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改良大脑半球离断术治疗儿童Sturge-Weber综合征并发癫痫的疗效分析

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中华神经外科杂志 2024年第9期40卷 891-896页

作者：彭鑫涛丁浩然孙卫进王雄飞周健王梦阳王静李天富栾国明关宇光首都医科大学三博脑科医院神经外科北京100093 首都医科大学三博脑科医院神经内科北京100093

目的探讨改良大脑半球离断术治疗儿童Sturge-Weber综合征(SWS)并发癫痫的手术疗效。方法回顾性分析2009年1月至2020年12月首都医科大学三博脑科医院神经外科采用改良大脑半球离断术治疗的38例SWS并发癫痫患儿的临床资料。术后2年通过门... 详细信息

目的探讨改良大脑半球离断术治疗儿童Sturge-Weber综合征(SWS)并发癫痫的手术疗效。方法回顾性分析2009年1月至2020年12月首都医科大学三博脑科医院神经外科采用改良大脑半球离断术治疗的38例SWS并发癫痫患儿的临床资料。术后2年通过门诊或网络平台随访并分析患儿的手术疗效,包括癫痫预后及认知功能的改善情况。癫痫预后采用国际抗癫痫联盟(ILAE)癫痫预后标准,认知功能评估采用Kelly神经学评分。同时按手术年龄≤1岁、>1~3岁、>3~6岁、>6岁分层比较患儿手术前、后的认知功能评分。结果38例患儿均顺利行改良大脑半球离断术。术后无一例患儿死亡或出现神经功能障碍。术后2年随访时,38例患儿中33例ILAE 1级,2例3级,1例4级,2例5级。认知功能方面,38例患儿术后2年的认知功能评分优于术前[分别为(1.32±0.96)分、(1.79±1.09)分],差异具有统计学意义(配对t=3.17,P=0.003)。38例患儿中,16例术后认知功能较术前改善,19例无变化,3例恶化。手术年龄≤1岁和>1~3岁的患儿术后认知功能评分[(0.90±0.57)分和(1.20±1.01)分]均优于术前[(1.80±1.14)分和(1.73±1.10)分],差异均具有统计学意义(均P3~6岁和>6岁患儿的术前与术后2年认知功能评分的差异均无统计学意义(均P>0.05)。结论改良大脑半球离断术可安全、有效地控制SWS并发药物难治性癫痫的发作,并可在一定程度上改善患儿的认知功能。

关键词： Sturge-Weber综合征耐药性癫痫治疗结果改良大脑半球离断术

Influence of cosmic radiation on lymphocyte micronucleus,serum lipid peroxide and antioxidation capacity in aircrew members

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Chinese Science Bulletin 2002年第8期47卷 647-653页

作者： CHEN Weiru FENG Yingjin LIU Jiangkuang ZHANG Haili GUO Ying ZHANG Yan DUAN Shiying peng xintao SUN Tianping JIA Baoshan ZHAO Junxian LI Hua Department of Aeromedicine Civil Aviation University of ChinaTianjin 300300China College of Medicine Nankai UniversityTianjin 300071China Xinjiang Aviaton Company Urumuqi 830016China

This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphocytes, serum levels of lipid peroxide, superoxide dismutase, and the total antioxidation capacity by chemical colorimetry all increased significantly in aircrew members. There exists a linear relationship between the CBMN and the average annual effective doses of radiation received or the average annual flying hours. With both of them, a trend shows that the serum lipid peroxide levels increase as well. Either the lipid peroxide or CBMN can sensitively reflect the recent changes in flight load. These findings indicate that cosmic radiation impairs the stability of chromosomes and genome, and induces lipid oxidative damage in aircrews; Lymphocyte CBMN and serum lipid peroxide can be used as monitoring indicators in the cosmic radiation protection for aircrew members.

关键词： cosmic radiation aircrew micronucleus lipid peroxide antioxidation capacity.

Bone marrow edema in a postpartum female following ankle sprain: a case report

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World Journal of Emergency Medicine 2024年第4期15卷 325-327页

作者： peng Zhang Junjie Zhang peng Chen Jianjing Lin Jiang Guo Weixuan Liu Zhiwen Luo Qing Wang xintao Zhang Department of Sports Medicine Peking University Shenzhen HospitalShenzhen 518000China Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Orthopaedics Kunshan Hospital of Traditional Chinese MedicineKunshan 215300China

Bone marrow edema(BME)is characterized by an accumulation of interstitial fluid within the bone marrow,the cancellous,hematopoietic compartment within bones.[1]BME is divided into two principal categories:idiopathic or primary BME,with an unknown etiology,and secondary BME,which occurs as a result of an identifiable underlying pathology.[2]Although the prevalence of BME is not limited to specific demographic parameters,it shows a predilection for males or individuals assigned male at birth,predominantly aged between the ages of 30 and 60 years,especially in cases of bone marrow edema syndrome(BMES),a rare idiopathic variant.[3]The etiological spectrum of BME is diverse,including oncological entities(such as acute myeloid leukemia and osteosarcoma),degenerative diseases(such as osteoarthritis),infectious processes(osteomyelitis),ischemic conditions(avascular necrosis),metabolic dysfunctions(osteoporosis),inflammatory disorders(rheumatoid arthritis),and traumatic injuries(such as stress fractures).[1,2]Clinically,BME primarily manifests as localized pain,often accompanied by joint effusion and warmth near the affected *** protocols typically include physical examination,serological assays,bone marrow biopsies,dual-energy X-ray absorptiometry(DEXA)scans,magnetic resonance imaging(MRI),and ultrasonography,with computed tomography(CT)scans and radiographs being less effective.

关键词： edema injuries female

迷走神经刺激术治疗超难治性癫痫持续状态2例

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临床神经外科杂志 2024年第3期21卷 262-266页

作者：彭鑫涛孙卫进马凯强王雄飞周健王梦阳王静李天富栾国明关宇光首都医科大学三博脑科医院神经外科北京100093 首都医科大学三博脑科医院神经内科北京100093 北京市临床医学研究癫痫病重点实验室北京脑重大疾病研究院癫痫研究所

目的探究迷走神经刺激术(VNS)治疗超难治性癫痫持续状态(SRSE)的疗效。方法纳入2例分别于2012年2月28日和2020年6月10日在首都医科大学三博脑科医院行VNS的SRSE患者,分析其临床特征及手术疗效。结果2例患者术中情况良好,病例1于刺激器开... 详细信息

目的探究迷走神经刺激术(VNS)治疗超难治性癫痫持续状态(SRSE)的疗效。方法纳入2例分别于2012年2月28日和2020年6月10日在首都医科大学三博脑科医院行VNS的SRSE患者,分析其临床特征及手术疗效。结果2例患者术中情况良好,病例1于刺激器开机1周后癫痫持续状态(SE)消失,术后7年随访提示未再发生SE且癫痫发作频率减少50%;病例2于刺激器开机1个月后SE消失,术后2年随访提示未再发生SE且癫痫发作频率减少80%。结论VNS是治疗SRSE的安全有效手段。

关键词：超难治性癫痫持续状态迷走神经刺激术疗效

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Time-Periodic Solutions to Quasilinear Hyperbolic Systems on General Networks

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 41-72页

作者： peng QU School of Mathematical Sciences Fudan UniversityShanghai 200433China

For quasilinear hyperbolic systems on general networks with time-periodic boundary-interface conditions with a dissipative structure,the existence and stability of the time-periodic classical solutions are discussed.

关键词： Time-periodic solution Quasilinear hyperbolic system General net-work Classical solution Asymptotic stability

Thermal and mechanical behavior of casting copper alloy wheel during wheel and belt continuous casting process

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China Foundry 2024年第1期21卷 82-90页

作者： Kun Gao Yan peng School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina

To investigate the thermal and mechanical behavior of casting wheel,a two-dimensional thermoelastic-plastic finite element model was used to predict the temperature,stress and distortion distribution of the casting wheel during the wheel and belt continuous casting *** effects of grinding thickness and casting speed on the thermal and mechanical behaviors of the center of the hot face of the casting wheel were discussed in *** each rotation,the casting wheel passes through four different spray *** results show that the temperature distribution of the casting wheel in different spray zones is similar,the temperature of the hot face is the highest and the temperature reaches the peak in the spray zoneⅢ.The stress and distortion depend on the temperature distribution,and the maximum stress and distortion of the hot face are 358.2 MPa and 1.82 mm,*** temperature at the center of the hot face decreases with increasing grinding thickness and increases with increasing casting speed.

关键词： casting wheel finite element model grinding thickness casting speed hot face spray zones

Numerical simulation of fluid flow and free surface fluctuations during wheel and belt casting process

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Journal of Iron and Steel Research International 2024年第5期31卷 1117-1126页

作者： Kun Gao Yan peng National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina

The unstable fluid flow and severe free surface fluctuations in the wheel and belt caster can affect the quality of the cast *** lower level height tends to entrap inclusions in the molten *** the other hand,the higher level height makes the production process more dangerous due to the overflow of high temperature fluid from the mold.A computational model of the molten metal pouring process was *** transient fluid flow and free surface fluctuations behavior were calculated using the three-dimensional large eddy simulation model and the volume of fluid *** results show that the flow velocity of the main jet gradually decreases under the influence of the low kinetic energy fluid in the *** is an obvious oscillation in the tail of the jet,while the flow field is asymmetric in *** jet is closer to the inside radius side due to the Coanda effect,and there is a recirculation zone on the inside radius and the outside radius respectively,according to the 10 s time-averaged *** with the industrial observation and simulation results,the shape of the free surface is a wave that varies with *** addition,the free surface height is lowest and the flow velocity is highest in the region near the jet.

关键词： Fluid flow Free surface Wheel and belt caster Large eddy simulation Volume of fluid method

Two-Stage Online Debiased Lasso Estimation and Inference for High-Dimensional Quantile Regression with Streaming Data

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Journal of Systems Science & Complexity 2024年第3期37卷 1251-1270页

作者： peng Yanjin WANG Lei School of Statistics and Data Science KLMDASRLEBPS and LPMCNankai UniversityTianjin 300071China

In this paper,the authors propose a two-stage online debiased lasso estimation and statistical inference method for high-dimensional quantile regression(QR)models in the presence of streaming *** the first stage,the authors modify the QR score function based on kernel smoothing and obtain the online lasso smoothed QR estimator through iterative *** estimation process only involves the current data batch and specific historical summary statistics,which perfectly accommodates to the special structure of streaming *** the second stage,an online debiasing procedure is carried out to eliminate biases caused by the lasso penalty as well as the accumulative approximation error so that the asymptotic normality of the resulting estimator can be *** authors conduct extensive numerical experiments to evaluate the performance of the proposed *** experiments demonstrate the effectiveness of the proposed method and support the theoretical *** application to the Beijing PM2.5 Dataset is also presented.

关键词： Adaptive tuning asymptotic normality debiased lasso online updating quantile regres-sion

Electronic origin of structural degradation in Li-rich transition metal oxides:The case of Li_(2)MnO_(3)and Li_(2)RuO_(3)

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Journal of Semiconductors 2024年第4期45卷 82-86页

作者： peng Zhang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics andOp toelec-tronic EngineeringShenzhen UniversityShenzhen 518060China

Li_(2)MnO_(3)and Li_(2)RuO_(3)represent two prototype Li-rich transition metal(TM)oxides as high-capacity cathodes for Li-ion batteries,which have similar crystal structures but show quite different cycling ***,based on the first-princi-ples calculations,we systematically studied the electronic structures and defect properties of these two Li-rich cathodes,in order to get more understanding on the structural degradation mechanism in Li-rich TM *** calculations indicated that the structural and cycling stability of Li_(2)MnO_(3)and Li_(2)RuO_(3)depend closely on their electronic structures,especially the energy of their highest occupied electronic states(HOS),as it largely determines the defect properties of these *** Li_(2)MnO_(3)with low-energy HOS,we found that,due to the defect charge transfer mechanism,various defects can form spontaneously in its host structure as Li ions are extracted upon delithiation,which seriously deteriorates its structural and cycling *** for Li_(2)RuO_(3),on the other hand,we identified that the high-energy HOS prevents it from the defect formation upon delithi-ation and thus preserve its cycling *** studies thus illustrated an electronic origin of the structural degradation in Li-rich TM oxides and implied that it is possible to improve their cycling performances by carefully adjusting their TM compo-nents.

关键词： defects Li-ion batteries first-principles calculations