua-tion scheme based on local data ***,the two most representative clients in each group are selected to optimize the global ***,the DYNAMIC-SELECT algorithm updates local computational efficiency and data representativity states to regroup clients after periodic average *** on real datasets show that FedS-DR improves client pa.ticipa.ion by 27.4%,37.9%,and 23.3%compa.ed with FedAvg,TiFL,and FedSS,respectively,tak-ing fairness into account in federated *** addition,FedSDR surpa.ses FedAvg,FedGS,and FedMS by 21.32%,20.4%,and 6.90%,respectively,in local test accuracy variance,balancing the performance bias of the global model across clients.

关键词： federated learning fairness computational efficiency data distribution client selection client grouping

1500 V超结功率MOS器件优化与电容特性研究

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电子学报 2024年第7期52卷 2271-2278页

作者：种一宁李珏乔明电子科技大学电子薄膜与集成器件全国重点实验室四川成都611731 电子科技大学广东电子信息工程研究院广东东莞523950 电子科技大学(深圳)高等研究院广东深圳518110

本文利用半超结结构进行高压超结功率金属氧化物半导体(Metal Oxide Semiconductor,MOS)器件的设计,基于Sentaurus TCAD(Technology Computer Aided Design)仿真平台设计超结元胞结构并优化高压超结功率MOS器件的击穿电压与导通电阻,随... 详细信息

本文利用半超结结构进行高压超结功率金属氧化物半导体(Metal Oxide Semiconductor,MOS)器件的设计,基于Sentaurus TCAD(Technology Computer Aided Design)仿真平台设计超结元胞结构并优化高压超结功率MOS器件的击穿电压与导通电阻,随后探究了寄生电容的特性.最后,基于多次外延工艺自主设计出一款器件结构仿真击穿电压1658 V、工艺仿真击穿电压1598 V、比导通电阻值303 mΩ·cm^(2)的高压超结功率MOS器件,与相同耐压值器件相比,比导通电阻值下降约50%.同时探究了超结掺杂浓度与厚度以及电压支持层掺杂浓度与厚度4个主要结构参数对器件寄生电容特性的影响.

关键词：超结VDMOS 元胞击穿电压比导通电阻寄生电容

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Modulation doping of p-type Cu_(12)Sb_(4)S_(13)toward improving thermoelectric performance

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Journal of Materials Science & Technology 2024年第4期171卷 71-79页

作者： Khak Ho Lim Mingquan Li Yu Zhang Yue Wu Qimin Zhou Qingyue Wang Xuan Yang Pingwei Liu Wen-jun Wang Ka Wai Wong Ka Ming Ng Yu Liu Andreu Cabot Institute of Zhejiang University-Quzhou Quzhou 324000China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310007China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Ostia Technologies Limited United Kingdom Depa.tment of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina ICREA Pg.Lluis Companys 23Barcelona 08010Spain Catalonia Energy Research Institute-IREC Sant Adria del BesosBarcelona 08930Spain

The commercial viability of thermoelectric(TE)devices relies heavily on two factors:cost reduction and efficiency *** this study,we first produce p-type Cu_(12)Sb_(4)S_(16-x)(x=0,3,4)using a low-temperature bottom-up approach and demonstrate Cu_(12)Sb_(4)S_(13)to show the best TE performance among the three tested ***,the TE energy conversion efficiency of Cu_(12)Sb_(4)S_(13)is further enhanced by optimizing its electronic band structure through the incorporation of small amounts of *** an optimal Te content of 5 mol%,more than a twofold increase in the TE figure of merit(zT)is *** gain insight into the mechanism of improvement on the transport properties of the mate-rial,we compa.e the interphase transport mechanism by incorporating nanodomains of different metals(Ag and Cu)into the Cu_(12)Sb_(4)S_(13)*** improved electrical conductivity obtained with Cu_(12)Sb_(4)S_(13)-Te nanocomposites is attributed to a charge flooding of the Cu_(12)Sb_(4)S_(13)*** contrast,excessive down-ward band-bending at the interphases of Ag/Cu metal-semiconductor drastically reduces the electrical ***,a weighted mobility(μw)analysis shows a dominant thermal activation of carri-ers in Cu_(12)Sb_(4)S_(13)-Te *** this material,a strong decrease in lattice thermal conductivity is also found,which is associated with a phonon-carrier scattering *** work shows the impor-tance of proper band-engineering in TE nanocomposites to decouple electrical and thermal transport to enhance TE performance,and the efficacy ofμw for electrical and thermal transport analysis.

关键词： Modulation doping Thermoelectric Interphase transport Charge flooding Phonon-carrier scattering