Antitumor Research on Artemisinin and Its Bioactive Derivatives
作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of the Chinese Academy of SciencesBeijing 100049China Yunnan Key Laboratory of Natural Medicinal ChemistryKunming 650201YunnanChina
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2018年第8卷第4期
页 面：303-319页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by CAS"Light of West China"Program(91 to Z.Z.) the Basic Research Plan of Yunnan Provincial Science and Technology Department(grant number 2014FA042) CAS Strategic biological resources service network(ZSTH-021) the Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No.XDA12030206
主 题：Artemisinin Artemisinin derivatives Antitumor Activity Mechanism
摘 要：Cancer is the leading cause of human death which seriously threatens human *** antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer ***,a variety of target-selective artemisinin-related compounds with high efficiency have been *** researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects,including inhibiting the proliferation of tumor cells,promoting apoptosis,inducing cell cycle arrest,disrupting cancer invasion and metastasis,preventing angiogenesis,mediating the tumor-related signaling pathways,and regulating tumor *** importantly,artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer ***,we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 *** is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.
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