Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis

作     者：Pan Luo Fu-Qiang Gao Wei Sun Jun-You Li Cheng Wang Qing-Yu Zhang Zhi-Zhuo Li Peng Xu Pan Luo;Fu-Qiang Gao;Wei Sun;Jun-You Li;Cheng Wang;Qing-Yu Zhang;Zhi-Zhuo Li;Peng Xu

作者机构：Department of Joint SurgeryHonghui HospitalXi'an Jiaotong UniversityXi'an 710054China Department of OrthopedicsChina-Japan Friendship HospitalBeijing 100029China Department of Orthopaedic Surgery of the Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA School of Mechanical EngineeringSungkyunkwan UniversitySuwon 16419South Korea Department of Orthopaedic SurgeryPeking University Third HospitalPeking UniversityBeijing 100191China Department of OrthopedicsShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China State Key Laboratory of Pharmaceutical BiotechnologyDivision of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2024年第11卷第2期

页      面：287-307页

核心收录：

学科分类：1002[医学-临床医学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0703[理学-化学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82072432) the China-Japan Friendship Hospital Horizontal Project/Spontaneous Research Funding(2022-HX-JC-7) the National High Level Hospital Clinical Research Funding(2022-NHLHCRF-PY-20) the Elite Medical Professionals project of China-Japan Friendship Hospital(ZRJY2021-GG12) 

主　　题：Rheumatoid arthritis Fluorescent probe Imaging Diagnosis Biomarker 

摘      要：Rheumatoid arthritis(RA)is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability,thus adversely affecting locomotion ability and life ***,good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of *** fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo ***,we review the fluorescent probes developed for the detection and imaging of RA biomarkers,namely reactive oxygen/nitrogen species(hypochlorous acid,peroxynitrite,hydroxyl radical,nitroxyl),pH,and cysteine,and address the related challenges and prospects to inspire the design of novel fluorescent probes and the improvement of their performance in RA studies.