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Magnetoelectric gradient structures: Properties and applications

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Journal of Advanced Dielectrics 2022年第4期12卷 24-29页

作者： A.O.Nikitin v.A.Kiselev v.A.Misilin Yu v.Kiliba R.v.petrov Institute of Electronic and Informative Systems Novgorod State UniversityNo.41B.St.Petersburgskaya Str.Veliky Novgorod 173003Russia

This paper is devoted to a comprehensive study on a new type of microwave structures named magnetoelectric(ME)gradient *** structures are studied in this paper to understand the possibilities and application principles in feasible *** structure under study was calculated at different values of the applied electric field and different values of the relative per-mittivity of the artificial dielectric *** layered multiferroic structure in inhomogeneous electric and magnetic fields was calculated on the basis of the previously proposed mathematical *** eigenwaves spectrum for several considered cases was the result of the performed *** concept of using ME gradient structures in the design of electronically controlled microwave devices is formed on the basis of the results of a numerical *** of this type will preferably be used in electronically controlled devices for the directional transmission of microwave signals,as it was shown in the theoretical part of the paper.

关键词： Composite structures multiferroics magnetoelectric gradient structures artificial dielectric eigenwave spectrum

Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander v.Romashchenko Dmitrii v.petrovskii Sergey Yu.Trotsky Ksenia N.Morozova Nina B.Illarionova Maria v.Zhukova Elena v.Kiseleva Marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov Ludmila A.Gerlinskaya Mikhail P.Moshkin yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(MRI)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the Mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

Top Limit Characteristics of New Type Cascade PC on the Basis of Homogeneous Semiconductor

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Journal of Energy and Power Engineering 2013年第10期7卷 1892-1897页

作者： yuri D. Arbuzov vladimir M. Evdokimov Olga v. Shepovalova The All-Russian Research Institute for Electrification of Agriculture (GNU vIESH) Moscow 109456 Russia

A new type homogeneous planar PC （photoelectric converter） on the basis of multijunction semiconductor n＋-p-p＋-n＋-p-p＋-...-n＋-p-p＋ structure has been investigated. The entire structure is a cascade PC consisting of a number of elements of the structure--single PCs connected in series and illuminated by light that has consistently passed through the previous semiconductor layers. The theory of converter of both monochromatic and solar radiation has been developed and the limiting values of their photoelectric and power characteristics have been determined, including the optimal thickness and number of single PCs layered on a base PC, their spectral sensitivity, current-voltage characteristics and efficiency. The open-circuit voltage grows practically linearly with the number of elements in the cascade. The top efficiency limit for a certain optimal elements number reaches its maximum that exceeds considerably that of the base PC, especially in the range of low collecting coefficient of charge carriers in the base PC.

关键词： Photoelectric converter multijunction monochromatic and solar radiation photoelectric and power characteristics.

Slipping Phenomenon in Polymeric Fluids Flow between Parallel Planes

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World Journal of Mechanics 2011年第6期1卷 294-298页

作者： yuri A. Altukhov Grigory v. Pyshnograi Ivan G. Pyshnograi 不详

At this article studies of nonlinear viscoelastic fluid with one internal tensor parameter flow between parallel planes under a constant pressure gradient, taking into account the slipping phenomenon on the boundary. Numerically depending found on the components of the stress tensor and the flow velocity of the pressure gradient and the distance to the wall, enabled us to explain the emergence of non-parabolic profile of the flow velocity of the polymeric melt.

关键词： Rheology Linear Polymers Rheological Equation of State Slipping

Modern trends in animal venom research-omics and nanomaterials

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World Journal of Biological Chemistry 2017年第1期8卷 4-12页

作者： yuri N Utkin Laboratory of Molecular Toxinology ShemyakinOvchinnikov Institute of Bioorganic Chemistry117997 MoscowRussia National University of Science and Technology MISiS 119049 MoscowRussia

Animal venom research is a specialized investigation field, in which a number of different methods are used and this array is constantly expanding. Thus, recently emerged omics and nanotechnologies have already been successfully applied to venom research. Animal venoms have been studied for quite a long time. The traditional reductionist approach has been to isolate individual toxins and then study their structure and function. Unfortunately, the characterization of the venom as a whole system and its multiple effects on an entire organism were not possible until recent times. The development of new methods in mass spectrometry and sequencing have allowed such characterizations of venom, encompassing the identification of new toxins present in venoms at extremely low concentrations to changes in metabolism of prey organisms after envenomation. In particular, this type of comprehensive research has become possible due to the development of the various omics technologies: Proteomics, peptidomics, transcriptomics, genomics and metabolomics. As in other research fields, these omics technologies ushered in a revolution for venom studies, which is now entering the era of big data. Nanotechnology is a very new branch of technology and developing at an extremely rapid pace. It has found application in many spheres and has not bypassed the venom studies. Nanomaterials are quite promising in medicine, and most studies combining venoms and nanomaterials are dedicated to medical applications. Conjugates of nanoparticles with venom components have been proposed for use as drugs or diagnostics. For example, nanoparticles conjugated with chlorotoxin- a toxin in scorpion venom, which has been shown to bind specifically to glioma cells- are considered as potential glioma-targeted drugs, and conjugates of neurotoxins with fluorescent semiconductor nanoparticles or quantum dots may be used to detect endogenous targets expressed in live cells. The data on application of omics and nanot

关键词： Animal venom Proteomics Peptidomics Transcriptomics Nanotechnology Genomics Quantum dots Nanoparticles Metabolomics

A Check-List of the Spiders (Araneae) of the Bolshekhekhtsyrski Nature Reserve,Khabarovsk Province,the Russian Far East

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蛛形学报 2007年第1期16卷 37-64页

作者： yuri M.Marusik Andrei v.Tanasevitch Dmitri K.Kurenshchikov Dmitri v.Logunov Institute for Biological Problems of the North FEB RAS Portovaya Str. 18Magadan 68500Russia All-Russian Research Institute for Nature Protection Ministry of the Protection of the Environment and Natural Resources of the Russian FederationMoscowRussia Institute for Aquatic and Ecological Problems Kim-Yu-Chen Str. 65Khabarovsk 680063 The Manchester Museum The University of ManchesterOxford RoadManchester M13 9PLUK.

326 species of spiders belonging to 26 families are recorded from the Bolshekhekhtsyrski State Nature Reserve,of them 70 are new records for the reserve and six are new to the fauna of Russia:Asperthorax borealis Ono et Saito,2001; Cyclosa kumadai Tanikawa,1992; Cyclosa okumae Tanikawa,1992(earlier it was identified as C. argenteoalba Bosenberg et Strand,1906); Haplodrassus taepaikensis Paik,1992; Hypselistes fossilobus Fei et Zhu,1993; and Pachygnatha gaoi Zhu et al.,2003. The name Pronous minutus (S. Saito,1939) is synonymized with Pronoides brunneus Schenkel,1936. The male of H. taepaikensis is illustrated for the first time. Composition of the fauna is briefly discussed; 41% of the recorded species have their ranges confined to the SE Palaearctics. By its species diversity,the reserve's fauna is the second largest local fauna eastward of the Urals. An expected spider diversity of this reserve is likely to be over 400 species.

关键词：蜘蛛俄罗斯新记录新种哈巴罗夫斯克省蛛形目

Animal venom studies: Current benefits and future developments

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World Journal of Biological Chemistry 2015年第2期6卷 28-33页

作者： yuri N Utkin Laboratory of Molecular Toxinology ShemyakinOvchinnikov Institute of Bioorganic Chemistry

Poisonous organisms are represented in many taxa, including kingdom Animalia. During evolution, animals have developed special organs for production and injection of venoms. Animal venoms are complex mixtures, compositions of which depend on species producing venom. The most known and studied poisonous terrestrial animals are snakes, scorpions and spiders. Among marine animals, these are jellyfishes, anemones and cone snails. The toxic substances in the venom ofthese animals are mainly of protein and peptide origin. Recent studies have indicated that the single venom may contain up to several hundred different components producing diverse physiological effects. Bites or stings by certain poisonous species result in severe envenomations leading in some cases to death. This raises the problem of bite treatment. The most effective treatment so far is the application of antivenoms. To enhance the effectiveness of such treatments, the knowledge of venom composition is needed. On the other hand, venoms contain substances with unique biological properties, which can be used both in basic science and in clinical applications. The best example of toxin application in basic science is α-bungarotoxin the discovery of which made a big impact on the studies of nicotinic acetylcholine receptor. Today compositions of venom from many species have already been examined. Based on these data, one can conclude that venoms contain a large number of individual components belonging to a limited number of structural types. Often minor changes in the amino acid sequence give rise to new biological properties. Change in the living conditions of poisonous animals lead to alterations in the composition of venoms resulting in appearance of new toxins. At the same time introduction of new methods of proteomics and genomics lead to discoveries of new compounds, which may serve as research tools or as templates for the development of novel drugs. The application of these sensitive and comprehensiv

关键词： venom Poison Snake Scorpion Spider Toxin

Last decade update for three-finger toxins: Newly emerging structures and biological activities

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World Journal of Biological Chemistry 2019年第1期10卷 17-27页

作者： yuri N Utkin Laboratory of Molecular Toxinology Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Three-finger toxins(TFTs) comprise one of largest families of snake venom toxins. While they are principal to and the most toxic components of the venoms of the Elapidae snake family, their presence has also been detected in the venoms of snakes from other families. The first TFT, α-bungarotoxin, was discovered almost 50 years ago and has since been used widely as a specific marker of the α7 and muscle-type nicotinic acetylcholine receptors. To date, the number of TFT amino acid sequences deposited in the UniProt Knowledgebase free-access database is more than 700, and new members are being added *** structural variations among the TFTs are not numerous, several new structures have been discovered recently; these include the disulfide-bound dimers of TFTs and toxins with nonstandard pairing of disulfide bonds. New types of biological activities have also been demonstrated for the well-known TFTs, and research on this topic has become a hot topic of TFT studies. The classic TFTs α-bungarotoxin and α-cobratoxin, for example, have now been shown to inhibit ionotropic receptors of γ-aminobutyric acid, and some muscarinic toxins have been shown to interact with adrenoceptors. New, unexpected activities have been demonstrated for some TFTs as well, such as toxin interaction with interleukin or insulin receptors and even TFT-activated motility of sperm. This minireview provides a summarization of the data that has emerged in the last decade on the TFTs and their activities.

关键词： Three-finger toxins Snake venom Structure Biological activity

How to stabilize standard perovskite solar cells to withstand operating conditions under an ambient environment for more than 1000 hours using simple and universal encapsulation

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Journal of Energy Chemistry 2023年第3期78卷 246-252,I0008页

作者： Nikolai A.Belich Andrey A.petrov Pavel A.Ivlev Natalia N.Udalova Alla A.Pustovalova Eugene A.Goodilin Alexey B.Tarasov Laboratory of New Materials for Solar Energetics Faculty of Materials ScienceLomonosov Moscow State University119991 MoscowRussia Department of Chemistry Lomonosov Moscow State University119991 MoscowRussia

We introduce a simple and universal scalable encapsulation strategy for perovskite solar cells based on thermal vacuum evaporation of MgF2or MoO3-xcapping layer followed by sealing the device with glass and Uv-curable *** proposed encapsulation method is beneficial to most of the other known encapsulation approaches being fully harmless to perovskite and transporting layers and processible at room *** deposition of the capping layer promotes efficient removal of water,oxygen and organic solvent residuals from the device prior to sealing and could be easily performed using standard equipment for metal electrode *** proposed strategy is transferrable to any lab-scale perovskite solar cell prototypes regardless of their geometry and architecture and results in excellent stability of the devices in ambient air and long operating *** the 1000 hours stability test at ambient air(30%-60% RH),the cells preserved 92.9% of their initial efficiency on average under 1 Sun illumination at constant maximum power point tracking(MPPT,ISOS-L-1) and over 96% under sto rage in the dark(ISOS-D-1),thus evidencing for the high effectiveness of the proposed encapsulation approach.

关键词： Perovskite solar cells Halide perovskites Encapsulation High stability ISOS-L-1