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Biomarkers of Aging: Changes in Circadian Rhythms Related to the Modulation of Metabolic Output

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Biomedical and Environmental Sciences 1991年第1期4卷 182-191页

作者： peter h.duffy ritchie j.feuers Food and Drug Administration Natiomd Center Jbr Toxicological Research JeffersonFood and Drug Administration Natiomd Center Jbr Toxicological Research Jefferson Arkansas 72079 To whom correspondence should be addressedArkansas 72079

Twenty-four hour (circadian) rhythmicity is an important component of biological variability associated with studies relating to biomarkers of aging. Chronobiological testing techniques must be utilized because (1) many variables that are related to the modulation of metabolic output vary dramatically at different times of the day; (2) various experimental variable and treatment groups must be synchronized with environmental cues that control circadian rhythms; and (3) multiple circadian variables may interact together to modulate the rate of aging. The rhythm for physiological factors such as whole animal metabolic output, body temperature, heart rate, urine flow, potassium, etc. were found to be dissociated or altered by the senescence process; behavioral variables such as spontaneous activity, wheel running, feeding and drinking, verbal performance, as well as sleep-wakefulness rhythms, seem to be accurate predictors of biological age. Circadian rhythms for a variety of enzymes of intermediary metabolism which are directly associated with energy metabolism have been well documented. These well-defined rhythms of enzyme activity have also been shown to degenerate with aging. Rhythms tend to lose amplitude as activity falls with age and as a general loss of regulation (especially time of day where maximal activity might be found) of activity across the 24-h span occurs. As with behavioral variables, changes in enzyme rhythms appear to accurately predict aging. Generally speaking, the loss of temporal organization with age, characterized by decreased circadian amplitude, loose internal synchronization, and poor response to external environmental time queues, is associated with poor health states and decreased longevity. Temporal rhythms for whole animal parameters are highly correlated with molecular events, such as regulation of cellular metabolism. DNA repair, and gene expression. Automated data acquisition and process control systems will be required for future C

关键词： Biomarkers of Aging Changes in Circadian Rhythms Related to the Modulation of Metabolic Output

Phytochrome-regulated Gene Expression

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journal of Integrative Plant Biology 2007年第1期49卷 11-20页

作者： peter h. Quail Department of Plant and Microbial Biology University of Cafifomia Berkeley CA 94720 USA U.S. Department of Agriculture/Agriculture Research Service-Plant Gene Expression Center 800 Buchanan Street Albany CA 94710 LISA

Identification of all genes involved in the phytochrome （phy）-medieted responses of plants to their light environment is an important goal in providing an overall understanding of light-regulated growth end development. This article highlights end integrates the central findings of two recent comprehensive studies in Arabidopsis that have identified the genome-wide set of phy-reguleted genes that respond rapidly to red-light signals upon first exposure of dark-grown seedlings, and have tested the functional relevance to normal seedling photomorphogenesis of an Initial subset of these genes. The data：（a） reveal considerable complexity in the channeling of the light signals through the different phy-femily members （phyA to phyE） to responsive genes; （b） identify a diversity of transcription-factor-encoding genes as major early, if not primary, targets of phy signaling, end, therefore, as potentially important regulators in the transcriptional-network hierarchy; and （c） identify auxin-related genes as the dominant class among rapidly-regulated, hormone-related genes. however, reverse-genetic functional profiling of a selected subset of these genes reveals that only a limited fraction are necessary for optimal phy-induced seedling deetioletion.

关键词： expression profiling phytochrome signaling transcriptional networks microarrays reverse genetics functional profiling transcription factors auxin-related genes

Quantitative image analysis of celiac disease

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World journal of Gastroenterology 2015年第9期21卷 2577-2581页

作者： Edward j Ciaccio Govind Bhagat Suzanne K Lewis peter h Green Department of Medicine Celiac Disease CenterColumbia UniversityNew YorkNY 10032United States

We outline the use of quantitative techniques that are currently used for analysis of celiac *** processing techniques can be useful to statistically analyze the pixular data of endoscopic images that is acquired with standard or videocapsule *** is shown how current techniques have evolved to become more useful for gastroenterologists who seek to understand celiac disease and to screen for it in suspected *** directions for focus in the development of methodology for diagnosis and treatment of this disease are *** is evident that there are yet broad areas where there is potential to expand the use of quantitative techniques for improved analysis in suspected or known celiac disease patients.

关键词： Celiac disease Frequency analysis Motility Videoca

Appreciation of a Great Man:Wu Zhengyi(1916-2013)

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Plant Diversity 2016年第6期38卷 262-263页

作者： peter h.Raven Missouri Botanical Garden

Wu Zhengyi was the leading systematic botanist of China during the second half of the 20th *** encyclopedic knowledge of Chinese plants,their medicinal uses,and their distributions was shared through a wide variety of... 详细信息

关键词： Appreciation of a Great Man FRPS

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Effect of coronary artery dynamics on the wall shear stress vector field topological skeleton in fluid–structure interaction analyses

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International journal of Mechanical System Dynamics 2023年第1期3卷 48-57页

作者： harry j.Carpenter Mergen h.Ghayesh Anthony C.Zander peter j.Psaltis School of Electrical and Mechanical Engineering University of AdelaideAdelaideSouth AustraliaAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research Institute(SAHMRI)AdelaideSouth AustraliaAustralia Adelaide Medical School University of AdelaideAdelaideSouth AustraliaAustralia Department of Cardiology Central Adelaide Local Health NetworkAdelaideSouth AustraliaAustralia

In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(CFD)*** one of the most common causes of death globally,coronary artery disease(CAD)is a significant economic burden;however,novel approaches are still needed to improve our ability to predict its *** can include the unique dynamical factors present in the coronary *** investigate the impact of these dynamical factors,we study an idealized artery model with sequential *** transient simulations made use of the hyperelastic artery and lipid constitutive equations,non‐Newtonian blood viscosity,and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary *** compare changes to established metrics of time‐averaged WSS(TAWSS)and the oscillatory shear index(OSI)to changes in the emerging WSS divergence,calculated here in a modified version to handle the deforming mesh of FSI *** suggest that the motion of the artery can impact downstream patterns in both divergence and *** magnitude is also decreased by up to 57%due to motion in some *** divergence patterns varied most significantly between simulations over the systolic period,the time of the largest *** investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.

关键词： computational fluid dynamics divergence fluid–structure interaction topology wall shear stress

Isolation of Microcystins from the Cyanobacterium Planktothrix rubescens Strain No80

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Natural Products and Bioprospecting 2014年第1期4卷 37-45页

作者： Timo h.j.Niedermeyer peter Schmieder Rainer Kurmayer Cyano Biotech Gmbh Magnusstr.1112489 BerlinGermany Interfaculty Institute for Microbiology and Infection Medicine Tubingen Eberhard Karls University TubingenAuf der Morgenstelle 2872076 TubingenGermany Leibniz Institut fur Molekulare Pharmakologie Robert-Rossle-Str.1013125 BerlinGermany Research Institute for Limnology University of InnsbruckMondseestrasse 95310 MondseeAustria

Three minor microcystins have been isolated from a Planktothrix rubescens *** structures have been elucidated by one-and two-dimensional NMR spectroscopy and high-resolution tandem mass spectrometry as the compounds[Asp^(3),(E)-Dhb^(7)]MC-LY(1),[Asp^(3),(E)-Dhb^(7)]MC-htyW(2),and[Asp^(3),(E)-Dhb^(7)]MC-LW(3).The amino acids found at the variable positions 2 and 4 of the microcystin core structure are in accordance with the predicted amino acid substrate activation selectivities of the non-ribosomal peptide synthetases McyA and McyB described earlier for this *** structural microcystin variants produced by this strain were shown to inhibit protein phosphatase 1 in the nanomolar range.

关键词： Planktothrix Cyanobacteria Microcystins Protein phosphatase inhibition

ChARACTERIZATION AND QUANTITATION OF VASOPRESSIN METABOLITES IN RAT BRAIN BY SPECIFIC RADIOIMMUNOASSAY AND hIGh-PRESSURE LIQUID ChROMATOGRAPhY

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Science China Chemistry 1986年第8期29卷 832-843页

作者：王新昌,j.peter h.BURBACh,jEROEN TENhAAF,DAVID DE WIED Department of Biology Nanjing University Rudolf Magnus Institute for Pharmacology Medical Faculty University of Utrecht The netherlands. Rudolf Magnus Institute for Pharmacology Medical Faculty University of Utrecht The netherlands. Rudolf Magnus Institute for Pharmacology Medical Faculty University of Utrecht The netherlands.

The content of endogenons vasopressin (AVP1-9) and its metabolites in rat's various brain areas and pituitary gland was investigated by the combination techniques of high pressure liquid chromatography （hPLC） and radioimmunoassay （RIA）. In addition to the AVP1-9, several compounds with C-terminal AVP immunoreactivity were detected in hypothalamus, hippceampus, amygdala, medulla oblongata and septum. The C-terminal AVP1-9metabolites were virtually absent in the pituitary gland. In view of the highly potent and selective effects oa memory processes of AVP metabolites, some endogenous AVP metabolites in the brain may play an important role in the central nervous system （CNS） function.

关键词： Cyt AV ChARACTERIZATION AND QUANTITATION OF VASOPRESSIN METABOLITES IN RAT BRAIN BY SPECIFIC RADIOIMMUNOASSAY AND hIGh-PRESSURE LIQUID ChROMATOGRAPhY RAT

Plant Conservation in the Future:New Challenges,New Opportunities

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植物分类与资源学报 2011年第1期33卷 1-9页

作者： peter h.RAVEN Missouri Botanical Garden

Throughout the world,plant diversity is being reduced rapidly by the extinction of species and of local differentiated *** presenting possible solutions to this very serious problem I will first briefly describe the factors that have led to the development of China's wealth of biodiversity;then examine the causes of extinction,with an emphasis on the situation in China;and conclude with recommendations on how to most effectively conserve plants in this huge and botanically diverse country.

关键词： Plant diversity Biological richness human impacts Plant conservation in China Strategies for plant conservation

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Non-alcoholic fatty liver disease in irritable bowel syndrome:More than a coincidence?

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World journal of hepatology 2021年第12期13卷 1816-1827页

作者： huw Purssell peter j Whorwell Varinder S Athwal Dipesh h Vasant hepatology Manchester University NHS Foundation TrustManchester M239LTUnited Kingdom Division of Diabetes Endocrinology and GastroenterologyUniversity of ManchesterManchester M239LTUnited Kingdom Neurogastroenterology Unit Wythenshawe HospitalManchester University NHS Foundation TrustManchester M239LTUnited Kingdom Neurogastroenterology Unit Department of GastroenterologyManchester University NHS Foundation TrustWythenshawe HospitalManchester M239LTUnited Kingdom

Irritable bowel syndrome(IBS)and non-alcoholic fatty liver disease(NAFLD)are amongst the most common gastrointestinal and liver conditions encountered in primary and secondary ***,there has been interest in the apparent coincidence of NAFLD in patients with IBS mainly driven by improved understanding of their shared risk factors and *** this paper we summarize the shared risk factors which include;overlapping nutritional and dietary factors as well as shared putative mechanisms of *** include changes in the gut microbiome,gut permeability,immunity,small bowel bacterial overgrowth and bile acid *** paper describes how these shared risk factors and etiological factors may have practical clinical implications for these highly prevalent *** also highlights some of the limitations of current epidemiological data relating to estimates of the overlapping prevalence of the two conditions which have resulted in inconsistent results and,therefore the need for further *** recognition and management of the overlap could potentially have impacts on treatment outcomes,compliance and morbidity of both *** with known IBS who have abnormal liver function tests or significant risk factors for NAFLD should be investigated appropriately for this ***,IBS should be considered in patients with NAFLD and symptoms of abdominal pain associated with defecation,an altered bowel habit and bloating.

关键词： Irritable bowel syndrome Non-alcoholic fatty liver disease Metabolic syndrome Obesity Prevalence Pathophysiology