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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

Ultrathin-shell epitaxial Ag@Au core-shell nanowires for high-performance and chemically-stable electronic, optical, and mechanical devices

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Nano Research 2021年第11期14卷 4294-4303页

作者： yangzhi Zhu Sanggon Kim Xuezhi Ma Peter Byrley Ning Yu Qiushi Liu Xiaoming Sun Da Xu Sangshan peng Martin C.Hartel Shiming Zhang Vadim Jucaud Mehmet R.Dokmeci Ali Khademhosseini Ruoxue Yan Department of Chemical and Environmental Engineering Bourns College of EngineeringUniversity of California-RiversideRiversideCA92521USA Terasaki Institute for Biomedical Innovation Los AngelesCA90064USA Department of Electrical and Computer Engineering University of California-RiversideRiversideCA92521USA State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China Department of Bioengineering University of California-Los AngelesLos AngelesCA90095USA Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina Material Science and Engineering Program University of California-RiversideRiversideCA92521USA

Silver nanowires (AgNWs) hold great promise for applications in wearable electronics, flexible solar cells, chemical and biological sensors, photonic/plasmonic circuits, and scanning probe microscopy (SPM) due to their unique plasmonic, mechanical, and electronic properties. However, the lifetime, reliability, and operating conditions of AgNW-based devices are significantly restricted by their poor chemical stability, limiting their commercial potentials. Therefore, it is crucial to create a reliable oxidation barrier on AgNWs that provides long-term chemical stability to various optical, electrical, and mechanical devices while maintaining their high performance. Here we report a room-temperature solution-phase approach to grow an ultra-thin, epitaxial gold coating on AgNWs to effectively shield the Ag surface from environmental oxidation. The Ag@Au core-shell nanowires (Ag@Au NWs) remain stable in air for over six months, under elevated temperature and humidity (80 °C and 100% humidity) for twelve weeks, in physiological buffer solutions for three weeks, and can survive overnight treatment of an oxidative solution (2% H2O2). The Ag@Au core-shell NWs demonstrated comparable performance as pristine AgNWs in various electronic, optical, and mechanical devices, such as transparent mesh electrodes, surface-enhanced Raman spectroscopy (SERS) substrates, plasmonic waveguides, plasmonic nanofocusing probes, and high-aspect-ratio, high-resolution atomic force microscopy (AFM) probes. These Au@Ag core-shell NWs offer a universal solution towards chemically-stable AgNW-based devices without compromising material property or device performance.

关键词： epitaxial growth core-shell nanowire plasmonic waveguides atomic force microscopy(AFM)probe transparent electrode wearable electronics

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废水中重金属离子去除技术的研究及进展

华电技术 2019年第12期41卷 31-36页

作者：刘扬志刘鹏中国华电集团有限公司河南分公司郑州450046 华电郑州机械设计研究院有限公司郑州450046

伴随着工业技术的飞速发展,各种各样的污染物被排放到环境中。其中,重金属因具有富集性而几乎不能发生降解,对环境和人体造成巨大的危害。通过描述国内外应用于废水中重金属离子脱除的相关方法及各类方法的研究现状,以各种脱除方法为框... 详细信息

伴随着工业技术的飞速发展,各种各样的污染物被排放到环境中。其中,重金属因具有富集性而几乎不能发生降解,对环境和人体造成巨大的危害。通过描述国内外应用于废水中重金属离子脱除的相关方法及各类方法的研究现状,以各种脱除方法为框架给出了相应的、有代表性的理论结果。通过描述各类方法的优缺点,介绍了具有巨大发展前景的新型水处理吸附材料,对其在重金属离子脱除领域的相关进展进行总结。

关键词：重金属离子脱除吸附离子交换复合型材料 MOFs 氧化石墨烯

Control of Emotion and Wakefulness by Neurotensinergic Neurons in the Parabrachial Nucleus

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Neuroscience Bulletin 2023年第4期39卷 589-601页

作者： Jingwen Chen Noam Gannot Xingyu Li Rongrong Zhu Chao Zhang peng Li Fundamental Research Center Shanghai Yangzhi Rehabilitation HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai201619China Life Sciences Institute University of MichiganAnn ArborMI48109USA Department of Biologic and Materials Sciences School of DentistryUniversity of MichiganAnn ArborMI 48109USA Department of Molecular and Integrative Physiology School of MedicineUniversity of MichiganAnn ArborMI 48109USA

The parabrachial nucleus(PBN)integrates interoceptive and exteroceptive information to control various behavioral and physiological processes including breathing,emotion,and sleep/wake regulation through the neural circuits that connect to the forebrain and the ***,the precise identity and function of distinct PBN subpopulations are still largely ***,we leveraged molecular characterization,retrograde tracing,optogenetics,chemogenetics,and electrocortical recording approaches to identify a small subpopulation of neurotensin-expressing neurons in the PBN that largely project to the emotional control regions in the forebrain,rather than the *** activation induces freezing and anxiety-like behaviors,which in turn result in *** addition,optogenetic and chemogenetic manipulations of these neurons revealed their function in promoting wakefulness and maintaining sleep *** propose that these neurons comprise a PBN subpopulation with specific gene expression,connectivity,and function,which play essential roles in behavioral and physiological regulation.

关键词： Parabrachial nucleus Neurotensin Anxiety Sleep Wakefulness Breathing Neural circuit Freezing Medulla

计及光热发电特性的光-风-火虚拟电厂双阶段优化调度

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电力系统及其自动化学报 2020年第4期32卷 21-28页

作者：彭院院周任军李斌方绍凤徐健王仰之湖南省清洁能源与智能电网协同创新中心(长沙理工大学) 长沙410004 国网江西省电力有限公司鹰潭供电分公司鹰潭335000

风电机组出力的间歇性和波动性导致风-火虚拟电厂的实际出力偏离其日前申报值。考虑到配置储热装置的光热电站出力可控的特点,将其聚合到风-火虚拟电厂中一同参与申报出力,建立计及光热发电特性的光-风-火虚拟电厂双阶段优化调度模型。... 详细信息

风电机组出力的间歇性和波动性导致风-火虚拟电厂的实际出力偏离其日前申报值。考虑到配置储热装置的光热电站出力可控的特点,将其聚合到风-火虚拟电厂中一同参与申报出力,建立计及光热发电特性的光-风-火虚拟电厂双阶段优化调度模型。以日前调度结果作为虚拟电厂申报出力,在实时调度中参与辅助平衡市场,通过改变光热电站的储热量来修正其输出功率,并采用收缩空间的和声搜索算法求解模型。仿真结果表明,光-风-火虚拟电厂可协调各单元出力,能够有效降低申报偏差,从而获得更高的运行收益,光热电站配置更大的储热容量,能够增强其调节能力,虚拟电厂可获得更高的经济效益。

关键词：光热发电辅助平衡市场光-风-火虚拟电厂双阶段优化调度收缩空间的和声搜索算法

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自制转移带在颈段脊髓损伤患者中的应用

中国实用护理杂志 2019年第32期35卷 2547-2551页

作者：吴爱荣王惠芳施娟彭雪娟韦翠翠陈英上海市养志康复医院(上海市阳光康复中心)脊髓损伤康复科 201601 上海市养志康复医院(上海市阳光康复中心)护理部 201601

目的制作一种体位转移带用于颈段脊髓损伤患者的体位转移,减少和预防因传统方法转移引起的相应护理问题.方法选取病区2017年1-6月收治的44例颈段脊髓损伤患者应用传统方法进行体位转移为对照组,2017年7-12月收治的48例颈段脊髓损伤患者... 详细信息

目的制作一种体位转移带用于颈段脊髓损伤患者的体位转移,减少和预防因传统方法转移引起的相应护理问题.方法选取病区2017年1-6月收治的44例颈段脊髓损伤患者应用传统方法进行体位转移为对照组,2017年7-12月收治的48例颈段脊髓损伤患者应用自制转移带进行体位转移为观察组.结果因转移致皮肤损伤,观察组0例,对照组有4例,2组比较差异有统计学意义(χ^2=1.91,P=0.049);因转移致跌倒,观察组0例,对照组有5例,2组比较差异有统计学意义(χ^2=2.39,P=0.026);减少的照顾者人数,观察组(1.21±0.08)人,对照组(0.86±0.09)人,2组比较差异有统计学意义(t=2.905,P=0.005);观察组照顾人员有46人占95.8%认为转移带方便了对患者实施转移,47人占97.9%认为转移带使用后更安全、更省力,47人占97.9%认为患者出院回家后会继续使用转移带进行转移.结论采用自制转移带方便照顾者对颈段脊髓损伤患者进行体位转移,有效预防了皮肤损伤、跌倒等护理问题的发生,提高了照顾者的照顾质量和照顾体验,值得推广.

关键词：颈段脊髓损伤体位转移康复护理转移带

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工伤康复在工伤认定阶段早期介入的研究

中国医疗保险 2015年第4期 58-60页

作者：王燕翟华冯烨张岩彭佳平上海市养志康复医院上海201619 上海市劳动能力鉴定中心上海200065

工伤康复的早期介入,可提高康复治疗效果、降低伤残程度,并且可缩短康复治疗期限、减少费用支出、优化工伤保险基金投入效益比。上海市劳动能力鉴定中心与上海市养志康复医院联手,在部分区县进行工伤康复早期介入的研究和实践,为我国工... 详细信息

工伤康复的早期介入,可提高康复治疗效果、降低伤残程度,并且可缩短康复治疗期限、减少费用支出、优化工伤保险基金投入效益比。上海市劳动能力鉴定中心与上海市养志康复医院联手,在部分区县进行工伤康复早期介入的研究和实践,为我国工伤康复早期介入工作积累了些许经验,具有一定的参考价值。

关键词：工伤康复工伤认定阶段早期介入

针对性护理干预对颈椎骨折伴高位截瘫患者压力性损伤的预防效果观察

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现代医药卫生 2020年第9期36卷 1284-1286页

作者：彭雪娟熊姗姗陈英张瑞荣吴爱荣同济大学附属养志康复医院(上海市阳光康复中心)康复医学科上海201619

目的探讨针对性护理干预对颈椎骨折伴高位截瘫患者压力性损伤的预防效果。方法选取2017年7月至2018年8月Braden压力性损伤评分低于15分的颈椎骨折伴高位截瘫患者40例作为研究对象。采用随机数字表法将其分为试验组与对照组,每组20例。2... 详细信息

目的探讨针对性护理干预对颈椎骨折伴高位截瘫患者压力性损伤的预防效果。方法选取2017年7月至2018年8月Braden压力性损伤评分低于15分的颈椎骨折伴高位截瘫患者40例作为研究对象。采用随机数字表法将其分为试验组与对照组,每组20例。2组患者均给予常规护理,试验组在此基础上,予以针对性护理干预,干预方法包括系统评估危险因素、扩大监控高危范围、实施针对性护理措施和落实改进护理干预。比较2组患者压力性损伤发生率及对护理工作的满意度。结果试验组患者出院前1周压力性损伤发生率低于对照组,患者及家属对护理工作的满意度高于对照组,差异均有统计学意义(P<0.05)。结论针对性护理干预方法可有效降低颈椎骨折伴高位截瘫患者的压力性损伤发生率,提高患者对护理工作的满意度。

关键词：针对性护理干预颈椎骨折高位截瘫压力性损伤预防效果观察

2022年中国阿尔茨海默病知晓与需求现状调查

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阿尔茨海默病及相关病杂志 2022年第4期5卷 265-277页

作者：徐勇王军王虹峥李坤成王慧芳王晓明汤彬乔立艳李缨李鹏马辛苏州大学公共卫生学院江苏215127 北京交通大学北京100091 北京协和医学院基础学院北京100005 首都医科大学宣武医院北京100053 同济大学附属养志康复医院上海200092 四川川北医学院附属医院四川637002 上海剪爱工艺发展中心上海201824 清华大学附属玉泉医院北京100049 上海脉动医疗器械股份有限公司上海200081 北京安定医院北京100120

目的:为了更加全面了解我国老年性痴呆(阿尔茨海默病)防治工作的现状及发展趋势,更加精准地为防治工作提供政策咨询及对策建议,开展了本次阿尔茨海默病知晓与需求现状调查。对象与方法:通过线上问卷,对18岁以上普通成年居民进行调查,居... 详细信息

目的:为了更加全面了解我国老年性痴呆(阿尔茨海默病)防治工作的现状及发展趋势,更加精准地为防治工作提供政策咨询及对策建议,开展了本次阿尔茨海默病知晓与需求现状调查。对象与方法:通过线上问卷,对18岁以上普通成年居民进行调查,居民来自全国各个省市自治区和港澳台地区,调查总样本为20671人。结果:被调查人群阿尔茨海默病的总知晓率为95.9%,经统计学标化后为91.5%。不同人群对阿尔茨海默病的总知晓率存在一定差异;认为阿尔茨海默病或老年痴呆病可以预防的比例是87.9%;被调查居民觉得居家照护患者遇到的困难最主要表现在精力不够、照护能力不足和缺少专业的失智养老服务机构;患者的最主要的照护者是配偶,占47.9%,对阿尔茨海默病康复治疗内容了解的仅占23.3%;对合理安排患者营养知晓率为39%,在被调查人群中,主动愿意去医院就诊的比例只有12.9%,其中农村居民和低学历居民主动就诊愿望较低。结论:本次调查结果为更加精准地制定阿尔茨海默病防治对策,提供了重要的科学依据。

关键词：调查阿尔茨海默病知晓率需求现状