Non-alcoholic fatty liver disease in irritable bowel syndrome:More than a coincidence?

作     者：Huw Purssell Peter J Whorwell Varinder S Athwal Dipesh H Vasant 

作者机构：HepatologyManchester University NHS Foundation TrustManchester M239LTUnited Kingdom Division of DiabetesEndocrinology and GastroenterologyUniversity of ManchesterManchester M239LTUnited Kingdom Neurogastroenterology UnitWythenshawe HospitalManchester University NHS Foundation TrustManchester M239LTUnited Kingdom Neurogastroenterology UnitDepartment of GastroenterologyManchester University NHS Foundation TrustWythenshawe HospitalManchester M239LTUnited Kingdom 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第12期

页      面：1816-1827页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Irritable bowel syndrome Non-alcoholic fatty liver disease Metabolic syndrome Obesity Prevalence Pathophysiology 

摘      要：Irritable bowel syndrome(IBS)and non-alcoholic fatty liver disease(NAFLD)are amongst the most common gastrointestinal and liver conditions encountered in primary and secondary ***,there has been interest in the apparent coincidence of NAFLD in patients with IBS mainly driven by improved understanding of their shared risk factors and *** this paper we summarize the shared risk factors which include;overlapping nutritional and dietary factors as well as shared putative mechanisms of *** include changes in the gut microbiome,gut permeability,immunity,small bowel bacterial overgrowth and bile acid *** paper describes how these shared risk factors and etiological factors may have practical clinical implications for these highly prevalent *** also highlights some of the limitations of current epidemiological data relating to estimates of the overlapping prevalence of the two conditions which have resulted in inconsistent results and,therefore the need for further *** recognition and management of the overlap could potentially have impacts on treatment outcomes,compliance and morbidity of both *** with known IBS who have abnormal liver function tests or significant risk factors for NAFLD should be investigated appropriately for this ***,IBS should be considered in patients with NAFLD and symptoms of abdominal pain associated with defecation,an altered bowel habit and bloating.