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A core scientific problem in the treatment of central nervous system diseases:newborn neurons

Neural Regeneration Research 2024年第12期19卷 2588-2601页

作者： peng hao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

It has long been asserted that failure to recover from central nervous system diseases is due to the system's intricate structure and the regenerative incapacity of adult *** over recent decades,numerous studies have established that endogenous neurogenesis occurs in the adult central nervous system,including humans'.This has challenged the long-held scientific consensus that the number of adult neurons remains constant,and that new central nervous system neurons cannot be created or ***,we present a comprehensive overview of the alterations and regulatory mechanisms of endogenous neurogenesis following central nervous system injury,and describe novel treatment strategies that to rget endogenous neurogenesis and newborn neurons in the treatment of central nervous system *** nervous system injury frequently results in alterations of endogenous neurogenesis,encompassing the activation,proliferation,ectopic migration,diffe rentiation,and functional integration of endogenous neural stem *** of the unfavorable local microenvironment,most activated neural stem cells diffe rentiate into glial cells rather than ***,the injury-induced endogenous neurogenesis response is inadequate for repairing impaired neural *** have attempted to enhance endogenous neurogenesis using various strategies,including using neurotrophic factors,bioactive materials,and cell reprogramming *** alone or in combination,these therapeutic strategies can promote targeted migration of neural stem cells to an injured area,ensure their survival and diffe rentiation into mature functional neurons,and facilitate their integration into the neural *** can integration re plenish lost neurons after central nervous system injury,by improving the local *** regulating each phase of endogenous neurogenesis,endogenous neural stem cells can be harnessed to promote effective regeneration of newborn ***

关键词： bioactive materials brain trauma endogenous neurogenesis hippocampal dentate gyrus neural stem cells neurotrophic factors newborn neurons spinal cord injury stroke subventricular zone

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PHLDA2 reshapes the immune microenvironment and induces drug resistance in hepatocellular carcinoma

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Oncology Research 2024年第6期32卷 1063-1078页

作者： KUN FENG hao peng QINGpeng LV YEWEI ZHANG Hepatopancreatobiliary Center The Second Affiliated Hospital of Nanjing Medical UniversityNanjing210000China Medical School Southeast UniversityNanjing210000China

Hepatocellular carcinoma(HCC)is a malignancy known for its unfavorable *** dysregulation of the tumor microenvironment(TME)can affect the sensitivity to immunotherapy or chemotherapy,leading to treatment *** elucidation of PHLDA2’s involvement in HCC is imperative,and the clinical value of PHLDA2 is also ***,bioinformatics analysis was performed in multiple cohorts to explore the phenotype and mechanism through which PHLDA2 may affect the progression of ***,the expression and function of PHLDA2 were examined via the qRT-PCR,Western Blot,and MTT *** findings indicate a substantial upregulation of PHLDA2 in HCC,correlated with a poorer *** methylation levels of PHLDA2 were found to be lower in HCC tissues compared to normal liver ***,noteworthy associations were observed between PHLDA2 expression and immune infiltration in *** addition,PHLDA2 upregulation is closely associated with stemness features and immunotherapy or chemotherapy resistance in *** vitro experiments showed that sorafenib or cisplatin significantly up-regulated PHLDA2 mRNA levels,and PHLDA2 knockdown markedly decreased the sensitivity of HCC cells to chemotherapy ***,we found that TGF-βinduced the expression of PHLDA2 in *** GSEA and in vitro experiment indicated that PHLDA2 may promote the HCC progression via activating the AKT signaling *** study revealed the novel role of PHLDA2 as an independent prognostic factor,which plays an essential role in TME remodeling and treatment resistance in HCC.

关键词： HCC Immune infiltration Drug resistance TME PHLDA2

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Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3429-3448页

作者： hao peng Meng Yang Kun Feng Qingpeng Lv Yewei Zhang Medical School Southeast UniversityNanjing 210009China Department of Ultrasound State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of MedicalSciencesPeking Union Medical CollegeBeijing 100730China Hepatopancreatobiliary Center The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210009China

More than 90% of hepatocellular carcinoma(HCC)cases develop in the presence of fibrosis or cirrhosis,making the tumor microenvironment(TME)of HCC distinctive due to the intricate interplay between cancer-associated fibroblasts(CAFs)and cancer stem cells(CSCs),which collectively regulate HCC ***,the mechanisms through which CSCs orchestrate the dynamics of the tumor stroma during HCC development remain *** study unveils a significant upregulation of Sema3C in fibrotic liver,HCC tissues,peripheral blood of HCC patients,as well as sorafenib-resistant tissues and cells,with its overexpression correlating with the acquisition of stemness properties in *** further identify NRP1 and ITGB1 as pivotal functional receptors of Sema3C,activating downstream AKT/Gli1/c-Myc signaling pathways to bolster HCC self-renewal and tumor ***,HCCcells-derived Sema3Cfacilitated extracellular matrix(ECM)contraction and collagen deposition in vivo,while also promoting the proliferation and activation of hepatic stellate cells(HSCs).Mechanistically,Sema3C interacted with NRP1 and ITGB1 in HSCs,activating downstream NF-kB signaling,thereby stimulating the release of IL-6 and upregulating HMGCR expression,consequently enhancing cholesterol synthesis in ***,CAF-secreted TGF-β1 activates AP1 signaling to augment Sema3C expression in HCC cells,establishing a positive feedback loop that accelerates HCC ***,blockade of Sema3C effectively inhibits tumor growth and sensitizes HCC cells to sorafenib in *** sum,our findings spotlight Sema3C as a novel biomarker facilitating the crosstalk between CsCs and stroma during hepatocarcinogenesis,thereby offering a promising avenue for enhancing treatment efficacy and overcoming drug resistance in HCC.

关键词： Sema hepatocellular thereby

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Adaptation analysis and fusion correction method of CMIP6 precipitation simulation data on the Qinghai-Tibetan Plateau

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Journal of Mountain Science 2024年第2期21卷 555-573页

作者： peng hao QIN Dahui WANG Zegen ZHANG Menghan YANG Yanmei YONG Zhiwei School of Civil Engineering and Geomatics Southwest Petroleum UniversityChengdu 610500China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China

In order to obtain more accurate precipitation data and better simulate the precipitation on the Tibetan Plateau,the simulation capability of 14 Coupled Model Intercomparison Project Phase 6(CMIP6)models of historical precipitation(1982-2014)on the Qinghai-Tibetan Plateau was evaluated in this *** indicate that all models exhibit an overestimation of precipitation through the analysis of the Taylor index,temporal and spatial statistical *** correct the overestimation,a fusion correction method combining the Backpropagation Neural Network Correction(BP)and Quantum Mapping(QM)correction,named BQ method,was *** this method,the historical precipitation of each model was corrected in space and time,*** correction results were then analyzed in time,space,and analysis of variance(ANOVA)with those corrected by the BP and QM methods,***,the fusion correction method results for each model were compared with the Climatic Research Unit(CRU)data for significance analysis to obtain the trends of precipitation increase and decrease for each *** results show that the IPSL-CM6A-LR model is relatively good in simulating historical precipitation on the Qinghai-Tibetan Plateau(R=0.7,RSME=0.15)among the uncorrected *** terms of time,the total precipitation corrected by the fusion method has the same interannual trend and the closest precipitation values to the CRU data;In terms of space,the annual average precipitation corrected by the fusion method has the smallest difference with the CRU data,and the total historical annual average precipitation is not significantly different from the CRU data,which is better than BP and ***,the correction effect of the fusion method on the historical precipitation of each model is better than that of the QM and BP *** precipitation in the central and northeastern parts of the plateau shows a significant increasing *** correlation coefficients between monthly

关键词： GCM CMIP6 Precipitation correction BP-QM fusion correction Spatio-temporal characteristics

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Expert Experience and Data-Driven Based Hybrid Fault Diagnosis for High-SpeedWire Rod Finishing Mills

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1827-1847页

作者： Cunsong Wang Ningze Tang Quanling Zhang Lixin Gao Haichen Yin hao peng Institute of Intelligent Manufacturing Nanjing Tech UniversityNanjing210009China Beijing Gaohuahan Intelligent Technology Co. Ltd.Beijing100084China BeijingWavelet Rhythm Technology Co. Ltd.Beijing100020China College of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211816China

The reliable operation of high-speed wire rod finishing mills is crucial in the steel production *** complex system-level equipment,it is difficult for high-speed wire rod finishing mills to realize fault location and real-time *** solve the above problems,an expert experience and data-driven-based hybrid fault diagnosis method for high-speed wire rod finishing mills is proposed in this ***,based on its mechanical structure,time and frequency domain analysis are improved in fault feature *** approach of combining virtual value,peak value with kurtosis value index,is adopted in time domain *** adjustment and side frequency analysis are proposed in frequency domain analysis to obtain accurate component characteristic frequency and its corresponding ***,according to time and frequency domain characteristics,fault location based on expert experience is proposed to get an accurate fault ***,the proposed method is implemented in the equipment intelligent diagnosis *** taking an equipment fault on site,for example,the effectiveness of the proposed method is illustrated in the system.

关键词： High-speed wire rod finishing mills expert experience data-driven fault diagnosis

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Ka-band thin film lithium niobate photonic integrated optoelectronic oscillator

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Photonics Research 2024年第6期12卷 1283-1293页

作者： RUI MA ZIJUN HUANG SHENGQIAN GAO JINGYI WANG XICHEN WANG XIAN ZHANG peng hao X.STEVE YAO XINLUN CAI State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China Photonics Information Innovation Center and Hebei Provincial Center for Optical Sensing College of Physics Science and TechnologyHebei UniversityBaoding 071002China NuVison Photonics Inc.Las VegasNevada 89109USA

Photonics integration of an optoelectronic oscillator(OEO)on a chip is attractive for fabricating low cost,compact,low power consumption,and highly reliable microwave sources,which has been demonstrated recently in silicon on insulator(SOI)and indium phosphide(InP)platforms at X-band around 8 *** we demonstrate the first integration of OEOs on the thin film lithium niobate(TFLN)platform,which has the advantages of lower Vπ,no chirp,wider frequency range,and less sensitivity to *** have successfully realized two different OEOs operating at Ka-band,with phase noises even lower than those of the X-band OEOs on SOI and InP *** is a fixed frequency OEO at 30 GHz realized by integrating a Mach–Zehnder modulator(MZM)with an add-drop microring resonator(MRR),and the other is a tunable frequency OEO at 20–35 GHz realized by integrating a phase modulator(PM)with a notch *** work marks the first step of using TFLN to fabricate integrated OEOs with high frequency,small size,low cost,wide range tunability,and potentially low phase noise.

关键词： optoelectronic modulator resonator

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Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke

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Neural Regeneration Research 2024年第2期19卷 409-415页

作者： Hongmei Duan Shulun Li peng hao Fei hao Wen Zhao Yudan Gao Hui Qiao Yiming Gu Yang Lv Xinjie Bao Kin Chiu Kwok-Fai So Zhaoyang Yang Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Department of Epidemiology and Statistics School of Public Health and ManagementNingxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Department of Physical Education Capital University of Economics and BusinessmBeijingChina Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Psychology State Key Lab of Brain and Cognitive SciencesThe University of Hong KongHong Kong Special Administration RegionChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain ***,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still *** this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in *** gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional *** study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.

关键词： adult endogenous neurogenesis angiogenesis basic fibroblast growth factor-chitosan gel chitosan functional recovery ischemic stroke neural stem cell newborn neuron

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Security of quantum key distribution with virtual mutually unbiased bases

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 13-21页

作者： Hong-Wei Li Chen-peng hao Zhi-Jiang Chen Li Gong Yi-Fei Lu Yang Wang Jia-Ji Li Chun-Mei Zhang Rong Wang Zhen-Qiang Yin Qing-Yu Cai Henan Key Laboratory of Quantum Information and Cryptography SSF IEUZhengzhou 450000China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Department of Physics University of Hong KongHong Kong 999077China Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China School of Information and Communication Engineering Hainan UniversityHaikou 570228China

In a perfect quantum key distribution(QKD)protocol,quantum states should be prepared and measured with mutually unbiased bases(MUBs).However,in a practical QKD system,quantum states are generally prepared and measured with imperfect MUBs using imperfect devices,possibly reducing the secret key rate and transmission *** analyze the security of a QKD system with imperfect MUBs,we propose virtual MUBs to characterize the quantum channel against collective attack,and analyze the corresponding secret key rate under imperfect state preparation and measurement *** generally,we apply the advantage distillation method for analyzing the security of QKD with imperfect MUBs,where the error tolerance and transmission distance can be sharply *** analysis method can be applied to benchmark and standardize a practical QKD system,elucidating the security analysis of different QKD protocols with imperfect devices.

关键词： quantum key distribution mutually unbiased bases advantage distillation

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高置信水平结构逆可靠度分析与优化方法研究进展

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力学学报 2024年第2期56卷 310-326页

作者：郝鹏杨浩冯少军王博工业装备结构分析优化与CAE软件全国重点实验室辽宁大连116024 大连理工大学工程力学系辽宁大连116024

不确定性客观存在于工程结构生产制造以及服役等各环节之中并对结构的承载性能影响显著.特别是对于服役条件苛刻的航空航天承载装备,在设计阶段考虑多源不确定性的影响对于结构安全至关重要.在众多不确定性分析方法中,逆可靠度分析方法... 详细信息

不确定性客观存在于工程结构生产制造以及服役等各环节之中并对结构的承载性能影响显著.特别是对于服役条件苛刻的航空航天承载装备,在设计阶段考虑多源不确定性的影响对于结构安全至关重要.在众多不确定性分析方法中,逆可靠度分析方法在效率和稳健性方面具有一定优势.为此,国内外学者在高置信水平结构逆可靠度分析与优化方法方面开展了大量研究并取得了长足进步,包括自适应迭代控制算法、先进可靠度优化策略与非充分样本下的高置信水平设计方法等.本文首先对国内外逆可靠度分析与优化方法取得的进展进行了系统梳理与总结,特别是逆可靠度分析方法的发展历程以及面临的挑战问题,主要包括强非线性功能函数、多设计点以及低失效概率问题.进一步,针对长期困扰可靠度方法实际应用的小样本问题,重点从结构高置信水平可靠度分析与优化理论角度开展系统介绍,详细论述了小样本诱发的认知不确定性到可靠度置信水平的传播链条.最后,基于现有成果和国家重大前沿需求,重点围绕航天装备可重复使用需求对结构可靠度未来研究方向进行了思考与展望,期望相关研究成果能够进一步助力我国航空航天结构实现高可靠性与极致轻量化设计.

关键词：航空航天结构逆可靠度分析可靠度优化设计置信水平优化设计小样本

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可逆交联聚丁二烯网络的技术进展

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高分子材料科学与工程 2024年第6期40卷 152-162页

作者：郝鹏陈艳君国家知识产权局专利局专利审查协作北京中心北京100160 宁波职业技术学院宁波市高性能石油树脂制备工程与技术重点实验室浙江宁波315800 宁波职业技术学院化学工程学院浙江宁波315800

简介了聚丁二烯的种类、优异性能及重要性,简述了聚丁二烯使用过程中硫化交联制备的含有不可逆交联网络带来的难以回收和资源浪费的问题,设计合成基于可逆交联键的聚丁二烯网络对于发展高弹性、高强度、可回收和其它功能的先进材料具有... 详细信息

简介了聚丁二烯的种类、优异性能及重要性,简述了聚丁二烯使用过程中硫化交联制备的含有不可逆交联网络带来的难以回收和资源浪费的问题,设计合成基于可逆交联键的聚丁二烯网络对于发展高弹性、高强度、可回收和其它功能的先进材料具有重要意义。构筑可逆交联聚丁二烯的关键是在聚丁二烯分子链上引入官能基团,再通过官能基团之间的反应或相互作用构筑可逆交联聚丁二烯网络。根据官能基团在聚丁二烯分子链的位置不同,介绍了基于链端官能化聚丁二烯的可逆交联网络、基于链中官能化聚丁二烯的可逆交联网络和基于链端和链中双重官能化聚丁二烯的可逆交联网络这3种聚丁二烯网络的制备方法和性能。最后提出,引入更多的可逆交联键以及功能基团,拓宽其应用领域是未来的重点研发方向。

关键词：聚丁二烯官能化可逆交联回收

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