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Computed tomography-based diagnostics might be insufficient in the determination of pancreatic cancer unresectability

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World Journal of Gastrointestinal Surgery 2013年第4期5卷 83-96页

作者： vyacheslav I Egorov Roman v petrov Elena N Solodinina Gregory G Karmazanovsky Natalia S Starostina Natalia A Kuruschkina Department of Surgical Oncology Ostroumov 14th City Hospital Sechenov First State Medical University Department of Surgical Oncology Ostroumov 14th City Hospital Department of Endoscopy Vishnevsky Institute of Surgery Department of Radiology Vishnevsky Institute of Surgery

AIM: To inquire into a question of an overestimation of arterial involvement in patients with pancreatic cancer (PC). METHODS: Radiology data were compared with the findings from 51 standard, 58 extended and 17 total pancreaticoduodenectomies; 9 distal resections with celiac artery (CA) excision; and 28 palliations for PC. The survival of 11 patients with controversial computed tomography (CT) and endoscopic ultrasound data with regard to arterial invasion, after R0/R1 procedures (false-positive CT results, Group A), was compared to survival after eight R2 resections (false-negative CT results, Group B) and after 12 bypass procedures for locally advanced cancer (true-positive CT results, Group C).RESULTS: In all of the cases in group A, operative exploration revealed no arterial invasion, which was predicted by CT. The one-year survival in Group A was 88.9%, and the two-year survival was 26.7%, with a median follow-up of 22 mo. One-year survival was not attained in groups B and C, with a significant difference in survival (P a-b = 0.0029, P b-c = 0.003).CONCLUSION: Arterial encasement on CT does not necessarily indicate arterial invasion. Whenever PC is considered unresectable, endoUS should be used. In patients with controversial CT an EUS data for peripan-creatic arteries involvement radical resection might be possible, providing survival benefits as compared to R2-resections or palliative surgery.

关键词： vascular invasion Cancer Pancreas Management Pancreaticoduodenectomy Distal pancreatectomy Computed tomography Endoscopic ultrasound Arteries Resectability

Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression

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Cellular & Molecular Immunology 2018年第11期15卷 994-997页

作者： Svetlana S.Sakhnevych Inna M.Yasinska Alison M.Bratt Ouafa Benlaouer Isabel Gonçalves Silva Rohanah Hussain Giuliano Siligardi Walter Fiedler Jasmin Wellbrock Bernhard F.Gibbs yuri A.Ushkaryov vadim v.Sumbayev Medway School of Pharmacy Universities of Kent and GreenwichChatham MaritimeUK Beamline B23 Diamond Light SourceDidcotUK Department of Oncology Hematology and Bone Marrow Transplantation with Section PneumologyHubertus Wald University Cancer CenterUniversity Medical Center Hamburg-EppendorfHamburgGermany Department of Medicine Dermatology and AllergologyUniversity of OldenburgOldenburgGermany

The progression of acute myeloid leukemia(AML)—the most severe blood/bone marrow cancer—is determined by the ability of malignant cells to escape host immune ***,the systemic regulatory mechanisms underlying this phenomenon remain largely *** this study,we discovered a fundamental systemic biochemical strategy that allows AML cells to employ physiological systems within the body to survive and escape immune *** found that AML cells use a crucial human adrenal cortex hormone(cortisol)to induce the expression of neuronal receptor latrophilin 1(LPHN1),which facilitates *** receptor interacts with the blood plasma protein fibronectin leucine rich transmembrane protein 3(FLRT3)to cause secretion of the immune suppressor galectin-9,which impairs the anticancer activities of cytotoxic lymphoid cells.

关键词： acute myeloid cortex

HvDC Macrogrid Modeling for Power-flow and Transient Stability Studies in North American Continental-level Interconnections

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CSEE Journal of Power and Energy Systems 2017年第4期3卷 390-398页

作者： Marcelo A.Elizondo Nihal Mohan James O’Brien Qiuhua Huang David Orser Warren Hess Hilary Brown Wenchun Zhu Divya Chandrashekhara yuri v.Makarov Dale Osborn James Feltes Harold Kirkham David Duebner Zhenyu Huang Pacific Northwest National Laboratory RichlandWA 99354USA Midcontinent Independent System Operator EaganMN 55121USA Siemens PTI SchenectadyNY 12305USA

voltage direct current(HvDC)transmission lines are being constructed throughout the world,aided by advancements in power electronics and the potential value to transfer power between distant areas and off-shore *** HvDC lines within and across large AC interconnections could bring about economic benefits such as interregional capacity exchange and transfer of low-cost,distant electric energy directly to load *** addition,network configuration of HvDC lines could result in additional benefits that have not been deeply *** paper describes the modeling process for continentallevel power system interconnections with the addition of multiple HvDC lines configured as a *** models used for study are based on industry-accepted power-flow and dynamic system models for the North American Eastern and Western *** model provides insight on feasibility and initial steady-state and stability tests of the HvDC macrogrid and its interactions with the existing electricity infrastructure,opening the door to analysis of the technical value of such a macrogrid.

关键词： HvDC models HvDC transmission modeling power-flow power system dynamic stability power system planning

Functional Conjugation of the Different Regulatory Responses to the Stress Stimuli in Healthy Human Subjects

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Open Journal of Applied Sciences 2016年第8期6卷 489-500页

作者： yurij G. Sukhovey Andrey v. Koptyug Tatjana A. Fisher Sergey A. petrov Evgenij L. Dotsenko Institute of Clinical Immunology Siberian Division of Russian Academy of Sciences Tyumen Russia Sports Tech Research Centre Mid Sweden University &Ouml stersund Sweden Tyumen Research Centre Siberian Division of Russian Academy of Sciences Tyumen Russia Tyumen State Oil and Gas Institute Tyumen Russia Tyumen State University Tyumen Russia

Present article discusses the physiological mechanisms of the state employees adaptation during active training in temporary groups. It is suggested that adaptive mechanisms to adverse effects may be studied basing on the concept of functional isomorphism of the psychic and immune systems. Adaptive mechanisms were studied through the monitoring of the stress factors’ impact upon the law enforcement officers when training outside the places of permanent deployment. The specific purpose of present study was to evaluate the physiological indicators of the psychic, immune and endocrine systems dynamics at different stages of adaptation of the live organism to a stressful situation, hoping to get better insight into possible relations between psychic and immune domains. Through monitoring of the dynamics of the endocrine and immune responses to the psychic stimuli, it was possible to correlate the stages of the stress onset to the phases of specific immune reactions. Strong correlations between the parameters characterizing activation of the psychic and immune responses support the hypothesis of the presence of “strong cooperation” between psychic and immune domains. It supports earlier hypothesis that we are monitoring different manifestations of the functioning of a complex inseparable psycho-immune meta-system.

关键词： Stress Immune and Psychic Domains Endocrine System Immune Response Stages Functional

Frequency of Juvenile Myoclonic Epilepsy Clinical Phenotypes in Siberia

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World Journal of Neuroscience 2016年第1期6卷 32-36页

作者： Olga S. Shilkina Kirill A. petrov Anna v. Diuzhakova Natalia A. Marueva Natalia A. Shnayder The voyno-Yasenetsky Krasnoyarsk State Medical University of the Health Ministry of Russia Krasnoyarsk Russia The Chita State Medical Academy of the Health Ministry of Russia Chita Russia

Juvenile myoclonic epilepsy (JME) is characterised by myoclonia during awakening, generalised tonic-clonic seizures, typical absences and usually presents for the first time at the age of 12 to 18 years old. This article describes the results of a clinical study into JME phenotypes in patients living in the Siberian Federal District. We have shown that the incidence of JME among males was lower than among females (1:1.9) and JME debut age for males was higher than in those women. Classical phenotype of JME (Type I) was dominant and more common in males compared to females—70.4% vs. 58.5%, respectively. The JME phenotype with worse prognosis in terms of achieving stable clinical remission (Type II) occurred 3.5 times more frequently among female patients compared to male (13.2% vs. 3.7% respectively). The findings resulting from this study give a deeper insight into the diagnosis and prognosis of this form of idiopathic generalised epilepsy in predisposed families.

关键词： Idiopathic Generalised Epilepsy Juvenile Myoclonic Epilepsy JME Janz Syndrome Clinic Phenotype Phenotyping Diagnosis Prognosis

Changes of Reef Community near Ku Lao Cham Islands (South China Sea) after Sangshen Typhoon

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American Journal of Climate Change 2012年第1期1卷 41-47页

作者： yuri Ya. Latypov Nikolai Selin A. v. Zhirmunsky Institute of Marine Biology Far East Branch of Russian Academy of Sciences (FEB RAS) Vladivostok Russia Far Eastern State Natural Marine Biosphere Reserve Vladivostok Russia

Coral reefs of Ku Lao Cham Islands in the Central vietnam were studied over a quarter of a century. It was established that the reefs of these Islands were lost after the Sangshen typhoon and a heavy flood, which happened in 2006. As a result of these natural phenomena a significant part of coral populations was physically destroyed, and a powerful export of clay substances from the nearest vietnamese coast and from the Bung River, flowing into the sea opposite the Islands, causing abundant sedimentation and death of almost all the remaining scleractinian corals. At present, where formerly there were coral reefs, now there is algal-alcyonarian stage of succession of reef communities. This is typical, as a rule, for restoration of reefs after a destructive typhoon effect.

关键词： Sangshen Typhoon Reef Community Change Succession

Recent results from the KEDR detector

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Chinese Physics C 2010年第6期34卷 650-655页

作者： v.v.Anashin v.M.Aulchenko E.M.Baldin A.K.Barladyan A.Yu.Barnyakov M.Yu.Barnyakov S.E.Baru I.v.Bedny O.L.Beloborodova A.E.Blinov v.E.Blinov A.v.Bobrov v.S.Bobrovnikov A.v.Bogomyagkov A.E.Bondar A.R.Buzykaev S.I.Eidelman Yu.M.Glukhovchenko v.v.Gulevich D.v.Gusev S.E.Karnaev S.v.Karpov T.A.Kharlamova v.A.Kiselev S.A.Kononov K.Yu.Kotov E.A.Kravchenko v.F.Kulikov G.Ya.Kurkin E.A.Kuper E.B.Levichev D.A.Maksimov v.M.Malyshev A.L.Maslennikov A.S.Medvedko O.I.Meshkov S.I.Mishnev I.I.Morozov N.Yu.Muchnoi v.v.Neufeld S.A.Nikitin I.B.Nikolaev I.N.Okunev A.P.Onuchin S.B.Oreshkin I.O.Orlov A.A.Osipov S.v.Peleganchuk S.G.Pivovarov P.A.Piminov v.v.petrov A.O.Poluektov I.N.Popkov v.G.Prisekin A.A.Ruban v.K.Sandyrev G.A.Savinov A.G.Shamov D.N.Shatilov B.A.Shwartz E.A.Simonov S.v.Sinyatkin Yu.I.Skovpen A.N.Skrinsky v.v.Smaluk A.v.Sokolov A.M.Sukharev E.v.Starostina A.A.Talyshev v.A.Tayursky v.I.Telnov Yu.A.Tikhonov K.Yu.Todyshev G.M.Tumaikin Yu.v.Usov A.I.vorobiov A.N.Yushkov v.N.Zhilich v.v.Zhulanov A.N.Zhuravlev Budker Institute of Nuclear Physics Novosibirsk State University Novosibirsk State Technical University 20Karl Marx prospectNovosibirsk630092Russia

We report results of experiments performed with the KEDR detector at the vEPP-4M e^＋e^- collider. They include precise measurement of the D^0 and D^± meson masses, determination of the ψ（3770） resonance parameter... 详细信息

关键词： D meson ψ(3770) mass narrow resonances

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各种生产过程最优节能参数的存在性(英文)

宁波大学学报（理工版） 2012年第1期25卷 48-52页

作者： BRATOv v petrov Y v vOLKOv G 圣彼得堡国立大学俄罗斯圣彼得堡198504 俄罗斯科学院力学研究所俄罗斯圣彼得堡198504

研究表明,在诸多生产过程中可以优化输入的断裂能量,使加工能耗最小.以一个简单的中心断裂为例,当加截脉冲具有某种特定形态时,施加到样品上引发破裂的能量可以取一个显著的最小值.研究结果显示,优化各种与断裂有关的生产过程,使得能量... 详细信息

研究表明,在诸多生产过程中可以优化输入的断裂能量,使加工能耗最小.以一个简单的中心断裂为例,当加截脉冲具有某种特定形态时,施加到样品上引发破裂的能量可以取一个显著的最小值.研究结果显示,优化各种与断裂有关的生产过程,使得能量消耗最小是可能的.这种优化的可能应用包括钻孔或岩石粉碎过程,此时能耗成本通常占生产成本的最大部分.上述方法可以预测钻孔或研磨机等的最优参数,从而大大降低生产成本.文章第二部分研究了接触作用条件下引发断裂的能量输入行为.考虑一个球型粒子冲击一个半空间靶的情形,接触导致的应力场可用赫兹解来估计.定义了断裂判据之后,即可确定引发断裂的球粒临界速度及相应的临界动能.该动能的大小依赖于加载的持续时间,并十分明显地存在一个最小值.据此可断定,存在一个动态冲击的能量最优模式.

关键词：节能最优工作模式孕育时间脆性断裂岩石

Gut dysbiosis and body composition in cirrhosis

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World Journal of Hepatology 2022年第6期14卷 1210-1225页

作者： Roman Maslennikov vladimir Ivashkin Aliya Alieva Elena Poluektova Anna Kudryavtseva George Krasnov Maria Zharkova yuri Zharikov Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Scientific Community for Human Microbiome Research Moscow 119435Russia Department of Internal Medicine Сonsultative and Diagnostic Center No.2Moscow City Health DepartmentMoscow 107564Russia Center for Precision Genome Editing and Genetic Technologies for Biomedicine Engelhardt Institute of Molecular BiologyRussian Academy of Sciences119991 MoscowRussia Laboratory of Postgenomic Research Engelhardt Institute of Molecular BiologyRussian Academy of Sciences119991 MoscowRussia Department of Anatomy Sechenov UniversityMoscow 119435Russia

BACKGROUND Gut dysbiosis and changes in body composition(i.e.,a decrease in the proportion of muscle mass and an increase in extracellular fluid)are common in *** To study the relationship between the gut microbiota and body composition in *** This observational study included 46 patients with *** microbiome was assessed using 16S rRNA gene *** bioelectrical impedance analysis was performed to assess body composition in these *** An increase in fat mass and a decrease in body cell mass were noted in 23/46(50.0%)and 15/46(32.6%)patients,*** in the gut microbiome were not independently associated with the fat mass percentage in *** abundance of Bacteroidaceae(P=0.041)and Eggerthella(P=0.001)increased,whereas that of Erysipelatoclostridiaceae(P=0.006),Catenibacterium(P=0.021),Coprococcus(P=0.033),Desulfovibrio(P=0.043),Intestinimonas(P=0.028),and Senegalimassilia(P=0.015)decreased in the gut microbiome of patients with body cell mass *** amount of extracellular fluid increased in 22/46(47.6%)*** abundance(Pvoraceceae(P=0.027),Christensenellaceae(P=0.038),Eggerthellaceae(P=0.047),Erysipelatoclostridiaceae(P=0.015),Erysipelotrichaceae(P=0.003),Oscillospiraceae(P=0.024),Rikenellaceae(P=0.002),Collinsella(P=0.030),Hungatella(P=0.040),Peptococcaceae(P=0.023),Slackia(P=0.008),and Senegalimassilia(P=0.024)abundance decreased in these *** with clinically significant ascites(n=9)had a higher abundance of Proteobacteria(P=0.031)and a lower abundance of Actinobacteria(P=0.019)and Bacteroidetes(P=0.046)than patients without clinically significant ascites(n=37).CONCLUSION Changes in the amount of body cell mass and extracellular fluid are associated with changes in the gut microbiome in cirrhosis patients.

关键词： Dysbiosis Microbiome Microbiota Gut-Liver axis Sarcopenia Malnutrition Cirrhosis