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Antitumor Research on Artemisinin and Its Bioactive Derivatives

Natural Products and Bioprospecting 2018年第4期8卷 303-319页

作者： Yunqin Zhang Guowei Xu Shuqun Zhang Dong Wang psaravana prabha Zhili Zuo State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of the Chinese Academy of Sciences Beijing 100049China Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming 650201YunnanChina

Cancer is the leading cause of human death which seriously threatens human *** antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer ***,a variety of target-selective artemisinin-related compounds with high efficiency have been *** researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects,including inhibiting the proliferation of tumor cells,promoting apoptosis,inducing cell cycle arrest,disrupting cancer invasion and metastasis,preventing angiogenesis,mediating the tumor-related signaling pathways,and regulating tumor *** importantly,artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer ***,we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 *** is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.

关键词： Artemisinin Artemisinin derivatives Antitumor Activity Mechanism

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